The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study
Open accessAbstract
BACKGROUND: Poor muscular strength has been shown to be associated with increased morbidity and mortality in diverse samples of middle-aged and elderly people. However, the oldest old population (i.e., over 85 years) is underrepresented in such studies. Our objective was to assess the association between muscular strength and mortality in the oldest old population. METHODS: We included 555 participants (65% women) from the Leiden 85-plus study, a prospective population-based study of all 85-year-old inhabitants of Leiden, Netherlands. We measured the handgrip strength of participants at baseline and again at age 89 years. We collected baseline data on comorbidities, functional status, levels of physical activity, and adjusted for potential confounders. During the follow-up period, we collected data on mortality. RESULTS: During a follow-up period of 9.5 years (range 8.5-10.5 years), 444 (80%) participants died. Risk for all-cause mortality was elevated among participants in the lowest tertile of handgrip strength at age 85 years (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.00-1.82, p = 0.047) and the lowest two tertiles of handgrip strength at age 89 years (HR 2.04, CI 1.24-3.35, p = 0.005 and HR 1.73, CI 1.11-2.70, p = 0.016). We also observed significantly increased mortality among participants in the tertile with the highest relative loss of handgrip strength over four years (HR 1.72, CI 1.07-2.77, p = 0.026). INTERPRETATION: Handgrip strength, a surrogate measurement of overall muscular strength, is a predictor of all-cause mortality in the oldest old population and may serve as a convenient tool for prognostication of mortality risk among elderly people.
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“Sarcopenia is highly prevalent among those aged 80 years and older, with reported rates exceeding 50%.(8) Reduced muscular strength is associated in turn with outcomes such as physical disability,(9,10) cognitive decline(11) and mortality.”
BackgroundSkeletal Muscle Strength as a Predictor of All-Cause Mortality in Healthy Men
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Grip strength, body composition, and mortality
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Cited by
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Frailty Assessment in the Cardiovascular Care of Older Adults
Afilalo, J., Alexander, K. P., Mack, M. J., Maurer, M. S., Green, P., Allen, L. A., Popma, J. J., Ferrucci, L., & Forman, D. E. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.070 · Cited by 1,173
García-Hermoso, A., Cavero-Redondo, I., Ramírez-Vélez, R., Ruiz, J. R., Ortega, F. B., Lee, D.-C., & Martínez-Vizcaíno, V. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2018.01.008 · Cited by 609
Rijk, J. M., Roos, P. R., Deckx, L., van den Akker, M., & Buntinx, F. (2016) · Geriatrics & Gerontology International · doi:10.1111/ggi.12508 · Cited by 376
Importance of frailty in patients with cardiovascular disease
Singh, M., Stewart, R., & White, H. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu197 · Cited by 323
Metadata
- Authors
- Ling, C. H. Y., Taekema, D., de Craen, A. J. M., Gussekloo, J., Westendorp, R. G. J., & Maier, A. B.
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Joule Inc.
- Published
- 2010-02-08
- Volume
- 182
- Issue
- 5
- Pages
- 429-435
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- OpenAlex
- W2145338083
- Cited by
- 386
- References
- 28
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ling, C. H. Y., Taekema, D., de Craen, A. J. M., Gussekloo, J., Westendorp, R. G. J., & Maier, A. B. (2010). Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. Canadian Medical Association Journal. https://doi.org/10.1503/cmaj.091278
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