Cited by 171Neural and Behavioral Psychology StudiesMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

Basolateral Amygdala to Orbitofrontal Cortex Projections Enable Cue-Triggered Reward Expectations

Open access

Lichtenberg, Nina T., Pennington, Zachary T., Holley, Sandra M., Greenfield, Venuz Y., Cepeda, Carlos, Levine, Michael S., Wassum, Kate M.·2017·The Journal of Neuroscience

DOI 10.1523/jneurosci.0486-17.2017PMC PMC5577854

Open this paper in CoChat — free account Open PDF

Abstract

To make an appropriate decision, one must anticipate potential future rewarding events, even when they are not readily observable. These expectations are generated by using observable information (e.g., stimuli or available actions) to retrieve often quite detailed memories of available rewards. The basolateral amygdala (BLA) and orbitofrontal cortex (OFC) are two reciprocally connected key nodes in the circuitry supporting such outcome-guided behaviors. But there is much unknown about the contribution of this circuit to decision making, and almost nothing known about the whether any contribution is via direct, monosynaptic projections, or the direction of information transfer. Therefore, here we used designer receptor-mediated inactivation of OFC→BLA or BLA→OFC projections to evaluate their respective contributions to outcome-guided behaviors in rats. Inactivation of BLA terminals in the OFC, but not OFC terminals in the BLA, disrupted the selective motivating influence of cue-triggered reward representations over reward-seeking decisions as assayed by Pavlovian-to-instrumental transfer. BLA→OFC projections were also required when a cued reward representation was used to modify Pavlovian conditional goal-approach responses according to the reward9s current value. These projections were not necessary when actions were guided by reward expectations generated based on learned action-reward contingencies, or when rewards themselves, rather than stored memories, directed action. These data demonstrate that BLA→OFC projections enable the cue-triggered reward expectations that can motivate the execution of specific action plans and allow adaptive conditional responding. SIGNIFICANCE STATEMENT Deficits anticipating potential future rewarding events are associated with many psychiatric diseases. Presently, we know little about the neural circuits supporting such reward expectation. Here we show that basolateral amygdala to orbitofrontal cortex projections are required for expectations of specific available rewards to influence reward seeking and decision making. The necessity of these projections was limited to situations in which expectations were elicited by reward-predictive cues. These projections therefore facilitate adaptive behavior by enabling the orbitofrontal cortex to use environmental stimuli to generate expectations of potential future rewarding events.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.0486-17.2017

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · cited 1×
“Disrupted amygdala and OFC activity and connectivity have also been associated with these diseases (Ressler and Mayberg, 2007; Price and Drevets, 2010; Goldstein and Volkow, 2011; Passamonti et al., 2012; Liu et al., 2014; Sladky et al., 2015).”
The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · cited 1×
“Disrupted amygdala and OFC activity and connectivity have also been associated with these diseases (Ressler and Mayberg, 2007; Price and Drevets, 2010; Goldstein and Volkow, 2011; Passamonti et al., 2012; Liu et al., 2014; Sladky et al., 2015).”
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541
Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys
Carmichael, S. T., & Price, J. L. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903630408 · Cited by 1,197
Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003) · Science · doi:10.1126/science.1087919 · Cited by 1,165
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007

Show all 95 references

Sorted by citations

Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making
Izquierdo, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1678-17.2017 · Cited by 269
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192
“Taken together, connections between midbrain dopamine cells, the basal ganglia (including structures within ventral striatum, such as the nucleus accumbens) and the PFC, with input from other structures, including the amygdala, thus form a reward circuit.”
