Comparative pathobiology of β-amyloid and the unique susceptibility of humans to Alzheimer's disease
Open accessAbstract
The misfolding and accumulation of the protein fragment β-amyloid (Aβ) is an early and essential event in the pathogenesis of Alzheimer's disease (AD). Despite close biological similarities among primates, humans appear to be uniquely susceptible to the profound neurodegeneration and dementia that characterize AD, even though nonhuman primates deposit copious Aβ in senile plaques and cerebral amyloid-β angiopathy as they grow old. Because the amino acid sequence of Aβ is identical in all primates studied to date, we asked whether differences in the properties of aggregated Aβ might underlie the vulnerability of humans and the resistance of other primates to AD. In a comparison of aged squirrel monkeys (Saimiri sciureus) and humans with AD, immunochemical and mass spectrometric analyses indicate that the populations of Aβ fragments are largely similar in the 2 species. In addition, Aβ-rich brain extracts from the brains of aged squirrel monkeys and AD patients similarly seed the deposition of Aβ in a transgenic mouse model. However, the epitope exposure of aggregated Aβ differs in sodium dodecyl sulfate-stable oligomeric Aβ from the 2 species. In addition, the high-affinity binding of (3)H Pittsburgh Compound B to Aβ is significantly diminished in tissue extracts from squirrel monkeys compared with AD patients. These findings support the hypothesis that differences in the pathobiology of aggregated Aβ among primates are linked to post-translational attributes of the misfolded protein, such as molecular conformation and/or the involvement of species-specific cofactors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Squirrel monkeys have all major Aβ species that are present in the human brain, including Aβ1-40, Aβ1-42, Aβ1-34, Aβ4-40, Aβ4-42, AβN3pE and oxidized Aβ.
“A recent mass spectrometry study showed that squirrel monkeys have all major Aβ species that are present in the human brain (including Aβ1–40, Aβ1–42, Aβ1–34, Aβ4–40, Aβ4–42, AβN3pE and oxidized Aβ)[125].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [125]
Squirrel monkey Aβ oligomers likely have a different tertiary or quaternary structure from human species.
“While squirrel monkey Aβ also formed SDS stable dimers and trimers similar to humans, these oligomers likely have a different tertiary or quaternary structure from human species [125].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [125]
Squirrel monkey Aβ formed SDS stable dimers and trimers similar to humans.
“While squirrel monkey Aβ also formed SDS stable dimers and trimers similar to humans, these oligomers likely have a different tertiary or quaternary structure from human species [125].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [125]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814 · see citing works
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils
Petkova, A. T., Leapman, R. D., Guo, Z., Yau, W.-M., Mattson, M. P., & Tycko, R. (2005) · Science · doi:10.1126/science.1105850 · Cited by 1,687 · see citing works
Alzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
Bitan, G., Kirkitadze, M. D., Lomakin, A., Vollers, S. S., Benedek, G. B., & Teplow, D. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222681699 · Cited by 1,280 · see citing works
Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue
Lu, J., Qiang, W., Yau, W., Schwieters, C. D., Meredith, S. C., & Tycko, R. (2013) · Cell · doi:10.1016/j.cell.2013.08.035 · Cited by 1,087 · see citing works
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works
Biomarker Modeling of Alzheimer’s Disease
Jack, C. R., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.12.003 · Cited by 1,002 · see citing works
Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., Neuenschwander, A., Abramowski, D., Frey, P., Jaton, A. L., et al. (2006) · Science · doi:10.1126/science.1131864 · Cited by 971 · see citing works
Self-citationThe Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
Hamley, I. W. (2012) · Chemical Reviews · doi:10.1021/cr3000994 · Cited by 881 · see citing works
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Biomolecules · doi:10.3390/biom6010006 · Cited by 698 · see citing works
Buchhave, P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.155 · Cited by 664 · see citing works
Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638 · see citing works
Water-soluble Aβ(N-40, N-42) oligomers in normal and Alzheimer disease brains
Kuo, Y.-M., Emmerling, M. R., Vigo-Pelfrey, C., Kasunic, T. C., Kirkpatrick, J. B., Murdoch, G. H., Ball, M. J., & Roher, A. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4077 · Cited by 618 · see citing works
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works
Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis
Eisele, Y. S., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S. A., Wolburg, H., Walker, L. C., Staufenbiel, M., Heikenwalder, M., & Jucker, M. (2010) · Science · doi:10.1126/science.1194516 · Cited by 568 · see citing works
Self-citationAβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice
McGowan, E., Pickford, F., Kim, J., Onstead, L., Eriksen, J., Yu, C., Skipper, L., Murphy, M. P., Beard, J., Das, P., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.030 · Cited by 565 · see citing works
Kuperstein, I., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Debulpaep, M., Vandersteen, A., Segers‐Nolten, I., Van Der Werf, K., Subramaniam, V., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.211 · Cited by 532 · see citing works
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works
Resolving controversies on the path to Alzheimer's therapeutics
Selkoe, D. J. (2011) · Nature Medicine · doi:10.1038/nm.2460 · Cited by 494 · see citing works
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Selkoe, D. J., Bell, D., Podlisny, M., Price, D. L., & Cork, L. (1987) · Science · doi:10.1126/science.3544219 · Cited by 471 · see citing works
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., et al. (2012) · Nature · doi:10.1038/nature11060 · Cited by 427 · see citing works
Jucker, M. (2010) · Nature Medicine · doi:10.1038/nm.2224 · Cited by 401 · see citing works
Kane, M. D., Lipinski, W. J., Callahan, M. J., Bian, F., Durham, R. A., Schwarz, R. D., Roher, A. E., & Walker, L. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03606.2000 · Cited by 394 · see citing works
Self-citationKlunk, W. E., Lopresti, B. J., Ikonomović, M. D., Lefterov, I. M., Koldamova, R. P., Abrahamson, E. E., Debnath, M. L., Holt, D. P., Huang, G.-F., Shao, L., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2990-05.2005 · Cited by 376 · see citing works
Ferreira, S. T., Lourenco, M. V., Oliveira, M. M., & De Felice, F. G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00191 · Cited by 373 · see citing works
Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions
Stöhr, J., Watts, J. C., Mensinger, Z. L., Oehler, A., Grillo, S. K., DeArmond, S. J., Prusiner, S. B., & Giles, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206555109 · Cited by 359 · see citing works
Tau Aggregation and Its Interplay with Amyloid-β
Nisbet, R. M., Polanco, J.-C., Ittner, L. M., & Götz, J. (2015) · Acta Neuropathologica · doi:10.1007/s00401-014-1371-2 · Cited by 359 · see citing works
Aβ40 Inhibits Amyloid Deposition<i>In Vivo</i>
Kim, J., Onstead, L., Randle, S., Price, R., Smithson, L., Zwizinski, C., Dickson, D. W., Golde, T., & McGowan, E. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4849-06.2007 · Cited by 359 · see citing works
Portelius, E., Bogdanovic, N., Gustavsson, M. K., Volkmann, I., Brinkmalm, G., Zetterberg, H., Winblad, B., & Blennow, K. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0690-1 · Cited by 348 · see citing works
Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro
Pike, C. J., Overman, M. J., & Cotman, C. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23895 · Cited by 302 · see citing works
Maeda, J., Ji, B., Irie, T., Tomiyama, T., Maruyama, M., Okauchi, T., Staufenbiel, M., Iwata, N., Ono, M., Saido, T. C., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0673-07.2007 · Cited by 300 · see citing works
Preclinical Alzheimer disease—the challenges ahead
Sperling, R. A., Karlawish, J., & Johnson, K. A. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.241 · Cited by 291 · see citing works
Jan, A., Gokce, O., Luthi-Carter, R., & Lashuel, H. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803159200 · Cited by 291 · see citing works
Cerebral Amyloid Angiopathies: A Pathologic, Biochemical, and Genetic View
Révész, T., Ghiso, J. A., Lashley, T., Plant, G. T., Rostagno, A. A., Frangione, B., & Holton, J. L. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.9.885 · Cited by 286 · see citing works
Self-citationInduction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
Eisele, Y. S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L. H., Yan, Z.-X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903200106 · Cited by 279 · see citing works
Self-citationSerial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients
Watts, J. C., Condello, C., Stöhr, J., Oehler, A., Lee, J., DeArmond, S. J., Lannfelt, L., Ingelsson, M., Giles, K., & Prusiner, S. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408900111 · Cited by 279 · see citing works
Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease
Pauwels, K., Williams, T. L., Morris, K. L., Jonckheere, W., Vandersteen, A., Kelly, G., Schymkowitz, J., Rousseau, F., Pastore, A., Serpell, L. C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.264473 · Cited by 253 · see citing works
Molecular Structure of beta-Amyloid Fibrils in Alzheimer's Disease Brain Tissue.
