The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.
Layer Acquisition by Cortical GABAergic Interneurons Is Independent of Reelin Signaling
Open accessAbstract
Functioning of the cerebral cortex requires the coordinated assembly of circuits involving glutamatergic projection neurons and GABAergic interneurons. Despite their segregated origin in different regions of the telencephalon, projection neurons and interneurons born synchronically end up adopting the same cortical layer, suggesting that layer acquisition is highly coordinated for both neuronal types. The radial migration and laminar arrangement of projection neurons depends on Reelin, a secreted glycoprotein expressed near the pial surface during embryogenesis. In contrast, the mechanisms controlling layer acquisition by cortical interneurons remain essentially unknown. Here, we have used an ultrasound-guided transplantation approach to analyze the mechanisms underlying the acquisition of laminar locations by cortical interneurons. We found that layer acquisition by cortical GABAergic interneurons does not directly depend on Reelin signaling. Moreover, interneurons invade their target layers well after synchronically generated projection neurons reach their final destination. These results suggest a model in which cues provided by projection neurons guide cortical interneurons to their appropriate layer, and reveal that, at least for some neuronal types, long-range radial migration does not directly require Reelin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“MGE-derived interneurons adopt their laminar distribution following an ‘inside-out’ sequence that correlates with their birthdate, similar to pyramidal cells”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Pla et al., 2006
In the citing paper
“First, interneurons systematically acquire their laminar position after the corresponding pyramidal cells have begun to differentiate into a particular cortical layer (Hevner et al., 2004; Miyoshi and Fishell, 2011; Pla et al., 2006).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Pla et al., 2006
In the citing paper
“Second, disruption of the normal layering of pyramidal cells modifies the normal laminar distribution of interneurons (Lodato et al., 2011; Pla et al., 2006).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Pla et al., 2006
In the citing paper
“Several lines of evidence suggest that the interneurons adopt their laminar distribution in response to cues provided by pyramidal cells.”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Pla et al., 2006
In the citing paper
“interneurons lacking the reelin receptor Dab1 migrate to the appropriate layer when transplanted into the cortex of wild-type mice”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [913]
In the citing paper
“MGE-derived interneurons laminate in the cortex according to birth order in the same inside-out manner as PCs: early born cells migrate deeper than those born later”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [913]
In the citing paper
“In the cortex of reeler mice, MGE-derived interneurons are inverted similar to PCs: early-born cells are found ectopically in superficial layers while those born later are found in the deep layers”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [913]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80782-5 · Cited by 1,261
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
A long, remarkable journey: Tangential migration in the telencephalon
Marín, Ó., & Rubenstein, J. L. R. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097509 · Cited by 1,077
Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80861-2 · Cited by 916
Ogawa, M., Miyata, T., Nakajimat, K., Yagyu, K., Seike, M., Ikenaka, K., Yamamoto, H., & Mikoshibat, K. (1995) · Neuron · doi:10.1016/0896-6273(95)90329-1 · Cited by 889
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873
Reelin Is a Ligand for Lipoprotein Receptors
D'Arcangelo, G., Homayouni, R., Keshvara, L., Rice, D. S., Sheldon, M., & Curran, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80860-0 · Cited by 808
Flagged first, then by citations
1 of the 57 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- (1982), Brain Res, 256, 293
- (1985), Brain Res, 355, 187
Cited by
Sorted by citations
Items 101–151 of 151
DCX knockout ferret reveals a neurogenic mechanism in cortical development
Wang, W., Yin, C., Wen, S., Liu, Z., Wang, B., Zeng, B., Sun, L., Zhou, X., Zhong, S., Zhang, J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114508 · Cited by 7
Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons
Sajukumar, K., Yadav, P., & Lee, G. H. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151444 · Cited by 7
Hsing, H.-W., Zhuang, Z.-H., Niou, Z., & Chou, S. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz291 · Cited by 8
Suzuki, T., & Sato, M. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.09.029 · Cited by 8
Tangential Migration in the Telencephalon
Marín, Ó. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-374245-2.00003-6 · Cited by 7
Homozygous and Heterozygous Reeler Mouse Mutants
Tueting, P. A., Pinna, G., & Costa, E. (2008) · Springer eBooks · doi:10.1007/978-0-387-76761-1_20 · Cited by 6
Hanson, M. A., Bibi, N., Safa, A., Nagarajan, D., Marshall, A. H., Johantges, A. C., & Wester, J. C. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0737-24.2024 · Cited by 6
Lee, S. E., & Lee, G. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147510 · Cited by 5
The generation of cortical interneurons
Batista‐Brito, R., Ward, C., & Fishell, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00020-5 · Cited by 6
Transcriptional Regulation of Cortical Interneuron Development
Pai, E. L.-L., Vogt, D. L., Hu, J. S., & Rubenstein, J. L. R. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0047 · Cited by 6
Cui, J., Wang, F., Wang, K., & Xiang, H. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9478-z · Cited by 5
Heterogeneous progenitor cell behaviors underlie the assembly of neocortical cytoarchitecturePreprint
Llorca, A., Ciceri, G., Beattie, R., Wong, F. K., Diana, G., Serafeimidou‐Pouliou, E., Fernández-Otero, M., Streicher, C., Arnold, S. J., Meyer, M. P., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/494088 · Cited by 5
Normal connectivity of thalamorecipient networks in barrel equivalents of the reeler cortex
Meeuwissen, A., Möck, M., Staiger, J. F., & Guy, J. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad072 · Cited by 4
Uribe, E., & Wix, R. (2011) · eNeurobiología · Cited by 4
Exciting Information for Inhibitory Neurons
Li, G., & Pleasure, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.011 · Cited by 4
Varela, M. C., Walker, M., Bok, J., Crespo, E. L., Thenstedt, T., Goldstein, L., Tidball, A. M., Yuan, Y., Isom, L. L., Fu, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.01.662594 · Cited by 6
Mathieu, R., Draia-Nicolau, T., Corbières, L., Govindan, A. D., Bensa, V., Pallesi‐Pocachard, E., Silvagnoli, L., Represa, A., Cardoso, C., Telley, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-68059-8 · Cited by 6
Focal cortical dysplasias: modeling pediatric drug-resistant epilepsy using human brain organoids
Petralla, S., Crocco, E., Giustizieri, M., Palma, L. D., Cremisi, F., Cherubini, E., Specchio, N., Cattaneo, A., & Marinelli, S. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1794559 · Cited by 3
Хожай, Л. И. (2023) · Cell and Tissue Biology · doi:10.1134/s1990519x23020086 · Cited by 3
Easton, C. R., Dickey, C. W., Moen, S. P., Neuzil, K. E., Barger, Z., Anderson, T. M., Moody, W. J., & Hevner, R. F. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22354 · Cited by 3
Leading Process Dynamics During Neuronal Migration
Valdeolmillos, M., & Moya, F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00025-9 · Cited by 3
A Tale of Two Genes: Reelin and BDNF
Ringstedt, T. (2008) · Springer eBooks · doi:10.1007/978-0-387-76761-1_16 · Cited by 2
Mechanisms of tangential migration of interneurons in the developing forebrain
Lepiemme, F., Silva, C. G., & Nguyen, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00016-x · Cited by 2
Parnell, A. A., McCarthy, D. M., Trupiano, M. X., Schatschneider, C. W., & Bhide, P. G. (2025) · Scientific Reports · doi:10.1038/s41598-025-19504-7 · Cited by 2
Organisation des lignées d’interneurones du cortex cérébral
Ciceri, G., & Dehorter, N. (2014) · médecine/sciences · doi:10.1051/medsci/20143002010 · Cited by 1
Genetic Control of Cajal–Retzius Cell Development
Miquelajáuregui, A., & Varela‐Echavarría, A. (2008) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195369007.003.0003 · Cited by 1
Transcriptional and posttranscriptional mechanisms of neuronal migration
Krsnik, Ž., Popovitchenko, T., & Rašin, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00022-5 · Cited by 2
Petros, T. J., & Anderson, S. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00031-4 · Cited by 1
Inferring Ligand-Receptor Interactions between neuronal subtypes during mouse cortical developmentPreprint
Mathieu, R., Corbières, L., Draia-Nicolau, T., Govindan, A. D., Bensa, V., Pallesi‐Pocachard, E., Silvagnoli, L., Represa, A., Cardoso, C., Telley, L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.02.610245 · Cited by 1
Xie, Y., Chang, L., Zhong, G., Rink, J. A., Baez-Becerra, T., Armand, E. J., Ding, W., Li, K., Bonne, É., Lie, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.02.703166 · Cited by 4
Molecular development and laminar distribution of GABAergic interneurons of the cerebral cortex
Lodato, S. (2011) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/8450
Molecular regulation of forebrain development and neural stem/progenitor cells
Hakanen, J. (2014) · Työväentutkimus Vuosikirja
Organisation des lignées d'interneurones du cortex
Dehorter, N. (2014)
Higginbotham, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00024-9
Cunningham, J. G. (2020) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.7739
The construction of 3D cognitive networks from iPSCs through precise spatiotemporal specification
Miu, K.-K., Cao, D., Wang, Z., Hao, S., & Chan, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823809-7.00012-8
Meeuwissen, A. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9058
Cayouette, M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736929171.793568964
Deficiency in neprilysin causes laminar impairments in the visual cortexPreprint
Bae, H., & Hensch, T. K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.05.531118
DCX knockout ferret reveals a neurogenic mechanism in cortical developmentPreprint
Wang, W., Yin, C., Wen, S., Liu, Z., Wang, B., Zeng, B., Sun, L., Zhou, X., Zhong, S., Zhang, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.13.598795
Selective Lis1 inactivation disrupts migration and positioning of cortical somatostatin interneurons
Pombero, A., García-López, R., Geijo‐Barrientos, E., & Martı́nez, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-38316-x
Etude du rôle de la kinésine KIF21B au cours du développement cortical
Asselin, L. (2019) · theses.fr (ABES) · doi:10.70675/bd543948zdb0fz4298zae3fzf4fc50923d78
Cajal-Retzius cells and Reelin in mouse cortical development and human pathologies
Riva, M. (2021) · theses.fr (ABES) · doi:10.70675/b321eca5ze455z480bzb6d4z43505d8c9faf
Metadata
- Authors
- Pla, R., Borrell, V., Flames, N., & Marín, O.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-06-28
- Volume
- 26
- Issue
- 26
- Pages
- 6924-6934
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673924
- OpenAlex
- W2042566086
- Cited by
- 151
- References
- 57
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 13 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- European Commission (005139)
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- GABAergic interneurons, Reelin signaling, radial migration, cortical lamination, projection neurons, interneuron migration, telencephalon, embryonic brain development
- MeSH terms
- Reelin Protein, Animals, Animals, Newborn, Cell Movement, Cerebral Cortex, Embryo, Mammalian, gamma-Aminobutyric Acid, Interneurons, Mice, Transgenic, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Serine Endopeptidases, Time Factors, Signal Transduction, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
