Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats
Open accessAbstract
Astaxanthin is a carotenoid pigment and has been shown to be an effective inhibitor of oxidative damage. We tested the hypothesis that astaxanthin intake would attenuate immobilization-induced muscle atrophy in rats. Male Wistar rats (14-week old) were fed for 24 days with either astaxanthin or placebo diet. After 14 days of each experimental diet intake, the hindlimb muscles of one leg were immobilized in plantar flexion position using a plaster cast. Following 10 days of immobilization, both the atrophic and the contralateral plantaris muscles were removed and analyzed to determine the level of muscle atrophy along with measurement of the protein levels of CuZn-superoxide dismutase (CuZn-SOD) and selected proteases. Compared with placebo diet animals, the degree of muscle atrophy in response to immobilization was significantly reduced in astaxanthin diet animals. Further, astaxanthin supplementation significantly prevented the immobilization-induced increase in the expression of CuZn-SOD, cathepsin L, calpain, and ubiquitin in the atrophied muscle. These results support the postulate that dietary astaxanthin intake attenuates the rate of disuse muscle atrophy by inhibiting oxidative stress and proteolysis via three major proteolytic pathways.
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Dietary astaxanthin intake attenuates immobilization-induced muscle atrophy in Wistar rats by inhibiting oxidative stress and proteolysis via lysosomal proteases, calpains, and ubiquitin-proteasome system.
“Dietary astaxanthin intake attenuates muscle atrophy caused by immobilization in Wistar mice rats by inhibiting oxidative stress and proteolysis via three major proteolytic pathways, including lysosomal proteases, calpains, and the ubiquitin–proteasome system [102].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [102]
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- Authors
- Shibaguchi, T., Yamaguchi, Y., Miyaji, N., Yoshihara, T., Naito, H., Goto, K., Ohmori, D., Yoshioka, T., & Sugiura, T.
- Affiliations
- Frontier Science and Social Co-creation Initiative, Kanazawa University (JP)
- Yamaguchi University (JP)
- Toyo Koso Kagaku Co. Ltd. Urayasu City Chiba Japan
- Juntendo University (JP)
- Graduate School of Health and Sports Science Juntendo University Inzai City Chiba Japan
- Toyohashi SOZO University (JP)
- Hirosaki Gakuin University (JP)
- Corresponding author
- Sugiura, Takao
- Venue
- Physiological Reports
- Publisher
- Wiley
- Published
- 2016-08
- Volume
- 4
- Issue
- 15
- ISSN
- 2051-817X (ISSN-L)
- PMC
- PMC4985550
- OpenAlex
- W2481215024
- Cited by
- 46
- References
- 39
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 1
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Physiological Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- astaxanthin, muscle atrophy, immobilization, disuse atrophy, oxidative stress, proteolysis, Cu/Zn superoxide dismutase, cathepsin L, calpain, ubiquitin, plantaris muscle, carotenoid supplementation, hindlimb muscles
- MeSH terms
- Animals, Antioxidants, Male, Muscular Atrophy, Restraint, Physical, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Xanthophylls, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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