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Protein aggregation in crowded environments
Abstract
The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.
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Metadata
- Authors
- Ellis, R. J., & Minton, A. P.
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2006-01-01
- Volume
- 387
- Issue
- 5
- Pages
- 485-97
- ISSN
- 1431-6730 (ISSN-L)
- 1437-4315
- OpenAlex
- W2053202443
- Cited by
- 421
- References
- 70
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
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