Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion
Abstract
BACKGROUND: The aim of this study was to evaluate the effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. METHODS: A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients with a diagnosis of metabolic syndrome. Glucose and insulin levels after a dextrose load were measured. Triglycerides and high-density lipoprotein cholesterol concentrations at baseline were also measured. Twelve patients received berberine hydrochloride (500 mg) three times daily before meals for 3 months. The remaining 12 patients received placebo. Area under the curve (AUC) of glucose and insulin, total insulin secretion, first-phase of insulin secretion, and insulin sensitivity were assessed. RESULTS: After berberine administration, patients had a remission of 36% (P=0.037) in the presence of metabolic syndrome and a significant decrease in waist circumference in females (106±4 vs. 103±3 cm, P<0.05), systolic blood pressure (SBP) (123±7 vs. 115±9 mmHg, P<0.01), triglycerides (2.4±0.7 vs. 1.4±0.5 mmol/L, P<0.01), area under the curve (AUC) of glucose (1182.1±253.6 vs. 1069.5±172.4 mmol/l, P<0.05), AUC of insulin (92,056±72,148 vs. 67,407±46,441 pmol/L, P<0.01), and insulinogenic index (0.78±0.69 vs. 0.62±0.46, P<0.05), as well as an increase in the Matsuda index (2.1±1.0 vs. 3.1±1.6, P<0.01). CONCLUSIONS: Administration of berberine leads to remission of metabolic syndrome and decreases in waist circumference, SBP, triglycerides, and total insulin secretion, with an increase in insulin sensitivity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391 · see citing works
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.
Stümvoll, M., Mitrakou, A., Pimenta, W. P., Jenssen, T. G., Yki-Järvinen, H., van Haeften, T. W., Renn, W., & Gerich, J. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.3.295 · Cited by 1,040 · see citing works
Efficacy of berberine in patients with type 2 diabetes mellitus
Yin, J., Xing, H., & Ye, J. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.013 · Cited by 801 · see citing works
Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine
Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2404 · Cited by 573 · cited 2× · see citing works
“This was certainly due to an increment in insulin sensitivity and decrease in insulin secretion.(14,15) Similar findings regarding metabolic control have recently been published with the administration of berberine alone or in combination with other nutraceutical compounds.”
van Harmelen, V., Dicker, A., Rydén, M., Hauner, H., Lönnqvist, F., Näslund, E. B., & Arner, P. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2029 · Cited by 188 · see citing works
Derosa, G., Maffioli, P., & Cicero, A. F. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.704014 · Cited by 171 · see citing works
Zhou, J. Y., Zhou, S. W., Zhang, K. B., Tang, J., Guang, L. X., Ying, Y., Xu, Y. X., Zhang, L., & Li, D. D. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1169 · Cited by 156 · see citing works
Waist Circumference, Visceral Obesity, and Cardiovascular Risk
Poirier, P., & Després, J. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200305000-00001 · Cited by 154 · see citing works
A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome
Affuso, F. (2012) · World Journal of Cardiology · doi:10.4330/wjc.v4.i3.77 · Cited by 75 · see citing works
Yang, J., Yin, J., Gao, H., Xu, L., Wang, Y., Xu, L., & Li, M. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/363845 · Cited by 72 · see citing works
Liu, L., Yu, Y., Yang, J., Yang, L., Liu, Y., Liang, Y., Liu, X., Xie, L. Y., & Wang, G. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0502-0 · Cited by 68 · see citing works
González-Ortı́z, M., Martínez‐Abundis, E., Jacques-Camarena, O., Hernández‐González, S. O., Valera-González, I. G., & Ramos-Zavala, M. G. (2006) · Acta Diabetologica · doi:10.1007/s00592-006-0218-2 · Cited by 22 · see citing works
Self-citationRobles-Cervantes, J. A., Martínez‐Abundis, E., González-Ortı́z, M., Cárdenas-Camarena, L., Hernández-Salazar, E., & Olvera-Ozuna, R. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9213-0 · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., & Assi, H. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020786 · Cited by 1,441 · see citing works
Metabolic syndrome: pathophysiology, management, and modulation by natural compounds
Rochlani, Y. M., Pothineni, N. V. K., Kovelamudi, S., & Mehta, J. L. (2017) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944717711379 · Cited by 1,103 · see citing works
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465 · see citing works
Berberine and barberry ( Berberis vulgaris ): A clinical review
Imenshahidi, M., & Hosseinzadeh, H. (2019) · Phytotherapy Research · doi:10.1002/ptr.6252 · Cited by 370 · see citing works
Pirillo, A., & Catapano, A. L. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.032 · Cited by 308 · see citing works
