The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Oxidative stress and diabetes mellitus
Abstract
Increasing evidences have suggested that oxidative stress plays a major role in the pathogenesis of diabetes mellitus (DM). Oxidative stress also appears to be the pathogenic factor in underlying diabetic complications. Reactive oxygen species (ROS) are generated by environmental factors, such as ionizing radiation and chemical carcinogens, and also by endogenous processes, including energy metabolism in mitochondria. ROS produced either endogenously or exogenously can attack lipids, proteins and nucleic acids simultaneously in living cells. There are many potential mechanisms whereby excess glucose metabolites traveling along these pathways might promote the development of DM complication and cause pancreatic β cell damage. However, all these pathways have in common the formation of ROS, that, in excess and over time, causes chronic oxidative stress, which in turn causes defective insulin gene expression and insulin secretion as well as increased apoptosis. Various methods for determining biomarkers of cellular oxidative stress have been developed, and some have been proposed for sensitive assessment of antioxidant defense and oxidative damage in diabetes and its complications. However, their clinical utility is limited by less than optimal standardization techniques and the lack of sufficient large-sized, multi-marker prospective trials.
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1 retracted
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RetractedEndoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
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Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
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Mitochondrial dysfunction in the elderly: possible role in insulin resistance
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Cited by
Reisz, J. A., Bansal, N., Qian, J., Zhao, W., & Furdui, C. M. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5489 · Cited by 833
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Metabolic stress-induced joint inflammation and osteoarthritis
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Preiser, J. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111434963 · Cited by 236
Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
Chong, Z. Z., Shang, Y. C., Wang, S., & Maiese, K. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.08.001 · Cited by 119
Metadata
- Authors
- Yang, H., Jin, X., Kei Lam, C. W., & Yan, S.-K.
- Venue
- Clinical Chemistry and Laboratory Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 2011-01-01
- Volume
- 49
- Issue
- 11
- Pages
- 1773-82
- ISSN
- 1434-6621 (ISSN-L)
- 1437-4331
- OpenAlex
- W2116946345
- Cited by
- 306
- References
- 78
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, H., Jin, X., Kei Lam, C. W., & Yan, S.-K. (2011). Oxidative stress and diabetes mellitus. Clinical Chemistry and Laboratory Medicine. https://doi.org/10.1515/cclm.2011.250
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
