The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Basolateral Amygdala to Orbitofrontal Cortex Projections Enable Cue-Triggered Reward Expectations
Open accessAbstract
To make an appropriate decision, one must anticipate potential future rewarding events, even when they are not readily observable. These expectations are generated by using observable information (e.g., stimuli or available actions) to retrieve often quite detailed memories of available rewards. The basolateral amygdala (BLA) and orbitofrontal cortex (OFC) are two reciprocally connected key nodes in the circuitry supporting such outcome-guided behaviors. But there is much unknown about the contribution of this circuit to decision making, and almost nothing known about the whether any contribution is via direct, monosynaptic projections, or the direction of information transfer. Therefore, here we used designer receptor-mediated inactivation of OFC→BLA or BLA→OFC projections to evaluate their respective contributions to outcome-guided behaviors in rats. Inactivation of BLA terminals in the OFC, but not OFC terminals in the BLA, disrupted the selective motivating influence of cue-triggered reward representations over reward-seeking decisions as assayed by Pavlovian-to-instrumental transfer. BLA→OFC projections were also required when a cued reward representation was used to modify Pavlovian conditional goal-approach responses according to the reward9s current value. These projections were not necessary when actions were guided by reward expectations generated based on learned action-reward contingencies, or when rewards themselves, rather than stored memories, directed action. These data demonstrate that BLA→OFC projections enable the cue-triggered reward expectations that can motivate the execution of specific action plans and allow adaptive conditional responding. SIGNIFICANCE STATEMENT Deficits anticipating potential future rewarding events are associated with many psychiatric diseases. Presently, we know little about the neural circuits supporting such reward expectation. Here we show that basolateral amygdala to orbitofrontal cortex projections are required for expectations of specific available rewards to influence reward seeking and decision making. The necessity of these projections was limited to situations in which expectations were elicited by reward-predictive cues. These projections therefore facilitate adaptive behavior by enabling the orbitofrontal cortex to use environmental stimuli to generate expectations of potential future rewarding events.
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“Reward value and deviations of expected and actual outcomes are encoded via the amygdala through its projections to the PFC (Lichtenberg et al., 2017; Wassum and Izquierdo, 2015).”
From The effects of early life stress on reward processing (2018) · cites this paper as Lichtenberg et al., 2017
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Cites
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“Disrupted amygdala and OFC activity and connectivity have also been associated with these diseases (Ressler and Mayberg, 2007; Price and Drevets, 2010; Goldstein and Volkow, 2011; Passamonti et al., 2012; Liu et al., 2014; Sladky et al., 2015).”
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“Disrupted amygdala and OFC activity and connectivity have also been associated with these diseases (Ressler and Mayberg, 2007; Price and Drevets, 2010; Goldstein and Volkow, 2011; Passamonti et al., 2012; Liu et al., 2014; Sladky et al., 2015).”
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Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making
Izquierdo, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1678-17.2017 · Cited by 269
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192
“Taken together, connections between midbrain dopamine cells, the basal ganglia (including structures within ventral striatum, such as the nucleus accumbens) and the PFC, with input from other structures, including the amygdala, thus form a reward circuit.”
BackgroundInfluentialSpecializations for reward-guided decision-making in the primate ventral prefrontal cortex
Murray, E. A., & Rudebeck, P. H. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0013-4 · Cited by 169
The Meaning of Behavior: Discriminating Reflex and Volition in the Brain
Balleine, B. W. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.024 · Cited by 186
Namboodiri, V. M. K., Otis, J. M., van Heeswijk, K., Voets, E. S., Alghorazi, R. A., Rodriguez-Romaguera, J., Mihalas, S., & Stuber, G. D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0408-1 · Cited by 150
Metadata
- Authors
- Lichtenberg, N. T., Pennington, Z. T., Holley, S. M., Greenfield, V. Y., Cepeda, C., Levine, M. S., & Wassum, K. M.
- Affiliations
- University of California, Los Angeles (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2017-07-25
- Volume
- 37
- Issue
- 35
- Pages
- 8374-8384
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC5577854
- OpenAlex
- W2736491203
- Cited by
- 171
- References
- 95
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 18 · 2021: 37 · 2020: 22 · 2019: 24 · 2018: 18 · 2017: 3
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (DA024635)
- University of California, Los Angeles
- National Institute on Drug Abuse (T32DA024635, R01DA035443)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- basolateral amygdala, orbitofrontal cortex, reward anticipation, Pavlovian-to-instrumental transfer, decision-making, reward seeking, goal-directed behavior, monosynaptic connectivity
- MeSH terms
- Animals, Conditioning, Operant, Cues, Decision Making, Extinction, Psychological, Male, Motivation, Neural Pathways, Reward, Prefrontal Cortex, Rats, Long-Evans, Rats, Anticipation, Psychological, Basolateral Nuclear Complex
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