Sirt1 and the Mitochondria

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Multiple Wearable Sensors in Parkinson and Huntington Disease Individuals: A Pilot Study in Clinic and at Home

Adams, J., Dinesh, K., Xiong, M., Tarolli, C. G., Sharma, S., Sheth, N., Aranyosi, A. J., Zhu, W. Y., Goldenthal, S. B., Biglan, K., et al. (2017) · Digital Biomarkers · doi:10.1159/000479018 · Cited by 3,190

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging

Kim, A., Kwon, D.-W., Yeom, E., Lee, K., Kwon, K., Yu, K., & Lee, K. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.06.080 · Cited by 7

Catalpol attenuates oxidative stress and promotes autophagy in TNF-α-exposed HAECs by up-regulating AMPK

Zhang, Y., Wang, C., Yang, Q., Jin, Y., Meng, Q., Liu, Q., Dai, Y., Liu, Z., Liu, K., & Sun, H. (2017) · RSC Advances · doi:10.1039/c7ra09085d · Cited by 7

Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis

Li, X., Gao, M., Zhu, S., Yin, L., Zhang, B., Qi, Y., Zhao, Y., Yu, Y., & Xu, L. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.635232 · Cited by 7

Associations of Poly (ADP-Ribose) Polymerase1 abundance in calf skeletal muscle with walking performance in peripheral artery disease

Saini, S. K., Li, L., Peek, C. B., Kosmac, K., Polonsky, T. S., Tian, L., Criqui, M. H., Ferrucci, L., Guralnik, J. M., Kibbe, M. R., et al. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111048 · Cited by 7

Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy

Kumar, J., & Kowluru, R. A. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101925 · Cited by 7

Antifreeze protein type I in the vitrification solution improves the cryopreservation of immature cat oocytes

Leal, G. R., Prellwitz, L., Correia, L. L. R., de Oliveira, T. A., Guimarães, M. P. P., Xavier-Getirana, B. R., Dias, Â. J. B., Batista, R. I. T. P., & Souza‐Fabjan, J. M. G. (2024) · Theriogenology · doi:10.1016/j.theriogenology.2024.08.002 · Cited by 6

Stroke in Pregnancy Brings Epigenetic Changes in Correlation with Affected Mitochondrial Dynamics and Inflammasome Mediated Apoptosis in Rodents

Datta, A., Rahane, D., Bhurle, G., Akundi, S., Mukherjee, U., Dubey, A., Barik, A., Karmarkar, G., Malik, N., Ghosh, B., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039411 · Cited by 6

Mono(2-ethylhexyl) Phthalate Disrupts Mitochondrial Function, Dynamics and Biogenesis in Human Trophoblast Cells at Human Exposure Range Concentrations

Martínez‐Razo, L. D., Rivero-Segura, N. A., Almeida-Aguirre, E. K. P., Mancilla‐Herrera, I., Rincón-Heredia, R., Martínez‐Ibarra, A., & Cerbón, M. (2025) · Toxics · doi:10.3390/toxics13090770 · Cited by 6

The Sirt1 Activator SRT1720 Mitigates Human Monocyte Activation and Improves Outcome During Gram-Negative Pneumosepsis in Mice

Blot, M., Léopold, V., de Beer, R., Florquin, S., Butler, J. M., Veer, C. V. ′., de Vos, A. F., & van der Poll, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199309 · Cited by 6

Aminochalcones Attenuate Neuronal Cell Death under Oxidative Damage via Sirtuin 1 Activity

Apiraksattayakul, S., Pingaew, R., Leechaisit, R., Prachayasittikul, V., Ruankham, W., Songtawee, N., Tantimongcolwat, T., Ruchirawat, S., Prachayasittikul, V., Prachayasittikul, S., et al. (2023) · ACS Omega · doi:10.1021/acsomega.3c03047 · Cited by 6

Cardioprotective properties of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids

Kranrod, J. W., Konkel, A., y Valencia, R. H., Darwesh, A. M., Fischer, R., Schunck, W.-H., & Seubert, J. M. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107372 · Cited by 7

Daily Vinegar Ingestion Improves Depression and Enhances Niacin Metabolism in Overweight Adults: A Randomized Controlled Trial

