The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.
The serotonergic system and cognitive function
Open accessAbstract
Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning and executive functions are characteristic features of both schizophrenia and Alzheimer’s disease (AD). The neurobiological mechanisms underlying cognition in healthy subjects and neuropsychiatric patients are not completely understood. Studies have focused on serotonin (5-hydroxytryptamine, 5-HT) as one of the possible cognitionrelated biomarkers. The aim of this review is to provide a summary of the current literature on the role of the serotonergic (5-HTergic) system in cognitive function, particularly in AD and schizophrenia. The role of the 5-HTergic system in cognition is modulated by the activity and function of 5-HT receptors (5-HTR) classified into seven groups, which differ in structure, action, and localization. Many 5-HTR are located in the regions linked to various cognitive processes. Preclinical studies using animal models of learning and memory, as well as clinical in vivo(neuroimaging) and in vitro(post-mortem) studies in humans have shown that alterations in 5-HTR activity influence cognitive performance. The current evidence implies that reduced 5-HT neurotransmission negatively influences cognitive functions and that normalization of 5-HT activity may have beneficial effects, suggesting that 5-HT and 5-HTR represent important pharmacological targets for cognition enhancement and restoration of impaired cognitive performance in neuropsychiatric disorders.
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Metadata
- Authors
- Švob Štrac, D., Pivac, N., & Mück-Šeler, D.
- Venue
- Translational Neuroscience
- Publisher
- Walter de Gruyter GmbH
- Published
- 2016-01-01
- Volume
- 7
- Issue
- 1
- Pages
- 35-49
- ISSN
- 2081-3856 (ISSN-L)
- 2081-6936
- OpenAlex
- W2461807154
- Cited by
- 285
- References
- 188
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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