The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function
Open accessAbstract
Pancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development, beta-cell differentiation, and maintenance of mature beta-cell function. PDX-1 expression is maintained in pancreatic precursor cells during pancreas development but becomes restricted to beta-cells in mature pancreas. In mature beta-cells, PDX-1 transactivates the insulin and other genes involved in glucose sensing and metabolism such as GLUT2 and glucokinase. MafA is a recently isolated beta-cell-specific transcription factor which functions as a potent activator of insulin gene transcription. Furthermore, these transcription factors play an important role in induction of insulin-producing cells in various non-beta-cells and thus could be therapeutic targets for diabetes. On the other hand, under diabetic conditions, expression and/or activities of PDX-1 and MafA in beta-cells are reduced, which leads to suppression of insulin biosynthesis and secretion. It is likely that alteration of such transcription factors explains, at least in part, the molecular mechanism for beta-cell glucose toxicity found in diabetes.
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Citations
Cites
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482
Robertson, R. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400019200 · Cited by 1,078
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007 · cited 1×
“mice, which express the Cre recombinase driven by the Ptf1a (PTF1-p48) gene promoter [102], PDX-1 was expressed in precursors of all three pancreatic cell”
BackgroundGlucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
Robertson, R. P., Harmon, J., Tran, P. O., Tanaka, Y., & Takahashi, H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.581 · Cited by 897
Poitout, V., & Robertson, R. P. (2002) · Endocrinology · doi:10.1210/endo.143.2.8623 · Cited by 743
Diabetes mellitus and genetically programmed defects in β-cell function
Bell, G. I., & Polonsky, K. S. (2001) · Nature · doi:10.1038/414788a · Cited by 475
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
Kaneto, H., Matsuoka, T.-A., Nakatani, Y., Kawamori, D., Miyatsuka, T., Matsuhisa, M., & Yamasaki, Y. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0640-x · Cited by 193
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Cited by
Back, S. H., Scheuner, D., Han, J., Song, B., Ribick, M., Wang, J., Gildersleeve, R. D., Pennathur, S., & Kaufman, R. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.002 · Cited by 366
Yang, B. T., Dayeh, T. A., Volkov, P. A., Kirkpatrick, C. L., Malmgren, S., Jing, X., Renström, E., Wollheim, C. B., Nitert, M. D., & Ling, C. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1004 · Cited by 301
Melkman‐Zehavi, T., Oren, R., Kredo‐Russo, S., Shapira, T., Mandelbaum, A. D., Rivkin, N., Nir, T., Lennox, K. A., Behlke, M. A., Dor, Y., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.361 · Cited by 280
Arcidiacono, B., Iiritano, S., Chiefari, E., Brunetti, F. S., Gu, G., Foti, D. P., & Brunetti, A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00237 · Cited by 68
Liang, Z., Sun, D., Lu, S., Lei, Z., Wang, S., Luo, Z., Zhan, J., Wu, S., Jiang, Y., Lu, Z., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-022-00713-7 · Cited by 59
Metadata
- Authors
- KANETO, H., MIYATSUKA, T., KAWAMORI, D., YAMAMOTO, K., KATO, K., SHIRAIWA, T., KATAKAMI, N., YAMASAKI, Y., MATSUHISA, M., & MATSUOKA, T.-A.
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 2008
- Volume
- 55
- Issue
- 2
- Pages
- 235-252
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W2042537754
- Cited by
- 161
- References
- 8
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function. https://app.cochat.ai/papers/10.1507/endocrj.k07e-041
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- KANETO, H., MIYATSUKA, T., KAWAMORI, D., YAMAMOTO, K., KATO, K., SHIRAIWA, T., KATAKAMI, N., YAMASAKI, Y., MATSUHISA, M., & MATSUOKA, T.-A. (2008). PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function. Endocrine Journal. https://doi.org/10.1507/endocrj.k07e-041
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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