Cited by 377Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuroscience of respiration and sleep

The DOI matches its Crossref record; 29 of the 38 references it cites were found in a registry or an index.

Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli

Open access

Abercrombie, ED, Jacobs, BL·1987·The Journal of Neuroscience

DOI 10.1523/jneurosci.07-09-02837.1987PMC PMC6569145

Open this paper in CoChat — free account Open PDF

Abstract

The present experiment was designed to explore the stress-relatedness of activity in noradrenergic neurons of the locus coeruleus (LC) of behaving cats. A stressor was defined as a stimulus that elicited a significant sympathoadrenal activation as measured by plasma norepinephrine level and heart rate. According to this definition, exposure to 15 min of 100 dB white noise or 15 min of restraint was stressful in cats. In contrast, exposure to inaccessible rats for 15 min was behaviorally activating but nonstressful. The single-unit activity of noradrenergic neurons in the LC of behaving cats was examined under these conditions. The stressful stimuli elicited a significant increase in LC neuronal activity for the entire 15 min stressor duration, whereas the behaviorally activating but nonstressful stimulus elicited no significant change in the activity of these neurons. These results provide evidence that behavioral activation per se is not sufficient to evoke a tonic activation of these neurons. Rather, these data support the hypothesis that the LC is involved in the CNS response to stress and provide additional evidence that the activity of LC noradrenergic neurons increases in association with sympathoadrenal activation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.07-09-02837.1987

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
Aston‐Jones, G., & Bloom, F. E. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,072 · cited 1×
“These characteristics have been observed in LC neurons of both the behaving rat (Aston-Jones and Bloom, 1981a) and cat (Rasmussen et al., 1986).”
Background
Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal
Foote, S. L., Aston-Jones, G., & Bloom, F. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3033 · Cited by 857 · cited 2×
“…electrophysiological studies of LC neurons in unanesthetized animals have shown that these neurons are activated by a wide variety of environmental stimuli of many modalities (Foote and Bloom, 1979; Foote et al., 1980; Aston-Jones and Bloom, 198 lb; Rasmussen et al., 1986).”
Background
Raphe unit activity in freely moving cats: correlation with level of behavioral arousal.
Trulson, M., & Jacobs, B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90157-4 · Cited by 815 · cited 1×
“These behavioral states were defined according to polygraphic and behavioral criteria previously published (Trulson and Jacobs, 1979).”
MethodSelf-citation
THE EMERGENCY FUNCTION OF THE ADRENAL MEDULLA IN PAIN AND THE MAJOR EMOTIONS
Cannon, W. (1914) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1914.33.2.356 · Cited by 644
A sensitive method for the determination of plasma catecholamines using liquid chromatography with electrochemical detection.
Hallman, H., Farnebo, L., Hamberger, B., & Jonsson, G. (1978) · Life Science · doi:10.1016/0024-3205(78)90665-3 · Cited by 452 · cited 1×
“NE levels in plasma were determined using high-pressure liquid chromatography (HPLC) with electrochemical detection (Hallman et al., 1978).”
Method
α 2 -Adrenoceptor-Mediated Hyperpolarization of Locus Coeruleus Neurons: Intracellular Studies in Vivo
Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Science · doi:10.1126/science.6278591 · Cited by 431 · cited 1×
“These observations have led to the proposal that the LC is a central analog of peripheral sympathetic ganglia (Amaral and Sinnamon, 1977; Aghajanian and VanderMaelen, 1982; Elam et al., 1986; Reiner, 1986).”
Background
Monoamine cell distribution in the cat brain stem. A fluorescence histochemical study with quantification of indolaminergic and locus coeruleus cell groups
Wiklund, L., Léager, L., & Persson, M. (1981) · The Journal of comparative neurology · doi:10.1002/cne.902030405 · Cited by 344
Single unit activity of locus coeruleus neurons in the freely moving cat
Rasmussen, K., Morilak, D. A., & Jacobs, B. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)90370-7 · Cited by 324 · cited 12×
“These characteristics have been observed in LC neurons of both the behaving rat (Aston-Jones and Bloom, 1981a) and cat (Rasmussen et al., 1986).”
BackgroundMethodResultInfluentialSelf-citation
Stress and brain noradrenaline: a review.
Glavin, G. (1985) · Neuroscience and Biobehavioral Reviews · doi:10.1016/0149-7634(85)90048-x · Cited by 322 · cited 1×
“…locus coeruleus (LC), which contains as many as half of all NE neurons in the brain (Chu and Bloom, 1974; Jones and Moore, 1974; Wiklund et al., 198 l), has been hypothesized to play an important role in this response (Korf et al., 1973; Cassens et al., 1980; Glavin, 1985; Weiss and Simson, 1985).”
Background
Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus
Korf, J., Aghajanian, G. K., & Roth, R. H. (1973) · Neuropharmacology · doi:10.1016/0028-3908(73)90024-5 · Cited by 311 · cited 2×
“…locus coeruleus (LC), which contains as many as half of all NE neurons in the brain (Chu and Bloom, 1974; Jones and Moore, 1974; Wiklund et al., 198 l), has been hypothesized to play an important role in this response (Korf et al., 1973; Cassens et al., 1980; Glavin, 1985; Weiss and Simson, 1985).”
Background