Lu, J., Qiang, W., Yau, W., Schwieters, C. D., Meredith, S. C., & Tycko, R. (2013) · Cell · doi:10.2210/pdb2m4j/pdb · Cited by 246 · see citing works
Soluble Aβ Seeds Are Potent Inducers of Cerebral β-Amyloid Deposition
Langer, F., Eisele, Y. S., Fritschi, S. K., Staufenbiel, M., Walker, L. C., & Jucker, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3088-11.2011 · Cited by 237 · see citing works
Self-citationAlzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates
Forny‐Germano, L., Silva, N. M. L. E., Batista, A. F., Brito‐Moreira, J., Gralle, M., Boehnke, S. E., Coe, B. C., Lablans, A., Marques, S. A., Martinez, A. M. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1353-14.2014 · Cited by 232 · see citing works
Lemere, C. A., Beierschmitt, A., Iglesias, M., Spooner, E. T., Bloom, J. K., Leverone, J. F., Zheng, J. B., Seabrook, T. J., Louard, D., Li, D., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63296-8 · Cited by 230 · see citing works
Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides
Schlenzig, D., Manhart, S., Cinar, Y., Kleinschmidt, M., Hause, G., Willbold, D., Funke, S. A., Schilling, S., & Demuth, H.-U. (2009) · Biochemistry · doi:10.1021/bi900818a · Cited by 228 · see citing works
Neurotoxic protein oligomers — what you see is not always what you get
Bitan, G., Fradinger, E. A., Spring, S. M., & Teplow, D. B. (2005) · Amyloid · doi:10.1080/13506120500106958 · Cited by 221 · see citing works
The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms☆
Finch, C. E., & Sapolsky, R. M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00053-6 · Cited by 204 · see citing works
Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β
Cohen, M. L., Kim, C., Haldiman, T., ElHag, M., Mehndiratta, P., Termsarasab, P., Lissemore, F. M., Shea, M., Cohen, Y., Chen, W., et al. (2015) · Brain · doi:10.1093/brain/awv006 · Cited by 202 · see citing works
β-Amyloid Is Different in Normal Aging and in Alzheimer Disease
Piccini, A., Russo, C., Gliozzi, A., Relini, A., Vitali, A., Borghi, R., Giliberto, L., Armirotti, A., D’Arrigo, C., Bachi, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501694200 · Cited by 193 · see citing works
De novo induction of amyloid-β deposition in vivo
Morales, R., Duran-Aniotz, C. A., Castilla, J., Estrada, L. D., & Soto, C. A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.120 · Cited by 190 · see citing works
Solution State Characterization of Amyloid β-Derived Diffusible Ligands
Hepler, R. W., Grimm, K. M., Nahas, D. D., Breese, R., Chen-Dodson, E., Acton, P. J., Keller, P. M., Yeager, M. D., Wang, H., Shughrue, P. J., et al. (2006) · Biochemistry · doi:10.1021/bi061850f · Cited by 181 · see citing works
Kuo, Y.-M., Emmerling, M. R., Woods, A. S., Cotter, R. J., & Roher, A. E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7083 · Cited by 178 · see citing works
Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice
Stöhr, J., Condello, C., Watts, J. C., Bloch, L., Oehler, A., Nick, M., DeArmond, S. J., Giles, K., DeGrado, W. F., & Prusiner, S. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408968111 · Cited by 176 · see citing works
Tau Biology and Tau-Directed Therapies for Alzheimer’s Disease
Bakota, L., & Brandt, R. (2016) · Drugs · doi:10.1007/s40265-015-0529-0 · Cited by 170 · see citing works
Schöll, M., Wall, A., Thordardottir, S., Ferreira, D., Bogdanovic, N., Långström, B., Almkvist, O., Graff, C., & Nordberg, A. (2012) · Neurology · doi:10.1212/wnl.0b013e31825fdf18 · Cited by 169 · see citing works
Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy
Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315885 · Cited by 169 · see citing works
A canine model of human aging and Alzheimer's disease
Head, E. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.016 · Cited by 160 · see citing works
Tauopathy with paired helical filaments in an aged chimpanzee
Rosen, R. F., Farberg, A. S., Gearing, M., Dooyema, J., M. Long, P., Anderson, D. C., Davis‐Turak, J., Coppola, G., Geschwind, D. H., Paré, J., et al. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21744 · Cited by 153 · see citing works
