Cited by 85Stress Responses and CortisolAdrenal Hormones and DisordersMedicinal Plants and Bioactive Compounds

Correlation of cortisol in 1-cm hair segment with salivary cortisol in human: hair cortisol as an endogenous biomarker

Xie, Qiaozhen, Gao, Wei, Li, Jifeng, Qiao, Ting, Jin, Jing, Deng, Huihua, Lu, Zuhong·2011·Clinical Chemistry and Laboratory Medicine (CCLM)

Abstract

BACKGROUND: Cortisol level in human hair would be an endogenous biomarker for the retrospective assessment of long-term central hypothalamo-pituitary-adrenal activity. However, no direct evidence supports that blood-related diffusion is a biologically endogenous source of hair cortisol in humans. The present study aims to validate the direct correlation between cortisol in 1-cm hair segments and salivary cortisol in healthy humans. METHODS: We collected three saliva samples from the same participant at Time 1, Time 2 (1 week later) and Time 3 (2 weeks later), and hair 4 weeks later. Cortisol levels in 1-cm hair segments and saliva were determined with high performance liquid chromatography tandem mass spectrometry. RESULTS: Salivary cortisol at Time 1 was significantly associated with that at Time 2 (r=0.514, p=0.003), but not with that at Time 3 (r=0.187, p=0.305); and the one at Time 2 was significantly associated with that at Time 3 (r=0.380, p=0.032). Hair cortisol was significantly correlated with salivary cortisol at Time 2 (r=0.389, p<0.05) and average salivary cortisol (r=0.383, p<0.05) from three sampling. CONCLUSIONS: Our results confirmed that blood-related diffusion mechanism is a biologically endogenous source of hair cortisol.

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Crossref · 10.1515/cclm.2011.706

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  • Three independent published samples report cortisol decline rates per 1-cm hair segment of 2.5 pg/mg, 2.7±0.3 pg/mg, and 2.9±0.6 pg/mg.

    “Three independent, published samples report cortisol decline rates per 1-cm hair segment of 2.5 pg/mg (Kirschbaum et al., 2009), 2.7±0.3 pg/mg (Gao et al., 2010), and 2.9±0.6 pg/mg (Xie et al., 2011).”

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Authors
Xie, Q., Gao, W., Li, J., Qiao, T., Jin, J., Deng, H., & Lu, Z.
Affiliations
Southeast University (CN)
Corresponding author
Deng, Huihua
Venue
Clinical Chemistry and Laboratory Medicine (CCLM)
Published
2011-01-01
Volume
49
Issue
12
Pages
2013-9
ISSN
  • 1434-6621 (ISSN-L)
  • 1437-4331
OpenAlex
W2052995288
Cited by
85
References
16
Citations by year
2025: 2 · 2024: 6 · 2023: 8 · 2022: 2 · 2021: 4 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
2.25
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Program for New Century Excellent Talents in University
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
Keywords
hair cortisol, salivary cortisol, cortisol, hypothalamic-pituitary-adrenal axis, chronic stress, biomarker validation
MeSH terms
Adult, Chromatography, High Pressure Liquid, Female, Hair, Humans, Hydrocortisone, Male, Retrospective Studies, Saliva, Biomarkers, Tandem Mass Spectrometry, Young Adult

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