BackgroundInfluential
Specializations for reward-guided decision-making in the primate ventral prefrontal cortex
Murray, E. A., & Rudebeck, P. H. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0013-4 · Cited by 169
The Meaning of Behavior: Discriminating Reflex and Volition in the Brain
Balleine, B. W. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.024 · Cited by 186
Single-cell activity tracking reveals that orbitofrontal neurons acquire and maintain a long-term memory to guide behavioral adaptation
Namboodiri, V. M. K., Otis, J. M., van Heeswijk, K., Voets, E. S., Alghorazi, R. A., Rodriguez-Romaguera, J., Mihalas, S., & Stuber, G. D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0408-1 · Cited by 150
Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes
Groman, S. M., Keistler, C., Keip, A. J., Hammarlund, E., Dileone, R., Pittenger, C., Lee, D., & Taylor, J. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.042 · Cited by 147
CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience
Mahler, S. V., & Aston‐Jones, G. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.299 · Cited by 141
The use of chemogenetics in behavioural neuroscience: receptor variants, targeting approaches and caveats
Campbell, E. J., & Marchant, N. J. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14146 · Cited by 150
Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction
Ramanathan, K. R., Jin, J., Giustino, T. F., Payne, M. R., & Maren, S. (2018) · Nature Communications · doi:10.1038/s41467-018-06970-z · Cited by 140
Distinct cortical–amygdala projections drive reward value encoding and retrieval
Malvaez, M., Shieh, C., Murphy, M. D., Greenfield, V. Y., & Wassum, K. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0374-7 · Cited by 130
Self-citation
Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice
Zhang, Z., Reis, F. M., He, Y., Park, J. W., DiVittorio, J. R., Sivakumar, N., van Veen, J. E., Maesta‐Pereira, S., Shum, M., Nichols, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20050-1 · Cited by 144
Connectivity characterization of the mouse basolateral amygdalar complex
Hintiryan, H., Bowman, I., Johnson, D. L., Korobkova, L., Zhu, M., Khanjani, N., Gou, L., Gao, L., Yamashita, S., Bienkowski, M. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22915-5 · Cited by 127
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 114
A thalamic bridge from sensory perception to cognition
Wolff, M., Morceau, S., Folkard, R., Martín-Cortecero, J., & Groh, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.013 · Cited by 114
Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior
Collins, A. L., Aitken, T. J., Huang, I.-W., Shieh, C., Greenfield, V. Y., Monbouquette, H. G., Ostlund, S. B., & Wassum, K. M. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.014 · Cited by 110
Self-citation
Cortico-Limbic Interactions Mediate Adaptive and Maladaptive Responses Relevant to Psychopathology
Kovner, R., Oler, J. A., & Kalin, N. H. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19101064 · Cited by 111
Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat
Alcaraz, F., Fresno, V., Marchand, A. R., Kremer, E. J., Coutureau, É., & Wolff, M. (2018) · eLife · doi:10.7554/elife.32517 · Cited by 108
Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse
Mahler, S. V., Brodnik, Z. D., Cox, B. M., Buchta, W. C., Bentzley, B. S., Quintanilla, J., Cope, Z. A., Lin, E. C., Riedy, M. D., Scofield, M. D., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0537-18.2018 · Cited by 104
Identity prediction errors in the human midbrain update reward-identity expectations in the orbitofrontal cortex
Howard, J. D., & Kahnt, T. (2018) · Nature Communications · doi:10.1038/s41467-018-04055-5 · Cited by 95
The orbitofrontal cortex, food intake and obesity