Barrong, H., Coven, H., Lish, A., Fessler, S. N., Jasbi, P., & Johnston, C. S. (2024) · Nutrients · doi:10.3390/nu16142305 · Cited by 7

Effect of Nicotinamide Riboside Against the Exhaustion of CD8+ T Cells via Alleviating Mitochondrial Dysfunction

Xiao, Y., Pang, N., Ma, S., Gao, M., & Yang, L. (2024) · Nutrients · doi:10.3390/nu16213577 · Cited by 6

Alpha‐Linolenic Acid Supplementation Improves Testosterone Production in an Aged Breeder Rooster Model: Role of Mitochondrial Modulation and SIRT1 Activation

Long, C., Zhi-xian, Z., Willing, B. P., Sheng, X., Wang, X., Xiao, L., & Qi, X. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400522 · Cited by 6

Estrogen Regulates Ca2+ to Promote Mitochondrial Function Through G-Protein-Coupled Estrogen Receptors During Oocyte Maturation

Liu, Q., Li, J., Li, Y.-X., Cheng, M. Y., Zhang, H., & Ma, B. (2024) · Biomolecules · doi:10.3390/biom14111430 · Cited by 6

[Wogonoside alleviates high glucose-induced dysfunction of retinal microvascular endothelial cells and diabetic retinopathy in rats by up-regulating SIRT1].

Shao, X., Yu, J., & Ni, W. (2022) · PubMed Central · doi:10.12122/j.issn.1673-4254.2022.04.02 · Cited by 6

SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis

Dong, C., Li, Z., Wang, X., Zou, D., Duan, H., Zhao, C., Zhou, Q., & Shi, W. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109464 · Cited by 6

Age-related advanced glycation end-product accumulation impairs mitochondrial regulation after vitrification

Ito, J., & Iwata, H. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad070 · Cited by 6

LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway

Bai, Y., Hei, N., Gao, M., Dong, X., Li, M., Jiang, S., & Zhang, L. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.07.009 · Cited by 6

Inter-organ differences in redox imbalance and apoptosis depict metabolic resilience in migratory redheaded buntings

Kumar, A., Bhardwaj, N., Rajaura, S., Afzal, M. F., & Gupta, N. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-71332-3 · Cited by 6

Arsenic Sulfide Nanoformulation Induces Megakaryocytic Differentiation through Histone Deacetylase Inhibition

Jia, M., Wang, T., Xu, S., Liu, J., Wen, T., Meng, J., & Xu, H. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900151 · Cited by 6

The reason for the amelioration of N-methyl-N-nitrosourea- induced retinitis pigmentosa in rats by hydrogen-rich saline

Yan, W., Chen, T., Wang, X., Qi, L., Zhao, G., Yang, G., Ma, Y., Tao, Y., Zhang, L., & Zhang, Z. (2017) · International Journal of Ophthalmology · doi:10.18240/ijo.2017.10.03 · Cited by 6

Postnatal and Juvenile Fluoxetine Treatment Evokes Sex-Specific, Opposing Effects on Mood-Related Behavior, Gene Expression, Mitochondrial Function, and Dendritic Architecture in the Rat Medial Prefrontal Cortex

Ghai, U., Chachra, P., Mendon, S., Janakiraman, B., Fanibunda, S. E., Sarkar, A., Gohil, D., Jayaprasad, A. B., Kukkemane, K., Singh, V. K., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.04.026 · Cited by 7

Biochanin A as a potential agent in the disease therapy via mitochondria-mediated mechanisms

Miao, M.-A., Wu, X.-Q., Yuan, Y., Wang, Y., & Dai, W.-T. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118363 · Cited by 7

Advancements in research on the anti-aging effects and mechanisms of flavonoids in natural products

Li, W., Zhang, L., Xie, X., Shi, X.-F., & Ma, Q. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1637992 · Cited by 5

Wenxin Keli regulates energy metabolism and improves Cx43 via the AMPK/SIRT1/PGC-1α pathway

