Cited by 625Lipid metabolism and disordersLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 74 of the 77 references it cites were found in a registry or an index.

Hypertriglyceridemia: its etiology, effects and treatment

Open access

Yuan, G., Al-Shali, K. Z., Hegele, R. A.·2007·Canadian Medical Association Journal

DOI 10.1503/cmaj.060963PMC PMC1839776

Open this paper in CoChat — free account Open PDF

Abstract

Elevated plasma triglyceride concentration is a common biochemical finding, but the evidence for the benefit of treating this lipid disturbance remains less robust than that for treating elevated low-density lipoprotein-cholesterol. Part of the difficulty in the provision of specific recommendations has been the frequent coexistence of elevated triglycerides with other conditions that affect cardiovascular disease risk, such as depressed high-density lipoprotein-cholesterol, obesity, metabolic syndrome, proinflammatory and prothrombotic biomarkers, and type 2 diabetes. Recent investigations of outcomes of cardiovascular disease when medications are used to reduce triglyceride levels suggest that, although a net benefit probably exists, both relative and absolute risk reductions seem underwhelming when compared with the benefit of reducing low-density lipoprotein-cholesterol levels with treatment. However, the totality of evidence suggests that elevated triglyceride levels likely contribute independently to increased risk of cardiovascular disease, although there is no consensus about appropriate target levels. Furthermore, severe hypertriglyceridemia is associated with an increased risk of acute pancreatitis, irrespective of its effect on risk of cardiovascular disease. We review the causes and classification of elevated triglyceride levels, the clinical manifestations of primary hypertriglyceridemia and the management of patients with elevated triglyceride levels.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1503/cmaj.060963

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,772
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881 · cited 2×
“The complex mechanism of action of fibrates includes modulation of the activity of peroxisome proliferator–activated receptor-α in the liver, with reduced hepatic secretion of VLDL and increased lipolysis of plasma triglycerides.37 Fibrates reduce the quantity of small, dense LDL particles and increase HDL-C.38 Fibrat…”
Background
Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol
Rubins, H. B., Robins, S. J., Collins, D., Fye, C. L., Anderson, J. W., Elam, M. B., Faas, F. H., Linares, E., Schaefer, E. J., Schectman, G., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410604 · Cited by 3,439
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67667-2 · Cited by 3,284
Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis
Farrell, G. C., & Larter, C. Z. (2006) · Hepatology · doi:10.1002/hep.20973 · Cited by 2,428 · cited 2×
“Among affected patients, up to one-third may also have nonalcoholic steatotic hepatitis.(13,14) Lipotoxicity, oxidative stress, cytokines and proinflammatory mediators contribute to the progression from steatosis to nonalcoholic steatotic hepatitis.”
Background
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
Canner, P. L., Berge, K. G., Wenger, N. K., Stamler, J., Friedman, L., Prineas, R. J., & Friedewald, W. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80293-5 · Cited by 1,824 · cited 1×
“Older clinical trials suggested a reduction in cardiovascular events related to niacin treatment.(47) However, niacin frequently causes light-headedness, cutaneous flushing, or”
Background
Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies
Hokanson, J. E., & Austin, M. A. (1996) · Journal of Cardiovascular Risk · doi:10.1097/00043798-199604000-00014 · Cited by 1,706 · cited 2×
“, obesity, type 2 diabetes, decreased levels of HDL-C, increased small dense LDL, increased free fatty acids, dysglycemia, hyperinsulinemia, increased plasma viscosity, increased inflammatory molecules, impaired fibrinolysis, prothrombosis) are often associated with elevated levels of triglycerides.(2,24,25) Furthermo…”
Background
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701 · cited 1×
“In contrast, chylomicron remnants, VLDL and intermediate-density liproproteins are atherogenic.(27) A newer concept is that postprandial lipemia is an independent predictor of cardiovascular disease,(28) although, since sample preparation and assay conditions are nonroutine, “postprandial” elevation of triglycerides h…”
Background

Flagged first, then by citations

Show all 77 references

3 of the 77 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Darkes MJ, Poole RM, Goa KL. Ezetimibe. Am J Cardiovasc Drugs 2003;3:67-76.