Seabrook, L. T., & Borgland, S. L. (2020) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190163 · Cited by 95
Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events
Jayachandran, M., Linley, S. B., Schlecht, M., Mahler, S. V., Vertes, R. P., & Allen, T. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.053 · Cited by 90
The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity
Millard, S. J., Bearden, C. E., Karlsgodt, K. H., & Sharpe, M. J. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01188-y · Cited by 83
Neural Substrates and Circuits of Drug AddictionPreprint
Feltenstein, M. W., See, R. E., & Fuchs, R. A. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039628 · Cited by 92
Food cue reactivity: Neurobiological and behavioral underpinnings
Kanoski, S. E., & Boutelle, K. N. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09724-x · Cited by 78
Amygdala-cortical collaboration in reward learning and decision making
Wassum, K. M. (2022) · eLife · doi:10.7554/elife.80926 · Cited by 88
Self-citation
Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories
Sias, A. C., Jafar, Y., Goodpaster, C. M., Ramírez-Armenta, K., Wrenn, T. M., Griffin, N. K., Patel, K., Lamparelli, A. C., Sharpe, M. J., & Wassum, K. M. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01586-7 · Cited by 86
Self-citation
Rodent medial and lateral orbitofrontal cortices represent unique components of cognitive maps of task space
Bradfield, L. A., & Hart, G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.009 · Cited by 71
Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats
Halbout, B., Marshall, A. T., Azimi, A., Liljeholm, M., Mahler, S. V., Wassum, K. M., & Ostlund, S. B. (2019) · eLife · doi:10.7554/elife.43551 · Cited by 69
Self-citation
Local modulation by presynaptic receptors controls neuronal communication and behaviour
Lovinger, D. M., Mateo, Y., Johnson, K. A., Engi, S. A., Antonazzo, M., & Cheer, J. F. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00561-0 · Cited by 69
The Limbic and Sensorimotor Pathways of the Human Amygdala: A Structural Connectivity Study
Rizzo, G., Milardi, D., Bertino, S., Basile, G. A., Mauro, D. D., Calamuneri, A., Chillemi, G., Silvestri, G., Anastasi, G., Bramanti, A., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.051 · Cited by 69
Prefrontal cortex interactions with the amygdala in primates
Murray, E. A., & Fellows, L. K. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01128-w · Cited by 66
Enhanced incentive motivation in obesity-prone rats is mediated by NAc core CP-AMPARs
Derman, R. C., & Ferrario, C. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.039 · Cited by 63
Prefrontal circuit organization for executive control
Kamigaki, T. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.08.017 · Cited by 69
A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories
Sias, A. C., Morse, A. K., Wang, S. C., Greenfield, V. Y., Goodpaster, C. M., Wrenn, T. M., Wikenheiser, A. M., Holley, S. M., Cepeda, C., Levine, M. S., et al. (2021) · eLife · doi:10.7554/elife.68617 · Cited by 62
Self-citation
Is the core function of orbitofrontal cortex to signal values or make predictions?
Zhou, J., Gardner, M. P., & Schoenbaum, G. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.02.011 · Cited by 57
To be specific: The role of orbitofrontal cortex in signaling reward identity.
Howard, J. D., & Kahnt, T. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000455 · Cited by 57
The Medial Orbitofrontal Cortex–Basolateral Amygdala Circuit Regulates the Influence of Reward Cues on Adaptive Behavior and Choice
Lichtenberg, N. T., Sepe-Forrest, L., Pennington, Z. T., Lamparelli, A. C., Greenfield, V. Y., & Wassum, K. M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0901-21.2021 · Cited by 58
Self-citation
The orbitofrontal cartographer.