Show all 38 references

Research works printed but not linked: 2

-- Anisman, H., L. Kokkinidis, and L. S. Sklar (1984) Neurochemical consequences of stress: Contributions of adaptive processes. In Psy- chological and Physiological Interaction in Response to Stress, S. Burchfield, ed., pp. 67-98, Hemisphere, New York.
Kennett, G. A., and M. H. Joseph (198 1) The functional importance ed., pp. 192-200, Elsevier, New York. of increased brain tryptophan in the serotonergic response to restraint

Sorted by citations

Items 101–200 of 349

Psychostimulants and motivated behavior: Arousal and cognition
Berridge, C. W., & Arnsten, A. F. T. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.005 · Cited by 104
Effects of beta-adrenoceptor blockade on components of human decision-making
Rogers, R. D., Lancaster, M., Wakeley, J., & Bhagwagar, Z. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1641-5 · Cited by 98
“This evidence includes early findings that stimulation of the locus coeruleus (LC) induces fearful states (Mason and Fibiger 1979), and that the somatic responses to various stressors relate directly to LC activity (Grant et al. 1980; Abercrombie and Jacobs 1987).”
Background
The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain.
Kawahara, H., Kawahara, Y., & Westerink, B. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00793-1 · Cited by 104
Stress modulates illness-course of substance use disorders: a translational review
Lijffijt, M., Hu, K., & Swann, A. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00083 · Cited by 103
“Norepinephrine can remain elevated throughout the duration of stressors (119), with an extended elevation after the end of the stressor among people with a history of childhood trauma (75), suggesting an increased risk of stress-induced poor decision making.”
Background
Interindividual differences in stress sensitivity: basal and stress-induced cortisol levels differentially predict neural vigilance processing under stress
Henckens, M. J. A. G., Klumpers, F., Everaerd, D., Kooijman, S. C., van Wingen, G. A., & Fernández, G. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv149 · Cited by 110
“This nucleus, as well as the hypothalamus, is known for its role in the initiation and maintenance of the stress response (Abercrombie and Jacobs, 1987; Valentino and van Bockstaele, 2008; Sara, 2009).”
Development and plasticity of the locus coeruleus: A review of recent physiological and pharmacological experimentation
Nakamura, S., & Sakaguchi, T. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90018-c · Cited by 94
Anxiolytic-like effect of neuropeptide Y (NPY) and NPY13-36 microinjected into vicinity of locus coeruleus in rats.
Kask, A., Rägo, L., & Harro, J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00076-6 · Cited by 101
Noradrenaline enhances temporal auditory contrast and neuronal timing precision in the cochlear nucleus of the mustached bat
Kössl, M., & Vater, M. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-12-04169.1989 · Cited by 91
“Noradrenaline (NA) is thought to modulate neuronal processing during orienting behavior, vigilance, and stress (Foote et al., 1980; Aston-Jones and Bloom, 198 1; Abercrombie and Jacobs, 1987).”
Background
The locus coeruleus, Barrington's nucleus, and neural circuits of stress
Sved, A. F., Cano, G., Passerin, A. M., & Rabin, B. S. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00927-7 · Cited by 96
Changes in pontine unit activity with REM sleep deprivation.
Mallick, B., Siegel, J. M., & Fahringer, H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90581-u · Cited by 100
Stress and the Neuroendocrinology of Anxiety Disorders
Pêgo, J. M., Sousa, J. C., Almeida, O., & Sousa, N. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_13 · Cited by 104
Peptides in the limbic system: Neurochemical codes for co-ordinated adaptive responses to behavioural and physiological demand
Herbert, J. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90033-o · Cited by 98
Biting Suppresses Stress-induced Expression of Corticotropin-releasing Factor (CRF) in the Rat Hypothalamus
Hori, N., Yuyama, N., & Tamura, K. (2004) · Journal of Dental Research · doi:10.1177/154405910408300208 · Cited by 94
