Autophagy Promotes Oligodendrocyte Survival and Function following Dysmyelination in a Long-Lived Myelin Mutant
Open accessAbstract
The Long–Evans shaker (les) rat has a mutation in myelin basic protein that results in severe CNS dysmyelination and subsequent demyelination during development. During this time,les oligodendrocytes accumulate cytoplasmic vesicles, including lysosomes and membrane-bound organelles. However, the mechanism and functional relevance behind these oligodendrocyte abnormalities in les have not been investigated. Using high-magnification electron microscopy, we identified the accumulations in les oligodendrocytes as early and late autophagosomes. Additionally, immunohistochemistry and Western blots showed an increase in autophagy markers in les. However, autophagy did not precede the death of les oligodendrocytes. Instead, upregulating autophagy promoted membrane extensions in les oligodendrocytes in vitro. Furthermore, upregulating autophagy in les rats via intermittent fasting increased the proportion of myelinated axons as well as myelin sheath thickness in les and control rats. Overall, this study provides insight into the abnormalities described in les as well as identifying a novel mechanism that promotes the survival and function of oligodendrocytes.
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Autophagy activation enhances oligodendrocyte survival and promotes myelination in a rat model of demyelinating disease.
“Consistent with these findings, autophagy activation enhances oligodendrocyte survival and promotes myelination in a rat model of demyelinating disease [448].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [448]
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · see citing works
Methods in Mammalian Autophagy Research
Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497 · see citing works
Autophagy as a regulated pathway of cellular degradation.
Klionsky, D., & Emr, S. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,794 · see citing works
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,560 · see citing works
Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832 · see citing works
Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin
Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889 · see citing works
Autophagy: in sickness and in health
Cuervo, A. M. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.12.002 · Cited by 816 · see citing works
Axon-Glial Signaling and the Glial Support of Axon Function
Nave, K., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 659 · see citing works
Readhead, C. W., Popko, B., Takahashi, N., Shine, H. D., Saavedra, R. A., Sidman, R. L., & Hood, L. (1987) · Cell · doi:10.1016/0092-8674(87)90248-0 · Cited by 397 · see citing works
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
Martin, B., Mattson, M. P., & Maudsley, S. R. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.002 · Cited by 394 · see citing works
ROACH, A., TAKAHASHI, N., PRAVTCHEVA, D., RUDDLE, F., & HOOD, L. (1985) · Cell · doi:10.1016/s0092-8674(85)80110-0 · Cited by 336 · see citing works
p62/SQSTM1: A Missing Link between Protein Aggregates and the Autophagy Machinery
Bjørkøy, G., Lamark, T., & Johansen, T. (2006) · Autophagy · doi:10.4161/auto.2.2.2405 · Cited by 322 · see citing works
He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303800200 · Cited by 273 · see citing works
Caspases function in autophagic programmed cell death inDrosophila
Martin, D. N., & Baehrecke, E. H. (2003) · Development · doi:10.1242/dev.00933 · Cited by 258 · see citing works
Chapter 10 Monitoring Autophagy by Electron Microscopy in Mammalian Cells
Ylä‐Anttila, P., Vihinen, H., Jokitalo, E., & Eskelinen, E. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(08)03610-0 · Cited by 257 · see citing works
Harauz, G., Ishiyama, N., Hill, C. M. D., Bates, I. R., Libich, D. S., & Farès, C. (2004) · Micron · doi:10.1016/j.micron.2004.04.005 · Cited by 256 · see citing works
Endoplasmic reticulum stress in disorders of myelinating cells
Lin, W., & Popko, B. (2009) · Nature Neuroscience · doi:10.1038/nn.2273 · Cited by 253 · see citing works
Tanida, I., Ueno, T., & Kominami, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407016200 · Cited by 244 · see citing works
Selective turnover of p62/A170/SQSTM1 by autophagy
Ichimura, Y., Kominami, E., Tanaka, K., & Komatsu, M. (2008) · Autophagy · doi:10.4161/auto.6826 · Cited by 228 · see citing works
Wrapping it up: the cell biology of myelination
Simons, M., & Trotter, J. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.08.003 · Cited by 227 · see citing works
Central myelin in the mouse mutant shiverer
D, J. R. M. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901940310 · Cited by 223 · see citing works
Axonal pathology in myelin disorders
