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Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli
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The present experiment was designed to explore the stress-relatedness of activity in noradrenergic neurons of the locus coeruleus (LC) of behaving cats. A stressor was defined as a stimulus that elicited a significant sympathoadrenal activation as measured by plasma norepinephrine level and heart rate. According to this definition, exposure to 15 min of 100 dB white noise or 15 min of restraint was stressful in cats. In contrast, exposure to inaccessible rats for 15 min was behaviorally activating but nonstressful. The single-unit activity of noradrenergic neurons in the LC of behaving cats was examined under these conditions. The stressful stimuli elicited a significant increase in LC neuronal activity for the entire 15 min stressor duration, whereas the behaviorally activating but nonstressful stimulus elicited no significant change in the activity of these neurons. These results provide evidence that behavioral activation per se is not sufficient to evoke a tonic activation of these neurons. Rather, these data support the hypothesis that the LC is involved in the CNS response to stress and provide additional evidence that the activity of LC noradrenergic neurons increases in association with sympathoadrenal activation.
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“Studies in animals show that early stressors lead to increased activity of the locus coeruleus with resultant increased release of nor-epinephrine in the brain (Abercrombie and Jacobs 1987).”
From The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology (2006) · cites this paper as Abercrombie and Jacobs 1987
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“These characteristics have been observed in LC neurons of both the behaving rat (Aston-Jones and Bloom, 1981a) and cat (Rasmussen et al., 1986).”
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Circadian rhythm in c-fos protein expression in the rat adrenal cortex.
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“Stress is known to activate the noradrenergic system, leading to increased synthesis and release of noradrenaline (NA) in brain regions to which noradrenergic neurons project (Saavedra, 1982; Abercrombie and Jacobs, 1987a,b; reviewed by Stanford, 1993).”
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Metadata
- Authors
- Abercrombie, E., & Jacobs, B.
- Affiliations
- University of Pittsburgh (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1987-09-01
- Volume
- 7
- Issue
- 9
- Pages
- 2837-2843
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6569145
- OpenAlex
- W1924384005
- Cited by
- 377
- References
- 38
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 5 · 2014: 12 · 2013: 12 · 2012: 10
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute of Mental Health (MH23433, MH09256)
- Air Force Office of Scientific Research
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- locus coeruleus, noradrenergic neurons, stress response, single-unit activity, plasma norepinephrine, heart rate, restraint stress, white noise, behavioral activation, cats
- MeSH terms
- Animals, Behavior, Animal, Cats, Female, Heart Rate, Locus Coeruleus, Male, Neurons, Norepinephrine, Stress, Physiological
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