Gardner, M., & Schoenbaum, G. M. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000463 · Cited by 60
Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences
Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenländer, L., Neumann, I. D., & Grinevich, V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.019 · Cited by 53
Organization of Afferents along the Anterior–posterior and Medial–lateral Axes of the Rat Orbitofrontal Cortex
Barreiros, I. V., Panayi, M. C., & Walton, M. E. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.02.017 · Cited by 51
Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior
Rudebeck, P. H., & Izquierdo, A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01140-0 · Cited by 55
Stress induces insertion of calcium-permeable AMPA receptors in the OFC–BLA synapse and modulates emotional behaviours in mice
Kuniishi, H., Yamada, D., Wada, K., Yamada, M., & Sekiguchi, M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0837-3 · Cited by 47
Value-free reinforcement learning: policy optimization as a minimal model of operant behavior
Bennett, D., Niv, Y., & Langdon, A. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.04.020 · Cited by 48
Sign-tracking is an expectancy-mediated behavior that relies on prediction error mechanismsPreprint
Derman, R. C., Schneider, K. N., Juarez, S., & Delamater, A. R. (2018) · Learning & Memory · doi:10.1101/lm.047365.118 · Cited by 48
Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex
Askew, C. E., López, A. J., Wood, M. A., & Metherate, R. (2019) · Synapse · doi:10.1002/syn.22116 · Cited by 45
Dopamine signals related to appetitive and aversive events in paradigms that manipulate reward and avoidability
Gentry, R. N., Schuweiler, D. R., & Roesch, M. R. (2018) · Brain Research · doi:10.1016/j.brainres.2018.10.008 · Cited by 41
Neural circuits in goal-directed and habitual behavior: Implications for circuit dysfunction in obsessive-compulsive disorder
Simmler, L. D., & Ozawa, T. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104464 · Cited by 40
Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
Zhan, J. J., Komal, R., Keenan, W. T., Hattar, S. S., & Fernandez, D. C. (2019) · Journal of Visualized Experiments · doi:10.3791/59439 · Cited by 39
Effects of Limited and Extended Pavlovian Training on Devaluation Sensitivity of Sign- and Goal-Tracking Rats
Keefer, S. E., Bacharach, S. Z., Kochli, D. E., Chabot, J. M., & Calu, D. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00003 · Cited by 40
Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain
Sherman, B. E., Turk‐Browne, N. B., & Goldfarb, E. V. (2023) · Perspectives on Psychological Science · doi:10.1177/17456916231179146 · Cited by 48
Processing in Lateral Orbitofrontal Cortex Is Required to Estimate Subjective Preference during Initial, but Not Established, Economic Choice
Gardner, M., Sanchez, D. C., Conroy, J. C., Wikenheiser, A. M., Zhou, J., & Schoenbaum, G. M. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.010 · Cited by 39
Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals
Sarlitto, M. C., Foilb, A. R., & Christianson, J. P. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.037 · Cited by 37
Optogenetic Activation of the Basolateral Amygdala Promotes Both Appetitive Conditioning and the Instrumental Pursuit of Reward Cues
Servonnet, A., Hernández, G., Hage, C. E., Rompré, P.-P., & Samaha, A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2196-19.2020 · Cited by 43
mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking
Morisot, N., Berger, A. L., Phamluong, K., Laguesse, S., Moffat, J. J., & Dorit Ron, A. (2019) · eLife · doi:10.7554/elife.51333 · Cited by 31
Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems
Schalbetter, S. M., Mueller, F. S., Scarborough, J., Richetto, J., Weber‐Stadlbauer, U., Meyer, U., & Notter, T. (2021) · Lab Animal · doi:10.1038/s41684-021-00723-0 · Cited by 34
Value-Related Neuronal Responses in the Human Amygdala during Observational Learning
Aquino, T. G., Minxha, J., Dunne, S., Ross, I. B., Mamelak, A. N., Rutishauser, U., & O’Doherty, J. P. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2897-19.2020 · Cited by 28
Disinhibition of the orbitofrontal cortex biases decision-making in obesity
Seabrook, L. T., Naef, L., Baimel, C., Judge, A., Kenney, T., Ellis, M., Tayyab, T., Armstrong, M., Qiao, M., Floresco, S., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01210-6 · Cited by 32
Prefrontal cortex modulates firing pattern in the nucleus reuniens of the midline thalamus via distinct corticothalamic pathways
Zimmerman, E. C., & Grace, A. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14111 · Cited by 31
Higher Adherence to the Mediterranean Diet Is Associated With Preserved White Matter Integrity and Altered Structural Connectivity
Rodrigues, B., Coelho, A., Portugal‐Nunes, C., Magalhães, R. J. D. S., Moreira, P. S., Castanho, T. C., Amorim, L., Marques, P., Soares, J. M., Sousa, N., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00786 · Cited by 33
Noninvasive Brain Stimulation Rescues Cocaine-Induced Prefrontal Hypoactivity and Restores Flexible Behavior
West, E. A., Niedringhaus, M. S., Ortega, H. K., Haake, R. M., Frӧhlich, F., & Carelli, R. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.027 · Cited by 34
Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action
Ozawa, A., & Arakawa, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113234 · Cited by 29
Avoid-approach conflict behaviors differentially affected by anxiolytics: implications for a computational model of risky decision-making
Walters, C. J., Jubran, J., Sheehan, A., Erickson, M. T., & Redish, A. D. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05197-0 · Cited by 31
Effects of hM4Di activation in CamKII basolateral amygdala neurons and CNO treatment on sensory-specific vs. general PIT: refining PIT circuits and considerations for using CNO
Derman, R. C., Bass, C. E., & Ferrario, C. R. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05453-8 · Cited by 28
Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making
Keefer, S. E., Gyawali, U., & Calu, D. J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113306 · Cited by 27
Roles of the prefrontal cortex in learning to time the onset of pre-existing motor programs
Lee, B.-C., Choi, J., & Martin, B. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241562 · Cited by 26
Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters
Fraser, K. M., & Janak, P. H. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06227-0 · Cited by 26
Impaired Expected Value Computations in Schizophrenia Are Associated With a Reduced Ability to Integrate Reward Probability and Magnitude of Recent Outcomes
Hernaus, D., Frank, M. J., Brown, E. C., Brown, J. K., Gold, J. M., & Waltz, J. A. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.11.011 · Cited by 27
Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?
Shields, C. N., & Gremel, C. M. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14441 · Cited by 26
Instrumental and Pavlovian Mechanisms in Alcohol Use Disorder
Doñamayor, N., Ebrahimi, C., Garbusow, M., Wedemeyer, F., Schlagenhauf, F., & Heinz, A. (2020) · Current Addiction Reports · doi:10.1007/s40429-020-00333-9 · Cited by 24
Role of mPFC and nucleus accumbens circuitry in modulation of a nicotine plus alcohol compound drug state
Randall, P. A., McElligott, Z. A., & Besheer, J. (2019) · Addiction Biology · doi:10.1111/adb.12782 · Cited by 22
Defining an Orbitofrontal Compass: Functional and Anatomical Heterogeneity Across Anterior-Posterior and Medial-Lateral Axes
Barreiros, I. V., Ishii, H., Walton, M., & Panayi, M. C. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000442 · Cited by 20
Chemogenetic Silencing of Prelimbic Cortex to Anterior Dorsomedial Striatum Projection Attenuates Operant Responding
Shipman, M. L., Johnson, G. C., Bouton, M. E., & Green, J. T. (2019) · eNeuro · doi:10.1523/eneuro.0125-19.2019 · Cited by 20
Different methods of fear reduction are supported by distinct cortical substrates
Lay, B. P. P., Pitaru, A. A., Boulianne, N., Esber, G. R., & Iordanova, M. D. (2020) · eLife · doi:10.7554/elife.55294 · Cited by 21
Distinct alterations of amygdala subregional functional connectivity in early- and late-onset obsessive-compulsive disorder
Cao, L., Li, H., Hu, X., Liu, J., Gao, Y., Liang, K., Zhang, L., Hu, X., Bu, X., Lu, L., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.005 · Cited by 22
In vivo electrophysiological validation of DREADD‐based modulation of pallidal neurons in the non‐human primate
Deffains, M., Nguyen, T. H., Orignac, H., Biendon, N., Doveró, S., Bézard, E., & Boraud, T. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14746 · Cited by 20
Insights into the Neurobiology of Craving in Opioid Use Disorder
Lueptow, L. M., Shashkova, E., Miller, M. G., Evans, C. J., & Cahill, C. M. (2020) · Current anesthesiology reports · doi:10.1007/s40140-020-00420-7 · Cited by 20
Social incentivization of instrumental choice in mice requires amygdala-prelimbic cortex-nucleus accumbens connectivity
Kietzman, H. W., Trinoskey-Rice, G., Blumenthal, S. A., Guo, J., & Gourley, S. L. (2022) · Nature Communications · doi:10.1038/s41467-022-32388-9 · Cited by 21
Parallel Lemniscal and Non-Lemniscal Sources Control Auditory Responses in the Orbitofrontal Cortex (OFC)
Srivastava, H. K., & Bandyopadhyay, S. (2020) · eNeuro · doi:10.1523/eneuro.0121-20.2020 · Cited by 19
Selective Prefrontal–Amygdala Circuit Interactions Underlie Social and Nonsocial Valuation in Rhesus Macaques
Pujara, M. S., Ciesinski, N. K., Reyelts, J. F., Rhodes, S. E. V., & Murray, E. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0794-21.2022 · Cited by 19
Mindfulness Meditation and Network Neuroscience: Review, Synthesis, and Future Directions
Prakash, R. S., Shankar, A., Tripathi, V., Yang, W. F. Z., Fisher, M. E., Bauer, C. C. C., Betzel, R. F., & Sacchet, M. D. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.11.005 · Cited by 24
Cross-species studies on orbitofrontal control of inference-based behavior.
