Antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae in Streptozotocin-induced diabetic rats
Open accessAbstract
Background: It is well documented that biologically active components of microalgae can be utilized for treatment of different diseases. This study was conducted to evaluate the antihyperglycemic and antihyperlipidemic activities and weight control of Nannochloropsis oculata microalgae (NOM) in Streptozotocin-induced diabetic male rats. Methods: Diabetes was induced by intraperitoneal administration of Streptozotocin (55 mg/kg). Healthy and diabetic rats were divided in to six groups. Healthy and diabetic rats orally received distilled water or NOM (10 and 20 mg/kg) for three weeks. Results: Oral administration of NOM to diabetic rats significantly reduced the serum concentrations of glucose, cholesterol, triglycerides, LDL and increased the serum concentration of insulin and HDL-C ( P <0.05). Treatment with NOM had no significant effect on blood parameters in healthy rats ( P >0.05). Also, NOM maintained body weight in diabetic rats (P<0.05). Conclusion: It can be concluded that NOM has antihyperglycemic and antihyperlipidemic activities in diabetic rats.
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Oral administration of Nannochloropsis oculata significantly reduced serum glucose and increased insulin levels in diabetic rats.
“Oral administration of Nannochloropsis oculata significantly reduced serum glucose and increased insulin levels in diabetic rats [107].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [107]
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- Authors
- Nasirian, F., Sarir, H., & Moradi-kor, N.
- Affiliations
- University of Birjand (IR)
- Research Center of Physiology, Semnan University of Medical Sciences , Semnan , Iran
- ORCID
- Sarir, Hadi
- Venue
- Biomolecular Concepts
- Publisher
- Walter de Gruyter GmbH
- Published
- 2019-01-01
- Volume
- 10
- Issue
- 1
- Pages
- 37-43
- ISSN
- 1868-5021 (ISSN-L)
- 1868-503X
- OpenAlex
- W2923048696
- Cited by
- 42
- References
- 45
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BioMolecular Concepts (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Keywords
- Nannochloropsis oculata, microalgae, antidiabetic activity, hypolipidemic activity, streptozotocin-induced diabetes, type 2 diabetes, blood glucose, lipid profile, cholesterol, triglycerides, low-density lipoprotein, HDL cholesterol, insulin, weight management
- MeSH terms
- Administration, Oral, Animals, Hypolipidemic Agents, Diabetes Mellitus, Experimental, Hypoglycemic Agents, Male, Plant Extracts, Rats, Wistar, Rats, Microalgae
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