Sorted by citations

Items 201–300 of 625

A 1-month-old infant with chylomicronemia due to GPIHBP1 gene mutation treated by plasmapheresis
Jung, M. K., Jin, J., Kim, H. O., Kwon, A., Chae, H. W., Kang, S. J., Kim, D. H., & Kim, H.-S. (2017) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2017.22.1.68 · Cited by 14
The weight lowering effect of sibutramine and its impact on serum lipids in cardiovascular high risk patients with and without type 2 diabetes mellitus - an analysis from the SCOUT lead-in period
Weeke, P. E., Andersson, C., Fosbøl, E. L., Brendorp, B., Køber, L., Sharma, A. M., Finer, N., James, P., Caterson, I. D., Rode, R. A., et al. (2010) · BMC Endocrine Disorders · doi:10.1186/1472-6823-10-3 · Cited by 16
“Our findings on triglyceride reductions are similar to the previously reported findings with sibutramine in the STORM study [23], but the reduced relative and absolute risk for CVD following reductions in triglyceride levels is not as great as the benefit of lower LDL-C levels[24].”
Result
The Changes in Plasma Retinol-Binding Protein 4 Levels are Associated With Those of the Apolipoprotein B-Containing Lipoproteins During Dietary and Drug Treatment
Christou, G. A., Tellis, C. C., Elisaf, M., Tselepis, A. D., & Kiortsis, D. N. (2011) · Angiology · doi:10.1177/0003319711407628 · Cited by 16
“1 WC, cm 117 + 12 112 + 12 112 + 12 TC, mg/dL 248 + 28 239 + 30 229 + 30 TG, mg/dL 219 + 75 197 + 61 167 + 56 HDL-C, mg/dL 45 + 8 44 + 8 42 + 8 VLDL-C, mg/dL 56 + 10 53 + 11 48 + 7 IDL-C, mg/dL 58 + 14 56 + 11 59 + 12 LDL-C, mg/dL 139 + 23 132 + 21 127 + 23 Non-HDL-C, mg/dL 203 + 25 195 + 28 186 + 28 sdLDL-C, mg/dL 11…”
Acute Pancreatitis: Review and Clinical Update
Vanwoerkom, R. C., & Adler, D. G. (2009) · Cited by 16
Cost-Effectiveness of Lorlatinib as a First-Line Therapy for Untreated Advanced Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer
Li, S., Li, J., Peng, L., Li, Y., & Wan, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.684073 · Cited by 17
Chinese Metabolic Syndrome Risk Score
Hsiao, F., Wu, C., Hsieh, C., He, C., Hung, Y.-J., & Pei, D. (2009) · Southern Medical Journal · doi:10.1097/smj.0b013e3181836b19 · Cited by 17
“These two components have always been considered closely related to each other.(9,10) Our findings demonstrate that they have independent influences on the future development of MetS.”
Background
Uncloaking the Genetic Determinants of Metabolic Syndrome
Lahiry, P., Pollex, R. L., & Hegele, R. A. (2008) · Lifestyle Genomics · doi:10.1159/000112459 · Cited by 16
“while polymorphisms in genes encoding apolipoproteins E and C-II ( APOE and APOC2 , respectively) are associated with the dyslipidemia component [”
Background
Perfil clínico de los pacientes con hipertrigliceridemia muy severa del Registro de Hipertrigliceridemias de la Sociedad Española de Arteriosclerosis
Pedragosa, À., Merino, J., Aranda, J. L., Galiana, J., Godoy, D., Panisello, J. M., Ascaso, J. F., Civeira, F., Masana, L., & Pedro‐Botet, J. (2012) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2012.11.001 · Cited by 16
Two Siblings with Familial Chylomicronemia Syndrome: Disease Course and Effectiveness of Early Treatment
Azkawi, H. S. A., & Al-Alwan, I. A. (2010) · Case Reports in Medicine · doi:10.1155/2010/807434 · Cited by 16
“There is no history of sudden death, premature cardiovascular disease, or recurrent pancreatitis in the family.”
BackgroundInfluential
Arterial Wall Stiffness and the Risk of Atherosclerosis in Egyptian Patients with Overt and Subclinical Hypothyroidism
Mousa, S., Hemeda, A., Ghorab, H., Abdelhamid, A., & Saif, A. (2019) · Endocrine Practice · doi:10.4158/ep-2019-0322 · Cited by 17
The N-Terminus of Apolipoprotein A-V Adopts a Helix Bundle Molecular Architecture
Mauldin, K., Beckstead, J. A., Lee, D., Weers, P. M. M., Guigard, E., Kay, C. M., & Ryan, R. O. (2008) · Biochemistry · doi:10.1021/bi800515c · Cited by 16
“In a manner similar to that of known helix bundle apolipoproteins, apoA-V(1-146) induced a relatively small enhancement in 8-anilino-1-naphthalenesulfonic acid fluorescence intensity.”
Influential
Ascorbic acid inhibits transcriptional activities of LXRα to ameliorate lipid metabolism disorder
Wang, D., Yin, Z., Han, L., Zhang, M., Li, H., Yang, X., Chen, Y., Zhang, S., Han, J., & Duan, Y. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104901 · Cited by 16
Olezarsen, a liver-directed APOC3 ASO therapy for hypertriglyceridemia
Hooper, A. J., Bell, D. A., & Burnett, J. R. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2408369 · Cited by 16
“This increased risk becomes clinically significant above a TG of ~10 mmol/L, or 1000 mg/dL, the level at which CM are present [10].”
Apolipoprotein C-III inhibitors for the treatment of hypertriglyceridemia: a meta-analysis of randomized controlled trials
de Souza, M. D. M., Mendes, B. X., Defante, M. L. R., Morais, B. A. D. A. D. H., Martins, O. C., Prizão, V. M., & Romaniello, G. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156187 · Cited by 15
Body mass index and blood pressure in bipolar patients: Target cardiometabolic markers for clinical practice
