Adenoviruses as gene/vaccine delivery vectors: Promises and pitfalls

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

Buchbinder, S. P., Mehrotra, D. V., Duerr, A., Fitzgerald, D. W., Mogg, R., Li, D., Gilbert, P. B., Lama, J. R., Marmor, M., del Rio, C., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61591-3 · Cited by 1,713 · see citing works

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

Raper, S. E., Chirmule, N. B., Lee, F. S., Wivel, N. A., Bagg, A., Gao, G., Wilson, J. M., & Batshaw, M. L. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.08.016 · Cited by 1,502 · see citing works

Adenoviruses: update on structure and function

Russell, W. C. (2008) · Journal of General Virology · doi:10.1099/vir.0.003087-0 · Cited by 462 · see citing works

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

Barnes, E. J., Folgori, A., Capone, S., Swadling, L., Aston, S., Kurioka, A., Meyer, J., Huddart, R., Smith, K., Townsend, R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003155 · Cited by 404 · see citing works

International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations

Barouch, D. H., Kik, S. V., Weverling, G. J., Dilan, R., King, S. L., Maxfield, L. F., Clark, S., Ng’ang’a, D., Brandariz, K., Abbink, P., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.05.025 · Cited by 305 · see citing works

Virus-mediated gene delivery for human gene therapy

Giacca, M., & Zacchigna, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.008 · Cited by 302 · see citing works

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

Parker, A. L., Waddington, S. N., Nicol, C. G., Shayakhmetov, D. M., Buckley, S. M. K., Denby, L., Kemball‐Cook, G., Ni, S., Lieber, A., McVey, J. H., et al. (2006) · Blood · doi:10.1182/blood-2006-04-008532 · Cited by 297 · see citing works

International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials

Mast, T. C., Kierstead, L. S., Gupta, S. B., Nikas, A. A., Kallas, E. G., Novitsky, V., Mbewe, B., Pitisuttithum, P., Schechter, M., Vardas, E., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.10.145 · Cited by 276 · see citing works

Adenovirus Receptors

Zhang, Y., & Bergelson, J. M. (2005) · Journal of Virology · doi:10.1128/jvi.79.19.12125-12131.2005 · Cited by 262 · see citing works

Trial watch

Vacchelli, E., Eggermont, A. M. M., Sautès‐Fridman, C., Galon, J., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2013) · OncoImmunology · doi:10.4161/onci.24612 · Cited by 255 · see citing works

Safety and Immunogenicity of a Replication‐Incompetent Adenovirus Type 5 HIV‐1 Clade B gag/pol/nef Vaccine in Healthy Adults

Priddy, F. H., Brown, D. D., Kublin, J. G., Monahan, K., Wright, D. P., Lalezari, J. P., Santiago, S., Marmor, M. F., Lally, M., Novak, R. M., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587993 · Cited by 249 · see citing works

Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

Koski, A., Kangasniemi, L., Escutenaire, S., Pesonen, S. A., Cerullo, V., Diaconu, I., Nokisalmi, P., Raki, M., Rajecki, M., Guse, K., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.161 · Cited by 243 · see citing works

Integration Specificity of Phage ϕC31 Integrase in the Human Genome

Chalberg, T. W., Portlock, J. L., Olivares, E. C., Thyagarajan, B., Kirby, P. J., Hillman, R. T., Hoelters, J., & Calos, M. P. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.11.098 · Cited by 239 · see citing works

Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses

Mok, H. S., Palmer, D. J., Ng, P., & Barry, M. A. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.09.015 · Cited by 232 · see citing works

The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults

Abel, B., Tameris, M. D., Mansoor, N., Gelderbloem, S., Hughes, J., Abrahams, D. A., Makhethe, L., Erasmus, M., de Kock, M., van der Merwe, L., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200910-1484oc · Cited by 227 · see citing works

Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

Cerullo, V., Pesonen, S. A., Diaconu, I., Escutenaire, S., Arstila, P. T., Ugolini, M., Nokisalmi, P., Raki, M., Laasonen, L., Särkioja, M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3567 · Cited by 226 · see citing works

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance

Othman, M., Labelle, A., Mazzetti, I., Elbatarny, H. S., & Lillicrap, D. (2006) · Blood · doi:10.1182/blood-2006-06-032524 · Cited by 220 · see citing works

Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector

O’Hara, G. A., Duncan, C. J. A., Ewer, K., Collins, K. A., Elias, S. C., Halstead, F. D., Goodman, A. L., Edwards, N. J., Reyes‐Sandoval, A., Bird, P., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir850 · Cited by 214 · see citing works

ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

Hodgson, S. H. C., Duncan, C. J. A., Elias, S. C., Choudhary, P., Biswas, S., Halstead, F. D., Collins, K. A., Edwards, N. J., Douglas, A. D., Anagnostou, N. A., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2012.223 · Cited by 212 · see citing works

Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting

Campos, S., & Barry, M. (2007) · Current Gene Therapy · doi:10.2174/156652307780859062 · Cited by 210 · see citing works

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1

Carlisle, R. C., Di, Y., Cerny, A., Sonnen, A. F. ‐., Sim, R. B., Green, N. K., Šubr, V., Ulbrich, K., Gilbert, R. J. C., Fisher, K., et al. (2009) · Blood · doi:10.1182/blood-2008-09-178459 · Cited by 203 · see citing works

Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent Mechanisms

Lähteenvuo, J., Lähteenvuo, M., Kivelä, A., Hagberg, C. E., Falkevall, A., Klar, J., Heikura, T., Rissanen, T. T., Vähäkangas, E., Korpisalo, P., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.816454 · Cited by 199 · see citing works

Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement

Xu, Z., Tian, J., Smith, J. S., & Byrnes, A. P. (2008) · Journal of Virology · doi:10.1128/jvi.01320-08 · Cited by 199 · see citing works

Current Issues and Future Directions of Oncolytic Adenoviruses

Yamamoto, M., & Curiel, D. T. (2009) · Molecular Therapy · doi:10.1038/mt.2009.266 · Cited by 197 · see citing works

Trial Watch:

Pol, J. G., Bloy, N., Obrist, F., Eggermont, A., Galon, J., Cremer, I., Erbs, P., Limacher, J., Preville, X., Zitvogel, L., et al. (2014) · Oncoimmunology · doi:10.4161/onci.28694 · Cited by 180 · see citing works

Latest Insights on Adenovirus Structure and Assembly

Martı́n, C. S. (2012) · Viruses · doi:10.3390/v4050847 · Cited by 177 · see citing works

Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine

Gray, G., Buchbinder, S., & Duerr, A. C. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32833d2d2b · Cited by 172 · see citing works

Tumor detection and elimination by a targeted gallium corrole

Agadjanian, H., Ma, J., Rentsendorj, A., Valluripalli, V., Hwang, J. Y., Mahammed, A., Farkas, D. L., Gray, H. B., Gross, Z., & Medina‐Kauwe, L. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901531106 · Cited by 167 · see citing works

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

Liikanen, I., Ahtiainen, L., Hirvinen, M., Bramante, S., Cerullo, V., Nokisalmi, P., Hemminki, O., Diaconu, I., Pesonen, S. A., Koski, A., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.51 · Cited by 165 · see citing works

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

Xu, Z., Qiu, Q., Tian, J., Smith, J. S., Conenello, G. M., Morita, T., & Byrnes, A. P. (2013) · Nature Medicine · doi:10.1038/nm.3107 · Cited by 162 · see citing works

Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study

Gurwith, M., Lock, M. D., Taylor, E. M., Ishioka, G. Y., Alexander, J., Mayall, T., Ervin, J. E., Greenberg, R. N., Strout, C. B., Treanor, J. J., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70345-6 · Cited by 157 · see citing works

Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

Khare, R., Chen, C. Y., Weaver, E. A., & Barry, M. A. (2011) · Current Gene Therapy · doi:10.2174/156652311796150363 · Cited by 156 · see citing works

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

Benlahrech, A., Harris, J. D., Meiser, A., Papagatsias, T., Hornig, J., Hayes, P., Lieber, A., Athanasopoulos, T., Bachy, V. S., Csomor, E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907898106 · Cited by 153 · see citing works

Adenovirus Serotype 5 Neutralizing Antibodies Target both Hexon and Fiber following Vaccination and Natural Infection

Bradley, R. R., Lynch, D. M., Iampietro, M. J., Borducchi, E. N., & Barouch, D. H. (2011) · Journal of Virology · doi:10.1128/jvi.06254-11 · Cited by 147 · see citing works