“Acute restraint stress activates noradrenergic neurons in the locus coeruleus (LC) (Abercrombie and Jacobs, 1987) and induces a high level of Fos expression in both the LC and PVN (Chowdhury et al., 2000), confirming the involvement of the sympathetic system as well as the HPA axis in mediating…”
Background
Differences in heart rate and blood pressure in children with conduct disorder, major depression, and separation anxiety.
Rogeness, G., Cepeda, C., Macedo, C., Fisher, C., & Harris, W. R. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90074-f · Cited by 98
The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis.
Pudovkina, O., Kawahara, Y., de Vries, J. D., & Westerink, B. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02553-7 · Cited by 94
Effects of chronic social stress on tyrosine hydroxylase mRNA and protein levels.
Watanabe, Y., McKittrick, C., Blanchard, D., Blanchard, R. J., Mcewen, B. S., & Sakai, R. R. (1995) · Brain Research. Molecular Brain Research · doi:10.1016/0169-328x(95)00081-3 · Cited by 92
A passion of the soul: an introduction to pain for consciousness researchers.
Chapman, C., & Nakamura, Y. (1999) · Consciousness and Cognition · doi:10.1006/ccog.1999.0411 · Cited by 91
“Abercrombie and Jacobs (1987a,b) demonstrated a noradrenergically mediated increase in heart rate in cats exposed to white noise. Elevated heart rate decreased with repeated exposure, as did LC activation and circulating levels of norepinephrine. Libet and Gleason (1994) found that stimulation via permanently implante…”
Background
Stress and the adaptive self‐organization of neuronal connectivity during early childhood
Huether, G. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00023-9 · Cited by 91
The neuroanatomical basis of anxiety
Pratt, J. A. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90014-q · Cited by 89
Bladder distention activates noradrenergic locus coeruleus neurons by an excitatory amino acid mechanism
Page, M. E., Akaoka, H., Aston‐Jones, G., & Valentino, R. J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90295-d · Cited by 92
Systemic naloxone administration potentiates locus coeruleus noradrenergic neuronal activity under stressful but not non-stressful conditions.
Abercrombie, E., & Jacobs, B. (1988) · Brain Research · doi:10.1016/0006-8993(88)91415-1 · Cited by 89
Self-citation
Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse.
Takahashi, S., Yokota, S.-I., Hara, R., Kobayashi, T., Akiyama, M., Moriya, T., & Shibata, S. (2001) · Endocrinology · doi:10.1210/en.142.11.4910 · Cited by 88
Psychiatric symptoms of noradrenergic dysfunction: A pathophysiological view
Yamamoto, K., Shinba, T., & Yoshii, M. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12126 · Cited by 88
Presynaptic Inhibition of Diverse Afferents to the Locus Ceruleus by -Opiate Receptors: A Novel Mechanism for Regulating the Central Norepinephrine System
Kreibich, A., Reyes, B. A. S., Curtis, A. L., Ecke, L. E., Chavkin, C., Bockstaele, E. J. V., & Valentino, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0390-08.2008 · Cited by 104
“LC neurons are activated by diverse sensory stimuli, visceral stimuli, and internal and environmental stressors (Foote et al., 1980; Aston-Jones and Bloom, 1981a; Abercrombie and Jacobs, 1987; Morilak et al., 1987; Svensson, 1987).”
Background
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups
Shionoya, K., Moriceau, S., Bradstock, P., & Sullivan, R. M. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.06.004 · Cited by 85
“…determined that the brain’s noradrenergic system is stimulated by a vast diversity of stressful stimuli, such as immobilization, noise, shock, cold and others (Abercrombie and Jacobs, 1987; Glavin, 1985; Morilak et al., 1987a, b; Pacak et al., 1993; Pardon et al., 2003; Valentino et al., 1998).”
Background
Damage to ceruleo-cortical noradrenergic projections impairs locally cued but enhances spatially cued water maze acquisition
Selden, N. R. W., Cole, B. J., Everitt, B. J., & Robbins, T. W. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90119-y · Cited by 81
Stress increases noradrenaline release in the rat frontal cortex: prevention by diazepam.
Rossetti, Z., Portas, C., Pani, L., Carboni, S., & Gessa, G. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90533-c · Cited by 83
Mild electrical stimulation of pontine tegmentum around locus coeruleus reduces rapid eye movement sleep in rats.