Xu, X., Yi, H., Wu, J., Kuang, T., Zhang, J., Li, Q., Du, H., Xu, T., Jiang, G., & Fan, G. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110984 · Cited by 246 · see citing works
Biological Activity of Berberine—A Summary Update
Och, A., Podgórski, R., & Nowak, R. (2020) · Toxins · doi:10.3390/toxins12110713 · Cited by 223 · see citing works
Chang, W., Chen, L., & Hatch, G. M. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0107 · Cited by 159 · see citing works
Nanoformulations of natural products for management of metabolic syndrome
Taghipour, Y. D., Hajialyani, M., Naseri, R., Hesari, M., Mohammadi, P., Stefanucci, A., Mollica, A., Farzaei, M. H., & Abdollahi, M. R. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s213831 · Cited by 127 · see citing works
Nutrition in Patients with Type 2 Diabetes: Present Knowledge and Remaining Challenges
Petroni, M. L., Brodosi, L., Marchignoli, F., Sasdelli, A. S., Caraceni, P., Marchesini, G., & Ravaioli, F. (2021) · Nutrients · doi:10.3390/nu13082748 · Cited by 116 · see citing works
Belwal, T., Bisht, A., Devkota, H. P., Ullah, H., Khan, H. Z., Pandey, A., BHATT, I. D., & Echeverría, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00041 · Cited by 115 · see citing works
Yu, Y., Zhao, Y., Teng, F., Li, J., Guan, Y., Xu, J., Lv, X., Guan, F., Zhang, M., & Chen, L. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1015-7 · Cited by 110 · see citing works
Ye, Y., Liu, X., Wu, N., Han, Y., Wang, J., Yu, Y., & Chen, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653887 · Cited by 109 · see citing works
Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule
Elhassan, Y., Philp, A., & Lavery, G. G. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00092 · Cited by 92 · see citing works
Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases
Hesari, M., Mohammadi, P., Khademi, F., Shackebaei, D., Momtaz, S., Moasefi, N., Farzaei, M. H., & Abdollahi, M. R. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s295508 · Cited by 82 · see citing works
Wei, X., Wang, C., Hao, S., Song, H., & Yang, L. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/3593951 · Cited by 82 · see citing works
A Descriptive Review of the Antioxidant Effects and Mechanisms of Action of Berberine and Silymarin
García‐Muñoz, A. M., Victoria‐Montesinos, D., Ballester, P., Cerdá, B., & Zafrilla, P. (2024) · Molecules · doi:10.3390/molecules29194576 · Cited by 74 · see citing works
Wang, Y., & Zidichouski, J. A. (2018) · Cholesterol · doi:10.1155/2018/7173920 · Cited by 68 · see citing works
Carresi, C., Gliozzi, M., Musolino, V., Scicchitano, M., Scarano, F., Bosco, F., Nucera, S., Maiuolo, J., Macrì, R., Ruga, S., et al. (2020) · Nutrients · doi:10.3390/nu12051504 · Cited by 67 · see citing works
Geng, F., Li, G., Zhang, X., Zhang, P., Dong, M., Zhao, Z., Zhang, Y., Dong, L., & Gao, F. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13466 · Cited by 68 · see citing works
Nie, Q., Li, M., Huang, C., Yongwei, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05011-2 · Cited by 65 · see citing works
The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease
Zhu, X., Bian, H., & Gao, X. (2016) · Molecules · doi:10.3390/molecules21101336 · Cited by 62 · see citing works
Villarroel-Vicente, C., Gutiérrez-Palomo, S., Ferri, J., Cortés, D., & Cabedo, N. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113535 · Cited by 63 · see citing works
Zhao, J. V., Yeung, W.-F., Chan, Y.-H., Vackova, D., Leung, J. Y. Y., Ip, D. K. M., Zhao, J., Ho, W.-K., Tse, H.-F., & Schooling, C. M. (2021) · Nutrients · doi:10.3390/nu13082550 · Cited by 58 · see citing works
Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review
Li, J., Bai, L., Wei, F., Zhao, J., Wang, D., Xiao, Y., Yan, W., & Wei, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00661 · Cited by 58 · see citing works
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
Koperska, A., Wesołek, A., Moszak, M., & Szulińska, M. (2022) · Nutrients · doi:10.3390/nu14173459 · Cited by 55 · see citing works
Xiong, P., Niu, L., Talaei, S., Kord‐Varkaneh, H., Clark, C. C. T., Găman, M., Rahmani, J., Dorosti, M., Mousavi, S. M., Zarezadeh, M., et al. (2020) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2020.101113 · Cited by 56 · see citing works
A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant
Purwaningsih, I., Maksum, I. P., Sumiarsa, D., & Sriwidodo, S. (2023) · Molecules · doi:10.3390/molecules28031294 · Cited by 61 · see citing works
Metabolic Syndrome: The Constellation of Co-morbidities, A Global Threat
Madan, K., Paliwal, S., Sharma, S. K., Kesar, S., Chauhan, N., & Madan, M. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230309144825 · Cited by 55 · see citing works
Fatahian, A., Haftcheshmeh, S. M., Azhdari, S., Farshchi, H. K., Nikfar, B., & Momtazi‐Borojeni, A. A. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_42 · Cited by 51 · see citing works
Berberine prevents NAFLD and HCC by modulating metabolic disorders.
