Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

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Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

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Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

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Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

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Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

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[ 11 C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease

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Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease

Liu, Y., Zhuang, D., Wang, J., Huang, H., Li, R., Wu, C., Deng, Y., Hu, G., & Guo, B. (2022) · The Analyst · doi:10.1039/d2an01327d · Cited by 53

Neuroimaging modalities in the detection of Alzheimer's disease-associated biomarkers

Dang, C., Wang, Y., Li, Q., & Lu, Y. (2023) · Psychoradiology · doi:10.1093/psyrad/kkad009 · Cited by 53

Cross-Sectional Comparison of Small Animal [18F]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models

Brendel, M., Jaworska, A. M., Grießinger, E., Rötzer, C., Burgold, S., Gildehaus, F., Carlsen, J., Cumming, P. D., Baumann, K., Haass, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116678 · Cited by 53

Presenilin‐2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer′s Disease

Toda, T., Noda, Y., Ito, G., Maeda, M., & Shimizu, T. (2010) · BioMed Research International · doi:10.1155/2011/617974 · Cited by 53

Molecular polymorphism of Aβ in Alzheimer's disease

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Disorder-to-order conformational transitions in protein structure and its relationship to disease

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Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice

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Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease

Sundaram, G. S. M., Dhavale, D. D., Prior, J. L., Yan, P., Cirrito, J. R., Rath, N. P., Laforest, R. A., Cairns, N. J., Lee, J., Kotzbauer, P. T., et al. (2016) · Scientific Reports · doi:10.1038/srep35636 · Cited by 50

Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study

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Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells

Lee, Y., Choi, D., Choi, I. S., Han, J., Jeong, H., Han, S., Oh, K., & Hong, J. T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-132 · Cited by 48

Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease

Lopez‐Picon, F. R., Snellman, A., Eskola, O., Helin, S., Solin, O. H., Haaparanta‐Solin, M., & Rinne, J. O. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.197608 · Cited by 49

Visualization of early infarction in rat brain after ischemia using a translocator protein (18 kDa) PET ligand [11C]DAC with ultra-high specific activity

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Mouse models in neurological disorders: Applications of non-invasive imaging

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Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities

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Comparative pathobiology of β-amyloid and the unique susceptibility of humans to Alzheimer's disease

Rosen, R. F., Tomidokoro, Y., Farberg, A. S., Dooyema, J., Ciliax, B., Preuss, T. M., Neubert, T. A., Ghiso, J. A., LeVine, H., & Walker, L. C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.019 · Cited by 46

The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update

Bales, K. R. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.666234 · Cited by 46

Ethanol Extract of Magnolia officinalis Prevents Lipopolysaccharide‐Induced Memory Deficiency via Its Antineuroinflammatory and Antiamyloidogenic Effects

Lee, Y., Choi, D., Yun, Y., Han, S., Kim, H. M., Lee, K., Choi, S. H., Yang, M., Jeon, H. S., Jeong, J., et al. (2012) · Phytotherapy Research · doi:10.1002/ptr.4740 · Cited by 43

Alzheimer's Aβ Peptides with Disease-Associated N-Terminal Modifications: Influence of Isomerisation, Truncation and Mutation on Cu2+ Coordination

Drew, S. C., Masters, C. L., & Barnham, K. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015875 · Cited by 42

Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors

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Early risk assessment for Alzheimer's disease

Carrillo, M. C., Blackwell, A. D., Hampel, H. J., Lindborg, J., Sperling, R. A., Schenk, D., Sevigny, J., Ferris, S. H., Bennett, D. A., Craft, S., et al. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.01.019 · Cited by 42

In Vivo SPECT Imaging of Amyloid-β Deposition with Radioiodinated Imidazo[1,2-a]Pyridine Derivative DRM106 in a Mouse Model of Alzheimer's Disease

Chen, C.-J., Bando, K., Ashino, H., Taguchi, K., Shiraishi, H., Shima, K., Fujimoto, O., Kitamura, C., Matsushima, S., Uchida, K., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.146944 · Cited by 43

[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment

Teng, E., Kepe, V., Frautschy, S. A., Liu, J., Satyamurthy, N., Yang, F., Chen, P., Cole, G. B., Jones, M. R., Huang, S., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.003 · Cited by 42

11C-PiB and124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention

Meier, S. R., Sehlin, D., Roshanbin, S., Falk, V. L., Saito, T., Saido, T. C., Neumann, U., Rokka, J., Eriksson, J., & Syvänen, S. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262083 · Cited by 39

Plaque Deposition Dependent Decrease in 5-HT2A Serotonin Receptor in AβPPswe/PS1dE9 Amyloid Overexpressing Mice

Holm, P. C., Ettrup, A., Klein, A. B., Santini, M. A., El-Sayed, M., Elvang, A. B., Stensbøl, T. B., Mikkelsen, J. D., Knudsen, G. M., & Aznar, S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100117 · Cited by 40

Imaging Neuroinflammation – from Bench to Bedside

Pulli, B. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000226 · Cited by 41

Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease

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MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research

Zimmer, E. R., Parent, M. J., Cuello, A. C., Gauthier, S. G., & Rosa‐Neto, P. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.002 · Cited by 41

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice

Yousefi, B. H., von Reutern, B., Scherübl, D., Manook, A., Schwaiger, M., Grimmer, T., Henriksen, G., Förster, S., Drzezga, A. E., & Wester, H. (2015) · EJNMMI Research · doi:10.1186/s13550-015-0090-6 · Cited by 38

In vivo Imaging With 18F-FDG- and 18F-Florbetaben-PET/MRI Detects Pathological Changes in the Brain of the Commonly Used 5XFAD Mouse Model of Alzheimer's Disease

Franke, T. N., Irwin, C., Bayer, T. A., Brenner, W., Beindorff, N., Bouter, C., & Bouter, Y. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00529 · Cited by 37

A Machine Learning–Based Approach to Discrimination of Tauopathies Using [ 18F ] PM‐PBB3 PET Images

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Advances on the Understanding of the Origins of Synaptic Pathology in AD

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In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer’s disease models

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In vivo molecular neuroimaging of glucose utilization and its association with fibrillar amyloid-β load in aged APPPS1-21 mice

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Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET

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Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains.

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Statistical parametric maps of 18F-FDG PET and 3-D autoradiography in the rat brain: a cross-validation study

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Preclinical studies of potential amyloid binding PET/SPECT ligands in Alzheimer's disease

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Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model

Frost, G. R., Longo, V. A., Li, T., Jonas, L. A., Judenhofer, M. S., Cherry, S. R., Koutcher, J. A., Lekaye, C., ZANZONICO, P. B., & Li, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-67284-z · Cited by 33

Amyloid Imaging in Alzheimer’s Disease and Other Dementias

Fodero‐Tavoletti, M. T., Cappai, R., McLean, C., Pike, K. E., Adlard, P. A., Cowie, T., Connor, A. R., Masters, C. L., Rowe, C. C., & Villemagne, V. L. (2009) · Brain Imaging and Behavior · doi:10.1007/s11682-009-9067-2 · Cited by 33

Evaluation ofN‐benzyl‐N‐[11C]methyl‐2‐ (7‐methyl‐8‐oxo‐2‐phenyl‐7,8‐dihydro‐9H‐purin‐9‐yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid‐lesioned rat

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Molecular imaging of dementia

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Quantitative Analysis of Peripheral Benzodiazepine Receptor in the Human Brain Using PET with11C-AC-5216

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Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model

Ji, B., Kumata, K., Onoe, H., Kaneko, H., Zhang, M., Seki, C., Ono, M., Shukuri, M., Tokunaga, M., Minamihisamatsu, T., et al. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.026 · Cited by 29

Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [18F]-florbetaben PET

Brendel, M., Delker, A., Rötzer, C., Böning, G., Carlsen, J., Cyran, C. C., Mille, E., Gildehaus, F. J., Cumming, P. D., Baumann, K., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.09.017 · Cited by 29

Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression

Teipel, S. J., Buchert, R., Thome, J., Hampel, H. J., & Pahnke, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.004 · Cited by 31

Quantitative assessment of cerebral venous blood T2 in mouse at 11.7T: Implementation, optimization, and age effect

Wei, Z., Xu, J., Liu, P., Chen, L., Li, W., van Zijl, P. C. M., & Lu, H. (2017) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27046 · Cited by 27

Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice

Wang, B., Tanaka, K., Ji, B., Ono, M., Fang, Y., Ninomiya, Y., Maruyama, K., Nakajima, N. I., Begum, N. N. F., Higuchi, M., et al. (2013) · Journal of Radiation Research · doi:10.1093/jrr/rrt096 · Cited by 29

Amyloid PET Ligands for Dementia

Villemagne, V. L., & Rowe, C. C. (2010) · PET Clinics · doi:10.1016/j.cpet.2009.12.008 · Cited by 31

Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer’s disease

Qian, Z., Wang, Z., Li, B., Meng, X., Kuang, Z., Li, Y., Yang, Y., & Ye, K. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02565-x · Cited by 28

PET Imaging in Animal Models of Alzheimer’s Disease

Chen, B., Marquez-Nostra, B. V., Belitzky, E., Toyonaga, T., Tong, J., Huang, Y. H., & Cai, Z. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.872509 · Cited by 27

Alzheimer's disease biomarkers: correspondence between human studies and animal models

Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.010 · Cited by 27

2-(2′-((Dimethylamino)methyl)-4′-(3-[18F]fluoropropoxy)-phenylthio)benzenamine for positron emission tomography imaging of serotonin transporters

Wang, J. L., Parhi, A. K., Oya, S., Lieberman, B. P., Kung, M., & Kung, H. F. (2008) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2008.02.009 · Cited by 27

The Effects of Physiological and Methodological Determinants on 18 F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model

Deleye, S., Waldron, A., Richardson, J. C., Schmidt, M. E., Langlois, X., Stroobants, S. G., & Staelens, S. G. (2016) · Molecular Imaging · doi:10.1177/1536012115624919 · Cited by 26

Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease

Deleye, S., Waldron, A., Verhaeghe, J. A. J., Bottelbergs, A., Wyffels, L., Broeck, B. V., Langlois, X., Schmidt, M. E., Stroobants, S. G., & Staelens, S. G. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.187625 · Cited by 25

Small Molecules and Alzheimer’s Disease: Misfolding, Metabolism and Imaging

Patel, V., Zhang, X., Tautiva, N., Nyabera, A., Owa, O., Baidya, M., Sung, H., Taunk, P., Abdollahi, S., Charles, S., et al. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150504145646 · Cited by 25

In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol

Snellman, A., Rokka, J., Lopez‐Picon, F. R., Eskola, O., Salmona, M., Forloni, G., Scheinin, M., Solin, O. H., Rinne, J. O., & Haaparanta‐Solin, M. (2014) · EJNMMI Research · doi:10.1186/s13550-014-0037-3 · Cited by 25

Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben

Son, H. J., Jeong, Y. J., Yoon, H. J., Lee, S. Y., Choi, G.-E., Park, J. A., Kim, M. H., Lee, K. C., Lee, Y. J., Kim, M. K., et al. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0447-7 · Cited by 23

Half-curcumin analogues as PET imaging probes for amyloid beta species

Yang, J., Cheng, R., Fu, H., Yang, J., Kumar, M., Lu, J., Xu, Y., Liang, S. H., Cui, M., & Ran, C. (2019) · Chemical Communications · doi:10.1039/c8cc10166c · Cited by 24

Quantitative Brain Positron Emission Tomography in Female 5XFAD Alzheimer Mice: Pathological Features and Sex-Specific Alterations

Bouter, C., Irwin, C., Franke, T. N., Beindorff, N., & Bouter, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.745064 · Cited by 27

Alzheimer's disease biomarkers in animal models: closing the translational gap.

Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Europe PMC (PubMed Central) · Cited by 24

Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET

Oh, S. J., Lee, H., Kang, K. J., Han, S. J., Lee, Y. J., Lee, K. C., Lim, S. M., Yoon, D., Kim, K. M., Park, J. A., et al. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/5272014 · Cited by 23

Molecular imaging of beta-amyloid deposition in late-life depression

Smith, G. S., Kuwabara, H., Nandi, A., Gould, N. F., Nassery, N., Savonenko, A. V., Joo, J. H., Kraut, M. A., Brašić, J. R., Holt, D. P., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.002 · Cited by 27

Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice

Takeuchi, H., Imamura, K., Ji, B., Tsukita, K., Enami, T., Takao, K., Miyakawa, T., Hasegawa, M., Sahara, N., Iwata, N., et al. (2020) · npj Vaccines · doi:10.1038/s41541-020-0172-y · Cited by 22

Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula

Shinotoh, H., Shimada, H., Kokubo, Y., Tagai, K., Niwa, F., Kitamura, S., Endo, H., Ono, M., Kimura, Y., Hirano, S., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000006736 · Cited by 22

New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein

Stevenson, L. M., Tavares, A., Brunet, A., McGonagle, F. I., Dewar, D., Pimlott, S. L., & Sutherland, A. J. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.12.061 · Cited by 21

In vivo detection of amyloid plaques by gadolinium-stained MRI can be used to demonstrate the efficacy of an anti-amyloid immunotherapy.

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In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models

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