Singh, S., & Mallick, B. (1996) · Neurosciences research · doi:10.1016/0168-0102(95)00998-1 · Cited by 82
Effect of novel stressors on gene expression of tyrosine hydroxylase and monoamine transporters in brainstem noradrenergic neurons of long-term repeatedly immobilized rats.
Rusnák, M., Kvetnan̆ský, R., Jeloková, J., & Palkovits, M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02126-6 · Cited by 81
Relation of Locus Coeruleus Neurons in Monkeys to Pavlovian and Operant Behaviors
Bouret, S., & Richmond, B. J. (2008) · Journal of Neurophysiology · doi:10.1152/jn.91048.2008 · Cited by 78
Increased plasma norepinephrine concentration in cats with interstitial cystitis.
Buffington, C. A. T., & Pacak, K. (2001) · Journal of Urology · doi:10.1016/s0090-4295(01)01021-4 · Cited by 77
Chronic cold exposure potentiates CRH-evoked increases in electrophysiologic activity of locus coeruleus neurons.
Jedema, H., Finlay, J. M., Sved, A., & Grace, A. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01057-x · Cited by 77
“Acute exposure to a stressor transiently increases the discharge rate of noradrenergic neurons (Abercrombie and Jacobs 1987), resulting in an increase in the release of norepinephrine (Abercrombie et al 1988).”
Background
Heightened transcription for enzymes involved in norepinephrine biosynthesis in the rat locus coeruleus by immobilization stress.
Serova, L., Nankova, B., Feng, Z., Hong, J.-S., Hutt, M., & Sabban, E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)90360-2 · Cited by 77
“foot shock, repeated white noise, restraint or axonal injury were found to increase NE turnover rates in the brain regions receiving NE from the LC (Korf et al 1973; Cassens et al 1980; Levin 1983) and LC neuronal activity (Abercrombie and Jacobs 1987).”
Background
Role of glucocorticoids in the cholinergic degeneration in rat hippocampus induced by ethylcholine aziridinium (AF64A)
Hörtnagl, H., Berger, M. L., Havelec, L., & Hornykiewicz, O. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-02939.1993 · Cited by 77
“…receive their noradrenergic innervation from the locus coeruleus occur in response to stressful stimuli and to microelectrophoretic application ofcorticosterone (Thierry et al., 1968; Korfet al., 1973; Cassens et al., 1980; Tanaka et al., 1983; Abercrombie and Jacobs, 1987; Avanzino et al., 1987).”
Background
Amphetamine increases persistent inward currents in human motoneurons estimated from paired motor-unit activity.
Udina, E., D'Amico, J., Bergquist, A., & Gorassini, M. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00734.2009 · Cited by 75
Effects of acute restraint stress on tyrosine hydroxylase mRNA expression in locus coeruleus of Wistar and Wistar-Kyoto rats
Sands, S. A., Strong, R., Corbitt, J., & Morilak, D. A. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00255-7 · Cited by 64
Amygdaloid noradrenaline is involved in the sensitization of the acoustic startle response in rats.
Fendt, M., Koch, M., & Schnitzler, H. (1994) · Pharmacology, Biochemistry and Behavior · doi:10.1016/0091-3057(94)90532-0 · Cited by 72
Single-unit and physiological analyses of brain norepinephrine function in behaving animals.
Jacobs, B. L., Abercrombie, E., Fornal, C., Levine, E., Morilak, D. A., & Stafford, I. (1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)63805-4 · Cited by 70
Self-citation
Fos expression in afferents to the rat midline thalamus following immobilization stress.
Otake, K., Kin, K., & Nakamura, Y. (2002) · Neurosciences research · doi:10.1016/s0168-0102(02)00042-1 · Cited by 69
Individual differences in behavioral reactivity: correlation with stress-induced norepinephrine efflux in the hippocampus of Sprague-Dawley rats.
Rosario, L., & Abercrombie, E. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00040-4 · Cited by 68
Self-citation
Role of locus coeruleus in foot shock-evoked Fos expression in rat brain.
Passerin, A., Cano, G., Rabin, B., Delano, B., Napier, J. L., & Sved, A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00372-9 · Cited by 67
Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats.
Kask, A., Rägo, L., & Harro, J. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00076-7 · Cited by 67
Chronic cold stress alters the basal and evoked electrophysiological activity of rat locus coeruleus neurons
Mana, M. J., & Grace, A. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00225-x · Cited by 66