Cui, X., Lou, L., Nie, B., Zhao, Y., Zhao, J., Yang, D., Wang, Z., Zheng, S., & Wu, A. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1624595 · Cited by 5

ntegrating traditional chinese medicine and modern pharmacology: The role of (curcumin) in cardiovascular health

Wasim, R., Azmi, S., & Ahmad, A. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100706 · Cited by 5

Cannabidiol Protects the Heart From Ischemia–Reperfusion Injury Through SIRT-1/PGC-1α Activation and Nuclear Factor Kappa B Modulation: Experimental Insights

Aksoy, F., Savran, M., Uysal, D., Bağcı, A., İLHAN, İ. İ., İmeci, O. B., Sevük, M. A., Ozmen, O., Tepebaşı, M. Y., & Asci, H. (2026) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001806 · Cited by 5

Resveratrol and the neuroinflammation axis in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and cerebral ischemia

Wang, H., Li, F., Wang, H., Tian, Z., Fan, H., & 时志斌 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1758356 · Cited by 5

The curious case of mitochondrial sirtuin in rewiring breast cancer metabolism: Mr Hyde or Dr Jekyll?

Tharayil, J. S., Kandettu, A., & Chakrabarty, S. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167691 · Cited by 5

Malnutrition Risk in Older Adults: Evaluating the Diagnostic Relevance of Serum Biomarkers: SIRT-1, CCK-8, Melatonin, and Total Antioxidant Capacity (TAC)

Kujawowicz, K., Mirończuk-Chodakowska, I., Cyuńczyk, M., & Witkowska, A. M. (2025) · Nutrients · doi:10.3390/nu17040726 · Cited by 5

Regulation of the NRF2 Transcription Factor Activity by SIRT1-Induced Deacetylation: A Possible SIRT1–NRF2 Feedback Loop

Gureev, A. P., & Krutskikh, E. P. (2025) · Russian Journal of Genetics · doi:10.1134/s1022795424701485 · Cited by 5

Effect of Antioxidant Therapy on Oxidative Stress in Vivo

Pasini, A. M. F., & Cominacini, L. (2021) · Antioxidants · doi:10.3390/antiox10030344 · Cited by 5

Differences in autophagy marker levels at birth in preterm vs. term infants

Künstle, N., Gorlanova, O., Marten, A., Müller, L. L., Sharma, P. K., Röösli, M., Sinues, P., Schär, P., Schürmann, D., Rüttimann, C., et al. (2024) · Pediatric Research · doi:10.1038/s41390-024-03273-6 · Cited by 5

Ways to become old: Role of lifestyle in modulation of the hallmarks of aging

Accardi, G., & Aiello, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822569-1.00009-3 · Cited by 5

Effect of Qingyangshen glycosides on social defeat mice model

Liu, D., Wang, J., Chang, L., Zhu, Q., Jiang, N., Azhar, M., & Zeng, G. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115253 · Cited by 4

Mitochondrial activity is the key to the protective effect of β-Lapachone, a NAD+ booster, in healthy cells against cisplatin cytotoxicity

Lin, S.-Y., Syu, J.-P., Lo, Y., Chau, Y., Don, M., Shy, H.-T., Lai, S.-M., & Kung, H. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154094 · Cited by 4

Effects of the anti-inflammatory drug celecoxib on cell death signaling in human colon cancer

Maruyama, R., Kiyohara, Y., Kudo, Y., & Sugiyama, T. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02399-4 · Cited by 5

Involvement of TGF-β, mTOR, and inflammatory mediators in aging alterations during myxomatous mitral valve disease in a canine model

Grzeczka, A., Graczyk, S., & Kordowitzki, P. (2025) · GeroScience · doi:10.1007/s11357-025-01520-0 · Cited by 6

Neutrophils shape the therapeutic efficacy of sirtuin 1 activity modulators in murine influenza virus infection

Simeonova, L. S., Leseva, M. N., Stoyanov, K., Mai, A., Saso, L., & Dimitrova, P. A. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167915 · Cited by 4

Alpha-asarone relieves nasal inflammation, epithelial barrier damage, and mitochondrial damage in allergic rhinitis by inhibiting mitochondrial ROS via the SIRT1/PGC-1α pathway

