Cited by 334Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesNeural dynamics and brain function

Cognitive impairment in epilepsy: the role of network abnormalities

Open access
Holmes, Gregory L·2015·Epileptic Disorders

Abstract

The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities in epilepsy are very common and are often more problematic to individuals than the seizures themselves. In this review, the pathophysiological mechanisms of cognitive impairment are discussed. While aetiology of the epilepsy has a significant influence on cognition, there is increasing evidence that prolonged or recurrent seizures can cause or exacerbate cognitive impairment. Alterations in signalling pathways and neuronal network function play a major role in both the pathophysiology of epilepsy and the epilepsy comorbidities. However, the biological underpinnings of cognitive impairment can be distinct from the pathophysiological processes that cause seizures.

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Crossref · 10.1684/epd.2015.0739

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  • Childhood frontal lobe epilepsy (FLE) has various clinical outcomes but most often results in multi-cognitive symptoms.

    “Epilepsy, specifically childhood frontal lobe epilepsy (FLE) has various clinical outcomes but most often resulting in multi-cognitive symptoms [384–387].”

    From Development of prefrontal cortex (2022) · cites this paper as [385]

    The Introduction describes varied comorbidities in epilepsy and says cognitive difficulties are common, including among children. It does not establish that childhood frontal lobe epilepsy specifically most often produces multiple cognitive symptoms. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • Epileptic activity contributes to, and exacerbates cognitive decline.

    “Though cognitive deficits can independently occur in seizure disorders as a direct result of disease etiology, such as trauma, epileptic activity contributes to, and exacerbates cognitive decline (Holmes, 2015).”

    From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Holmes, 2015

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Authors
Holmes, G. L.
Affiliations
University of Vermont (US)
Corresponding author
Holmes, Gregory L
Venue
Epileptic Disorders
Publisher
Wiley
Published
2015-06
Volume
17
Issue
2
Pages
101-116
ISSN
  • 1294-9361 (ISSN-L)
  • 1950-6945
OpenAlex
W1606616855
Cited by
334
References
89
Citations by year
2026: 32 · 2025: 37 · 2024: 48 · 2023: 28 · 2022: 52 · 2021: 43 · 2020: 42 · 2019: 23 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 1
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • Epileptic Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS073083, NS074450, NS073083, R01NS078279, R01NS074450)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
cognitive impairment, epilepsy, epilepsy comorbidity, epilepsy pathophysiology, recurrent seizures, signaling pathways
MeSH terms
Animals, Cognition Disorders, Epilepsy, Humans, Nerve Net, Brain Waves

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