The influence of innate and pre‐existing immunity on adenovirus therapy

Zaiss, A. K., Machado, H. B., & Herschman, H. R. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22328 · Cited by 141 · see citing works

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

Frahm, N., deCamp, A. C., Friedrich, D. P., Carter, D. K., Defawe, O., Kublin, J. G., Casimiro, D. R., Duerr, A. C., Robertson, M. N., Buchbinder, S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci60202 · Cited by 141 · see citing works

The adenovirus capsid: major progress in minor proteins

Vellinga, J., van der Heijdt, S., & Hoeben, R. C. (2005) · Journal of General Virology · doi:10.1099/vir.0.80877-0 · Cited by 140 · see citing works

Oncolytic Immunotherapy of Advanced Solid Tumors with a CD40L-Expressing Replicating Adenovirus: Assessment of Safety and Immunologic Responses in Patients

Pesonen, S. A., Diaconu, I., Kangasniemi, L., Ranki, T., Kanerva, A., Pesonen, S. K., Gerdemann, U., Leen, A. M., Kairemo, K., Oksanen, M., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3001 · Cited by 137 · see citing works

Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors

Coughlan, L., Alba, R., Parker, A. L., Bradshaw, A. C., McNeish, I. A., Nicklin, S. A., & Baker, A. H. (2010) · Viruses · doi:10.3390/v2102290 · Cited by 120 · see citing works

Chemical Modification with High Molecular Weight Polyethylene Glycol Reduces Transduction of Hepatocytes and Increases Efficacy of Intravenously Delivered Oncolytic Adenovirus

Doronin, K., Shashkova, E. V., May, S. M., Hofherr, S. E., & Barry, M. A. (2009) · Human Gene Therapy · doi:10.1089/hum.2009.028 · Cited by 112 · see citing works

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases

Kimball, K. J., Preuss, M. A., Barnes, M. N., Wang, M., Siegal, G. P., Wan, W., Kuo, H., Saddekni, S., Stockard, C. R., Grizzle, W. E., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0791 · Cited by 109 · see citing works

Cancer selective adenoviruses

Alemany, R. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.12.002 · Cited by 108 · see citing works

Adenovirus-Based Vaccines for Fighting Infectious Diseases and Cancer: Progress in the Field

Majhen, D., Calderón, H., Chandra, N., Fajardo, C. A., Rajan, A., Alemany, R., & Custers, J. H. H. V. (2014) · Human Gene Therapy · doi:10.1089/hum.2013.235 · Cited by 102 · see citing works

Use of adenovirus protein IX (pIX) to display large polypeptides on the virion—generation of fluorescent virus through the incorporation of pIX-GFP

Meulenbroek, R. A., Sargent, K. L., Lunde, J. A., Jasmin, B. J., & Parks, R. J. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.01.012 · Cited by 101 · see citing works

Development of hybrid viral vectors for gene therapy

Huang, S., & Kamihira, M. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.10.001 · Cited by 99 · see citing works

Integrin targeted oncolytic adenoviruses Ad5‐D24‐RGD and Ad5‐RGD‐D24‐GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

Pesonen, S. A., Diaconu, I., Cerullo, V., Escutenaire, S., Raki, M., Kangasniemi, L., Nokisalmi, P., Dotti, G., Guse, K., Laasonen, L., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26216 · Cited by 99 · see citing works

Fully Detargeted Polyethylene Glycol-coated Adenovirus Vectors Are Potent Genetic Vaccines and Escape from Pre-existing Anti-adenovirus Antibodies

Wortmann, A., Vöhringer, S., Engler, T., Corjon, S., Schirmbeck, R., Reimann, J., Kochanek, S., & Kreppel, F. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300306 · Cited by 97 · see citing works

A recombinant adenovirus expressing immunodominant TB antigens can significantly enhance BCG-induced human immunity

Hoft, D. F., Blazevic, A., Stanley, J., Landry, B., Sizemore, D. R., Kpamegan, E. P., Gearhart, J., Scott, A. J., Kik, S. V., Pau, M. G., et al. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.048 · Cited by 94 · see citing works

Aerosol and Lobar Administration of a Recombinant Adenovirus to Individuals with Cystic Fibrosis. II. Transfection Efficiency in Airway Epithelium

Perricone, M. A., Morris, J. E., Pavelka, K. L., Plog, M. S., O'Sullivan, B. P., Joseph, P. M., Dorkin, H. L., Lapey, A., Balfour, R., Meeker, D. P., et al. (2001) · Human Gene Therapy · doi:10.1089/104303401750298544 · Cited by 91 · see citing works

Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer

Hemminki, O., Diaconu, I., Cerullo, V., Pesonen, S. K., Kanerva, A., Joensuu, T. K., Kairemo, K., Laasonen, L., Partanen, K. P. L., Kangasniemi, L., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2012.115 · Cited by 87 · see citing works

Oncolytic Viruses as Anticancer Vaccines

Woller, N., rlevik, E. G. ⁄., Ureche, C.-I., Schumacher, A., & hnel, F. K. ⁄. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00188 · Cited by 85 · see citing works

Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X

Bradshaw, A. C., Parker, A. L., Duffy, M. R., Coughlan, L., van Rooijen, N., Kähäri, V., Nicklin, S. A., & Baker, A. H. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001142 · Cited by 84 · see citing works

Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

Tamminga, C. L., Sedegah, M., Regis, D. P., Chuang, I., Epstein, J. E., Spring, M., Mendoza-Silveiras, J., McGrath, S. M., Maiolatesi, S. E., Reyes, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025868 · Cited by 80 · see citing works

Safety and Immunogenicity of Heterologous Prime-Boost Immunisation with Plasmodium falciparum Malaria Candidate Vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in Healthy Gambian and Kenyan Adults

Ogwang, C., Afolabi, M. O., Kimani, D., Jagne, Y. J., Hodgson, S. H. C., Bliss, C. M., Duncan, C. J. A., Collins, K. A., Garcia-Knight, M., Kimani, E. N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057726 · Cited by 80 · see citing works

Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1

Lambe, T., Carey, J. B., Li, Y., Spencer, A. J., van Laarhoven, A., Mullarkey, C. E., Vrdoljak, A., Moore, A., & Gilbert, S. C. (2013) · Scientific Reports · doi:10.1038/srep01443 · Cited by 76 · see citing works

Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B

Mück-Häusl, M., Zhang, W., Müther, N., Rauschhuber, C., Franck, H. W. G., Merricks, E. P., Nichols, T. C., Kay, M. A., & Ehrhardt, A. (2010) · Molecular Therapy · doi:10.1038/mt.2010.169 · Cited by 76 · see citing works

Adeno-associated Virus: A Key to the Human Genome?

Henckaerts, E., & Linden, R. M. (2010) · Future Virology · doi:10.2217/fvl.10.48 · Cited by 71 · see citing works

From the first to the third generation adenoviral vector: What parameters are governing the production yield?

Dormond, E., Perrier, M., & Kamen, A. (2008) · Biotechnology Advances · doi:10.1016/j.biotechadv.2008.10.003 · Cited by 70 · see citing works

Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

Peters, W., Brandl, J. R., Lindbloom, J. D., Martínez, C., Scallan, C. D., Trager, G. R., Tingley, D. W., Kabongo, M. L., & Tucker, S. N. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.01.023 · Cited by 69 · see citing works

Comparison of Replication-Competent, First Generation, and Helper-Dependent Adenoviral Vaccines

Weaver, E. A., Nehete, P. N., Buchl, S. J., Senac, J. S., Palmer, D. J., Ng, P., Sastry, K. J., & Barry, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005059 · Cited by 68 · see citing works

Redundant and Synergistic Mechanisms Control the Sequestration of Blood-born Adenovirus in the Liver

Paolo, N. C. D., van Rooijen, N., & Shayakhmetov, D. M. (2009) · Molecular Therapy · doi:10.1038/mt.2008.307 · Cited by 67 · see citing works

China offers alternative gateway for experimental drugs

Jia, H., & Kling, J. (2006) · Nature Biotechnology · doi:10.1038/nbt0206-117 · Cited by 64 · see citing works

A Mechanistic Study of Tumor-Targeted Corrole Toxicity

Hwang, J. Y., Lubow, J., Chu, D., Ma, J., Agadjanian, H., Sims, J. D., Gray, H. B., Gross, Z., Farkas, D. L., & Medina‐Kauwe, L. K. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200094w · Cited by 63 · see citing works

Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives

Vetrini, F., & Ng, P. (2010) · Viruses · doi:10.3390/v2091886 · Cited by 63 · see citing works

Syrian Hamster as an Animal Model to Study Oncolytic Adenoviruses and to Evaluate the Efficacy of Antiviral Compounds