Inhibition of noradrenergic locus coeruleus neurons by C1 adrenergic cells in the rostral ventral medulla.
Aston-Jones, G., Astier, B., & Ennis, M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90497-p · Cited by 67
The Role of Layer I in Cortical Function
Vogt, B. A. (1991) · Cerebral cortex · doi:10.1007/978-1-4615-6622-9_2 · Cited by 70
Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress.
Singewald, N., Zhou, G.-Y., & Schneider, C. (1995) · Brain Research · doi:10.1016/0006-8993(95)01102-1 · Cited by 66
Hemodynamic stress activates locus coeruleus neurons of unanesthetized rats.
Curtis, A., Drolet, G., & Valentino, R. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90150-a · Cited by 66
Noradrenergic Alterations in Posttraumatic Stress Disorder
Southwick, S. M., Morgan, C. A., Bremner, A. D., Grillon, C., Krystal, J. H., Nagy, L. M., & Charney, D. S. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48274.x · Cited by 64
Enhanced Tyrosine Hydroxylation in Hippocampus of Chronically Stressed Rats upon Exposure to a Novel Stressor
Nisenbaum, L., & Abercrombie, E. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09307.x · Cited by 65
Self-citation
Lack of response of serotonergic neurons in the dorsal raphe nucleus of freely moving cats to stressful stimuli.
Wilkinson, L., & Jacobs, B. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90055-6 · Cited by 65
Self-citation
Randomized controlled trial of the efficacy of short-term amitriptyline administration for treatment of acute, nonobstructive, idiopathic lower urinary tract disease in cats.
Kruger, J., Conway, T., Kaneene, J., Perry, R. L., Hagenlocker, E., Golombek, A., & Stuhler, J. (2003) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.2003.222.749 · Cited by 64
Relationship of thalamic basal forebrain projection neurons to the peptidergic innervation of the midline thalamus
Freedmanand, L. J., & Cassell, M. (1994) · The Journal of comparative neurology · doi:10.1002/cne.903480302 · Cited by 63
Brain transcription factor gene expression, neurotransmitter levels, and novelty response behaviors: Alterations during rat amphetamine withdrawal and following chronic injection stress
Persico, A., Schindler, C. W., Zaczek, R., Brannock, M., & Uhl, G. (1995) · Synapse · doi:10.1002/syn.890190309 · Cited by 62
Norepinephrinergic afferents and cytology of the macaque monkey midline, mediodorsal, and intralaminar thalamic nuclei
Vogt, B. A., Hof, P. R., Friedman, D. P., Sikes, R. W., & Vogt, L. J. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0178-0 · Cited by 66
“heaviest LC innervation and considers the consequences of heavy inputs in a system that is involved in flight-or-fight coordination (Abercrombie and Jacobs 1987).”
Background
Chronic Exposure to Cold Stress Alters Electrophysiological Properties of Locus Coeruleus Neurons Recorded In Vitro
Jedema, H., & Grace, A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300020 · Cited by 61
“Thus, it is well established that acute stress exposure can increase the discharge activity and NE release from noradrenergic LC neurons (Korf et al, 1973; Abercrombie and Jacobs, 1987; Abercrombie et al, 1988).”
Background
Separation-induced body weight loss, impairment in alternation behavior, and autonomic tone: effects of tyrosine
Hao, S., Avraham, Y., Bonne, O. B., & Berry, E. M. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00448-2 · Cited by 59
Attenuation of α2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood
Shishkina, G. T., Kalinina, T., & Dygalo, N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.015 · Cited by 59
Role of Barrington’s nucleus in the activation of rat locus coeruleus neurons by colonic distension
Rouzade‐Dominguez, M., Curtis, A. L., & Valentino, R. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02917-1 · Cited by 55
Posttraumatische Belastungsstörung
Vermetten, E. H. G. J. M., Charney, D. S., & Bremner, J. D. (2000) · Springer eBooks · doi:10.1007/978-3-642-59627-8_4 · Cited by 62
Monitoring extracellular norepinephrine in brain using in vivo microdialysis and HPLC-EC
Abercrombie, E. D., & Finlay, J. M. (1991) · Techniques in the behavioral and neural sciences · doi:10.1016/b978-0-444-81194-3.50016-2 · Cited by 51
Self-citation
Increased transcription of the tyrosine hydroxylase gene in individual locus coeruleus neurons following footshock stress.