Lin, X., Zhang, J.-H., Chu, Y., Nie, Q.-Y., & Zhang, J.-M. (2024) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2024.108593 · Cited by 52 · see citing works
Natural Alkaloids Intervening the Insulin Pathway: New Hopes for Anti-Diabetic Agents?
Christodoulou, M., Tchoumtchoua, J., Skaltsounis, A., Scorilas, A., & Halabalaki, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180430152618 · Cited by 49 · see citing works
Figueiredo, P. S., Inada, A. C., Fernandes, M. R., Arakaki, D. G., Freitas, K. D. C., Guimarães, R. D. C. A., do Nascimento, V. A., & Hiane, P. A. (2018) · Molecules · doi:10.3390/molecules23040877 · Cited by 48 · see citing works
Asbaghi, O., Ghanbari, N., shekari, M., Reiner, Ž., Amirani, E., Hallajzadeh, J., Mirsafaei, L., & Asemi, Z. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.04.010 · Cited by 47 · see citing works
Zhu, B., Cao, H.-T., Sun, L., Лі, Б., Guo, L., Duan, J., Zhu, H., & Zhang, Q. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.01.015 · Cited by 45 · see citing works
Anti-hypertensive and renoprotective effects of berberine in spontaneously hypertensive rats
Guo, Z., Sun, H., Zhang, H., & Zhang, Y. (2015) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2014.972560 · Cited by 44 · see citing works
Chen, S., Jiang, X., Liu, N., Ren, M., Wang, Z., Li, M., Chen, N., & Li, S. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738023 · Cited by 42 · see citing works
Current understanding and future prospects on Berberine for anticancer therapy
Goel, A. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14231 · Cited by 43 · see citing works
Novel nutraceutic therapies for the treatment of metabolic syndrome
Martínez‐Abundis, E., Villar, M. M.-D., Pérez-Rubio, K. G., Zúñiga, L. Y., Cortez-Navarrete, M., Ramírez-Rodríguez, A. M., & González-Ortı́z, M. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i7.142 · Cited by 39 · see citing works
Self-citationLi, J., Du, H., Zhang, M., Zhang, Z., Teng, F., Zhao, Y., Zhang, W., Yu, Y., Feng, L., Cui, X., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.32020 · Cited by 37 · see citing works
Rhizoma Coptidis for Alzheimer’s Disease and Vascular Dementia: A Literature Review
Wang, Z., Yang, Y., Liu, M., Wei, Y., Liu, J., Pei, H., & Li, H. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190710151545 · Cited by 38 · see citing works
Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
Firouzi, S., Malekahmadi, M., Ghayour‐Mobarhan, M., Ferns, G. A., & Rahimi, H. R. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s181572 · Cited by 37 · see citing works
Molecular updates on berberine in liver diseases: Bench to bedside
Bansod, S., Saifi, M. A., & Godugu, C. (2021) · Phytotherapy Research · doi:10.1002/ptr.7181 · Cited by 38 · see citing works
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation
Silva, C. B., Zingg, J.-M. A., Fassini, P. G., & Suen, V. M. M. (2022) · BioFactors · doi:10.1002/biof.1921 · Cited by 35 · see citing works
Liu, L., Liu, J., Gao, Y., Yu, X., Xu, G., & Huang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12666 · Cited by 35 · see citing works
Wang, S., Zhang, X., Cai, B., & Chen, Q. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200910105612 · Cited by 33 · see citing works
Moon, J. M., Ratliff, K. M., Hagele, A. M., Stecker, R. A., Mumford, P. W., & Kerksick, C. M. (2021) · Nutrients · doi:10.3390/nu14010124 · Cited by 33 · see citing works
Nguyen, L. T. H., Ahn, S. H., Nguyen, T. U., & Yang, I. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.04.051 · Cited by 30 · see citing works
SR-BI as a target of natural products and its significance in cancer
Wang, D., Huang, J., Gui, T., Yang, Y., Feng, T., Tzvetkov, N. T., Xu, T., Gai, Z., Zhou, Y., Zhang, J.-J., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.12.025 · Cited by 30 · see citing works
