The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Glyoxal and Methylglyoxal Levels in Diabetic Patients: Quantitative Determination by a New GC/MS Method
Abstract
Determination of glyoxal and methylglyoxal levels in plasma is of great interest, since it allows us to evaluate oxidation processes occurring in glycated proteins. A method based on a simple derivatization procedure followed by gas chromatography/mass spectrometry (GC/MS) analysis has been developed. Ten diabetic patients were evaluated before and after improvement of glycemic control. Fasting plasma glucose, hemoglobin A1c (HbA1c), advanced glycation end products (AGE), pentosidine, glyoxal and methylglyoxal levels were measured. The percentage decreases of the levels of fasting plasma glucose, HbA1c and AGE were larger than those of pentosidine, glyoxal and methylglyoxal. These results may be explained by considering the different position of these compounds in the Maillard reaction pathways: these two sets of metabolic parameters give different pictures of patients' metabolic control. The measurement of glyoxal and methylglyoxal may be particularly important in the evaluation of the possible effect of oxidative stress. Other metabolic pathways can contribute to glyoxal production, and the observed minor decrease in these compounds can be, in principle, ascribed to such effect. However, a similar behavior of pentosidine indicates that these alternative pathways can be only partially responsible for glyoxal and methylglyoxal production.
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Cites
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Glycosylated Hemoglobins and Long-Term Blood Glucose Control in Diabetes Mellitus
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Cited by
Schalkwijk, C. G., & Stehouwer, C. D. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00001.2019 · Cited by 622
Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings
Yeh, W.-J., Hsia, S.-M., Lee, W.-H., & Wu, C.-H. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.10.017 · Cited by 353
Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis
Knani, I., Bouzidi, H., Zrour, S., Bergaoui, N., Hammami, M., & Kerkeni, M. (2018) · Disease Markers · doi:10.1155/2018/8735926 · Cited by 25
Metadata
- Authors
- Lapolla, A., Flamini, R., Vedova, A. D., Senesi, A., Reitano, R., Fedele, D., Basso, E., Seraglia, R., & Traldi, P.
- Venue
- Clinical Chemistry and Laboratory Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 2003-01-16
- Volume
- 41
- Issue
- 9
- Pages
- 1166-73
- ISSN
- 1434-6621 (ISSN-L)
- OpenAlex
- W2027470518
- Cited by
- 288
- References
- 20
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lapolla, A., Flamini, R., Vedova, A. D., Senesi, A., Reitano, R., Fedele, D., Basso, E., Seraglia, R., & Traldi, P. (2003). Glyoxal and Methylglyoxal Levels in Diabetic Patients: Quantitative Determination by a New GC/MS Method. Clinical Chemistry and Laboratory Medicine. https://doi.org/10.1515/cclm.2003.180
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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