Xu, B., Gao, W., Li, H., Cao, X., Chen, X., Dong, N., Wu, L., & Luo, Y. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04338-x · Cited by 4

Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes

Kadam, L., Chan, K., Tawater, E., & Myatt, L. (2025) · Placenta · doi:10.1016/j.placenta.2025.09.019 · Cited by 4

Mechanism-driven multitarget therapeutics for diabetic peripheral neuropathy

Kong, S., Nan, G., Wang, Y., Du, M., Kong, Y., Zhu, L., Shen, X., Li, X., & Dong, C. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.10.053 · Cited by 5

Signaling complexity in diabetic neuropathy: a multitargeted perspective on pathogenesis and therapy

Gupta, T., Singh, T. G., & Singh, R. (2025) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2025.2603983 · Cited by 6

Depression: epigenetics and epitranscriptomic modifications

Banerjee, S., Shrilaxmi, M. S., Banerjee, S., Prajwal, B. G., Smith, C., D’Mello, S. R., & Dastidar, S. G. (2025) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2025.2602171 · Cited by 4

Eicosapentaenoic Acid Attenuates Type 2 Diabetes Mellitus-Related Sarcopenia in Mice and Its Potential Mechanisms

Wu, S.-X., Zhou, M.-Q., Wei, H.-N., Zheng, Y., Wu, Z., Zhao, X.-Y., Zou, Q.-Y., Yang, C.-Y., Tian, A., Yang, Y., et al. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c11649 · Cited by 4

Quercetin enhances skin flap survival via SIRT1-regulated mitophagy promotion and pyroptosis inhibition

Wang, A., Chen, S., Yang, J., Deng, J., Song, W., Xu, P., Pan, H., Chen, K., Bian, Z., Cai, W., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121525 · Cited by 4

Comparison of Transcriptomic Analysis of the Conjunctiva in Glaucoma-Treated Eyes with Dry Eyes and Healthy Controls

Carnero, E., Irigoyen-Bañegil, C., Gutiérrez, I., Extramiana, L., Sabater, A. L., & Moreno‐Montañés, J. (2023) · Biomolecules · doi:10.3390/biom14010030 · Cited by 4

Short-term swimming induces the enhancement of mitochondrial-, survival-, and proliferation-related proteins in the hippocampus of healthy aged mice without affecting behavior

Sousa, R. A. L. D., Magalhães, C. O. D. E., Cruz, P. P., de Oliveira, G. H. B., Prates, J. T. A. C., Ferreira, C. M. D. A., Silva, R. R., & Cassilhas, R. C. (2025) · Sport Sciences for Health · doi:10.1007/s11332-025-01353-6 · Cited by 5

Protective Effect of the SIRT1-Mediated NF-κB Signaling Pathway against Necrotizing Enterocolitis in Neonatal Mice

Zhang, R.-B., Ren, L., Ding, D., Wang, H.-D., Peng, J., & Zheng, K. (2022) · European Journal of Pediatric Surgery · doi:10.1055/s-0042-1758157 · Cited by 4

Alterations in energy balance and the antioxidant system due to heat stress: focus on animal production

Montesinos‐Cruz, V., Parra-Forero, L. Y., & Contreras, A. D. C. G. (2023) · Frontiers in Animal Science · doi:10.3389/fanim.2023.1275290 · Cited by 4

Equisetin inhibits adiposity through AMPK-dependent regulation of brown adipocyte differentiation

Zhong, Q., Wang, X., Wei, R., Liu, F., Alamin, M., Sun, J., & Gui, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25458 · Cited by 4

Unveiling the regulatory role of SIRT1 in the oxidative stress response of bovine mammary cells

Zhang, Y., Liu, J., Yuan, S., Liu, S., Zhang, M., Hu, H., Cao, Y., Hu, G., Fu, S., & Guo, W. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-24936 · Cited by 5

The Changes of Mitochondria during Aging and Regeneration

Li, A., Qin, Y. H., & Gong, G. (2024) · Advanced Biology · doi:10.1002/adbi.202300445 · Cited by 5

Adaptive effects of gestational caloric restriction in the mitochondria of Wistar rats' brain: A DOHaD approach

