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Animal models of skin disease for drug discovery
Open accessAbstract
INTRODUCTION: Discovery of novel drugs, treatments, and testing of consumer products in the field of dermatology is a multi-billion dollar business. Due to the distressing nature of many dermatological diseases, and the enormous consumer demand for products to reverse the effects of skin photodamage, aging, and hair loss, this is a very active field. AREAS COVERED: In this paper, we will cover the use of animal models that have been reported to recapitulate to a greater or lesser extent the features of human dermatological disease. There has been a remarkable increase in the number and variety of transgenic mouse models in recent years, and the basic strategy for constructing them is outlined. EXPERT OPINION: Inflammatory and autoimmune skin diseases are all represented by a range of mouse models both transgenic and normal. Skin cancer is mainly studied in mice and fish. Wound healing is studied in a wider range of animal species, and skin infections such as acne and leprosy also have been studied in animal models. Moving to the more consumer-oriented area of dermatology, there are models for studying the harmful effect of sunlight on the skin, and testing of sunscreens, and several different animal models of hair loss or alopecia.
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“Animal models, though valuable for systemic analyses, remain constrained by interspecies differences in cytokine networks, immune repertoires and epidermal structure, thereby limiting translational relevance 10 .”
From Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro (2026) · cites this paper as [10]
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Metadata
- Authors
- Avci, P., Sadasivam, M., Gupta, A., De Melo, W. C., Huang, Y.-Y., Yin, R., Chandran, R., Kumar, R., Otufowora, A., Nyame, T., & Hamblin, M. R.
- Affiliations
- Harvard University (US)
- Amity University (IN)
- Massachusetts General Hospital (US)
- ORCID
- Venue
- Expert Opinion on Drug Discovery
- Publisher
- Informa UK Limited
- Published
- 2013-01-08
- Volume
- 8
- Issue
- 3
- Pages
- 331-355
- ISSN
- 1746-0441 (ISSN-L)
- 1746-045X
- PMC
- PMC3580014
- OpenAlex
- W2102728708
- Cited by
- 130
- References
- 190
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 18 · 2023: 13 · 2022: 10 · 2021: 19 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 3 · 2014: 3
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Expert Opinion on Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI050875)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Keywords
- transgenic mouse model, inflammatory skin diseases, autoimmune skin disease, wound healing model, acne, leprosy, sunburn, sunscreen testing, hair loss
- MeSH terms
- Animals, Autoimmune Diseases, Disease Models, Animal, Inflammation, Skin Diseases, Drug Discovery
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