Specializations for reward-guided decision-making in the primate ventral prefrontal cortex

Murray, Elisabeth A.; Rudebeck, Peter H.

doi:10.1038/s41583-018-0013-4

Cited by 169Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral Economics

Specializations for reward-guided decision-making in the primate ventral prefrontal cortex

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Murray, Elisabeth A., Rudebeck, Peter H.·2018·Nature Reviews Neuroscience

DOI 10.1038/s41583-018-0013-4PMC PMC6432632

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Abstract

The estimated values of choices, and therefore decision-making based on those values, are influenced by both the chance that the chosen items or goods can be obtained (availability) and their current worth (desirability) as well as by the ability to link the estimated values to choices (a process sometimes called credit assignment). In primates, the prefrontal cortex (PFC) has been thought to contribute to each of these processes; however, causal relationships between particular subdivisions of the PFC and specific functions have been difficult to establish. Recent lesion-based research studies have defined the roles of two different parts of the primate PFC - the orbitofrontal cortex (OFC) and the ventral lateral frontal cortex (VLFC) - and their subdivisions in evaluating each of these factors and in mediating credit assignment during reward-based decision-making.

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Area 14 in the medial OFC/caudal vmPFC appears more important for comparing values of alternative options.
“Conversely, area 14 in the medial OFC/caudal vmPFC appears more important for comparing values of alternative options.”
From Prefrontal cortex and depression (2022) · cites this paper as [115]
The ‘Medial versus lateral orbitofrontal cortex’ section says the medial OFC seems important for choices based on value comparisons, and describes impaired choices after medial OFC lesions. The paper does not specifically assign that function to area 14; its anatomy section identifies area 14 as a subdivision of the OFC without establishing the narrower functional claim. Page numbers were not available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Detailed parcellation studies in macaques have shown the importance of central regions of OFC in updating the valuations of expected outcomes on the basis of an animal's current state (area 13) and translating that information into goals for action selection (area 11).
“In summary, detailed parcellation studies in macaques have shown the importance of central regions of OFC in updating the valuations of expected outcomes on the basis of an animal's current state (area 13) and translating that information into goals for action selection (area 11).”
From Prefrontal cortex and depression (2022) · cites this paper as [115]
Damage to the lateral OFC (mainly area 12, extending around the inferior convexity, described as VLPFC) impairs the ability to make choices based on whether reward versus non-reward had been received.
“In a more recent study, damage to the lateral OFC (mainly area 12 as shown in Fig. 1, and extending around the inferior convexity, but described as VLPFC—ventrolateral prefrontal cortex) was found to impair the ability to make choices based on whether reward versus non-reward had been received (Rudebeck et al., 2017; Murray and Rudebeck, 2018)”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Murray and Rudebeck, 2018

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The macaque lateral grasping network: A neural substrate for generating purposeful hand actions
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Role of the Primate Orbitofrontal Cortex in Mediating Anxious Temperament
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Crossed corticothalamic and thalamocortical connections of macaque prefrontal cortex
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Orality, Preference Behavior, and Reinforcement Value of Nonfood Object in Monkeys with Orbital Frontal Lesions
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Reward-Guided Learning with and without Causal Attribution
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Amygdala Contributions to Stimulus–Reward Encoding in the Macaque Medial and Orbital Frontal Cortex during Learning
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Functional Interaction of Medial Mediodorsal Thalamic Nucleus But Not Nucleus Accumbens with Amygdala and Orbital Prefrontal Cortex Is Essential for Adaptive Response Selection after Reinforcer Devaluation
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Integration of Multiple Determinants in the Neuronal Computation of Economic Values
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Imbalanced Activity in the Orbitofrontal Cortex and Nucleus Accumbens Impairs Behavioral Inhibition
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Perseveration of responding and nonresponding in monkeys with orbital frontal ablations.
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Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance
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Specialized Pathways from the Primate Amygdala to Posterior Orbitofrontal Cortex
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Satiety-responsive neurons in the medial orbitofrontal cortex of the macaque.
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Ventrolateral Prefrontal Neuronal Activity Related to Active Controlled Memory Retrieval in Nonhuman Primates
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Merchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2

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Authors: Murray, E. A., & Rudebeck, P. H.
Affiliations: National Institutes of Health (US)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Murray, Elisabeth A.
ORCID: Murray, Elisabeth A.
Rudebeck, Peter H.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-05-23
Volume: 19
Issue: 7
Pages: 404-417
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-018-0013-4
PMC: PMC6432632
OpenAlex: W2804557255
Cited by: 169
References: 151
Citations by year: 2026: 8 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 26 · 2021: 35 · 2020: 28 · 2019: 17 · 2018: 5
FWCI: 2.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH110822, ZIAMH002887)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords: ventral prefrontal cortex, orbitofrontal cortex, credit assignment, value-based choice, desirability, availability, lesion studies, non-human primates
MeSH terms: Animals, Decision Making, Humans, Learning, Macaca mulatta, Neurons, Reward, Prefrontal Cortex

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Specializations for reward-guided decision-making in the primate ventral prefrontal cortex

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