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Cited by 116Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsProteins in Food Systems

The DOI matches its Crossref record; 98 of the 102 references it cites were found in a registry or an index.

Oral delivery of peptides and proteins using lipid-based drug delivery systems

Li, Ping, Nielsen, Hanne Mørck, Müllertz, Anette·2012·Expert Opinion on Drug Delivery
DOI 10.1517/17425247.2012.717068
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Abstract

INTRODUCTION: In order to successfully develop lipid-based drug delivery systems (DDS) for oral administration of peptides and proteins, it is important to gain an understanding of the colloid structures formed by these DDS, the mode of peptide and protein incorporation as well as the mechanism by which intestinal absorption of peptides and proteins is promoted. AREAS COVERED: The present paper reviews the literature on lipid-based DDS, employed for oral delivery of peptides and proteins and highlights the mechanisms by which the different lipid-based carriers are expected to overcome the two most important barriers (extensive enzymatic degradation and poor transmucosal permeability). This paper also gives a clear-cut idea about advantages and drawbacks of using different lipidic colloidal carriers ((micro)emulsions, solid lipid core particles and liposomes) for oral delivery of peptides and proteins. EXPERT OPINION: Lipid-based DDS are safe and suitable for oral delivery of peptides and proteins. Significant progress has been made in this area with several technologies on clinical trials. However, a better understanding of the mechanism of action in vivo is needed in order to improve the design and development of lipid-based DDS with the desired bioavailability and therapeutic profile.

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Crossref · 10.1517/17425247.2012.717068

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4 of the 102 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

  1. Legrand P, 1999, Stp Pharma Sci, 9, 411
  2. Sarmento B, 2007, Int J Nanomed, 2, 743
  3. Lee JH, 2008, J Tisuue Eng Regen Med, 5, 215
  4. 10.1046/j.1365-2710.2000.00306.x · DOI
  5. Cavalli R, 1999, Stp Pharma Sci, 9, 183
  6. 10.1016/j.ijpharm.2005.06.028 · DOI
  7. 10.1080/10611860600648346 · DOI

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Metadata

Authors
Li, P., Nielsen, H. M., & Müllertz, A.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
Expert Opinion on Drug Delivery
Publisher
Informa Healthcare
Published
2012-08-17
Volume
9
Issue
10
Pages
1289-1304
ISSN
  • 1742-5247 (ISSN-L)
  • 1744-7593
DOI
10.1517/17425247.2012.717068
OpenAlex
W2049764487
Cited by
116
References
102
Citations by year
2026: 4 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 14 · 2013: 9
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Drug Delivery (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Mokslo, Inovaciju ir Technologiju Agentura
  • Danish Agency for Science and Higher Education
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Keywords
oral drug delivery, peptides, proteins, lipid-based drug delivery, microemulsions, liposomes, enzymatic degradation, intestinal absorption, bioavailability
MeSH terms
Administration, Oral, Animals, Biological Availability, Drug Carriers, Emulsions, Humans, Intestinal Absorption, Lipids, Liposomes, Peptides, Permeability, Proteins, Drug Delivery Systems

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