Barboza, A. B. C., Cabello-Arreola, A., Winham, S. J., Colby, C. L., Romo‐Nava, F., Núñez, N. A., Morgan, R. J., Gupta, R., Bublitz, J. T., Prieto, M. L., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.121 · Cited by 19
Severe acquired hypertriglyceridemia following COVID-19
Fijen, L. M., Grefhorst, A., Levels, J. H. M., & Cohn, D. M. (2021) · BMJ Case Reports · doi:10.1136/bcr-2021-246698 · Cited by 15
Association between the Erythrocyte Membrane Fatty Acid Profile and Cognitive Function in the Overweight and Obese Population Aged from 45 to 75 Years Old
Shen, J., Li, J., Hua, Y., Ding, B., Zhou, C. L., Yu, H., Xiao, R., & Ma, W. (2022) · Nutrients · doi:10.3390/nu14040914 · Cited by 12
Quantifying the contribution of triglycerides to metabolic resilience through the mixed meal model
O’Donovan, S. D., Erdõs, B., Jacobs, D. M., Wanders, A. J., Thomas, E. L., Bell, J. D., Rundle, M., Frost, G. S., Arts, I. C. W., Afman, L. A., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105206 · Cited by 14
Use of a meal challenge test to estimate peak postprandial triglyceride concentrations in dogs
Elliott, K. F., Rand, J. S., Fleeman, L. M., Morton, J. M., & Markwell, P. J. (2011) · American Journal of Veterinary Research · doi:10.2460/ajvr.72.2.161 · Cited by 15
Lipemia retinalis preceding acute pancreatitis
Horton, M., & Thompson, K. (2011) · Optometry · doi:10.1016/j.optm.2011.01.011 · Cited by 15
Red algal cellular biomass lowers circulating cholesterol concentrations in Syrian golden hamsters consuming hypercholesterolaemic diets
Harding, S., Zhao, H. L., Marinangeli, C. P. F., Day, A. G., Dillon, H. F., Jain, D., & Jones, P. J. H. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509380046 · Cited by 15
Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes
Yang, J., Koo, J., Yoon, H., Lee, J.-H., Park, B., Kim, J., Chi, M., & Park, J. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.4.527 · Cited by 15
Correction of Hypertriglyceridemia as the Way to Reduce Residual Risk in Diseases Caused by Atherosclerosis. Conclusion of the Advisory Board of the Russian Society of Cardiology, the Russian Scientific Medical Society of Therapists, the Eurasian Association of Therapists, the Russian National Atherosclerosis Society, the Russian Association of Endocrinologists, and the National League of Cardiologic Genetics
Arutyunov, G. P., Boytsov, S. A., Voyevoda, M. I., Gurevich, V. S., Drapkina, O. M., Kukharchuk, V. V., Ai, M., Sergiyenko, I. V., Shestakova, M. V., Aliyeva, A. S., et al. (2019) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2019-15-2-282-288 · Cited by 17
The enigma of soluble LDLR: could inflammation be the key?
Mbikay, M., Mayne, J., & Chrétien, M. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-1199-9 · Cited by 16
Elevated Levels of Triglyceride and Triglyceride-Rich Lipoprotein Triglyceride Induced by a High-Carbohydrate Diet Is Associated with Polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese Healthy Young Adults
Jia, L., Fang, D. Z., Du, J., Shigdar, S. L., Xiao, L., Zhou, X., & Duan, W. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000327913 · Cited by 14
“HTG is a complex disorder with many factors (e.g. genetic and environmental) contributing to its etiology [”
Background
Plasmapheresis for hypertriglyceridemia: The association between blood viscosity and triglyceride clearance rate
Wu, H., Lee, L., & Wang, W. (2018) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22688 · Cited by 14
Lipoprotein Lipase Deficiency: Clinical, Biochemical and Molecular Characteristics in Three Patients with Novel Mutations in the LPL Gene
Kolářová, H., Tesařová, M., Švecová, Š., Stránecký, V., Přistoupilová, A., Zima, T., Uhrová, J., Volgina, S. Y., Zeman, J., & Honzík, T. (2014) · Folia Biologica · doi:10.14712/fb2014060050235 · Cited by 15
“…environmental factors including imbalance between caloric intake and expenditure, alcohol consumption, various diseases (obesity, renal failure, hypothyroidism, type 2 diabetes) or medications with corticosteroids, oestrogens, retinoids or β-blockers (Ballantyne et al., 2000; Yuan et al., 2007).”
Background
Hypertriglyceridemia Induced Pancreatitis
Ippisch, H. M., Alfaro-Cruz, L., Fei, L., Zou, Y., Thompson, T., & Abu‐El‐Haija, M. A. (2020) · Pancreas · doi:10.1097/mpa.0000000000001505 · Cited by 14
“ATG level of 1000mg/dL or greater is an absolute risk for HTG-AP.(19,22,25) However, the risk of pancreatitis with TGs of less than 1000 mg/dL has also been reported but less clearly defined.”
BackgroundInfluential
The effect of continuous combined conjugated equine estrogen plus medroxyprogesterone acetate and tibolone on cardiovascular metabolic risk factors
Skouby, S. O., Sidelmann, J. J., Nilas, L., Gram, J., & Jespersen, J. (2008) · Climacteric · doi:10.1080/13697130802455150 · Cited by 14
Plasmapheresis in the Management of Severe Hypertriglyceridemia
Seda, G., Meyer, J. M., Amundson, D. E., & Daheshia, M. (2013) · Critical Care Nurse · doi:10.4037/ccn2013346 · Cited by 14
Genetic Predisposition of Human Plasma Triglyceride Concentrations
Schwarzová, L., Hubacek, J. A., & Vrablı́k, M. (2015) · Physiological Research · doi:10.33549/physiolres.933197 · Cited by 14
Severe hypertriglyceridemia due to two novel loss-of-function lipoprotein lipase gene mutations (C310R/E396V) in a Chinese family associated with recurrent acute pancreatitis