Bjartmar, C., Yin, X., & Trapp, B. D. (1999) · Journal of Neurocytology · doi:10.1023/a:1007010205037 · Cited by 180 · see citing works
Molecular cloning and characterization of rat LC3A and LC3B—Two novel markers of autophagosome
Wu, J., Dang, Y., Su, W., Liu, C., Ma, H., Shan, Y., Pei, Y., Wan, B., Guo, J., & Yu, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.211 · Cited by 174 · see citing works
Aggresome Formation in Neuropathy Models Based on Peripheral Myelin Protein 22 Mutations
Ryan, M. C., Shooter, E. M., & Notterpek, L. M. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0500 · Cited by 157 · see citing works
PMP22 Accumulation in Aggresomes: Implications for CMT1A Pathology
Notterpek, L. M., Ryan, M. C., Tobler, A. R., & Shooter, E. M. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0274 · Cited by 156 · see citing works
Rapamycin Activates Autophagy and Improves Myelination in Explant Cultures from Neuropathic Mice
Rangaraju, S., Verrier, J. D., Madorsky, I., Nicks, J., Dunn, W. A., & Notterpek, L. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1356-10.2010 · Cited by 154 · see citing works
The dysmyelinating mouse mutations shiverer (shi) and myelin deficient (shi mld )
Readhead, C. W., & Hood, L. (1990) · Behavior Genetics · doi:10.1007/bf01067791 · Cited by 153 · see citing works
Evolution of a neuroprotective function of central nervous system myelin
Yin, X., Baek, R. C., Kirschner, D. A., Peterson, A. C., Fujii, Y., Nave, K., Macklin, W. B., & Trapp, B. D. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509174 · Cited by 141 · see citing works
The Pathobiology of Myelin Mutants Reveal Novel Biological Functions of the MBP and PLP Genes
Campagnoni, A. T., & Skoff, R. P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00383.x · Cited by 138 · see citing works
Myelin basic protein‐dependent plasma membrane reorganization in the formation of myelin
Fitzner, D., Schneider, A., Kippert, A., Möbius, W., Willig, K. I., Hell, S. W., Bunt, G., Gaus, K., & Simons, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601376 · Cited by 135 · see citing works
Fortun, J., Go, J. C., Li, J., Amici, S. A., Dunn, W. A., & Notterpek, L. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.10.010 · Cited by 128 · see citing works
Generation of oligodendroglial progenitors from neural stem cells
Zhang, S., Lundberg, C. G., Lipsitz, D., O’Connor, L. T., & Duncan, I. D. (1998) · Journal of Neurocytology · doi:10.1023/a:1006953023845 · Cited by 112 · see citing works
Self-citationvan Kollenburg, B., van Dijk, J., Garbern, J. Y., Thomas, A. A. M., Scheper, G. C., Powers, J. M., & van der Knaap, M. S. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000228201.27539.50 · Cited by 108 · see citing works
The Unfolded Protein Response in Vanishing White Matter Disease
van der Voorn, J. P., van Kollenburg, B., Bertrand, G. A. M., van Haren, K. P., Scheper, G. C., Powers, J. M., & van der Knaap, M. S. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178446.41595.3a · Cited by 102 · see citing works
Avellana‐Adalid, V., Nait‐Oumesmar, B., Lachapelle, F., & Evercooren, A. B. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960901)45:5 · Cited by 100 · see citing works
Dhaunchak, A. S., & Nave, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704975104 · Cited by 80 · see citing works
Madorsky, I., Opalach, K., Waber, A. J., Verrier, J. D., Solmo, C., Foster, T. C., Dunn, W. A., & Notterpek, L. M. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.01.002 · Cited by 77 · see citing works
Morphological and morphometric studies of the dysmyelinating mutant, the Long Evans shaker rat
Kwiecień, J. M., O’Connor, L. T., Goetz, B. D., & Delaney, K. H. (1998) · Journal of Neurocytology · doi:10.1023/a:1006922227791 · Cited by 66 · see citing works
Insertion of a Retrotransposon inMbpDisrupts mRNA Splicing and Myelination in a New Mutant Rat
O’Connor, L. T., Goetz, B. D., Kwiecień, J. M., Delaney, K. H., Fletch, A. L., & Duncan, I. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03404.1999 · Cited by 64 · see citing works
Self-citationMyelin Loss Does Not Lead to Axonal Degeneration in a Long-Lived Model of Chronic Demyelination
Smith, C. M., Cooksey, E., & Duncan, I. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4627-12.2013 · Cited by 61 · see citing works
Self-citationReactive microglia in dysmyelination and demyelination
Zhang, S., Goetz, B. D., Carré, J., & Duncan, I. D. (2001) · Glia · doi:10.1002/glia.1045 · Cited by 51 · see citing works
Self-citationD’Antonio, M., Feltri, M. L., & Wrabetz, L. G. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22066 · Cited by 50 · see citing works
Biogenesis and Significance of Central Nervous System Myelin
Soldán, M. M. P., & Pirko, I. (2012) · Seminars in Neurology · doi:10.1055/s-0032-1306381 · Cited by 43 · see citing works
Familial dysmyelination in a Long Evans rat mutant.