Chang, M., Sved, A. F., Zigmond, M., & Austin, M. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00352-3 · Cited by 57
Noradrenergic modulation of the masseteric reflex in behaving cats. II. Physiological studies
Stafford, I., & Jacobs, B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00099.1990 · Cited by 32
Self-citation
Clonidine injections into the lateral nucleus of the amygdala block acquisition and expression of fear‐potentiated startle
Schulz, B., Fendt, M., & Schnitzler, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01831.x · Cited by 51
CRF receptor antagonist attenuates immobilization stress-induced norepinephrine release in the prefrontal cortex in rats.
Smagin, G., Zhou, J., Harris, R., & Ryan, D. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00368-1 · Cited by 55
Effect of novel environmental stimuli on rat behaviour and central noradrenaline function measured by in vivo microdialysis
McQuade, R., Creton, D., & Stanford, S. (1999) · Psychopharmacology · doi:10.1007/s002130051073 · Cited by 54
Activation of the mesocortical dopamine system by feeding: lack of a selective response to stress
Taber, M. T., & Fibiger, H. C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00529-5 · Cited by 53
An Analysis of the Effects of Acute and Chronic Fluoxetine on Extracellular Norepinephrine in the Rat Hippocampus during Stress
Page, M., & Abercrombie, E. (1997) · Neuropsychopharmacology · doi:10.1016/s0006-3223(97)87154-5 · Cited by 52
Self-citation
Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment.
Nakamura, S. (1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)63836-4 · Cited by 52
The locus coeruleus and regulation of behavioral flexibility and attention: clinical implications
Aston‐Jones, G., Iba, M., Clayton, E. C., Rajkowski, J., & Cohen, J. D. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544156.008 · Cited by 49
Locus coeruleus stimulation by corticotropin-releasing hormone suppresses in vitro cellular immune responses
Rassnick, S., Sved, A. F., & Rabin, B. S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06033.1994 · Cited by 50
“Locus coeruleus neurons are activated by CRH and stress (Korf et al., 1973; Ehlers et al., 1983; Valentino et al., 1983; Abercrombie and Jacobs, 1987; Valentino and Foote, 1987, 1988; Lachuer et al., 1991; Weiner et al., 1991; De Sarro et al., 1992; Curtis et al., 1993; Pezzone et al., 1993).”
Background
Corticosterone administration up‐regulated expression of norepinephrine transporter and dopamine β‐hydroxylase in rat locus coeruleus and its terminal regions
Fan, Y., Chen, P., Li, Y., Cui, K., Noel, D. M., Cummins, E. D., Peterson, D. J., Brown, R. W., & Zhu, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12459 · Cited by 49
Increased tyrosine hydroxylase immunoreactivity in the locus coeruleus of cats with interstitial cystitis.
Reche, A., & Buffington, C. A. T. (1998) · Journal of Urology · doi:10.1016/s0022-5347(01)63833-3 · Cited by 49
Blocking beta2-adrenergic receptor attenuates acute stress-induced amyloid beta peptides production.
Yu, N.-N., Wang, X.-X., Yu, J.-T., Wang, N.-D., Lu, R.-C., Miao, D., Tian, Y., & Tan, L. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.087 · Cited by 48
The mGlu2/3 receptor agonist, LY354740, blocks immobilization‐induced increases in noradrenaline and dopamine release in the rat medial prefrontal cortex
Swanson, C., Perry, K., & Schoepp, D. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02125.x · Cited by 48
Effects of lesioning noradrenergic neurones in the locus coeruleus on conditioned and unconditioned aversive behaviour in the rat.
Neophytou, S. I., Aspley, S., Butler, S., Beckett, S., & Marsden, C. A. (2001) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00181-6 · Cited by 48
Chapter 11 Serotonin, norepinephrine and associated neuropeptides: effects on somatic motoneuron excitability
White, S. R., Fung, S. J., Jackson, D. A., & Imel, K. M. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61865-8 · Cited by 44
Brain noradrenaline and the mechanisms of action of antidepressant drugs
Svensson, T. (2000) · Acta Psychiatrica Scandinavica Supplementum · doi:10.1034/j.1600-0447.2000.02604.x · Cited by 47
Can you handle it? Validating negative responses to restraint in cats
