The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Role of gemcitabine in cancer therapy
Abstract
Gemcitabine, a pyrimidine nucleoside antimetabolite, is one of the most promising new cytotoxic agents. The drug has shown activity in a variety of solid tumors, and has been approved for the treatment of non-small cell lung cancer, pancreatic, bladder, and breast cancer. Recent data showed that gemcitabine is also active against ovarian cancer. Gemcitabine has a good toxicity profile, with myelosuppression being the most common side effect, while non-hematological events are relatively uncommon. The low toxicity profile makes the drug a valid option for unfit and elderly patients. Due to the synergistic activity with other chemotherapeutic compounds, mainly cisplatinum, several trials have been conducted to evaluate the efficacy and tolerability of gemcitabine in combination with other cytotoxic agents. Current clinical trials are evaluating the role of gemcitabine in combination with new targeted therapies.
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COMPARISON OF FOUR CHEMOTHERAPY REGIMENS FOR ADVANCED NON-SMALL-CELL LUNG CANCER
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Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Interaction of tumor-associated macrophages and cancer chemotherapy
Larionova, I., Cherdyntseva, N., Liu, T., Patysheva, M., Rakina, M., & Kzhyshkowska, J. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1596004 · Cited by 322
Barriers and opportunities for gemcitabine in pancreatic cancer therapy
Beutel, A. K., & Halbrook, C. J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00331.2022 · Cited by 150
Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery
Jurczyk, M., Jelonek, K., Musiał-Kulik, M., Beberok, A., Wrześniok, D., & Kasperczyk, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030326 · Cited by 133
Imiquimod-gemcitabine nanoparticles harness immune cells to suppress breast cancer
Singh, B., Maharjan, S., Pan, D. C., Zhao, Z., Gao, Y., Zhang, Y. S., & Mitragotri, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121302 · Cited by 49
Metadata
- Authors
- Toschi, L., Finocchiaro, G., Bartolini, S., Gioia, V, & Cappuzzo, F.
- Venue
- Future Oncology
- Publisher
- Informa UK Limited
- Published
- 2005-02
- Volume
- 1
- Issue
- 1
- Pages
- 7-17
- ISSN
- 1479-6694 (ISSN-L)
- 1744-8301
- OpenAlex
- W2098158472
- Cited by
- 373
- References
- 56
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Toschi, L., Finocchiaro, G., Bartolini, S., Gioia, V, & Cappuzzo, F. (2005). Role of gemcitabine in cancer therapy. Future Oncology. https://doi.org/10.1517/14796694.1.1.7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
