Cited by 740Sirtuins and Resveratrol in MedicineAdipose Tissue and MetabolismAutophagy in Disease and Therapy

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Sirt1 and the Mitochondria

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Luen Tang, Bor·2016·Molecules and Cells

DOI 10.14348/molcells.2016.2318PMC PMC4757807

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Abstract

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1α (PGC-1α) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1's role in caloric restriction and impacts on longevity. The notion of Sirt1's regulation of PGC-1α activity and its role in mitochondrial biogenesis has, however, been controversial. Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy. I discuss here evidences for Sirt1's regulation of mitochondrial biogenesis and turnover, in relation to PGC-1α deacetylation and various aspects of cellular physiology and disease.

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Authors: Luen Tang, B.
Venue: Molecules and Cells
Publisher: Elsevier BV
Published: 2016-02
Volume: 39
Issue: 2
Pages: 87-95
ISSN: 0219-1032 (ISSN-L)
1016-8478
DOI: 10.14348/molcells.2016.2318
PMC: PMC4757807
OpenAlex: W2280212630
Cited by: 740
References: 135
Citations by year: 2026: 71 · 2025: 92 · 2024: 110 · 2023: 96 · 2022: 92 · 2021: 99 · 2020: 87 · 2019: 39 · 2018: 26 · 2017: 21 · 2016: 6
FWCI: 3.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-sa/3.0/ (vor, 1 d)
Locations: Molecules and Cells (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: SIRT1, sirtuins, class III histone deacetylase, PGC-1α, mitochondrial biogenesis, mitophagy, mitochondrial turnover, caloric restriction, longevity, healthspan, metabolic control
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Organelle Biogenesis, Gene Expression Regulation, Humans, Longevity, Mitochondria, Transcription Factors, Signal Transduction, Caloric Restriction, AMP-Activated Protein Kinases, Sirtuin 1, Mitophagy

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