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The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study

Open access
Ioannidis, G., Papaioannou, A., Hopman, W. M., Akhtar-Danesh, N., Anastassiades, T., Pickard, L., Kennedy, C. C., Prior, J. C., Olszynski, W. P., Davison, K. S., Goltzman, D., Thabane, L., Gafni, A., Papadimitropoulos, E. A., Brown, J. P., Josse, R. G., Hanley, D. A., Adachi, J. D.·2009·Canadian Medical Association Journal

Abstract

BACKGROUND: Fractures have largely been assessed by their impact on quality of life or health care costs. We conducted this study to evaluate the relation between fractures and mortality. METHODS: A total of 7753 randomly selected people (2187 men and 5566 women) aged 50 years and older from across Canada participated in a 5-year observational cohort study. Incident fractures were identified on the basis of validated self-report and were classified by type (vertebral, pelvic, forearm or wrist, rib, hip and "other"). We subdivided fracture groups by the year in which the fracture occurred during follow-up; those occurring in the fourth and fifth years were grouped together. We examined the relation between the time of the incident fracture and death. RESULTS: Compared with participants who had no fracture during follow-up, those who had a vertebral fracture in the second year were at increased risk of death (adjusted hazard ratio [HR] 2.7, 95% confidence interval [CI] 1.1-6.6); also at risk were those who had a hip fracture during the first year (adjusted HR 3.2, 95% CI 1.4-7.4). Among women, the risk of death was increased for those with a vertebral fracture during the first year (adjusted HR 3.7, 95% CI 1.1-12.8) or the second year of follow-up (adjusted HR 3.2, 95% CI 1.2-8.1). The risk of death was also increased among women with hip fracture during the first year of follow-up (adjusted HR 3.0, 95% CI 1.0-8.7). INTERPRETATION: Vertebral and hip fractures are associated with an increased risk of death. Interventions that reduce the incidence of these fractures need to be implemented to improve survival.

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Metadata

Authors
Ioannidis, G., Papaioannou, A., Hopman, W. M., Akhtar-Danesh, N., Anastassiades, T., Pickard, L., Kennedy, C. C., Prior, J. C., Olszynski, W. P., Davison, K. S., Goltzman, D., Thabane, L., Gafni, A., Papadimitropoulos, E. A., Brown, J. P., Josse, R. G., Hanley, D. A., & Adachi, J. D.
Venue
Canadian Medical Association Journal
Published
2009-08-04
Volume
181
Issue
5
Pages
265-271
ISSN
  • 0820-3946 (ISSN-L)
  • 1488-2329
OpenAlex
W2147001135
Cited by
432
References
22
FWCI
32.65
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. https://app.cochat.ai/papers/10.1503/cmaj.081720
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Ioannidis, G., Papaioannou, A., Hopman, W. M., Akhtar-Danesh, N., Anastassiades, T., Pickard, L., Kennedy, C. C., Prior, J. C., Olszynski, W. P., Davison, K. S., Goltzman, D., Thabane, L., Gafni, A., Papadimitropoulos, E. A., Brown, J. P., Josse, R. G., Hanley, D. A., & Adachi, J. D. (2009). Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. Canadian Medical Association Journal. https://doi.org/10.1503/cmaj.081720

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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