The DOI matches its Crossref record; 29 of the 38 references it cites were found in a registry or an index.
Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli
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The present experiment was designed to explore the stress-relatedness of activity in noradrenergic neurons of the locus coeruleus (LC) of behaving cats. A stressor was defined as a stimulus that elicited a significant sympathoadrenal activation as measured by plasma norepinephrine level and heart rate. According to this definition, exposure to 15 min of 100 dB white noise or 15 min of restraint was stressful in cats. In contrast, exposure to inaccessible rats for 15 min was behaviorally activating but nonstressful. The single-unit activity of noradrenergic neurons in the LC of behaving cats was examined under these conditions. The stressful stimuli elicited a significant increase in LC neuronal activity for the entire 15 min stressor duration, whereas the behaviorally activating but nonstressful stimulus elicited no significant change in the activity of these neurons. These results provide evidence that behavioral activation per se is not sufficient to evoke a tonic activation of these neurons. Rather, these data support the hypothesis that the LC is involved in the CNS response to stress and provide additional evidence that the activity of LC noradrenergic neurons increases in association with sympathoadrenal activation.
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“Studies in animals show that early stressors lead to increased activity of the locus coeruleus with resultant increased release of nor-epinephrine in the brain (Abercrombie and Jacobs 1987).”
From The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology (2006) · cites this paper as Abercrombie and Jacobs 1987
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“These characteristics have been observed in LC neurons of both the behaving rat (Aston-Jones and Bloom, 1981a) and cat (Rasmussen et al., 1986).”
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“…electrophysiological studies of LC neurons in unanesthetized animals have shown that these neurons are activated by a wide variety of environmental stimuli of many modalities (Foote and Bloom, 1979; Foote et al., 1980; Aston-Jones and Bloom, 198 lb; Rasmussen et al., 1986).”
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“These observations have led to the proposal that the LC is a central analog of peripheral sympathetic ganglia (Amaral and Sinnamon, 1977; Aghajanian and VanderMaelen, 1982; Elam et al., 1986; Reiner, 1986).”
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“These characteristics have been observed in LC neurons of both the behaving rat (Aston-Jones and Bloom, 1981a) and cat (Rasmussen et al., 1986).”
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“…locus coeruleus (LC), which contains as many as half of all NE neurons in the brain (Chu and Bloom, 1974; Jones and Moore, 1974; Wiklund et al., 198 l), has been hypothesized to play an important role in this response (Korf et al., 1973; Cassens et al., 1980; Glavin, 1985; Weiss and Simson, 1985).”
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“These shared elements are: AOS (1) results in ¡ (2) an activation of the brain stem locus coeruleus (LC) (Abercrombie and Jacobs 1987), resulting in ¡ (3) an activation of the lateral olivocochlear (LOC) system (Mulders and Robertson 2005c; Puel et al. 1998).”
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“Noradrenergic neurons release transmitter throughout the brain which is associated with an increase in alerting and vigilance behaviors, critical for coping with acute threat (Abercrombie & Jacobs, 1987; Bremner et al., 1996a,b).”
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“…NA inputs (Semba & Fibiger, 1992), the extracellular NA concentration in the LDT may be increased with cocaine administration or stress exposure that has been shown to increase the activity of LC neurons (Abercrombie & Jacobs, 1987; Hahn & Bannon, 1999; Chowdhuly et al., 2000; Takase et al., 2005).”
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“Hence, LC ’ s transient excitatory responses to the light and tone likely re fl ect attention shifts rather than stress responses (Abercrombie and Jacobs, 1987).”
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“, white noise (Abercrombie and Jacobs 1987) increased blood pressure in sham rats.”
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“…stressors cause large increases in norepinephrine, (al’Absi, et al., 2002; Atterhög, Eliasson, & Hjemdahl, 1981; Nater, et al., 2006; Thoma, et al., 2012), which causes the release of high levels of norepinephrine via the tonic mode of firing (Abercrombie & Jacobs, 1987; Valentino & Foote, 1988).”
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“La noradrénaline (NA) est impliquée de manière générale dans les mécanismes attentionnels (Berridge and Waterhouse, 2003) et de réponse à un environnement nouveau ou à un stress (Foote et al., 1983; Abercrombie and Jacobs, 1987; Aston-Jones et al., 1999; McQuade et al., 1999; Aston-Jones et al., 2000; Cecchi et al., 2…”
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“…structures associated with the behavioural, cognitive, affective and neuroendocrine changes in response to a wide array of rodent stressors (Abercrombie and Jacobs, 1987; Cecchi et al., 2002; Morilak et al., 1987a,b; Pacak et al., 1995; Page et al., 1992; Svensson, 1987; Valentino et al.,…”
Background
Metadata
- Authors
- Abercrombie, E., & Jacobs, B.
- Affiliations
- University of Pittsburgh (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1987-09-01
- Volume
- 7
- Issue
- 9
- Pages
- 2837-2843
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6569145
- OpenAlex
- W1924384005
- Cited by
- 377
- References
- 38
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 5 · 2014: 12 · 2013: 12 · 2012: 10
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute of Mental Health (MH23433, MH09256)
- Air Force Office of Scientific Research
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- locus coeruleus, noradrenergic neurons, stress response, single-unit activity, plasma norepinephrine, heart rate, restraint stress, white noise, behavioral activation, cats
- MeSH terms
- Animals, Behavior, Animal, Cats, Female, Heart Rate, Locus Coeruleus, Male, Neurons, Norepinephrine, Stress, Physiological
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