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Analysis of Knock-Out Mice to Determine the Role of HPC-1/Syntaxin 1A in Expressing Synaptic Plasticity
Open accessAbstract
The protein HPC-1/syntaxin 1A is abundantly expressed in neurons and localized in the neuronal plasma membrane. It forms a complex with SNAP-25 (25 kDa synaptosomal-associated protein) and VAMP-2 (vesicle-associated membrane protein)/synaptobrevin called SNARE (a soluble N -ethylmaleimide-sensitive fusion protein attachment protein receptor) complex, which is considered essential for synaptic vesicle exocytosis; thus, HPC-1/syntaxin 1A is considered crucial for synaptic transmission. To examine the physiological function of HPC-1/syntaxin 1A in vivo , we produced knock-out (KO) mice by targeted gene disruption. Although HPC-1/syntaxin 1A expression was completely depleted without any effect on the expression of other SNARE proteins, the KO mice were viable. They grew normally, were fertile, and displayed no difference in appearance compared with control littermate. In cultured hippocampal neurons derived from the KO mice, the basic synaptic transmission in vitro was normal. However, the mutant mice had impaired long-term potentiation in the hippocampal slice. Also, although KO mice exhibited normal spatial memory in the hidden platform test, consolidation of conditioned fear memory was impaired. Interestingly, the KO mice had impaired conditioned fear memory extinction. These observations suggest that HPC-1/syntaxin 1A may be closely related to synaptic plasticity.
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“have already identified CAPGLY domain containing linker protein 2 (CLIP2), LIM domain kinase 1 (LIMK1), General transcription factor II, i (GTF2i), and Syntaxin 1A (STX1A) as the leading candidates among the 22 genes within the region for involvement in the cognitive and social phenotypes.”
From Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism (2011) · cites this paper as Fujiwara et al., 2006
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Cites
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Applications of the Morris water maze in the study of learning and memory
D’Hooge, R., & Deyn, P. P. D. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00067-4 · Cited by 2,083
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136
Postsynaptic signaling and plasticity mechanisms
Sheng, M., & Kim, M. J. (2002) · Science · doi:10.1126/science.1075333 · Cited by 731
Profound neuronal plasticity in response to inactivation of the dopamine transporter
Jones, S. R., Gainetdinov, R. R., Jaber, M., Giros, B., Wightman, R. M., & Caron, M. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4029 · Cited by 712
Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice
Meng, Y., Zhang, Y., Tregoubov, V., Janus, C., Cruz, L., Jackson, M., Lu, W.-Y., MacDonald, J. F., Wang, J. Y., Falls, D. L., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00758-4 · Cited by 688
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M. G., Sara, Y., Südhof, T. C., & Kavalali, E. T. (2001) · Science · doi:10.1126/science.1064335 · Cited by 664
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Patil, S. S., Schlick, F., Höger, H., & Lübec, G. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.12.013 · Cited by 5
Shen, J., Wang, Y., Liu, Y., Lan, J., Long, S., Li, Y., Chen, D., Yu, P., Zhao, J., Wang, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202415224 · Cited by 4
Li, C., Li, J., He, T., Shan, J., Liu, F., Deng, X., Lin, Y., Xu, L., Fu, L., Wang, B., et al. (2021) · European journal of medical research · doi:10.1186/s40001-021-00599-3 · Cited by 4
Syntaxins on granules promote docking of granules via interactions with munc18
Borisovska, M. (2018) · Scientific Reports · doi:10.1038/s41598-017-18597-z · Cited by 4
The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins
Usher, S., Toulmé, E., Florea, R., Yatskevich, S., Jao, C. C., Dijkhof, L. R. H., Colding, J. M., Joshi, P., Zilberleyb, I., Trimbuch, T., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads6004 · Cited by 3