Petrangolini, G., Corti, F., Ronchi, M., Arnoldi, L., Allegrini, P., & Riva, A. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/7563889 · Cited by 29 · see citing works
The Metabolic Syndrome Puzzles; Possible Pathogenesis and Management
Marzoog, B. A. (2022) · Current Diabetes Reviews · doi:10.2174/1573399818666220429100411 · Cited by 29 · see citing works
Zamani, M., Zarei, M., Nikbaf-Shandiz, M., Hosseini, S., Shiraseb, F., & Asbaghi, O. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1013055 · Cited by 28 · see citing works
Yu, Y., Zhang, M., Hu, Y., Zhao, Y., Teng, F., Lv, X., Li, J., Zhang, Y., Hatch, G. M., & Chen, L. (2018) · International Heart Journal · doi:10.1536/ihj.17-458 · Cited by 28 · see citing works
Cicero, A. F. G., Fogacci, F., Bove, M., Giovannini, M., Veronesi, M., & Borghi, C. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.11.018 · Cited by 26 · see citing works
Amini, M. R., Sheikhhossein, F., Naghshi, S., Djafari, F., Askari, M., Shahinfar, H., Safabakhsh, M., Jafari, A., & Shab‐Bidar, S. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102337 · Cited by 26 · see citing works
Ashkar, F., Eftekhari, M. H., Tanideh, N., Koohpeyma, F., Mokhtari, M., Irajie, C., & Iraji, A. (2020) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v13i8.7505 · Cited by 25 · see citing works
Zych, M., Wojnar, W., Kielanowska, M., Folwarczna, J., & Kaczmarczyk‐Sedlak, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124278 · Cited by 25 · see citing works
From Prejudice to Evidence: The Case of Rhizoma Coptidis in Singapore
Ho, C. E., Goh, Y. L., & Zhang, C. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/871720 · Cited by 24 · see citing works
Liu, D., Zhao, H., Zhang, Y., Hu, J., & Xu, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1572197 · Cited by 24 · see citing works
Li, M., Liu, Y., Qiu, Y., Zhang, J., Zhang, Y., Zhao, Y., Jia, Q., & Li, J. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113899 · Cited by 21 · see citing works
Coppinger, C., Pomales, B., Movahed, M. R., Marefat, M. M., & Hashemzadeh, M. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328250471231222094648 · Cited by 21 · see citing works
The Possible Role of Nutraceuticals in the Prevention of Cardiovascular Disease
Rivellese, A. A., Ciciola, P., Costabile, G., Vetrani, C., & Vitale, M. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-019-00309-5 · Cited by 22 · see citing works
Effect of Fucoxanthin on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
López-Ramos, A., González-Ortı́z, M., Martínez‐Abundis, E., & Pérez-Rubio, K. G. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2022.0103 · Cited by 21 · see citing works
Self-citationShenoy, A., Buttar, H. S., Dicholkar, P., Kaur, G., & Chintamaneni, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819815-5.00017-3 · Cited by 21 · see citing works
Liu, Y., Wang, H., Geng, Y.-H., Han, L., Tu, S., & Wang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1112088 · Cited by 19 · see citing works
Alkanad, M. A., Hani, U., Annegowda, H. V., Ghazwani, M., Haider, N., Osmani, R. A. M., Pandareesh, M. D., Hamsalakshmi, & Bhat, R. (2024) · BioFactors · doi:10.1002/biof.2034 · Cited by 17 · see citing works
Increased Oxidative Stress in Cultured 3T3-L1 Cells was Attenuated by Berberine Treatment
Dong, S., Yasui, N., Negishi, H., Kishimoto, A., Sun, J., & Ikeda, K. (2015) · Natural Product Communications · doi:10.1177/1934578x1501000626 · Cited by 17 · see citing works
Aryaeian, N., Sedehi, S. K., Khorshidi, M., Zarezadeh, M., Hosseini, A. F., & Shahram, F. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102331 · Cited by 17 · see citing works
Kavyani, Z., shahhosseini, E., Moridpour, A. H., Falahatzadeh, M., Vajdi, M., Musazadeh, V., & Askari, G. (2023) · PharmaNutrition · doi:10.1016/j.phanu.2023.100364 · Cited by 17 · see citing works
Ke, Z., Zhu, Z., Xu, Z., Fang, C., & Hu, S. (2015) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v14i5.1 · Cited by 16 · see citing works
Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus
Aram, K., Bahari, Z., Elliyeh, M., & Ghasemi, M. (2021) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-021-00159-0 · Cited by 16 · see citing works
Understanding the prevalence, progression, and management of metabolic syndrome in Saudi Arabia
Alshehri, F. F. (2023) · Saudi Medical Journal · doi:10.15537/smj.2023.44.10.20230450 · Cited by 14 · see citing works
Tehrani, S. D., Shojaei, M., Bagherniya, M., Pirro, M., & Sahebkar, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7763 · Cited by 13 · see citing works
Zhao, J. V., Huang, X., Zhang, J., Chan, Y., Tse, H., & Blais, J. E. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.08.016 · Cited by 11 · see citing works
Zhao, J. V., & Schooling, C. M. (2020) · Diabetologia · doi:10.1007/s00125-020-05163-y · Cited by 13 · see citing works
Kermani, T., Kazemi, T., Molki, S., Ilkhani, K., & Sharifzadeh, G. R. (2020) · Modern Care Journal · doi:10.5812/modernc.93955 · Cited by 11 · see citing works
Lei, L., Li, J., & Wang, B. (2023) · Cardiology Discovery · doi:10.1097/cd9.0000000000000087 · Cited by 9 · see citing works
Owumi, S. E., Chimezie, J., Otunla, M. T., Oluwawibe, B. J., Agbarogi, H., Anifowose, M. M., Arunsi, U. O., & Owoeye, O. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02250-2 · Cited by 9 · see citing works
An aptamer-based fluorometric method for the rapid berberine detection in Kampo medicines
Nuntawong, P., Senoo, A., Tayama, Y., Caaveiro, J. M. M., Morimoto, S., & Sakamoto, S. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342930 · Cited by 8 · see citing works
Effects of Nutritional Supplements on Human Health
Cádiz‐Gurrea, M. D. L. L., Soares, S., Leyva‐Jiménez, F. J., Fernández‐Ochoa, Á., Pinto, D., Delerue-Matos, C. M., Segura‐Carretero, A., & Rodrigues, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816450-1.00004-0 · Cited by 8 · see citing works
The effect of berberine on obesity indices: a systematic review and meta-analysis
Vahed, I. E., Shahir-Roudi, E., Nojumi, S., Golmohammadi, S., Shahrebabak, M. M., Moghadam, N. S. T., Bagheryan, A. S., Moftakhar, M., Shamsipour, F., Jafari, M., et al. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01943-x · Cited by 9 · see citing works
Villegas-Aguilar, M. D. C., Fernández‐Ochoa, Á., Leyva‐Jiménez, F. J., Miranda-Segura, Á., Cádiz‐Gurrea, M. D. L. L., & Segura‐Carretero, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823569-0.00001-1 · Cited by 7 · see citing works
Kishimoto, A., Dong, S., Negishi, H., Yasui, N., Sun, J., & Ikeda, K. (2015) · Natural Product Communications · doi:10.1177/1934578x1501000914 · Cited by 7 · see citing works
Exploring Phytotherapeutic Alternatives for Obesity, Insulin Resistance and Diabetes Mellitus
Chávez-Castillo, M., Núñez, V., Rojas, M., Ortega, Á., Durán, P., Pírela, D., Marquina, M. A., Cano, C., Chacín, M., Velasco, M., et al. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200701205132 · Cited by 7 · see citing works
Nyakundi, B. B., Wall, M. M., & Yang, J. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04320-1 · Cited by 6 · see citing works
Srivastava, A., Sinha, A., Lall, R., & Gupta, R. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_5 · Cited by 6 · see citing works
Rostami, H., Babaali, F., Moradi, L., Golfakhrabadi, F., & Abdi, L. (2023) · Iranian Journal of Psychiatry · doi:10.18502/ijps.v18i3.13015 · Cited by 6 · see citing works
Quality evaluation of berberine food supplements with high-field and compact 1H NMR spectrometers
Danoun, S., Balayssac, S., Gilard, V., Martino, R., & Malet‐Martino, M. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2022.115161 · Cited by 6 · see citing works
Dietary and Nutritional Aspects of Metabolic Syndrome Management: An Overview
Singh, P., Kaushik, U., Mir, S. R., Kukreti, N., & Visht, S. (2025) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/0118715303316445241108100017 · Cited by 5 · see citing works
Sharma, A., & Lee, H. (2024) · Antioxidants · doi:10.3390/antiox13111389 · Cited by 4 · see citing works
Natural Chemical Constituents and Polymer Used in to Reduce PCOS Pain
Sarwade, P. P., Dhanasree, B., Gaisamudre, K. N., Kumar, R., Banerjee, A., Dubey, S. A., Otia, M. K., & Kumar, V. (2025) · Journal for Research in Applied Sciences and Biotechnology · doi:10.55544/jrasb.4.1.10 · Cited by 5 · see citing works
Sharma, S., & Tanwar, S. S. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100576 · Cited by 3 · see citing works
Bi, X. J., Lv, Y. Q., Yang, X. H., Ge, Y., Han, H., Feng, J. S., Zhang, M., Chen, L., Xu, M., & Guan, F. (2022) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-022-05547-7 · Cited by 3 · see citing works
Blais, J. E., Huang, X., & Zhao, J. V. (2022) · medRxiv · doi:10.1101/2022.06.20.22276676
“(18, 24, 33, 37) Although the overall number of any adverse events or proportion of patients with an adverse event were similar in five studies (23, 24, 29, 35, 37), gastrointestinal adverse events, such as constipation, diarrhea, and nausea, appeared”
BackgroundPathophysiological Approach to the Development of Plant Compositions with 'Anti-Age' Activity
(2025) · Acta Scientific Medical Sciences · doi:10.31080/asms.2025.09.2075 · Cited by 2 · see citing works
Integrative Therapies in Metabolic Syndrome
Lucius, K. (2024) · Integrative and Complementary Therapies · doi:10.1089/ict.2024.88345.kl · Cited by 1 · see citing works
Herbs for Diabetes: Update—Part 1
Yarnell, E. L., & Abascal, K. (2014) · Alternative and Complementary Therapies · doi:10.1089/act.2014.20607 · Cited by 1 · see citing works
Infantino, V., Riva, A., Petrangolini, G., Allegrini, P., Perna, S., Iannello, G., Peroni, G., Gasparri, C., & Rondanelli, M. (2021) · Current Nutrition & Food Science · doi:10.2174/1573401317666211125101041 · Cited by 1 · see citing works
Fatty liver disease: Functional foods offer natural remedies
Zhao, M., Yi, Z., Zhang, B., Chen, S., Zhuang, X., Yin, H., & Zhao, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91747-6.00001-9 · Cited by 1 · see citing works
- Authors
- Pérez-Rubio, K. G., González-Ortiz, M., Martínez-Abundis, E., Robles-Cervantes, J. A., & Espinel-Bermúdez, M. C.
- Affiliations
- Universidad de Guadalajara (MX)
- Cardiovascular Research Unit, Physiology Department, Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
- Mexican Social Security Institute (MX)
- Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
- Venue
- Metabolic Syndrome and Related Disorders
- Publisher
- SAGE Publications
- Published
- 2013-10
- Volume
- 11
- Issue
- 5
- Pages
- 366-369
- ISSN
- 1540-4196 (ISSN-L)
- 1557-8518
- OpenAlex
- W4229627330
- Cited by
- 113
- References
- 15
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 16 · 2023: 14 · 2022: 8 · 2021: 14 · 2020: 16 · 2019: 10 · 2018: 9 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 4
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolic Syndrome and Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- berberine, metabolic syndrome, insulin sensitivity, insulin secretion, first-phase insulin secretion, insulinogenic index, Matsuda index, triglycerides, waist circumference, systolic blood pressure, glucose tolerance, berberine hydrochloride
- MeSH terms
- Insulin Secretion, Adult, Berberine, Blood Glucose, Blood Pressure, Double-Blind Method, Female, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, Male, Triglycerides, Area Under Curve, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
