The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Neurobiology of Tourette Syndrome: Current Status and Need for Further Investigation: Table 1.
Open accessAbstract
Tourette syndrome (TS) is a common, chronic neuropsychiatric disorder characterized by the presence of fluctuating motor and phonic tics. The typical age of onset is ∼5-7 years, and the majority of children improve by their late teens or early adulthood. Affected individuals are at increased risk for the development of various comorbid conditions, such as obsessive-compulsive disorder, attention deficit hyperactivity disorder, school problems, depression, and anxiety. There is no cure for tics, and symptomatic therapy includes behavioral and pharmacological approaches. Evidence supports TS being an inherited disorder; however, the precise genetic abnormality remains unknown. Pathologic involvement of cortico-striatal-thalamo-cortical (CSTC) pathways is supported by neurophysiological, brain imaging, and postmortem studies, but results are often confounded by small numbers, age differences, severity of symptoms, comorbidity, use of pharmacotherapy, and other factors. The primary site of abnormality remains controversial. Although numerous neurotransmitters participate in the transmission of messages through CSTC circuits, a dopaminergic dysfunction is considered a leading candidate. Several animal models have been used to study behaviors similar to tics as well as to pursue potential pathophysiological deficits. TS is a complex disorder with features overlapping a variety of scientific fields. Despite description of this syndrome in the late 19th century, there remain numerous unanswered neurobiological questions.
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“There is increasing evidence for frontal–striatal dysfunction in TS [for reviews, see Albin and Mink (2006) and Felling and Singer (2011)].”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Felling and Singer (2011)
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Course of Tic Severity in Tourette Syndrome: The First Two Decades
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Mink, J. W. (2003) · Archives of Neurology · doi:10.1001/archneur.60.10.1365 · Cited by 552
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
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A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
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- 10.1097/00019052-200306000-00017 · DOI
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Kalueff, A. V., Stewart, A. M., Song, C., Berridge, K. C., Graybiel, A. M., & Fentress, J. C. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.8 · Cited by 852
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Dale, R. C., Merheb, V., Pillai, S. C., Wang, D., Cantrill, L. C., Murphy, T. K., Ben‐Pazi, H., Varadkar, S., Aumann, T. D., Horne, M. K., et al. (2012) · Brain · doi:10.1093/brain/aws256 · Cited by 392
Worbe, Y., Marrakchi‐Kacem, L., Lecomte, S., Valabrègue, R., Poupon, F., Guevara, P., Tucholka, A., Mangin, J., Vidailhet, M., Lehéricy, S., et al. (2014) · Brain · doi:10.1093/brain/awu311 · Cited by 257
Neuromodulation in Tourette syndrome: dopamine and beyond
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Imaging the where and when of tic generation and resting state networks in adult Tourette patients
Neuner, I., Werner, C. J., Arrubla, J., Stöcker, T., Ehlen, C., Wegener, H. P., Schneider, F. W., & Shah, N. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00362 · Cited by 198
Metadata
- Authors
- Felling, R. J., & Singer, H. S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Singer, Harvey S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-08-31
- Volume
- 31
- Issue
- 35
- Pages
- 12387-12395
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6703258
- OpenAlex
- W1970375293
- Cited by
- 227
- References
- 138
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 14 · 2022: 7 · 2021: 8 · 2020: 20 · 2019: 16 · 2018: 17 · 2017: 24 · 2016: 26 · 2015: 22 · 2014: 16 · 2013: 18 · 2012: 6
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Social Sciences › Psychology › Clinical Psychology › Stuttering Research and Treatment
- Keywords
- Tourette syndrome, neurobiology, dopaminergic dysfunction, tics, genetic inheritance, comorbidities, neurotransmitters, neuroimaging
- MeSH terms
- Animals, Disease Models, Animal, Tourette Syndrome, Humans, Neurobiology, History, 19th Century
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