Fukushima, T., Tsuda, M., Otsubo, T., & Hori, Y. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.062 · Cited by 3
Novel role of glial syntaxin‐1B in supporting neuronal survival
Park, S., Bin, N., & Sugita, S. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12723 · Cited by 2
Ogihara, A., Abe, T., Shimoda, K., Sasaki, T., & Kudo, H. (2024) · Fish Physiology and Biochemistry · doi:10.1007/s10695-024-01360-3 · Cited by 2
Fusion Machinery: SNARE Protein Complex
Milošević, I., & Sørensen, J. B. (2014) · Springer eBooks · doi:10.1007/978-4-431-55166-9_4 · Cited by 2
Multiple overlapping SNARE complexes drive endosome maturation in Drosophila nephrocytes
Hargitai, D., Molnár, M., Rubics, A., Bodor, I., Baukál, D., Nagy, A., Balogh, V., Simon‐Vecsei, Z., Juhász, G., & Lőrincz, P. (2026) · Nature Communications · doi:10.1038/s41467-026-77479-z · Cited by 1
Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function
Atasoy, D., & Kavalali, E. T. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_4 · Cited by 1
Exocytotic Machinery as a Target for the Development of New Drugs for Schizophrenia
Guerrero, M. J., Hormaeche, I., Uribarri, M., Massé, J., & Palacios, J. M. (2012) · Wiley eBooks · doi:10.1002/9781118185537.ch11 · Cited by 1
Molecular Genetics of Williams–Beuren Syndrome
Merla, G., Micale, L., Fusco, C., & Loviglio, M. N. (2012) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022436 · Cited by 1
Investigation of SNARE function in the early endosomal compartment
Bethani, I. (2009) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3220
Lam, E. (2012) · TSpace (University of Toronto)
Structure and Function Relationship of Syntaxin-1 in Neurotransmitter Release
Park, S. (2015) · TSpace (University of Toronto)
Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsionPreprint
Martínez‐Mármol, R., Muhaisen, A., Cotrufo, T., Roselló-Busquets, C., Hernaiz-Llorens, M., Pérez‐Brangulí, F., Andrés, R. M., Ros, O., Pascual, M., Ulloa, F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.20.444954
Faculty Opinions recommendation of Open syntaxin docks synaptic vesicles.
Chapman, E. R. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1091993.549887
Huang, M., Wang, Y., Chow, C. H., Stepien, K. P., Indrawinata, K., Xu, J., Argiropoulos, P., Xie, X., Sugita, K., Tien, C.-W., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.18.553709
Changes in synaptic proteins in hippocampal area CA1 of a rat learned helpless model of depression
Bieler, M. (2013) · BIBSYS Brage (BIBSYS (Norway))
Mobilisation de l'acide arachidonique et sensibilité au peptide ß-amyloïde
Thomas, M. H. (2015) · theses.fr (ABES) · doi:10.70675/904987d5zc8c8z4104z95dfz2f7e680d8be3
Synaptopathies auditives et vestibulaires : de la physiologie moléculaire à la thérapie génique
Calvet, C. (2020) · theses.fr (ABES) · doi:10.70675/8920e327zd8ffz457ez9711zcfc53af428dc
Haag, C., Gsell, F., Vinogradov, O., Oquendo, M. B., Liu, Y.-Y., Uysal, B., Löffler, H., Stehle, F., Klopfer, F., Crönlein, J., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106451
Metadata
- Authors
- Fujiwara, T., Mishima, T., Kofuji, T., Chiba, T., Tanaka, K., Yamamoto, A., & Akagawa, K.
- Affiliations
- Kyorin University (JP)
- University of Tsukuba (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- Nagahama Institute of Bio-Science and Technology (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-05-24
- Volume
- 26
- Issue
- 21
- Pages
- 5767-5776
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6675267
- OpenAlex
- W2036209745
- Cited by
- 125
- References
- 58
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- syntaxin 1A, synaptic plasticity, long-term potentiation, SNARE complex, synaptic vesicle exocytosis, synaptic transmission, conditioned fear memory, fear extinction, spatial memory, hippocampal neurons, knockout mice
- MeSH terms
- Animals, Hippocampus, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Long-Term Potentiation, Syntaxin 1, Mice
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