Stone, V., August, P. M., Crestani, M. S., Saccomori, A. B., Magro, B. M. D., Maurmann, R. M., dos Santos, B. G., Klein, C. P., & Matté, C. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.09.004 · Cited by 5

Bicalutamide Exhibits Potential to Damage Kidney via Destroying Complex I and Affecting Mitochondrial Dynamics

Chen, K., Chen, C.-R., Chen, C.-Y., Peng, C., & Peng, R. Y. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010135 · Cited by 4

Biomarkers for biosensors to monitor space-induced cardiovascular ageing

Rehnberg, E., Quaghebeur, K., Baselet, B., Rajan, N., Shazly, T. M., Moroni, L., Baatout, S., & Tabury, K. (2023) · Frontiers in Sensors · doi:10.3389/fsens.2023.1015403 · Cited by 6

Detecting Embryo Developmental Potential by Single Blastomere RNA-Seq

Nõmm, M., Ivask, M., Pärn, P., Reimann, E., Kõks, S., & Jaakma, Ü. (2023) · Genes · doi:10.3390/genes14030569 · Cited by 4

Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice

Hsu, Y.-J., Lee, M., Fan, H.-Y., & Lo, Y.-C. (2025) · Nutrients · doi:10.3390/nu17193148 · Cited by 3

Targeting mitophagy and ferroptosis: A new direction for the treatment of intervertebral disc degeneration

Zhou, Y., Mei, Y., Wang, H., Hao, P., Song, C., Liu, Z., & Chen, J. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103227 · Cited by 4

Chronic environmental temperature affects protein expression in the eye of adult zebrafish (Danio rerio)

Maffioli, E., Nonnis, S., Scalvini, F. G., Grana, J., Negri, A. L., Frabetti, F., Tedeschi, G., & Toni, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-29745-1 · Cited by 3

SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation

Iniesta‐Cuerda, M., Valentova, I., Moravec, J., Liška, F., Králíčková, M., Krapf, D., & Nevoral, J. (2026) · Biology Direct · doi:10.1186/s13062-025-00710-2 · Cited by 3

Microbiota–mitochondria crosstalk in the gut–brain axis: a missing link in the etiology and treatment of major depressive disorder

Adu, O. M., Chukwu, C. A., Ogunmiluyi, O. E., Aregbesola, O. C., Awonowo, D. O., & Ajenikoko, S. J. (2026) · Exploration of neuroscience · doi:10.37349/en.2026.1006133 · Cited by 3

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy

Atici, A. E., Jena, P. K., de Carvalho, T. T., Ross, B. E., Aubuchon, E. A., Lane, M. E., Gomez, A. C., Lee, Y., Fishbein, M. C., Azer, J., et al. (2026) · Circulation Research · doi:10.1161/circresaha.125.327991 · Cited by 5

Scalp bacterial species influence SIRT1 and TERT expression in keratinocytes

Yamada, A., Watanabe, K., Nishi, Y., Oshiro, M., Katakura, Y., Sakai, K., & Tashiro, Y. (2023) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbad122 · Cited by 3

More than a mutagenic Aflatoxin B1 precursor: The multiple cellular targets of Versicolorin A revealed by global gene expression analysis

Al-Ayoubi, C., Rocher, O., Naylies, C., Lippi, Y., Vignard, J., Puel, S., Puel, O., Oswald, I. P., & Soler, L. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125138 · Cited by 3

Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis

Wang, W., Yuan, G., Li, G., Zhao, T., Chen, Y., & Xu, Y. (2025) · Human & Experimental Toxicology · doi:10.1177/09603271251332251 · Cited by 3

Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation

Zhao, J., Shu, Z., Li, X., Zhang, W., Sun, M., Song, W., Cheng, H., & Shi, S. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02611-9 · Cited by 3

Epigenetic and epitranscriptomic regulation of cardiac metabolism in aging and disease

Liu, J., Yang, M., & Zhou, B. (2025) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2025.06 · Cited by 3

The Role of NAD+ in Anti-Aging Therapies

Huang, T. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.06.001080 · Cited by 3

Chronic Royal Jelly Administration Induced Antidepressant-Like Effects Through Increased Sirtuin1 and Oxidative Phosphorylation Protein Expression in the Amygdala of Mice

Nguyen, T. T., Kambe, Y., & Miyata, A. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200424160153 · Cited by 3

MicroRNA 132-3p Is Upregulated in Laron Syndrome Patients and Controls Longevity Gene Expression

Yaron-Saminsky, D., Nagaraj, K., Sarfstein, R., Laron, Z., Pasmanik‐Chor, M., & Werner, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111861 · Cited by 3

[The role of chondrocyte mitochondrial biogenesis in the pathogenesis of osteoarthritis].