Yu, L., Sun, X., Wang, P., Chi, J., Hou, X., & Wang, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.17762 · Cited by 14
Primary Hypertriglyceridemia: A Look Back on the Clinical Classification and Genetics of the Disease
Musambil, M., Al-Rubeaan, K. A., Al-Qasim, S., Alnaqeb, D., & Al-Soghayer, A. (2020) · Current Diabetes Reviews · doi:10.2174/1573399815666190502164131 · Cited by 16
Higher On-admission Serum Triglycerides Predict Less Severe Disability and Lower All-cause Mortality after Acute Ischemic Stroke
Pikija, S., Trkulja, V., Juvan, L., Ivanec, M., & Dukši, D. (2012) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2012.03.006 · Cited by 14
Application and validation of a diagnostic algorithm for the atherogenic apoB dyslipoproteinemias
Holewijn, S., Sniderman, A. D., den Heijer, M., Swinkels, D. W., Stalenhoef, A. F. H., & Graaf, J. D. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02426.x · Cited by 14
The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials
Tehrani, S. D., Shojaei, M., Bagherniya, M., Pirro, M., & Sahebkar, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7763 · Cited by 14
“The mechanisms that underline the association of TG and ASCVD are complex but biochemical abnormalities such as metabolic syndrome, hyperinsulinemia, increased plasma viscosity and inflammatory factors are considered as main contributing factors (Yuan et al., 2007).”
Background
Design and rationale of the CORE-TIMI 72a and CORE2-TIMI 72b trials of olezarsen in patients with severe hypertriglyceridemia
Marston, N. A., Bergmark, B. A., Alexander, V. J., Karwatowska‐Prokopczuk, E., Kang, Y. M., Moura, F. A., Prohaska, T. A., Zimerman, A., Zhang, S. M., Murphy, S. A., et al. (2025) · American Heart Journal · doi:10.1016/j.ahj.2025.03.003 · Cited by 13
Icosapent Ethyl for Treatment of Elevated Triglyceride Levels
Nelson, S. D., & Munger, M. A. (2013) · Annals of Pharmacotherapy · doi:10.1177/1060028013504079 · Cited by 14
“Treatment for mild-moderate hypertriglyceridemia consists of lifestyle changes.(8) Reduction in carbohydrates and saturated fat in the diet combined with 30 to 60 minutes of moderate-intensity aerobic activity, such as brisk walking, at least 5 days, preferably 7 days, per week, supplemented by an increase in daily li…”
BackgroundInfluential
Digenic Inheritance and Gene-Environment Interaction in a Patient With Hypertriglyceridemia and Acute Pancreatitis
Yang, Q., Pu, N., Li, X., Shi, X., Chen, W., Zhang, G., Hu, Y., Zhou, J., Chen, F., Li, B., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.640859 · Cited by 13
Polygenic Risk of Hypertriglyceridemia Is Modified by BMI
Esteve-Luque, V., Fanlo‐Maresma, M., Padró‐Miquel, A., Corbella, E., Rivas-Regaira, M., Pintó, X., & Candás‐Estébanez, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179837 · Cited by 13
“An unbalanced diet, sedentary lifestyle, obesity, metabolic syndrome and type II diabetes are secondary causes of HTG [13,14], and their prevalence has progressively”
Background
A Comparative Study of Lipid-Lowering Effects of Guggul and Atorvastatin Monotherapy in Comparison to Their Combination in High Cholesterol Diet-Induced Hyperlipidemia in Rabbits
Das, S., Datta, A., Bagchi, C., Chakraborty, S., Mitra, A., & Tripathi, S. (2016) · Journal of Dietary Supplements · doi:10.3109/19390211.2015.1118654 · Cited by 13
“dysglycemia, increased plasma viscosity, increased inflammatory molecules and impaired fibrinolysis (Yuan et al., 2010).”
Background
Genetic Disorders Causing Hypertriglyceridemia in Children and Adolescents
SHAH, A. S., & Wilson, D. P. (2016) · MDText.com, Inc. eBooks · Cited by 13
A Compound Heterozygous Mutation of Lipase Maturation Factor 1 is Responsible for Hypertriglyceridemia of a Patient
Liu, Y., Xu, J., Tao, W., Yu, R., & Zhang, X. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.44537 · Cited by 13
Eruptive Xanthome bei Hypertriglyzeridämie
Renner, R., Teuwen, I., Harth, W., Treudler, R., & Simon, J. C. (2008) · Der Hautarzt · doi:10.1007/s00105-008-1534-y · Cited by 15
Correction of hypertriglyceridemia in order to reduce the residual risk in atherosclerosis-related diseases. Expert Council Opinion
Arutyunov, G. P., Boytsov, S. A., Voevoda, M. I., Drapkina, O. M., Kukharchuk, V. V., Ai, M., Shestakova, M. V., Gurevich, V. S., Сергиенко, И. В., Alieva, A. S., et al. (2019) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2019-9-44-51 · Cited by 14
Structure–activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo
Caraballo, R., Larsson, M., Nilsson, S. K., Ericsson, M., Qian, W., Tran, N. P. N., Kindahl, T., Svensson, R., Saar-Kovrov, V., Artursson, P., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.08.058 · Cited by 12
The Effect of a Fat-Restricted Diet in Four Patients with Familial Chylomicronemia Syndrome: A Long-Term Follow-Up Study
Thajer, A., Skacel, G., de Gier, C., & Greber‐Platzer, S. (2021) · Children · doi:10.3390/children8111078 · Cited by 12
SEA 2024 Standards for Global Control of Vascular Risk
Mostaza, J. M., Pintó, X., Armario, P., Masana, L., Real, J. T., Valdivielso, P., Arrobas-Velilla, T., Baeza‐Trinidad, R., Calmarza, P., Cebollada, J., et al. (2024) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2024.06.001 · Cited by 11
Hemostatic effects of bezafibrate and ω-3 fatty acids in isolated hypertriglyceridemic patients
Krysiak, R. G., Gdula‐Dymek, A., & Okopień, B. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70588-6 · Cited by 12
Triglycerides Revisited to the Serial
Viecili, P. R. N., da Silva, B., Hirsch, G. E., Porto, F. G., Parisi, M. M., Castanho, A. R., Wender, M., & Klafke, J. Z. (2017) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.11.001 · Cited by 14
Icosapent Ethyl: Niche Drug or for the Masses?
Bazarbashi, N., & Miller, M. J. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01356-4 · Cited by 12
Differences in Cardiovascular Risk Factors in Swedes and Assyrians/Syrians with Type 2 Diabetes: Association with Lifestyle-Related Factors
Taloyan, M., Stattin, N. S., Johansson, S., Agréus, L., & Wändell, P. E. (2010) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000110 · Cited by 12
“Food intake, especially increased carbohydrate intake, is a common reason for elevated triglycerides [31].”
Background
MULTICOLOR SCANNING LASER IMAGING IN LIPEMIA RETINALIS
la Parra, D. R.-D., Pérez-Peralta, L., Toldi, J., Levine, J., Fikhman, M., & Graue-Hernández, E. O. (2016) · Retinal Cases & Brief Reports · doi:10.1097/icb.0000000000000469 · Cited by 11
Acute pancreatitis secondary to hypertriglyceridemia
Munoz, M. A., Sathyakumar, K., & Babu, B. A. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.19156 · Cited by 11
A machine learning approach to personalized predictors of dyslipidemia: a cohort study
Gutiérrez-Esparza, G. O., Pulido, T., Martínez-García, M., Ramírez-delReal, T. A., Groves-Miralrio, L. E., Márquez-Murillo, M. F., Amezcua-Guerra, L. M., Vargas‐Alarcón, G., & Lemus, E. H. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1213926 · Cited by 12
“Hypertriglyceridemia is a common lipid abnormality characterized by elevated triglyceride (TG) levels, often aﬀecting individuals with visceral obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM) (4, 5).”
BackgroundInfluential
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities
Sato, K., Takahagi, H., Kubo, O., Hidaka, K., Yoshikawa, T., Kamaura, M., Nakakariya, M., Amano, N., Adachi, R., Maki, T., et al. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.06.003 · Cited by 11
ω-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation
Tripathi, C. B., Gupta, N., Kumar, P., Singh, A. K., Raj, V., Parashar, P., Singh, M. V., Kanoujia, J., Arya, M., Saraf, S. A., et al. (2017) · AAPS PharmSciTech · doi:10.1208/s12249-017-0933-8 · Cited by 11
Clinical Characteristics and Sequelae of Severe Hypertriglyceridemia in Pediatrics
Richardson, T., Aslibekyan, S. W., & Ashraf, A. P. (2018) · Endocrine Practice · doi:10.4158/ep-2018-0106 · Cited by 11
A Metabolically Unhealthy Phenotype Is Associated with ADIPOQ Genetic Variants and Lower Serum Adiponectin Levels
Torres‐Castillo, N., Campos-Perez, W. Y., Rodriguez‐Echevarría, R., Rodríguez-Reyes, S. C., & Martínez‐López, E. (2020) · Lifestyle Genomics · doi:10.1159/000510021 · Cited by 12
Secondary Causes of Hypertriglyceridemia are Prevalent Among Patients Presenting With Hypertriglyceridemia Induced Acute Pancreatitis
Qureshi, T. M., Khan, A., Javaid, H., Tabash, A., Hussein, M. S., & Othman, M. O. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.01.005 · Cited by 12
Apolipoprotein A-V Genetic Variation and Plasma Lipoprotein Response to Fibrates
Hegele, R. A., & Pollex, R. L. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.144980 · Cited by 11
Familial chylomicronemia syndrome: importance of diagnostic vigilance
Ueda, M. (2022) · Translational Pediatrics · doi:10.21037/tp-22-488 · Cited by 12
“21037/tp-22-488 common or polygenic HTG (8,21,22).”
Severe hypertriglyceridemia prevalence at a primary care setting in Catalonia, Spain
Ortega, E., Vlacho, B., Treserres, R. P., Mata‐Cases, M., Altés, A., Mauricio, D., & Franch‐Nadal, J. (2023) · Journal of clinical lipidology · doi:10.1016/j.jacl.2023.09.002 · Cited by 10
Protective effects of Sulforaphene on kidney damage and gut dysbiosis in high-fat diet plus streptozotocin-induced diabetic mice
Zhang, B., Xu, K., Deng, W., Liu, C., Xu, Q., Sheng, H., Feng, J., & Yuan, Q. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142558 · Cited by 10
Hypertriglyceridemia in Preterm Infants
Chan, A. P., Robinson, D. T., & Calkins, K. L. (2022) · NeoReviews · doi:10.1542/neo.23-8-e528 · Cited by 10
Monocyte-Suppressing Effect of Bezafibrate but not Omega-3 Fatty Acids in Patients with Isolated Hypertriglyceridaemia
Krysiak, R. G., Gdula‐Dymek, A., & Okopień, B. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00675.x · Cited by 10
Predictive factors of achieving therapeutic goals of hypertriglyceridemia
Pintó, X., Valdivielso, P., Juan, J., Plana, N., García-Arias, C., Fuentes, F. J., Hernández‐Mijares, A., Mostaza, J. M., & on behalf of the Spanish Registry of Hypertriglyceridemia (Spanish Society of Arteriosclerosis, S. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.850069 · Cited by 10
Association of acute pancreatitis or high level of serum pancreatic enzymes in patients with acute spinal cord injury: a prospective study