Wold, W. S. M., & Tóth, K. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-398342-8.00003-3 · Cited by 61 · see citing works

Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity

Hwang, J. Y., Lubow, D. J., Chu, D., Sims, J. D., Alonso-Valenteen, F., Gray, H. B., Gross, Z., Farkas, D. L., & Medina‐Kauwe, L. K. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.015 · Cited by 60 · see citing works

Immunization with recombinant adenovirus synthesizing the secretory form of Japanese encephalitis virus envelope protein protects adenovirus-exposed mice against lethal encephalitis

Appaiahgari, M. B., Saini, M., Rauthan, M., Jyoti, J., & Vrati, S. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.05.023 · Cited by 60 · see citing works

Substitution of Adenovirus Serotype 3 Hexon onto a Serotype 5 Oncolytic Adenovirus Reduces Factor X Binding, Decreases Liver Tropism, and Improves Antitumor Efficacy

Short, J. J., Rivera, Á. A., Wu, H., Walter, M. R., Yamamoto, M., Mathis, J. M., & Curiel, D. T. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0332 · Cited by 59 · see citing works

Adenovirus Protein Involved in Virus Internalization Recruits Ubiquitin−Protein Ligases

Galinier, R., Gout, E., Lortat‐Jacob, H., Wood, J., & Chroboczek, J. (2002) · Biochemistry · doi:10.1021/bi020125b · Cited by 57 · see citing works

Systemic Delivery of a Novel Liver-Detargeted Oncolytic Adenovirus Causes Reduced Liver Toxicity but Maintains the Antitumor Response in a Breast Cancer Bone Metastasis Model

Zhang, Z., Krimmel‐Morrison, J. D., Zhang, Z., Hu, Z., & Seth, P. K. (2011) · Human Gene Therapy · doi:10.1089/hum.2011.003 · Cited by 54 · see citing works

Induction of Interferon Pathways Mediates In Vivo Resistance to Oncolytic Adenovirus

Liikanen, I., Monsurrò, V., Ahtiainen, L., Raki, M., Hakkarainen, T., Diaconu, I., Escutenaire, S., Hemminki, O., Dias, J. D., Cerullo, V., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.144 · Cited by 53 · see citing works

Safety and Immunogenicity of a Replication-Defective Adenovirus Type 5 HIV Vaccine in Ad5-Seronegative Persons: A Randomized Clinical Trial (HVTN 054)

Peiperl, L., Morgan, C. A., Moodie, Z., Li, H., Russell, N. D., Graham, B. S., Tomaras, G. D., Rosa, S. C. D., McElrath, M. J., & the NIAID HIV Vaccine Trials Network (2010) · PLoS ONE · doi:10.1371/journal.pone.0013579 · Cited by 53 · see citing works

Comparative Cell‐Mediated Immunogenicity of DNA/DNA, DNA/Adenovirus Type 5 (Ad5), or Ad5/Ad5 HIV‐1 Clade BgagVaccine Prime‐Boost Regimens

Asmuth, D. M., Brown, E. L., DiNubile, M. J., Sun, X., del Rı́o, C., Harro, C. D., Keefer, M. C., Kublin, J. G., Dubey, S. A., Kierstead, L. S., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/648591 · Cited by 51 · see citing works

Viruses—from pathogens to vaccine carriers

Small, J. C., & Ertl, H. C. J. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.07.009 · Cited by 45 · see citing works

Increasing the Efficacy of Oncolytic Adenovirus Vectors

Tóth, K., & Wold, W. S. M. (2010) · Viruses · doi:10.3390/v2091844 · Cited by 43 · see citing works

Cardiovascular gene therapy with vascular endothelial growth factors

Ylä‐Herttuala, S. (2013) · Gene · doi:10.1016/j.gene.2013.03.051 · Cited by 40 · see citing works

An Infection-enhanced Oncolytic Adenovirus Secreting H. pylori Neutrophil-activating Protein with Therapeutic Effects on Neuroendocrine Tumors

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Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands

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rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors

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Scavenger Receptors in the Pathogenesis of Viral Infections

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Gene Therapy in Skin and Wound Healing

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Hitching a Ride: Enhancing Nucleic Acid Delivery into Target Cells Through Nanoparticles

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A Critical Assessment of COVID-19 Genomic Vaccines

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Gene Therapy Approaches for Cochlear Repair

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