Zhou, S., Si, H., Peng, L., & Shen, B. (2022) · PubMed · doi:10.7507/1002-1892.202109091 · Cited by 3

Protective effect of microorganism biotransformation-produced resveratrol on the high fat diet-induced hyperlipidemia, hepatic steatosis and synaptic impairment in hamsters

Su, C.-H., Wang, H.-L., Tsai, M.-L., Lin, Y.-C., Liao, J., Yen, C., Ting, H.-C., & Yu, C. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.59018 · Cited by 3

Mitochondrial modulators

Naumova, N., Koliada, A. K., Kuzub, N., & Vaiserman, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00012-6 · Cited by 3

Alcoholic Hericium erinaceus mycelia extract induces SIRT-1/ERK-1/2 mediated autophagy to prevent accumulation and spreading of alpha-synuclein and amyloid-beta peptide on the A53T transgenic mice

Lin, Y., Huang, C., Tsai, B. C., Kumar, K. A., Hsieh, D. J., Chiu, P., Chang, Y., Ho, T., Kuo, W., & Ju, D. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105874 · Cited by 4

Polygala fallax Hemsl. ameliorated high glucose-induced podocyte injury by modulating mitochondrial mPTP opening through the SIRT1/PGC-1α pathway

shih-Wei, C., Chen, B., Mao, Y., Xu, Q. L., & Chen, Y. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2392298 · Cited by 3

High glucose potentiates Zika virus induced-astroglial dysfunctions

Thomaz, N. K., Bobermin, L. D., Sesterheim, P., Varela, A. P. M., Fumaco, T., Seady, M., Parmeggiani, B., Leite, M. C., Leipnitz, G., Santi, L., et al. (2024) · Journal of NeuroVirology · doi:10.1007/s13365-024-01238-3 · Cited by 3

NAD+ Boosting Strategies

Rice, J., Lautrup, S., & Fang, E. F. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_4 · Cited by 4

Role and therapeutic considerations of SIRT1 in epilepsy

Zeng, S., Huang, X., Qu, S.-L., & Hu, Q.-P. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.029 · Cited by 5

miRNA Dysregulation of AGE/RAGE Pathway in Metabolic Syndrome: A Novel Analysis Strategy Utilizing miRNA-profiling Data

Bograya, M., Voronova, S. S., Lopatin, M., Vulf, M. A., Тодосенко, Н. М., & Larisa, L. (2025) · Gene Expression · doi:10.14218/ge.2025.00039 · Cited by 3

Efficacy of Dangua Fang on endothelial cells damaged by oxidative stress.

Xianpei, H., Liang, L., Liuqin, Y., & Zhita, W. (2022) · PubMed Central · doi:10.19852/j.cnki.jtcm.20220815.001 · Cited by 3

Effects of intermittent exposure to hypobaric hypoxia and cold on skeletal muscle regeneration: Mitochondrial dynamics, protein oxidation and turnover

Sánchez-Nuño, S., Santocildes, G., Rebull, J., Bardallo, R. G., Farrés, M. G., Viscor, G., Carbonell, T., & Torrella, J. R. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.09.032 · Cited by 2

Promoting mitocytosis via gene-engineered aligned fibers for fascia regeneration

Xu, Y., Saiding, Q., Zhou, X. M., Wang, R., Wang, J., Cui, W., & Chen, X. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113725 · Cited by 2

Enzyme-modified and fermented pea protein (EFPP) containing IQRPVKEL and IENPVKEL attenuate dexamethasone-induced muscle atrophy via FoxO3 signaling in C2C12 myotubes