Pirolla, E. H., Filho, T. E. P. D. B., Godoy‐Santos, A. L., & Fregni, F. (2014) · Spinal Cord · doi:10.1038/sc.2014.109 · Cited by 10
Factors affecting carotid intima media thickness predicts early atherosclerosis in overweight and obese adolescents
Özgüven, I., Ersoy, B., Ozguven, A., Özkol, M., & Onur, E. (2009) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2009.06.003 · Cited by 10
“In adults at risk of atherosclerosis, hypertriglyceridemia is commonly associated with low high density lipoprotein-cholesterol (HDL-C) which is, in turn, a powerful predictor of adverse cardiovascular events [5].”
Background
Type V hypertriglyceridemia in children, a therapeutic challenge in pediatrics
Mărginean, C. O., Meliţ, L. E., Dobreanu, M., & Săsăran, M. O. (2017) · Medicine · doi:10.1097/md.0000000000008864 · Cited by 10
“multiple genetic factors, being defined as multigenic or polygenic.([5]) Therefore, HTg in individuals that carry a genetic susceptibility is further exacerbated by exposure to nongenetic secondary factors, such as overweight/obesity or alcohol abuse.”
BackgroundInfluential
Effect of fenofibrate in 1113 patients at low-density lipoprotein cholesterol goal but high triglyceride levels: Real-world results and factors associated with triglyceride reduction
Woo, Y., Shin, J.-S., Shim, C. Y., Kim, J., Kim, B., Park, S., Chang, H., Hong, G., Ko, Y., Kang, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205006 · Cited by 11
Management strategy and novel ophthalmological findings in neonatal severe hypertriglyceridemia: a case report and literature review
El-Koofy, N. M., Abdo, Y. A., El-Fayoumi, D. M. S., Esmael, A. F., Elmonem, M. A., & Ezzeldin, Z. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01464-2 · Cited by 10
Determinants of Lipid Parameters in Patients without Diagnosed Cardiovascular Disease—Results of the Polish Arm of the EUROASPIRE V Survey
Ratajczak, J. M., Kubica, A., Michalski, P., Pietrzykowski, Ł., Białczyk, A., Kosobucka, A., Bergmann, K., Buczkowski, K., Krintus, M., Jankowski, P., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072738 · Cited by 13
“Obesity and history of DM were independent risk factors of abnormal TG concentration in the current analysis, similar to other observational studies [7,12,23].”
BackgroundResult
An Evidence Map of Systematic Reviews to Inform Interventions in Prediabetes
Singh, K., Ansari, M. T., Galipeau, J., Garritty, C., Keely, E., Malcolm, J., Pratt, M., Skidmore, B., & Sorisky, A. (2012) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2012.06.004 · Cited by 11
Acute Pancreatitis Secondary to Gestational Hypertriglyceridaemia
Cahalane, A. M., Smith, M. J. F., Ryan, J., & Maguire, D. (2012) · Case Reports in Medicine · doi:10.1155/2012/627890 · Cited by 10
“HTG can be categorized as primary and secondary, although an underlying molecular basis can be found in less than 5% of cases [9].”
Background
Cardiovascular risk factors in Assyrians/Syrians and native Swedes with type 2 diabetes: a population-based epidemiological study
Taloyan, M., Wajngot, A., Johansson, S., Tovi, J., & Sundquist, J. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-59 · Cited by 10
“It is a known fact that food intake, especially increased carbohydrate intake, is a common reason for elevated triglycerides [24].”
Diversity of aging of the immune system classified in the cotton rat (Sigmodon hispidus) model of human infectious diseases
Guichelaar, T., van Erp, E. A., Hoeboer, J., Smits, N. A. M., van Els, C. A. C. M., Pieren, D. K. J., & Luytjes, W. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.12.026 · Cited by 10
Severe Hypertriglyceridemia due to a novel p.Q240H mutation in the Lipoprotein Lipase gene
Soto, A. G., McIntyre, A. D., Agrawal, S., Bialo, S. R., Hegele, R. A., & Boney, C. M. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0107-1 · Cited by 11
“Pancreatitis is common in these patients and risk increases with TG levels over 1,000 mg/dl [14].”
Prevalence of Obesity and Its Association with Cardiovascular Disease Risk Factors in Adolescent Girls from a College in Central Taiwan
Lu, J. J.-Y., Jiang, D. D., Chou, S.-M., Hor, C., Lay, J., & Wang, H. (2008) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/s1607-551x(08)70142-6 · Cited by 10
“In addition, elevated blood triglyceride levels are correlated with obesity and boost the risk of cardiovascular disease and/or acute pancreatitis whenever the patient’s triglyceride levels are very high [22].”
Homeostasis Model Assessment for Insulin Resistance Mediates the Positive Association of Triglycerides with Diabetes
Wang, Y., Fang, Y., & Vrablı́k, M. (2024) · Diagnostics · doi:10.3390/diagnostics14070733 · Cited by 9
“Low-density lipoprotein (LDL) cholesterol [11], insulin resistance [12,13], and inflammation [14,15] emerge as potential players in elucidating this association.”
BackgroundInfluential
Hypertriglyceridemia in a Pediatric Referral Practice: Experience With 300 Patients
de Ferranti, S. D., Crean, S. M., Cotter, J., Boyd, D., & Osganian, S. K. (2010) · Clinical Pediatrics · doi:10.1177/0009922810379498 · Cited by 9
Lipoprotein Lipase Deficiency in an Infant With Chylomicronemia, Hepatomegaly, and Lipemia Retinalis
Vidanapathirana, D. M., Rodrigo, T., Waidyanatha, S., Jasinge, E. A., Hooper, A. J., & Burnett, J. R. (2017) · Global Pediatric Health · doi:10.1177/2333794x17715839 · Cited by 9
“Pancreatitis is common in these patients and risk increases with triglyceride levels greater than 1000 mg/dL.(8)Most clinical signs and symptoms of LPL deficiency are attributed to the hypertriglyceridemia.”
Background
Neonatal hyperlipidemia with pancreatitis
Shah, M., Roshan, R., Desai, R., & Kadam, S. (2018) · Journal of Postgraduate Medicine · doi:10.4103/jpgm.jpgm_731_17 · Cited by 9
“[9,10] Hyperchylomicronemia-induced recurrent pancreatitis occurs when triglyceride level exceeds 2,000 mg/dL leading to pancreatic insufficiency, which is the major complication of this disease.”
Risk Factors for Acute Kidney Injury in Acute Pancreatitis
Yu, B., He, W., & Lü, N. (2020) · Pancreas · doi:10.1097/mpa.0000000000001613 · Cited by 9
65-jähriger Patient mit gelb-orange farbenen Papeln an beiden Unterarmen
Streit, E., & Helmbold, P. (2009) · Der Hautarzt · doi:10.1007/s00105-009-1847-5 · Cited by 9
“Bei den Hyperlipoproteinämien vom Typ II– IV ist zusätzlich das Arterioskleroserisiko aufgrund von Lipidablagerungen in den arteriellen Gefäßwänden zum Teil massiv erhöht [10].”
Background
Dislipidemia relacionada à fibrose cística
Alves, C., & Lima, D. S. (2008) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37132008001000012 · Cited by 9
Dysbetalipoproteinemia: Two cases report and a diagnostic algorithm
Kei, A. A. (2015) · World Journal of Clinical Cases · doi:10.12998/wjcc.v3.i4.371 · Cited by 9
Acute and residual effects of aerobic exercise on fructose-induced postprandial lipemia on lean male subjects
Macedo, R. C. O., Boeno, F. P., Farinha, J. B., Ramis, T. R., Rodrigues-Krause, J. D. C., Vieira, A., Queiroz, J. D. N., Moritz, C. E. J., & Reischak-Oliveira, Á. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1780-4 · Cited by 10
Environmental Heavy Metal Exposure and Associated Cardiovascular Diseases in Light of the Triglyceride Glucose Index
Sardar, M. B., Raza, M., Fayyaz, A., Nadir, M. A., Nadeem, Z. A., & Babar, M. (2024) · Cardiovascular Toxicology · doi:10.1007/s12012-024-09913-x · Cited by 9
Approach to the Adult Patient with Chylomicronemia
Hegele, R. A. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf701 · Cited by 11
New Hope for Lipid-Lowering Beyond Statins: Effect of IMPROVE-IT on Understanding and Implementation of Atherosclerosis Prevention
Anderson, T. J. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.03.019 · Cited by 8
The interaction of FTO-rs9939609 polymorphism with artichoke leaf extract effects on cardiometabolic risk factors in hypertriglyceridemia: A randomized clinical trial
Rezazadeh, K., Jafarabadi, M. A., & Ebrahimi-Mameghani, M. (2018) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2018.08.006 · Cited by 9
Synthesis and biological activity of fibrate-based acyl- and alkyl-phenoxyacetic methyl esters and 1,2-dihydroquinolines
Pucheta, A., Mendieta‐Moctezuma, A., Madrigal-Aguilar, D. A., Hernández‐Benitez, R. I., Romero, L., Garduño‐Siciliano, L., Rugerio-Escalona, C., Cruz, M. D. C., Jiménez, F., Ramírez-Villalva, A., et al. (2020) · Medicinal Chemistry Research · doi:10.1007/s00044-019-02496-1 · Cited by 7
Genetic risk prediction of the plasma triglyceride response to independent supplementations with eicosapentaenoic and docosahexaenoic acids: the ComparED Study
Marcotte, B. V., Allaire, J., Guénard, F., de Toro‐Martín, J., Couture, P., Lamarche, B., & Vohl, M. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00669-x · Cited by 8
Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers
Mansoor, M. A., Hervig, T. A., Stakkestad, J. A., Drabløs, P. A., Apeland, T., Wentzel‐Larsen, T., & Bates, C. J. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000325537 · Cited by 8
“Therefore, folate may have a regulatory role in the metabolism of triglycerides. High concentrations of serum triglycerides are a well-documented risk factor for CVD in most populations [ ,”
Background
Changes in Serum Lipid Profiles among Canine Patients Suffering from Chronic Hepatitis
Assawarachan, S. N., Chuchalermporn, P., Maneesaay, P., & Thengchaisri, N. (2021) · Veterinary Sciences · doi:10.3390/vetsci8100221 · Cited by 8
TAME-Esterase and Oxidative Stress Contribute to Dysmetabolic Syndrome in Dyslipidaemia
Subratty, A. H., ., L. H. S., & Manraj, M. (2007) · Asian Journal of Biochemistry · doi:10.3923/ajb.2007.323.329 · Cited by 7
Quetiapine is associated with pancreatitis: A real-world pharmacovigilance study
Frey, C. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.01.042 · Cited by 7
Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip
Parihar, A., Wood, G. C., Chu, X., Jin, Q., Argyropoulos, G. A., Still, C. D., Shuldiner, A. R., Mitchell, B. D., & Gerhard, G. S. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00222 · Cited by 7
“For example, triglyceride levels are particularly sensitive to prandial state and other influences (Yuan et al., 2007).”
BackgroundMethod
O Papel dos Ácidos Gordos na Nutrição Humana e Desenvolvimentos Sobre o Modo Como Influenciam a Saúde
Guiné, R. P. F., & Henriques, F. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 7

Authors: Yuan, G., Al-Shali, K. Z., & Hegele, R. A.
Affiliations: Western University (CA)
Corresponding author: Hegele, R. A.
ORCID: Hegele, R. A.
Venue: Canadian Medical Association Journal
Publisher: CMA Impact Inc.
Published: 2007-04-10
Volume: 176
Issue: 8
Pages: 1113-1120
ISSN: 0820-3946 (ISSN-L)
1488-2329
DOI: 10.1503/cmaj.060963
PMC: PMC1839776
OpenAlex: W1982040758
Cited by: 624
References: 77
Citations by year: 2026: 26 · 2025: 24 · 2024: 42 · 2023: 30 · 2022: 35 · 2021: 36 · 2020: 40 · 2019: 25 · 2018: 31 · 2017: 31 · 2016: 35 · 2015: 35 · 2014: 29 · 2013: 32 · 2012: 35
FWCI: 5.55
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Canadian Medical Association Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Genome Canada
Ontario Genomics
Ontario Genomics Institute
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: hypertriglyceridemia, triglyceride-lowering therapy, cardiovascular risk, acute pancreatitis, primary hypertriglyceridemia, LDL cholesterol, HDL cholesterol, metabolic syndrome, type 2 diabetes, pro-inflammatory markers
MeSH terms: Hypolipidemic Agents, Clofibric Acid, Coronary Artery Disease, Diet, Humans, Niacin, Pancreatitis, Risk Factors, Triglycerides, Hypertriglyceridemia, Weight Loss, Exercise, Practice Guidelines as Topic, Hydroxymethylglutaryl-CoA Reductase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypertriglyceridemia: its etiology, effects and treatment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks