Neuromodulation in Tourette syndrome: dopamine and beyond

Buse, Judith; Schoenefeld, Katja; Münchau, Alexander; Roessner, Veit

doi:10.1016/j.neubiorev.2012.10.004

Cited by 185Obsessive-Compulsive Spectrum DisordersNeurological disorders and treatmentsNeurotransmitter Receptor Influence on Behavior

Neuromodulation in Tourette syndrome: dopamine and beyond

Buse, Judith, Schoenefeld, Katja, Münchau, Alexander, Roessner, Veit·2013·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2012.10.004

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Abstract

Almost since the beginning of research on Tourette syndrome (TS), tics have been linked to a dysfunction of the dopamine (DA) system. At first, this assumption was mainly based on clinical findings of DA antagonists being the most effective drug in treating tics, but in recent years nuclear imaging has enabled a much deeper understanding of DA neurotransmission in TS. Based on the findings of various PET and SPECT studies the first part of the review discusses four hypotheses on DA dysfunctions in TS: (i) DA hyperinnervation, (ii) supersensitive DA receptors, (iii) pre-synaptic DA abnormality and (iv) DA tonic-phasic dysfunction. According to the latter hypothesis, reduced levels of tonic DA in the extracellular space lead to higher concentrations of DA in the axon terminal and an increase of stimulus-dependent DA release. The second part of the review addresses the modulating role of DA in some major clinical features of TS, like the exacerbation with stress or infection and the association with deficient sensorimotor gating.

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OCD, TTM, and TS can be regarded as hyperdopaminergic disorders.
“Nevertheless, current evidence suggests that ADHD can be seen as a hypodopaminergic disorder, whereas OCD, TTM, and TS can be regarded as hyperdopaminergic disorders (Buse et al., 2013).”
From Response Inhibition and Interference Control in Obsessiveâ€“Compulsive Spectrum Disorders (2014) · cites this paper as Buse et al., 2013
ADHD can be seen as a hypodopaminergic disorder.
“Nevertheless, current evidence suggests that ADHD can be seen as a hypodopaminergic disorder, whereas OCD, TTM, and TS can be regarded as hyperdopaminergic disorders (Buse et al., 2013).”
From Response Inhibition and Interference Control in Obsessiveâ€“Compulsive Spectrum Disorders (2014) · cites this paper as Buse et al., 2013

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Authors: Buse, J., Schoenefeld, K., Münchau, A., & Roessner, V.
Affiliations: Technische Universität Dresden (DE)
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author: Roessner, Veit
ORCID: Buse, Judith
Münchau, Alexander
Roessner, Veit
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2013-07
Volume: 37
Issue: 6
Pages: 1069-1084
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2012.10.004
OpenAlex: W1993130087
Cited by: 185
References: 205
Citations by year: 2026: 8 · 2025: 6 · 2024: 17 · 2023: 7 · 2022: 14 · 2021: 21 · 2020: 23 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 16 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 1
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: Tourette syndrome, dopamine, tics, dopamine receptor supersensitivity, dopamine antagonists, sensorimotor gating, neuromodulation
MeSH terms: Dopamine, Tourette Syndrome, Humans, Synaptic Transmission, Neurotransmitter Agents, Dopamine Antagonists, Neuroimaging

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Neuromodulation in Tourette syndrome: dopamine and beyond

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