Kim, H. D., Kim, S. M., Suh, H. J., Kim, B.-Y., Choi, H., & Chang, Y. B. (2025) · Applied Biological Chemistry · doi:10.1186/s13765-025-01010-z · Cited by 3

Administration of heat killed Fructobacillus fructosus OS-1010 attenuates metabolic disease induced by high fat diet in mice

Nakano, Y., Nakamura, R., Tanaka, H., Tokimoto, Y., Masuda, Y., Emoto, N., Nishikawa, K., & Idogaki, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-14312-5 · Cited by 2

A novel cardioprotective mechanism of rosuvastatin: restoring PINK1/parkin-mediated mitophagy via SIRT1/FOXO1 activation in doxorubicin-induced cardiotoxicity

Momen, Y. S., Kandeil, M. A., & Mahmoud, M. O. (2025) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-025-04805-5 · Cited by 2

SIRT1 targeted bioengineered extracellular vesicles chrono-reprogram microglia to reverse non-dipping hypertension - myocardial remodeling and comorbid neuropsychiatric disorders under stress

Zhang, S., Zhao, D., Huang, Y., Chen, M., Wang, F., Yang, S., Wang, C., & Yang, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115542 · Cited by 2

SIRT1–FOXO1 Signaling in Cancer

Abdulkhaliq, A. A., Khan, J., Ajoolabady, A., Praticò, D., Bahijri, S., Tuomilehto, J., Borai, A., Kim, B., Zhou, Y., & Ren, J. T. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70553 · Cited by 2

NAD + in fatty liver disease: mechanistic insights and associated targets

Guo, Y.-X., Wang, Y., Wu, S., Wang, Y., & Liu, X. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10106-7 · Cited by 3

The pivotal role of mitochondria in osteoporosis: From pathogenesis to future therapies

Shi, C., Chen, L., Li, J., Shi, T., Yang, C., & Zhao, L. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102407 · Cited by 2

Research advancements on dietary bioactive compounds ameliorating lipid deposition mechanisms via autophagy regulation

Ji, J., Yu, W., Kou, X., Chen, C., Shao, Y., Li, J., Lv, B., Li, J., & Xue, Z. (2026) · Food & Function · doi:10.1039/d5fo04520g · Cited by 2

FOXO3a-mediated structural and cellular remodeling in liver tissue: Implications for apoptosis and homeostasis

El‐Moaty, H. I. A., Saber, S., Hamad, R. S., Elmorsy, E. A., Farrag, A. A. M., Cavalu, S. D., Eissa, H., El-kott, A. F., Negm, S., AlShehri, M. A., et al. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103375 · Cited by 2

Pharmacological potential of Chinese botanical drugs in managing chronic kidney disease by targeting mitochondrial quality control

Liu, H., huang, S., Chen, S., Liang, S., Huang, M., Li, S., Xu, Y., & Xie, B. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1725842 · Cited by 3

Physical exercise therapy as an anti-aging strategy for osteosarcopenia: a narrative review

Liu, T. T., Zhang, P., Dong, W. T., Gong, Y. L., Fang, Z. J., Li, N., & Ma, X. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1791384 · Cited by 2

Glucose, glycolysis, and neurodegenerative disorders

Coelho, P., & Rego, A. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91704-9.00012-4 · Cited by 2

Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing

Suga, N., Ikeda, Y., Yoshikawa, S., & Matsuda, S. (2023) · Exploration of Medicine · doi:10.37349/emed.2023.00180 · Cited by 2

Sex hormones in neuroprotection and neurodegeneration

Heidari, R., Ommati, M. M., & Retana‐Márquez, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00061-0 · Cited by 2

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047

The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis

Gurd, B. J., Yoshida, Y., Lally, J., Holloway, G. P., & Bonen, A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.168096 · Cited by 94

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

Brenmoehl, J., & Hoeflich, A. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.04.002 · Cited by 248

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

Cruzat, V. F. (2022) · Figshare · doi:10.25905/21555243

Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse

Chabi, B., Adhihetty, P. J., O′Leary, M. F. N., Menzies, K. J., & Hood, D. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91451.2008 · Cited by 64