Cited by 173Berberine and alkaloids researchNatural Antidiabetic Agents StudiesMetabolism, Diabetes, and Cancer

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Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials

Derosa, Giuseppe, Maffioli, Pamela, Cicero, Arrigo FG·2012·Expert Opinion on Biological Therapy

DOI 10.1517/14712598.2012.704014

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Abstract

INTRODUCTION: Type 2 diabetes mellitus and hypercholesterolemia have proven to give an increased incidence of cardiovascular diseases (CVD). Recent studies have suggested that the natural alkaloid berberine could have pharmacological activities potentially useful in diabetes and hypercholesterolemia management. AREAS COVERED: The aim of this review is to evaluate the metabolic properties of the natural alkaloid berberine, and its potential application to the treatment of diabetes and CVD prevention. EXPERT OPINION: Berberine proved to be effective in improving glycemic control and lipid profile. The modern investigation on berberine pharmacological activity is actually developing and numerous scientific evidences are actually in progress and reported in international congresses. The near future perspective is the isolation or neo-synthesis of berberine analogs with a higher bioavailability. The anti-hyperlipidemic and anti-diabetic effects of berberine have to be related to markers of improvement in organ damage in humans; longer trials are needed to better evaluate the safety profile of the molecule, when administered alone or in association with other anti-hyperlipidemic or anti-diabetic drugs, especially in the European population.

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Authors: Derosa, G., Maffioli, P., & Cicero, A. F.
Affiliations: University of Pavia (IT)
University of Bologna (IT)
ORCID: Derosa, Giuseppe
Maffioli, Pamela
Cicero, Arrigo FG
Venue: Expert Opinion on Biological Therapy
Publisher: Informa UK Limited
Published: 2012-07-11
Volume: 12
Issue: 8
Pages: 1113-1124
ISSN: 1471-2598 (ISSN-L)
1744-7682
DOI: 10.1517/14712598.2012.704014
OpenAlex: W2008978505
Cited by: 171
References: 91
Citations by year: 2026: 5 · 2025: 8 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 9 · 2020: 17 · 2019: 8 · 2018: 16 · 2017: 10 · 2016: 21 · 2015: 19 · 2014: 16 · 2013: 8 · 2012: 1
FWCI: 1.63
Type: journal article
Language: en
Update notices: expression_of_concern (2018-05-16)
addendum (2018-05-11)
Open access: closed
Locations: Expert Opinion on Biological Therapy (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: berberine, type 2 diabetes, hypercholesterolemia, cardiovascular disease prevention, glycemic control, lipid profile, hypolipidemic effect, anti-diabetic effects, bioavailability, drug safety, natural alkaloids
MeSH terms: Animals, Anticholesteremic Agents, Berberine Alkaloids, Blood Glucose, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, Type 2, Humans, Hypercholesterolemia, Hypoglycemic Agents, Risk Factors, Biomarkers, Treatment Outcome, Risk Assessment

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Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials

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