Kahnt, T., & Schoenbaum, G. M. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000401 · Cited by 18
Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping
Nasser, H. M., Lafferty, D. S., Lesser, E. N., Bacharach, S. Z., & Calu, D. J. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.11.010 · Cited by 17
Inactivation of the Basolateral Amygdala to Insular Cortex Pathway Makes Sign-Tracking Sensitive to Outcome Devaluation
Keefer, S. E., Kochli, D. E., & Calu, D. J. (2022) · eNeuro · doi:10.1523/eneuro.0156-22.2022 · Cited by 16
Prediction errors and valence: From single units to multidimensional encoding in the amygdala
Brockett, A. T., Vázquez, D., & Roesch, M. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113176 · Cited by 14
A hippocampo-cortical pathway detects changes in the validity of an action as a predictor of reward
Piquet, R., Faugère, A., & Parkes, S. L. (2023) · Current Biology · doi:10.1016/j.cub.2023.11.036 · Cited by 14
Serotonin 2C Antagonism in the Lateral Orbitofrontal Cortex Ameliorates Cue-Enhanced Risk Preference and Restores Sensitivity to Reinforcer Devaluation in Male Rats
Hathaway, B. A., Schumacher, J. D., Hrelja, K. M., & Winstanley, C. A. (2021) · eNeuro · doi:10.1523/eneuro.0341-21.2021 · Cited by 14
Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty
Aguirre, C. G., Woo, J. H., Romero-Sosa, J. L., Rivera, Z. M., Tejada, A. N., Munier, J. J., Perez, J., Goldfarb, M., Das, K., Gomez, M., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0622-23.2023 · Cited by 14
Facing emotions: real-time fMRI-based neurofeedback using dynamic emotional faces to modulate amygdala activity
Watve, A., Haugg, A., Frei, N., Koush, Y., Willinger, D., Brühl, A. B., Stämpfli, P., Scharnowski, F., & Sladky, R. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1286665 · Cited by 17
Prelimbic cortex neural encoding dynamically tracks expected outcome value
Niedringhaus, M. S., & West, E. A. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113938 · Cited by 16
Quantity versus quality: Convergent findings in effort-based choice tasks
Hart, E. E., & Izquierdo, A. (2019) · Behavioural Processes · doi:10.1016/j.beproc.2019.05.009 · Cited by 14
Representation of foreseeable choice outcomes in orbitofrontal cortex triplet-wise interactions
Balaguer‐Ballester, E., Nogueira, R., Abofalia, J. M., Moreno‐Bote, R., & Sanchez-Vives, M. V. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007862 · Cited by 14
Regulation of dendritic spines in the amygdala following sleep deprivation
Rexrode, L., Tennin, M., Babu, J., Young, C., Bollavarapu, R., Lawson, L. A., Valeri, J., Pantazopoulos, H., & Gisabella, B. (2023) · Frontiers in Sleep · doi:10.3389/frsle.2023.1145203 · Cited by 15
Cell Adhesion Factors in the Orbitofrontal Cortex Control Cue-Induced Reinstatement of Cocaine Seeking and Amygdala-Dependent Goal Seeking
Whyte, A. J., Trinoskey-Rice, G., Davies, R. A., Woon, E. P., Foster, S. L., Shapiro, L. P., Li, D. C., Srikanth, K. D., Gil-Henn, H., & Gourley, S. L. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0781-20.2021 · Cited by 12
Mechanisms of higher-order learning in the amygdala
Gostolupce, D., Iordanova, M. D., & Lay, B. P. P. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113435 · Cited by 13
Pre-training inactivation of basolateral amygdala and mediodorsal thalamus, but not orbitofrontal cortex or prelimbic cortex, impairs devaluation in a multiple-response/multiple-reinforcer cued operant task
Fisher, H., Pajser, A., & Pickens, C. L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112159 · Cited by 15
Short- and Long-Term High-Fat Diet Exposure Differentially Alters Phasic and Tonic GABAergic Signaling onto Lateral Orbitofrontal Pyramidal Neurons
Seabrook, L. T., Peterson, C., Noble, D., Sobey, M., Tayyab, T., Kenney, T., Judge, A., Armstrong, M., Lin, S., & Borgland, S. L. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0831-23.2023 · Cited by 15
Task-Dependent Effective Connectivity of the Reward Network During Food Cue-Reactivity: A Dynamic Causal Modeling Investigation
Ghobadi‐Azbari, P., Khayati, R. M., Sangchooli, A., & Ekhtiari, H. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.899605 · Cited by 11
Pathways to adolescent social anxiety: Testing interactions between neural social reward function and perceived social threat in daily life
Sequeira, S. L., Silk, J. S., Jones, N. P., Forbes, E. E., Hanson, J. L., Hallion, L. S., & Ladouceur, C. D. (2024) · Development and Psychopathology · doi:10.1017/s0954579424001068 · Cited by 11
Deconstructing and reconstructing behaviour relevant to mental health disorders: The benefits of a psychological approach, with a focus on addiction
Rutherford, L. G., & Milton, A. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.104514 · Cited by 10
Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation
Garceau, C., Samaha, A., Cordahi, T., Servonnet, A., & Khoo, S. Y. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05907-7 · Cited by 9

Authors: Lichtenberg, N. T., Pennington, Z. T., Holley, S. M., Greenfield, V. Y., Cepeda, C., Levine, M. S., & Wassum, K. M.
Affiliations: University of California, Los Angeles (US)
ORCID: Lichtenberg, Nina T.
Pennington, Zachary T.
Holley, Sandra M.
Cepeda, Carlos
Levine, Michael S.
Wassum, Kate M.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2017-07-25
Volume: 37
Issue: 35
Pages: 8374-8384
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0486-17.2017
PMC: PMC5577854
OpenAlex: W2736491203
Cited by: 171
References: 95
Citations by year: 2026: 9 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 18 · 2021: 37 · 2020: 22 · 2019: 24 · 2018: 18 · 2017: 3
FWCI: 10.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: National Institutes of Health (DA024635)
University of California, Los Angeles
National Institute on Drug Abuse (T32DA024635, R01DA035443)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: basolateral amygdala, orbitofrontal cortex, reward anticipation, Pavlovian-to-instrumental transfer, decision-making, reward seeking, goal-directed behavior, monosynaptic connectivity
MeSH terms: Animals, Conditioning, Operant, Cues, Decision Making, Extinction, Psychological, Male, Motivation, Neural Pathways, Reward, Prefrontal Cortex, Rats, Long-Evans, Rats, Anticipation, Psychological, Basolateral Nuclear Complex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Basolateral Amygdala to Orbitofrontal Cortex Projections Enable Cue-Triggered Reward Expectations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks