The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Drug delivery from gelatin-based systems
Abstract
INTRODUCTION: Carriers for controlled drug release offer many advantages compared with conventional dosage forms. Gelatin has been investigated extensively as a drug delivery carrier, due to its properties and history of safe use in a wide range of medical applications. AREAS COVERED: Gelatin was shown to be versatile due to its intrinsic features that enable the design of different carrier systems, such as microparticles and nanoparticles, fibers and even hydrogels. Gelatin microparticles can serve as vehicles for cell amplification and for delivery of large bioactive molecules, whereas gelatin nanoparticles are better suited for intravenous delivery or for drug delivery to the brain. Gelatin fibers contain a high surface area-to-volume ratio, whereas gelatin hydrogels can trap molecules between the polymer's crosslink gaps, allowing these molecules to diffuse into the blood stream. Another interesting area is the combination of tissue bioadhesive-based gelatin with controlled drug release for pain management and wound healing. EXPERT OPINION: The modification of gelatin and its combinations with other biomaterials have demonstrated the flexibility of these systems and can be employed for meeting the challenges of finding ideal carrier systems that enable specific, targeted and controlled release in response to demands in the body.
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Citations
Cites
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Cited by
Current development of biodegradable polymeric materials for biomedical applications
Song, R., Murphy, M., Li, C., Ting, K., Soo, C., & Zheng, Z. (2018) · Drug Design, Development and Therapy · doi:10.2147/dddt.s165440 · Cited by 915
Biopolymer based nanomaterials in drug delivery systems: A review
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3D-poly (lactic acid) scaffolds coated with gelatin and mucic acid for bone tissue engineering
Ashwin, B., Abinaya, B., Prasith, T. P., Chandran, S. V., Yadav, L. R., Vairamani, M., Patil, S., & Selvamurugan, N. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.157 · Cited by 92
Metadata
- Authors
- Foox, M., & Zilberman, M.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2015-05-05
- Volume
- 12
- Issue
- 9
- Pages
- 1547-1563
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W1944943742
- Cited by
- 360
- References
- 103
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