Delaney, K. H., Jm, K., Wegiel, J., Hm, W., Dh, P., & Fletch, A. L. (1995) · PubMed · Cited by 36 · see citing works
Oligodendrocyte survival and function in the long-lived strain of the myelin deficient rat
Duncan, I. D., Nadon, N. L., Hoffman, R. L., Lunn, K. F., Csiza, C. K., & Wells, M. R. (1995) · Journal of Neurocytology · doi:10.1007/bf01191211 · Cited by 35 · see citing works
Self-citationMyelination in the CNS of mld mutant mice: Comparison between composition and structure
Matthieu, J.-M., Omlin, F. X., Ginalski-Winkelmann, H., & Cooper, B. J. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90086-5 · Cited by 35 · see citing works
Broadening the therapeutic scope for rapamycin treatment
Menzies, F. M., & Rubinsztein, D. C. (2010) · Autophagy · doi:10.4161/auto.6.2.11078 · Cited by 27 · see citing works
Inoue, Y., Inoue, K., Terashima, T., Mikoshiba, K., & Tsukada, Y. (1983) · Anatomy and Embryology · doi:10.1007/bf00315814 · Cited by 22 · see citing works
Autophagy aids membrane expansion by neuropathic Schwann cells
Rangaraju, S., & Notterpek, L. M. (2011) · Autophagy · doi:10.4161/auto.7.2.14278 · Cited by 19 · see citing works
Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis
Getts, M. T., Getts, D. R., Kohm, A. P., & Miller, S. D. (2008) · Therapy · doi:10.2217/14750708.5.5.631 · Cited by 18 · see citing works
Intermittent Dietary Restriction as a Practical Intervention in Aging
Sharma, S., & Kaur, G. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.031 · Cited by 17 · see citing works
Generation of Cultured Oligodendrocyte Progenitor Cells from Rat Neonatal Brains
Larsen, E. C., Kondo, Y., Fahrenholtz, C. D., & Duncan, I. D. (2008) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc02d01s6 · Cited by 7 · see citing works
Self-citationIncreased activity of surviving locus ceruleus neurons in Alzheimer's disease
Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1
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Compromised autophagy and neurodegenerative diseases
Menzies, F. M., Fleming, A., & Rubinsztein, D. C. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3961 · Cited by 851 · see citing works
Lysosomes as a therapeutic target
Bonam, S. R., Wang, F., & Muller, S. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0036-1 · Cited by 764 · see citing works
Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline
Glatigny, M., Moriceau, S., Rivagorda, M., Ramos-Brossier, M., Nascimbeni, A. C., Lante, F., Shanley, M. R., Boudarene, N., Rousseaud, A., Friedman, A. K., et al. (2019) · Current Biology · doi:10.1016/j.cub.2018.12.021 · Cited by 257 · see citing works
Progression in translational research on spinal cord injury based on microenvironment imbalance
Fan, B., Wei, Z., & Feng, S. (2022) · Bone Research · doi:10.1038/s41413-022-00199-9 · Cited by 248 · see citing works
Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma
Lipinski, M. M., Wu, J., Faden, A. I., & Sarkar, C. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6306 · Cited by 221 · see citing works
Autophagy and Its Normal and Pathogenic States in the Brain
Yamamoto, A., & Yue, Z. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014149 · Cited by 204 · see citing works
Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
“enhances oligodendrocyte survival and promotes myelination in a rat model of demyelinating disease [448].”