Self-citationRelevance of Transgenic Mouse Models to Human Alzheimer Disease
Morrissette, D. A., Parachikova, A. I., Green, K. N., & LaFerla, F. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800030200 · Cited by 147 · see citing works
Roher, A. E., Palmer, K. C., Yurewicz, E. C., Ball, M. J., & Greenberg, B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09834.x · Cited by 147 · see citing works
Amino-Terminally Truncated Aβ Peptide Species Are the Main Component of Cotton Wool Plaques
Miravalle, L., Calero, M., Takao, M., Roher, A. E., Ghetti, B. F., & Vidal, R. (2005) · Biochemistry · doi:10.1021/bi0508237 · Cited by 140 · see citing works
Seeded strain‐like transmission of β‐amyloid morphotypes in APP transgenic mice
Heilbronner, G., Eisele, Y. S., Langer, F., Kaeser, S. A., Novotny, R., Nagarathinam, A., Åslund, A., Hammarström, P., Nilsson, K. P. R., & Jucker, M. (2013) · EMBO Reports · doi:10.1038/embor.2013.137 · Cited by 139 · see citing works
β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans
Gearing, M., Tigges, J., Mori, H., & Mirra, S. S. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00012-2 · Cited by 130 · see citing works
Geula, C., Nagykery, N. G., & Wu, C. (2001) · Acta Neuropathologica · doi:10.1007/s004010100429 · Cited by 128 · see citing works
Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization
Murray, M. M., Bernstein, S. L., Nyugen, V., Condron, M. M., Teplow, D. B., & Bowers, M. T. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8092604 · Cited by 128 · see citing works
Toyama, H., Ye, D. G., Ichise, M., Liow, J., Cai, L., Jacobowitz, D. M., Musachio, J. L., Hong, J. S., Crescenzo, M., Tipre, D. N., et al. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1780-5 · Cited by 126 · see citing works
Exogenous seeding of cerebral β‐amyloid deposition in βAPP‐transgenic rats
Rosen, R. F., Fritz, J. J., Dooyema, J. M., Cintron, A. F., Hamaguchi, T., Lah, J. J., LeVine, H., Jucker, M., & Walker, L. C. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07551.x · Cited by 121 · see citing works
Self-citationWilhelmus, M. M. M., de Waal, R. M. W., & Verbeek, M. M. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0029-7 · Cited by 121 · see citing works
Hatami, A., Albay, R., Monjazeb, S., Milton, S. C. F., & Glabe, C. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.594846 · Cited by 121 · see citing works
An Alzheimer's disease-specific β-amyloid fragment signature in cerebrospinal fluid
Portelius, E., Zetterberg, H., Andréasson, U., Brinkmalm, G., Andreasen, N., Wallin, A., Brinkmalm, A., & Blennow, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.09.044 · Cited by 120 · see citing works
Amyloid in the brains of aged squirrel monkeys
Walker, L. C., Masters, C., Beyreuther, K., & Price, D. L. (1990) · Acta Neuropathologica · doi:10.1007/bf00307691 · Cited by 119 · see citing works
Self-citationMorawski, M., Schilling, S., Kreuzberger, M., Waniek, A., Jäger, C., Koch, B. M., Cynis, H., Kehlen, A., Arendt, T., Hartlage‐Rübsamen, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131535 · Cited by 114 · see citing works
Aβ40 is a major form of β-amyloid in nonhuman primates
Gearing, M., Tigges, J., Mori, H., & Mirra, S. S. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00164-9 · Cited by 114 · see citing works
Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases
Bilousova, T. V., Miller, C. A., Poon, W. W., Vinters, H. V., Corrada, M. M., Kawas, C. H., Hayden, E. Y., Teplow, D. B., Glabe, C. G., Albay, R., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.018 · Cited by 112 · see citing works
Chen, X., Errangi, B. K., Li, L., Glasser, M. F., Westlye, L. T., Fjell, A. M., Walhovd, K. B., Hu, X. P., Herndon, J. G., Preuss, T. M., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.028 · Cited by 111 · see citing works
Self-citationBrain weight throughout the life span of the chimpanzee
Herndon, J. G., Tigges, J., Anderson, D. C., Klumpp, S. A., & McClure, H. M. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990712)409:4 · Cited by 110 · see citing works
Bioluminescence imaging of Aβ deposition in bigenic mouse models of Alzheimer's disease
