The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a
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The acquisition of distinct neuronal fates is fundamental for the function of the cerebral cortex. We find that the development of subcerebral projections from layer 5 neurons in the mouse neocortex depends on the high levels of expression of the transcription factor CTIP1; CTIP1 is coexpressed with CTIP2 in neurons that project to subcerebral targets and with SATB2 in those that project to the contralateral cortex. CTIP1 directly represses Tbr1 in layer 5, which appears as a critical step for the acquisition of the subcerebral fate. In contrast, lower levels of CTIP1 in layer 6 are required for TBR1 expression, which directs the corticothalamic fate. CTIP1 does not appear to play a critical role in the acquisition of the callosal projection fate in layer 5. These findings unravel a key step in the acquisition of cell fate for closely related corticofugal neurons and indicate that differential dosages of transcriptions factors are critical to specify different neuronal identities.
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Interactions of several genes with Tbr1 determine corticothalamic projection of layer VI neurons, callosal projection of superficial cortical layer neurons, and subcortical projection of layer V neurons.
“Complex interactions of several genes with Tbr1 determine the corticothalamic projection of layer VI neurons, callosal projection of neurons in the cortical superficial layers [335] and subcortical projection of layer V neurons [50, 142, 232].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [50]
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- Authors
- Cánovas, J., Berndt, F. A., Sepúlveda, H., Aguilar, R., Veloso, F. A., Montecino, M., Oliva, C., Maass, J. C., Sierralta, J., & Kukuljan, M.
- Affiliations
- University of Chile (CL)
- Universidad Andrés Bello (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-05-13
- Volume
- 35
- Issue
- 19
- Pages
- 7552-7564
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6705430
- OpenAlex
- W1750971820
- Cited by
- 63
- References
- 56
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 1
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Repositorio Institucional Académico , Sistema de Bibliotecas Universidad Andrés Bello (UNAB) (Universidad Andrés Bello (UNAB)) (submittedVersion, cc-by)
- Funders
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- BCL11A, Tbr1, corticofugal neurons, layer 5 neurons, corticothalamic neurons, SATB2, callosal projections, neuronal fate specification, transcriptional repression, neocortex development
- MeSH terms
- Doublecortin Domain Proteins, Animals, Animals, Newborn, Carrier Proteins, Cells, Cultured, Cerebral Cortex, DNA-Binding Proteins, Embryo, Mammalian, Female, Histones, Humans, Male, Mice, Transgenic, Microtubule-Associated Proteins, Neural Pathways, Neurons, Neuropeptides, Nuclear Proteins, Repressor Proteins, Gene Expression Regulation, Developmental, Ki-67 Antigen, T-Box Domain Proteins, Mice, In Vitro Techniques
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