BackgroundHegdekar, N., Sarkar, C., Bustos, S., Ritzel, R. M., Hanscom, M., Ravishankar, P., Philkana, D., Wu, J., Loane, D. J., & Lipinski, M. M. (2023) · Autophagy · doi:10.1080/15548627.2023.2167689 · Cited by 158 · see citing works
Macroautophagy in CNS health and disease
Griffey, C. J., & Yamamoto, A. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00588-3 · Cited by 144 · see citing works
Inherited and acquired disorders of myelin: The underlying myelin pathology
Duncan, I. D., & Radcliff, A. B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.04.002 · Cited by 137 · see citing works
Self-citationAutophagy in Neurotrauma: Good, Bad, or Dysregulated
Wu, J., & Lipinski, M. M. (2019) · Cells · doi:10.3390/cells8070693 · Cited by 125 · see citing works
Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination
Bankston, A. N., Forston, M. D., Howard, R. M., Andres, K. R., Smith, A. E., Ohri, S. S., Bates, M. L., Bunge, M. B., & Whittemore, S. R. (2019) · Glia · doi:10.1002/glia.23646 · Cited by 112 · see citing works
Role of autophagy in the pathogenesis of multiple sclerosis
Liang, P., & Le, W. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1545-5 · Cited by 99 · see citing works
Autophagy in hemorrhagic stroke: Mechanisms and clinical implications
Li, H., Wu, J., Shen, H., Yao, X., Liu, C., Pianta, S., Han, J. Y., Borlongan, C. V., & Chen, G. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.04.002 · Cited by 73 · see citing works
Oligodendrocyte Precursor Cells in Spinal Cord Injury: A Review and Update
Li, N., & Leung, G. (2015) · BioMed Research International · doi:10.1155/2015/235195 · Cited by 78 · see citing works
Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases
Hu, Z., Yang, B., Mo, X., & Xiao, H. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8921-4 · Cited by 68 · see citing works
Liu, S.-Y., Chen, L., Li, X., Hu, Q., & He, L. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.12.011 · Cited by 67 · see citing works
Zhou, Y., Zhang, H., Zheng, B., Ye, L., Zhu, S., Johnson, N. R., Wang, Z., Wei, X., Chen, D., Cao, G., et al. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.13229 · Cited by 63 · see citing works
The role of glial autophagy in Alzheimer’s disease
Litwiniuk, A., Juszczak, G. R., Stankiewicz, A. M., & Urbańska, K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02242-5 · Cited by 54 · see citing works
Autophagy in Multiple Sclerosis: Two Sides of the Same Coin
Misrielal, C., Mauthe, M., Reggiori, F., & Eggen, B. J. L. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.603710 · Cited by 54 · see citing works
Glia-specific autophagy dysfunction in ALS
Strohm, L., & Behrends, C. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.024 · Cited by 53 · see citing works
Golgi trafficking defects in postnatal microcephaly: The evidence for “Golgipathies”
Passemard, S., Perez, F., Colin, E., Rasika, S., Gressèns, P., & Ghouzzi, V. E. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.007 · Cited by 50 · see citing works
Thangaraj, A., Sil, S., Tripathi, A., Chivero, E. T., Periyasamy, P., & Buch, S. J. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2019.11.001 · Cited by 51 · see citing works
Kim, S. E., Turkington, K., Kushmerick, C., & Kim, J. H. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00117.2013 · Cited by 41 · see citing works
Sphingolipid metabolism – an ambiguous regulator of autophagy in the brain
van Echten‐Deckert, G., & Alam, S. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0237 · Cited by 39 · see citing works
Assessment of Chloroquine Treatment for Modulating Autophagy Flux in Brain of WT and HD Mice
Vodička, P., Lim, J., Williams, D. T., Kegel, K. B., Chase, K. O., Park, H., Marchionini, D. M., Wilkinson, S., Mead, T. L., Birch, H., et al. (2014) · Journal of Huntington s Disease · doi:10.3233/jhd-130081 · Cited by 38 · see citing works
Hou, W., Hao, Y., Sun, L., Yang, Z., Zheng, X., & Song, L. (2022) · Molecular Brain · doi:10.1186/s13041-022-00899-7 · Cited by 38 · see citing works
Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury
Muñoz‐Galdeano, T., Reigada, D., del Águila, Á., Velez, I., Caballero-López, M. J., Maza, R. M., & Nieto‐Díaz, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00164 · Cited by 34 · see citing works
Zhou, Y., Zheng, B., Ye, L., Zhang, H., Zhu, S., Zheng, X., Xia, Q.-H., He, Z., Wang, Q., Xiao, J., et al. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1756-1 · Cited by 35 · see citing works
RetractedLC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
Satoh, J., Motohashi, N., Kino, Y., Ishida, T., Yagishita, S., Jinnai, K., Arai, N., Nakamagoe, K., Tamaoka, A., Saito, Y., et al. (2014) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-9-68 · Cited by 33 · see citing works
Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model
Doria, M., Nury, T., Delmas, D., Moreau, T., Lizard, G., & Véjux, A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.016 · Cited by 33 · see citing works
Tong, M., He, Z., Lin, X., Zhou, Y., Wang, Q., Zheng, Z., Chen, J., Xu, H., & Tian, N. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.119 · Cited by 32 · see citing works
Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis
Shen, D., Liu, K., Wang, H., & Wang, H. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac017 · Cited by 31 · see citing works
Wang, H., Liu, Y., Guo, Z., Cui, M., Pang, P., Yang, J., & Wu, C. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.03.014 · Cited by 27 · see citing works
The pathophysiological role of dihydroceramide desaturase in the nervous system
Tzou, F., Hornemann, T., Yeh, J., & Huang, S. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101236 · Cited by 26 · see citing works
Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis
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Kamaruzzaman, M. A., Romli, M. H., Abas, R., Vidyadaran, S., Baharuldin, M. T. H., Nasaruddin, M. L., Vishnumukkala, T., Sura, S., Warsito, K., Nor, N. H. M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1053680 · Cited by 25 · see citing works
Autophagy collaborates with apoptosis pathways to control oligodendrocyte number
Zhang, T., Bhambri, A., Zhang, Y., Barbosa, D., Bae, H., Xue, J., Wazir, S., Mulinyawe, S. B., Kim, J. H., & Sun, L. O. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112943 · Cited by 23 · see citing works
Chaperone-Mediated Autophagy after Spinal Cord Injury
Handa, K., Kanno, H., Matsuda, M., Sugaya, T., Murakami, T., Prudnikova, M., Ozawa, H., & Itoi, E. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6820 · Cited by 20 · see citing works
Pooyan, P., Karamzadeh, R., Mirzaei, M., Meyfour, A., Amirkhan, A., Wu, Y., Gupta, V., Baharvand, H., Javan, M., & Salekdeh, G. H. (2020) · GigaScience · doi:10.1093/gigascience/giaa116 · Cited by 13 · see citing works
Akbarian, F., Tabatabaiefar, M. A., Shaygannejad, V., Shahpouri, M. M., Badihian, N., Sajjadi, R. S., Dabiri, A., Jalilian, N., & Noori–Daloii, M. R. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00590-7 · Cited by 14 · see citing works
Autophagy in white matter disorders of the CNS : mechanisms and therapeutic opportunities
Nutma, E., Marzin, M. C., Cillessen, S. A. G. M., & Amor, S. (2020) · The Journal of Pathology · doi:10.1002/path.5576 · Cited by 14 · see citing works
Samy, D. M., Zaki, E. I., Hassaan, P. S., Abdelmonsif, D. A., Mohamed, D. Y., & Saleh, S. R. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-00959-z · Cited by 14 · see citing works
Modification of autophagy-lysosomal pathway as a neuroprotective treatment for spinal cord injury
Lipinski, M. M., & Wu, J. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.158344 · Cited by 14 · see citing works
Huiyang, W., Liu, Y., Cui, M., Guo, Z., Zhao, Y., Yang, J., & Wu, C. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155883 · Cited by 13 · see citing works
Damato, M., Cardon, T., Wisztorski, M., Fournier, I., Pieragostino, D., Cicalini, I., Salzet, M., Vergara, D., & Maffia, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105245 · Cited by 12 · see citing works
Traumatic Injury to Peripheral Nerves
Rotshenker, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802653-3.00088-9 · Cited by 11 · see citing works
Mei, X., Wang, H., Zhang, H., Liu, C., Guo, Z., Wang, Y., Yuan, Y., Zhao, Z., Li, D., & Tang, P. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.030 · Cited by 10 · see citing works
Drača, D., Krajnović, T., Vuković, N. L., Vukić, M., Mijatović, S., Tanić, N., Arsenijević, N., & Maksimović‐Ivanić, D. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09093-x · Cited by 9 · see citing works
Ceccariglia, S., Sibilia, D., Parolini, O., Michetti, F., & Sante, G. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713225 · Cited by 8 · see citing works
Takeda, K., Dezawa, M., & Kitada, M. (2015) · Histochemistry and Cell Biology · doi:10.1007/s00418-015-1384-5 · Cited by 8 · see citing works
Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice
Liu, Z., Zhao, Z., Du, H., Zhou, Q., Li, M., Gui, Z., Wu, J., Gao, Y., Zheng, N., Zhang, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.14476 · Cited by 7 · see citing works
Mitchell, S. J., & Mitchell, J. R. (2022) · Nutrition and Healthy Aging · doi:10.3233/nha-220162 · Cited by 7 · see citing works
Autophagy in Multiple Sclerosis: Phagocytosis and Autophagy of Oligodendrocyte Precursor Cells
Wang, J., Li, Q., He, J., Zhou, F. Q., Huang, Z.-H., Wang, L., Zhang, Y., & Li, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03996-x · Cited by 6 · see citing works
Jia, C., Zhao, X., Song, M., & Sun, X. (2024) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-024-05075-2 · Cited by 5 · see citing works
Expression of Unconventional Myosin VI in Oligodendrocytes
Yamazaki, R., Ishibashi, T., Baba, H., & Yamaguchi, Y. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2377-7 · Cited by 5 · see citing works
Autophagy-lysosome networks in oligodendrocytes: a dynamic framework for myelin integrity
Jiménez-Ridruejo, I., & Plaza‐Zabala, A. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1818512 · Cited by 4 · see citing works
Dying oligodendrocytes persist without mitochondriaPreprint
Bame, X., Gilani, S. Z., Kamen, Y., & Hill, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.699752 · Cited by 2 · see citing works
Lugli, E., Besio, R., Cavallo, M., Gaiaschi, L., Franco, W., Milanesi, G., Forlino, A., Bottone, M. G., & Luca, F. D. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02393-w · Cited by 1 · see citing works
Resende, M. T., August, B. K., Radecki, D. Z., Reilly, M. J., Komro, A., Svaren, J. P., Anaby, D., Duncan, I. D., & Cohen, Y. (2025) · Diagnostics · doi:10.3390/diagnostics15070837 · Cited by 1 · see citing works
Self-citationAutophagy collaborates with apoptosis pathways to control myelination specificity and functionPreprint
Zhang, T., Bae, H., Bhambri, A., Zhang, Y., Barbosa, D., Xue, J., Wazir, S., Mulinyawe, S. B., Kim, J. H., & Sun, L. O. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.31.522394 · Cited by 1 · see citing works
NEUTRON ACTIVATION ANALYSIS OF MANGANESE, IRON AND ZINC IN A RODENT MODEL OF DYSMYELINATION
Lobo, L. R. (2013) · MacSphere (McMaster University) · doi:10.71548/10467
Zhou, Y., Zheng, B., Ye, L., Zhang, H., Zhu, S., Zheng, X., Xia, Q.-H., He, Z., Wang, Q., Xiao, J., et al. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03149-1
RetractedAwwad, R. A. (2020) · Egyptian Dental Journal /Egyptian Dental Journal · doi:10.21608/edj.2020.40454.1223
Kitaoka, Y. (2014) · Springer eBooks · doi:10.1007/978-4-431-54965-9_9
Modulation de l'autophagie neuronale par la sérine protéase tPA en conditions ischémiques
Thiebaut, A. M. (2019) · theses.fr (ABES) · doi:10.70675/6586c0abz9e4cz455fz95ffzc52ec76397f8
Autophagy mediates the hormonal regulation of neuronal homeostasis and brain aging
Rivagorda, M. (2021) · theses.fr (ABES) · doi:10.70675/e4cd7313zfed5z4ebezb547z9b4557da55e6
Oligodendrocytes and lysosomal-autophagic networks: An emerging view
Jiménez-Ridruejo, I., & Plaza‐Zabala, A. (2026) · International review of cytology · doi:10.1016/bs.ircmb.2026.07.003
- Authors
- Smith, C. M., Mayer, J. A., & Duncan, I. D.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-05-01
- Volume
- 33
- Issue
- 18
- Pages
- 8088-8100
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4128639
- OpenAlex
- W2053863260
- Cited by
- 69
- References
- 54
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 9 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 9 · 2014: 5 · 2013: 2
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (T32-GM007507)
- Graduate Women in Science
- National Institute of General Medical Sciences (T32GM007507)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- autophagy, oligodendrocyte survival, dysmyelination, demyelination, autophagosomes, lysosomes, intermittent fasting, myelination, myelin thickness
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Autophagy, Bromodeoxyuridine, Cell Survival, Cells, Cultured, Chloroquine, Cytoplasm, Demyelinating Diseases, Myelin Basic Protein, Fasting, Female, Male, Microtubule-Associated Proteins, Mutation, Myelin Sheath, Oligodendroglia, Peptides, Rats, Mutant Strains, Spinal Cord, Up-Regulation, Myelin Proteolipid Protein, Rats, Long-Evans, Rats
About these checks
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