Moody, C., Picketts, V., Mason, G., Dewey, C., & Niel, L. (2018) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2018.04.012 · Cited by 46
Noradrenergic actions in the basolateral complex of the amygdala modulate Arc expression in hippocampal synapses and consolidation of aversive and non-aversive memory
McReynolds, J. R., Anderson, K. M., Donowho, K. M., & McIntyre, C. K. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.016 · Cited by 46
“…stress response involves locus coeruleus activation and increased norepinephrine in the amygdala and other brain regions at the same time, including the hippocampus (Abercrombie & Jacobs, 1987; Miyashita & Williams, 2004; Tanaka, 1999; Tanaka et al., 1983; Zigmond, Schon, & Iversen, 1974).”
Cortical connections of striate and extrastriate visual areas in tree shrews
Lyon, D. C., Jain, N., & Kaas, J. H. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981109)401:1 · Cited by 78
Extraneuronal noradrenaline in the prefrontal cortex of morphine-dependent rats: tolerance and withdrawal mechanis
Rossetio, Z. L., Longu, G., Mercuro, G., & Gessa, G. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)90889-u · Cited by 45
Natural locus coeruleus dynamics during feeding
Sciolino, N. R., Hsiang, M., Mazzone, C. M., Wilson, L. R., Plummer, N. W., Amin, J., Smith, K. G., McGee, C. A., Fry, S. A., Yang, C. X., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn9134 · Cited by 67
Novelty‐like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress‐inducing activation worsens its effects
Omoluabi, T., Torraville, S. E., Maziar, A., Ghosh, A., Power, K. D., Reinhardt, C., Harley, C. W., & Yuan, Q. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12231 · Cited by 53
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer’s patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability
Kelly, L., Seifi, M., Ma, R., Mitchell, S. J., Rudolph, U., Viola, K. L., Klein, W. L., Lambert, J. J., & Swinny, J. D. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12674 · Cited by 48
“This increased FR is likely to negatively impact on a range of behaviours, including cognitive performance [26], a heightened stress response [80], an increase in anxiety-like behaviour [27] and increased wakefulness [23].”
Background
Being a grump only makes things worse: a transactional account of acute stress on mind wandering
Vinski, M. T., & Watter, S. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00730 · Cited by 51
“Acute stress has been shown to induce a phasic release of norepinephrine (NE) from the LC/NE system (e.g., Abercrombie and Jacobs, 1987a,b; Svensson, 1987; Cecchi et al., 2002a,b).”
Background
GABAA Receptor Endocytosis in the Basolateral Amygdala Is Critical to the Reinstatement of Fear Memory Measured by Fear-Potentiated Startle
Lin, H., Tseng, Y.-C., Mao, S.-C., Chen, P.-S., & Gean, P. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0979-11.2011 · Cited by 42
“During this period of increased activity, the discharges of simultaneously recorded amygdala cells were more synchronized than before the shock (Abercrombie and Jacobs, 1987; Aston-Jones et al., 1991).”
Background
Previous stress increases in vivo biogenic amine response to swim stress
Jordan, S., Kramer, G., Zukas, P. K., & Petty, F. (1994) · Neurochemical Research · doi:10.1007/bf00969000 · Cited by 44
CRF receptor antagonist attenuates stress-induced noradrenaline release in the medial prefrontal cortex of rats.
Shimizu, N., Nakane, H., Hori, T., & Hayashi, Y. (1994) · Brain Research · doi:10.1016/0006-8993(94)91580-6 · Cited by 44
Injection of corticotropin-releasing hormone into the locus coeruleus or foot shock increases neuronal Fos expression.
Rassnick, S., Hoffman, G. E., Rabin, B., & Sved, A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00574-5 · Cited by 43
Incremental Changes in Extracellular Noradrenaline Availability in the Frontal Cortex Induced by Naturalistic Environmental Stimuli: A Microdialysis Study in the Freely Moving Rat
Dalley, J. W., & Stanford, S. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65062644.x · Cited by 43
Transcutaneous Cervical Vagal Nerve Stimulation in Patients with Posttraumatic Stress Disorder (PTSD): A Pilot Study of Effects on PTSD Symptoms and Interleukin-6 Response to Stress
Bremner, J. D., Wittbrodt, M. T., Gurel, N. Z., Shandhi, M. H., Gazi, A. H., Jiao, Y., Levantsevych, O. M., Huang, M., Beckwith, J., Herring, I., et al. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100190 · Cited by 51
“…fear, and anxiety behaviors, as well as activation of the peripheral sympathetic system with increased heart rate, blood pressure, and respiration (Abercrombie and Jacobs, 1987a, 1987b; Aston-Jones et al., 1991; Foote et al., 1983; Jedema et al., 2001; Levine et al., 1990; Nisenbaum and…”
Background
Pharmacological evidence for the implication of noradrenaline in effort
Borderies, N., Mattioni, J., Bornert, P., Gilardeau, S., & Bouret, S. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000793 · Cited by 49
“that clonidine leads to decreased LC activity ([46,60,70]).”
Background
Chronic cold exposure increases RGS7 expression and decreases α2‐autoreceptor‐mediated inhibition of noradrenergic locus coeruleus neurons
Jedema, H. P., Gold, S. J., González‐Burgos, G., Sved, A. F., Tobe, B. J., Wensel, T. G., & Grace, A. A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06208.x · Cited by 47
“Thus, LC neuron firing rate and NE release from axon terminals are increased by acute stress exposure (Grant & Redmond, 1984; Abercrombie & Jacobs, 1987; Abercrombie et al., 1992).”
Background
The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.
Harro, J., Tõnissaar, M., & Eller, M. (2001) · Neuropeptides · doi:10.1054/npep.2001.0851 · Cited by 42
Reciprocal cross-desensitization of locus coeruleus electrophysiological responsivity to corticotropin-releasing factor and stress
Conti, L. H., & Foote, S. L. (1996) · Brain Research · doi:10.1016/0006-8993(96)00175-8 · Cited by 41
The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming
Finnell, J. E., Moffitt, C. M., Hesser, L. A., Harrington, E. N., Melson, M. N., Wood, C. S., & Wood, S. K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.01.021 · Cited by 49
The basolateral amygdala determines the effects of fear memory on sleep in an animal model of PTSD
Wellman, L. L., Fitzpatrick, M. E., Machida, M., & Sanford, L. D. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3850-z · Cited by 43
“…2000; Farivar et al. 2004), in the locus coeruleus (lc), a brain region implicated in the regulation of REM (steriade and Mccarley 1990) and stress (abercrombie and Jacobs 1987a, b). as muscimol produces GaBaergicmediated inhibition and bicuculline blocks GaBaergic inhibition, these studies…”
Chronic social defeat up-regulates expression of norepinephrine transporter in rat brains
Chen, P., Fan, Y., Li, Y., Sun, Z., Bissette, G., & Zhu, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.11.003 · Cited by 43
“First, animal studies demonstrated that stress-induced activation of the LC-NE system (Abercrombie and Jacobs, 1987) alters the release and metabolism of NE in the noradrenergic neuronal cell bodies and their terminal regions (Pacak et al., 1995; Smagin et al., 1997).”
Background
Differential effects of reserpine on brainstem catecholaminergic neurons revealed by Fos protein immunohistochemistry.
Fritschy, J.-M., Frondoza, C., & Grzanna, R. (1991) · Brain Research · doi:10.1016/0006-8993(91)91185-4 · Cited by 41
Brain glycogen metabolism: A possible link between sleep disturbances, headache and depression
Petit, J.-M., Eren‐Koçak, E., Karataş, H., Magistretti, P. J., & Dalkara, T. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101449 · Cited by 53

Authors: Abercrombie, E., & Jacobs, B.
Affiliations: University of Pittsburgh (US)
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1987-09-01
Volume: 7
Issue: 9
Pages: 2837-2843
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.07-09-02837.1987
PMC: PMC6569145
OpenAlex: W1924384005
Cited by: 377
References: 38
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 5 · 2014: 12 · 2013: 12 · 2012: 10
FWCI: 6.22
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders: National Institute of Mental Health (MH23433, MH09256)
Air Force Office of Scientific Research
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: locus coeruleus, noradrenergic neurons, stress response, single-unit activity, plasma norepinephrine, heart rate, restraint stress, white noise, behavioral activation, cats
MeSH terms: Animals, Behavior, Animal, Cats, Female, Heart Rate, Locus Coeruleus, Male, Neurons, Norepinephrine, Stress, Physiological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks