Cited by 150Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

The Pathobiochemistry of Nitrogen Dioxide

Kirsch, M., Korth, H.-G., Sustmann, R., Groot, H. de·2002·Biological Chemistry

Abstract

Nitrogen dioxide (*NO2) is an oxidizing free radical which can initiate a variety of destructive pathways in living systems, and several diseases are suspected to be connected with both exogenously and endogenously formed *NO2. Peroxynitrite (ONOO-/ONOOH) is believed to be an important endogenous source of *NO2 radicals, but other sources, among them enzymatically ones, have been identified recently. It also became clear during the last few years that in vivo formation of 3-nitrotyrosine strictly depends on the availability of *NO2 radicals. Since nitrogen dioxide is a very toxic compound an arsenal of antioxidants (e.g. vitamin C, glutathione, vitamin E, and beta-carotene) must eliminate this harmful radical in vivo. Here the recently identified superoxide (O2*-)-dependent formation of peroxynitrate (O2NOO-) and the central role of vitamin C are of special importance.

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Crossref · 10.1515/bc.2002.043

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Authors
Kirsch, M., Korth, H.-G., Sustmann, R., & Groot, H. D.
Affiliations
Essen University Hospital (DE)
Venue
Biological Chemistry
Published
2002-01-12
Volume
383
Issue
3-4
Pages
389-99
ISSN
1431-6730 (ISSN-L)
OpenAlex
W1974264946
Cited by
150
References
110
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 7 · 2014: 3 · 2013: 2 · 2012: 7
FWCI
2.01
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
nitrogen dioxide, free radicals, peroxynitrite, nitrotyrosine, superoxide, vitamin C, antioxidants, glutathione, oxidative stress, nitrosative stress, nitric oxide
MeSH terms
Animals, Humans, Nitrogen Dioxide, Oxidants, Photochemical, Peroxynitrous Acid

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