Watts, J. C., Giles, K., Grillo, S. K., Lemus, A., DeArmond, S. J., & Prusiner, S. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019034108 · Cited by 109 · see citing works
The Role of Amyloid-Beta Derived Diffusible Ligands (ADDLs) in Alzheimers Disease
Catalano, S. M., Dodson, E., Henze, D. A., Joyce, J. G., Krafft, G. A., & Kinney, G. G. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606776743066 · Cited by 107 · see citing works
Struyfs, H., Broeck, B. V., Timmers, M., Fransén, E., Sleegers, K., Broeckhoven, C. V., Deyn, P. P. D., Streffer, J. R., Mercken, M. H., & Engelborghs, S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141986 · Cited by 104 · see citing works
Alexandru, A., Jagla, W., Graubner, S., Becker, A., Bäuscher, C., Kohlmann, S., Sedlmeier, R., Raber, K. A., Cynis, H., Rönicke, R., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1794-11.2011 · Cited by 102 · see citing works
N-terminal Heterogeneity of Parenchymal and Cerebrovascular Aβ Deposits
Tekirian, T. L., Saido, T. C., Markesbery, W. R., Russell, M. J., Wekstein, D. R., Patel, E., & Geddes, J. W. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199801000-00009 · Cited by 101 · see citing works
Hamaguchi, T., Eisele, Y. S., Varvel, N. H., Lamb, B. T., Walker, L. C., & Jucker, M. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0912-1 · Cited by 100 · see citing works
Self-citationRosen, R. F., Walker, L. C., & LeVine, H. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.02.011 · Cited by 97 · see citing works
Self-citationExogenous induction of cerebral β-amyloidosis in βAPP-transgenic mice
Walker, L. C., Callahan, M. J., Bian, F., Durham, R. A., Roher, A. E., & Lipinski, W. J. (2002) · Peptides · doi:10.1016/s0196-9781(02)00059-1 · Cited by 96 · see citing works
Self-citationPerez, S. E., Raghanti, M. A., Hof, P. R., Kramer, L., Ikonomovic, M. D., Lacor, P. N., Erwin, J. M., Sherwood, C. C., & Mufson, E. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23428 · Cited by 95 · see citing works
Senile plaques in aged squirrel monkeys
Walker, L. C., Kitt, C. A., Schwam, E., Buckwald, B., Garcia, F., Sepinwall, J., & Price, D. L. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90067-4 · Cited by 94 · see citing works
Self-citationPortelius, E., Andréasson, U., Ringman, J. M., Büerger, K., Daborg, J., Buchhave, P., Hansson, O., Harmsen, A., Gustavsson, M. K., Hanse, E., et al. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-2 · Cited by 94 · see citing works
Ikonomovic, M., Abrahamson, E., Price, J., Hamilton, R., Mathis, C., Paljug, W. R., Debnath, M., Cohen, A., Mizukami, K., Dekosky, S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0943-2 · Cited by 90 · see citing works
Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples
Watt, A. D., Perez, K. A., Rembach, A., Sherratt, N. A., Hung, L. W., Johanssen, T., McLean, C., Kok, W. M., Hutton, C. A., Fodero‐Tavoletti, M. T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1083-z · Cited by 85 · see citing works
Schlenzig, D., Rönicke, R., Cynis, H., Ludwig, H., Scheel, E., Reymann, K. G., Saido, T. C., Hause, G., Schilling, S., & Demuth, H. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07707.x · Cited by 82 · see citing works
Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer’s disease
Rosen, R. F., Ciliax, B. J., Wingo, T. S., Gearing, M., Dooyema, J. M., Lah, J. J., Ghiso, J. A., LeVine, H., & Walker, L. C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0583-3 · Cited by 82 · see citing works
Self-citationApolipoprotein E4 promotes the early deposition of Aβ42 and then Aβ40 in the elderly
Walker, L. C., Pahnke, J., Madauss, M., Vogelgesang, S., Pahnke, A., Herbst, E. W., Stausske, D., Walther, R., Kessler, C., & Warzok, R. (2000) · Acta Neuropathologica · doi:10.1007/s004010051190 · Cited by 81 · see citing works
Self-citationThe use of SELDI-TOF MS in the search for biological markers of Alzheimer’s disease
Watt, A. D. (2013) · Minerva Access (University of Melbourne) · Cited by 75 · see citing works
Commentary: is Alzheimer's disease uniquely human?
Finch, C. E., & Austad, S. N. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.025 · Cited by 72 · see citing works
Chang, Y., & Chen, Y. (2014) · FEBS Journal · doi:10.1111/febs.12813 · Cited by 68 · see citing works
Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging
Finch, C. E., & Austad, S. N. (2012) · AGE · doi:10.1007/s11357-011-9355-9 · Cited by 68 · see citing works
Aβ seeds resist inactivation by formaldehyde
Fritschi, S. K., Cintron, A. F., Ye, L., Mahler, J., Bühler, A., Baumann, F., Neumann, M., Nilsson, K. P. R., Hammarström, P., Walker, L. C., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1339-2 · Cited by 68 · see citing works
Self-citationTomidokoro, Y., Lashley, T., Rostagno, A., Neubert, T. A., Bojsen-Møller, M., Braendgaard, H., Plant, G., Holton, J., Frangione, B., Révész, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504038200 · Cited by 68 · see citing works
Self-citationErratum: De novo induction of amyloid-β deposition in vivo
Morales, R., Duran-Aniotz, C. A., Castilla, J., Estrada, L. D., & Soto, C. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.153 · Cited by 67 · see citing works
Carboxy terminal of β-amyloid deposits in aged human, canine, and polar bear brains
Tekirian, T. L., Cole, G. M., Russell, M. J., Yang, F., Weikstein, D. R., Patel, E., Snowdon, D. A., Markesbery, W. R., & Geddes, J. W. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02062-4 · Cited by 62 · see citing works
Persistence of Aβ seeds in APP null mouse brain
Ye, L., Fritschi, S. K., Schelle, J., Obermüller, U., Degenhardt, K., Kaeser, S. A., Eisele, Y. S., Walker, L. C., Baumann, F., Staufenbiel, M., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4117 · Cited by 58 · see citing works
Self-citationCerebral beta-amyloid angiopathy in aged squirrel monkeys.
Elfenbein, H. A., Rosen, R. F., Stephens, S. L., Switzer, R. C., Smith, Y., Paré, J., Mehta, P. D., Warzok, R., & Walker, L. C. (2007) · PubMed · doi:10.14670/hh-22.155 · Cited by 57 · see citing works
Self-citationProgression of Seed‐Induced A β Deposition within the Limbic Connectome
Ye, L., Hamaguchi, T., Fritschi, S. K., Eisele, Y. S., Obermüller, U., Jucker, M., & Walker, L. C. (2015) · Brain Pathology · doi:10.1111/bpa.12252 · Cited by 57 · see citing works
Self-citationLemere, C. A., Oh, J., Stanish, H. A., Peng, Y., Pepivani, I., Fagan, A. M., Yamaguchi, H., Westmoreland, S. V., & Mansfield, K. G. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0677 · Cited by 56 · see citing works
Serdons, K., Verduyckt, T., Vanderghinste, D., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.12.069 · Cited by 56 · see citing works
Tekirian, T. L., Yang, A., Glabe, C. G., & Geddes, J. W. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731584.x · Cited by 53 · see citing works
Molecular polymorphism of Aβ in Alzheimer's disease
LeVine, H., & Walker, L. C. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.026 · Cited by 52 · see citing works
Self-citationPortelius, E., Lashley, T., Westerlund, A., Persson, R., Fox, N. C., Blennow, K., Révész, T., & Zetterberg, H. (2015) · Neurodegenerative Diseases · doi:10.1159/000369465 · Cited by 50 · see citing works
Brain Weight Does Not Decrease with Age in Adult Rhesus Monkeys
Herndon, J. G., Tigges, J., Klumpp, S., & Anderson, D. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00054-2 · Cited by 49 · see citing works
Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer's disease
Morales, R., Bravo-Alegria, J. B., Duran-Aniotz, C. A., & Soto, C. A. (2015) · Scientific Reports · doi:10.1038/srep09349 · Cited by 49 · see citing works
Rüfenacht, P., Güntert, A., Bohrmann, B., et al. (2005) · Journal of Mass Spectrometry · doi:10.1002/jms.739 · Cited by 44 · see citing works
Activity and Architecture of Pyroglutamate-Modified Amyloid-β (AβpE3-42) Pores
Gillman, A. L., Jang, H., Lee, J., Ramachandran, S., Kagan, B. L., Nussinov, R., & Arce, F. T. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp5040954 · Cited by 44 · see citing works
Exogenous seeding of cerebral beta-amyloid deposition in beta APP-transgenic rats
Hamaguchi, T., & Jucker, M. (2012) · Journal of Neurochemistry · Cited by 44 · see citing works
Jonson, M., Pokrzywa, M., Starkenberg, A., Hammarström, P., & Thor, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133272 · Cited by 35 · see citing works
Becker, A., Kohlmann, S., Alexandru, A., Jagla, W., Canneva, F., Bäuscher, C., Cynis, H., Sedlmeier, R., Graubner, S., Schilling, S., et al. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-108 · Cited by 32 · see citing works
Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype
Morelli, L., Wei, L., Amorim, A., McDermid, J., Abee, C. R., Frangione, B., Walker, L. C., & Levy, E. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01491-8 · Cited by 28 · see citing works
Self-citationPiB Fails to Map Amyloid Deposits in Cerebral Cortex of Aged Dogs with Canine Cognitive Dysfunction
Fast, R., Rodell, A. B., GJEDDE, A. H., et al. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00099 · Cited by 27 · see citing works
Rosen, R. F., Tomidokoro, Y., Ghiso, J. A., & Walker, L. C. (2010) · Journal of Visualized Experiments · doi:10.3791/1916 · Cited by 26 · see citing works
Self-citation[7] Chemical modifications of deposited amyloid-β peptides
Lowenson, J. D., Clarke, S. G., & Roher, A. E. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)09009-6 · Cited by 21 · see citing works
Sawamura, N., Tamaoka, A., Shoji, S., Koo, E. H., Walker, L. C., & Mori, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00624-0 · Cited by 17 · see citing works
Self-citationContext dependence of protein misfolding and structural strains in neurodegenerative diseases
Mehta, A. K., Rosen, R. F., Childers, W. S., Gehman, J. D., Walker, L. C., & Lynn, D. G. (2013) · Biopolymers · doi:10.1002/bip.22283 · Cited by 14 · see citing works
Self-citationCerebral amyloid angiopathy in an aged sooty mangabey (Cercocebus atys).
D’Angelo, O., Dooyema, J. M., Courtney, C. L., et al. (2013) · PubMed · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Kim J Onstead L Randle S Price R Smithson L Zwizinski C Dickson DW Golde T McGowan E Abeta40 inhibits amyloid deposition in vivo. J Neurosci 2007 27 3 627 33 17234594 PMC6672801
- Selkoe DJ Terry RD R.K. Bick KL Sisodia SS Biology of beta-amyloid precursor protein and the mechanism of Alzheimer disease. Alzheimer Disease 1999 293 310 Lippincott Williams and Wilkins Philadelphia
- Walker LC Cork LC Terry RD The neurobiology of aging in nonhuman primates. Alzheimer Disease 1999 233 43 Lippincott Williams and Wilkins Philadelphia, PA
Cited by
Sorted by citations
Alzheimer's disease: experimental models and reality
Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810 · see citing works
- Authors
- Rosen, R. F., Tomidokoro, Y., Farberg, A. S., Dooyema, J., Ciliax, B., Preuss, T. M., Neubert, T. A., Ghiso, J. A., LeVine, H., & Walker, L. C.
- Affiliations
- Emory University (US)
- NYU Langone Health (US)
- University of Kentucky (US)
- Corresponding author
- Rosen, Rebecca F.
- Walker, Lary C.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 44
- Pages
- 185-196
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC4913040
- OpenAlex
- W2345680808
- Cited by
- 46
- References
- 127
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 9 · 2020: 8 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- MetLife Foundation (P51RR165, P51OD11132, R21NS077049, P30 NS050276, P50AG025688)
- BrightFocus Foundation (P01AG026423, R21NS080576, R21AG051266)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, Alzheimer's disease, squirrel monkey, Saimiri sciureus, amyloid fibril formation, epitope exposure, oligomeric amyloid, transgenic mouse model, amyloid plaques
- MeSH terms
- Aging, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Disease Susceptibility, Humans, Mice, Transgenic, Saimiri, Amyloid beta-Peptides, Tauopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
