Sirt1 and the Mitochondria

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Multiple Wearable Sensors in Parkinson and Huntington Disease Individuals: A Pilot Study in Clinic and at Home

Adams, J., Dinesh, K., Xiong, M., Tarolli, C. G., Sharma, S., Sheth, N., Aranyosi, A. J., Zhu, W. Y., Goldenthal, S. B., Biglan, K., et al. (2017) · Digital Biomarkers · doi:10.1159/000479018 · Cited by 3,190

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

Rhizoma Dioscoreae Nipponicae targets SIRT1 to regulate p38 MAPK and eosinophils mitophagy in asthma

Hong, H., Li, M., Xue, S., & Wang, W. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103599

Ocular surface and systemic responses to repeated carbon black exposure across different durations in a rat model

Kim, W., Kang, B., Piao, J., Jin, Y., Kim, D. H., & Song, J. S. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128346

Mitochondrial Dysfunction in MASLD: Evidence in Dietary Models and Potential Therapeutic Interventions

Villaseñor-Tapia, E. C., Mendieta-Condado, E., Curiel-Pedraza, D. A., Reza-Zaldívar, E. E., & Márquez-Aguirre, A. (2026) · Biochemistry Research International · doi:10.1155/bri/6641383

Galangin mitigates polystyrene microplastic-induced hepatotoxicity: modulation of mitochondrial biogenesis, NLRP3 inflammasome, and intrinsic apoptotic signaling

Bakhsh, A., Alanazi, S., Althobaiti, M. M., Alsufyani, S. E., ALI, M. A. M., Chaudhary, A. A., Almutairi, S., Abdelazeem, A. H., & Salama, S. A. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12065-6

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolismPreprint

Deng, F., Yang, R., Niu, J., Wang, M., Liu, Y., Li, X., Gao, Z., Yang, L., Liu, H., Yang, Y. Q., et al. (2026) · eLife · doi:10.7554/elife.111498

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolismPreprint

Deng, F., Yang, R., Li, X., Niu, J., Gao, Z., Wang, M., Liu, Y., Yang, L., Liu, H., Yang, Y. Q., et al. (2026) · eLife · doi:10.7554/elife.111498.1

Establishing a direct interaction between the 19,20-EDP analog SA-22 and SIRT3: impact on cardiac mitochondrial homeostasis

Kranrod, J. W., y Valencia, R. H., Heidari, M., Ibrahim, K. M., Adebesin, A. M., Munnuri, S., Falck, J. R., & Seubert, J. M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1805965

Embryo developmental and morphokinetic patterns in the domestic cat (Felis catus): associations with maternal age and SRT1720 supplementation during oocyte in vitro maturation

Meco, M., Payan‐Carreira, R., Ochota, M., & Niżański, W. (2026) · Theriogenology · doi:10.1016/j.theriogenology.2026.118026

Cyclin C nuclear release and mitochondrial dysfunction define molecular signatures of MED13L SyndromePreprint

Campbell, A. N., Jung, K. N., Doyle, S. J., Lebayle, E., Corneo, B., Feng, J., Ricupero, C. L., Bain, J., & Strich, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.729270

7,8-Dihydroxyflavone enhances recombinant proteins expression in CHO cells by modulating SIRT1 signalling to improve mitochondrial respiratory capacity and redox homeostasis

Sun, M., Mi, C., Dong, T., Xue, J., Lin, Y., Geng, S., Sun, Q., Chang, X., & Wang, T. (2026) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2026.06.009

Manipulating CD38 ectoenzymatic activity revitalizes regulatory T cells via deacetylase Sirt-1 in immune thrombocytopenia

Zhu, M., Wang, H. X., Xu, Y., Li, Y., Wang, W., Wang, L., Wang, R., Zhang, P., Wang, R., Cao, J., et al. (2026) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2026.06.019

Resveratrol and its effects on healthy aging

Mendoza-Núñez, V. M., García-Martínez, B. I., & Ruíz-Ramos, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29192-0.00036-4

Injectable Mn–Icariin-functionalized silk fibroin/PEG hydrogels restore redox homeostasis and reprogram osteogenic–angiogenic coupling for diabetic bone regeneration

Huang, Y., Zhang, X., Zhou, X. Y., Qin, L., Lin, Z., Yao, B., Gao, Z., He, H., Huang, J., Peng, J., et al. (2026) · Regenerative Biomaterials · doi:10.1093/rb/rbag143

A novel berberine derivative B12 exhibits superior anti-obesity effects via targeting brown and white adipocyte dynamics

Zhang, W., Feng, Y., Gao, C., Zhong, L., Wang, W., Xu, M., Zheng, B., Zhang, Y., Wang, S., Yi, S., et al. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02153-9

Occurrence of halonaphthoquinone disinfection byproducts in Shanghai’s drinking water and the hepatotoxic effects on lipid accumulation

Tian, Z., Diao, Y., Hu, J. B., Li, Y., Yu, X., & Wang, X. J. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1831866

Mangiferin attenuates aflatoxin B1–Induced ferroptosis by activating of Nrf2-Signaling and mitochondrial biogenesis in human ovarian granulosa cells

Ruan, C., Tsai, H.-Y., Hung, C., & Lin, M. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116271

Exercise and cold exposure as dual physiological stressors in MASLD: AMPK-mediated metabolic adaptation and interorgan crosstalk

Wang, S., Gao, Y., Wang, Y., Wang, J., & Liu, Y. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1865475

SLC25A12 mitigates mitochondrial dysfunction in myoblast senescence, and alleviates cuproptosis-related changes under copper stress

Wang, S., Wu, W. H., 尹华, Chen, Q., Zhang, L., & He, W. (2026) · Biology Direct · doi:10.1186/s13062-026-00918-w

Gut-derived metabolites and mitochondrial homeostasis in heart failure: mechanistic links and translational perspectives

Chen, D., Su, M., Xie, Z., Xu, S., & Luo, S. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1917012

Ginsenoside Re Attenuates D-Galactose-Induced Aging-like Oxidative Stress in Cultured Bovine Oocytes via Activation of the SIRT1/Nrf2 Signaling Pathway

Hyeon, S.-Y., Perera, C. D., Lee, S.-E., Kim, J.-H., Yoon, S., Kang, Y. J., Park, S., Idrees, M., & Kong, I. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177569

Short-chain fatty acids as key mediators of the microbiota–gut–brain axis in chronic cerebral hypoperfusion: mechanisms and therapeutics

Si, J., Wang, P., Li, Z., Hao, J., Wang, J., & Zhang, L. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01616-z

Cyclin C nuclear release and mitochondrial dysfunction define molecular signatures of MED13L syndrome

Campbell, A. N., Jung, K. N., Doyle, S. J., Lebayle, E., Corneo, B., Feng, J., Ricupero, C. L., Bain, J., & Strich, R. (2026) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2026.100670

Natural Small Molecules Targeting Mitochondrial Quality Control for the Treatment of Metabolic Diseases: Mechanisms, Novel Formulations, and Translational Perspectives

Zhao, C., Gao, Y., Zhou, T., Sun, L., & Qu, Q. (2026) · Pharmaceuticals · doi:10.3390/ph19091402

SIRT1 in Senescence: Mitochondria and Immune Crosstalk

Namkaew, J., Kongpracha, P., Mahawan, T., & Jaroonwitchawan, T. (2026) · Biology · doi:10.3390/biology15181573

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolismPreprint

Deng, F., Yang, R., Li, X., Niu, J., Gao, Z., Wang, M., Liu, Y., Yang, L., Liu, H., Yang, Y., et al. (2026) · eLife · doi:10.7554/elife.111498.2

Urolithin A Enhances the Development of Porcine Parthenogenetic Embryos by Promoting Mitochondrial Function and Quantity Through the SIRT1/PGC-1 α Signaling Pathway

Choi, S., Cha, D., Lee, Y., Kim, G., Lee, Y., Cho, J., & Lee, S. (2026) · Microscopy and Microanalysis · doi:10.1093/mam/ozag100 · Cited by 1

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential

Duan, J., Liu, J., Meng, Q., Liu, J., Yang, S., Zhou, F., & Cao, J. (2026) · The FASEB Journal · doi:10.1096/fj.202602361rr

Lysosomal dysfunction in vascular smooth muscle cells: Mechanisms and therapeutic targets in vascular disease

Zhu, Q., Du, W., Wang, C., Corriere, M. A., & Fan, Y. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.121901

Association between sirtuin 1 and markers of oxidative stress in master athletes

Maciel, L. A., Leite, P. L. D. A., Aguiar, S. D. S., Sousa, C. V., Neves, R. V. P., de Carvalho, J. V. S., Pereira, M. V. A., Rosa, T. D. S., Patricio, R. C. B., Neto, I. V. D. S., et al. (2026) · European Journal of Applied Physiology · doi:10.1007/s00421-026-06369-5

“Improving the beneficial effects of HDAC8 inhibition by simultaneously activation of SIRT1 in a zebrafish model of Duchenne muscular dystrophy

Carbone, S., Brix, A., Lociuro, L., Belleri, L., Gjana, O., Cannone, E., Bonusi, S., Schiavone, M., Marozzi, A., Bene, F. D., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108477

Novel applications of SIRT1 in Chronic Kidney Disease

Han, Y., Wang, Q., Pan, X., & Lijuan, D. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1922310

Microplastics and Nanoplastics and Their Effects on Reproductive Health: Potential Risks and Mechanisms

Gong, P., Jing, X., Han, S., Guo, J., Wang, J., Li, N., Long, H., & Yang, W. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70434

Exploring the potential targets and possible mechanisms of Shenqi Fuzheng Injection in the treatment of cancer-associated muscle wasting based on network pharmacology

Liu, C., Cheng, L., Ye, W., & Zhang, L. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1876819

Human colostrum extracellular vesicles as natural nanocarriers for promoting MC3T3-E1 cell proliferation and fracture healing via the AMPK-SIRT1-PGC1α pathway

Xu, S., Zhou, X., Meng, Z., Yao, Y., Chen, Y., Liu, Q., Jin, B., Zhou, H., Zhou, D., Gan, Q., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.182564

SIRT1 alleviates hypoxia-induced mitochondrial dysfunction and scleral remodeling in scleral fibroblasts by regulating AMPK via FOXO1

Hua, Z., Zhu, Q., Li, X., Zhou, G., Chen, L., Yin, J., Xu, X., Yang, J., & Zhang, L. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112941

Mesenchymal stem cells in diabetic kidney disease: Potential regulatory mechanisms and related signaling pathways of mesenchymal stem cells

Luo, L., Deng, Y., Sun, Y., Li, Z., Zhang, Y., Liu, H., Ding, J., Zhi, Y., Yan, Z., & Yuan, J. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004298

Sirtuin-1 in Hypertension: Linking Oxidative Stress and Mitochondrial Dysfunction to Vascular Aging and Therapeutic Potential

Budziak, S., Kloza, M., Baranowski, P., Antoniak, O., Saiyara, A., Żarczyńska-Buchowiecka, M., Hellmann, M., Kutryb-Zając, B. A., & Baranowska‐Kuczko, M. (2026) · Antioxidants · doi:10.3390/antiox15101353

BindingDB Entry 50021577: SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of 4-butyl-polyhydroxybenzophenone compounds against NAFLD.

BindingDB (2025) · UC San Diego · doi:10.7270/q2z03dsq

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047

The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis

Gurd, B. J., Yoshida, Y., Lally, J., Holloway, G. P., & Bonen, A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.168096 · Cited by 94

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

Brenmoehl, J., & Hoeflich, A. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.04.002 · Cited by 248

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

Cruzat, V. F. (2022) · Figshare · doi:10.25905/21555243

Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse

Chabi, B., Adhihetty, P. J., O′Leary, M. F. N., Menzies, K. J., & Hood, D. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91451.2008 · Cited by 64