Cited by 146Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsProtein Kinase Regulation and GTPase Signaling

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Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase II in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

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Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T., Okabe, S.·2009·Journal of Neuroscience

DOI 10.1523/jneurosci.0707-09.2009PMC PMC6665418

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Abstract

Ca2+/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) is an essential mediator of activity-dependent synaptic plasticity that possesses multiple protein functions. So far, the autophosphorylation site-mutant mice targeted at T286 and at T305/306 have demonstrated the importance of the autonomous activity and Ca2+/calmodulin-binding capacity of CaMKIIalpha, respectively, in the induction of long-term potentiation (LTP) and hippocampus-dependent learning. However, kinase activity of CaMKIIalpha, the most essential enzymatic function, has not been genetically dissected yet. Here, we generated a novel CaMKIIalpha knock-in mouse that completely lacks its kinase activity by introducing K42R mutation and examined the effects on hippocampal synaptic plasticity and behavioral learning. In homozygous CaMKIIalpha (K42R) mice, kinase activity was reduced to the same level as in CaMKIIalpha-null mice, whereas CaMKII protein expression was well preserved. Tetanic stimulation failed to induce not only LTP but also sustained dendritic spine enlargement, a structural basis for LTP, at the Schaffer collateral-CA1 synapse, whereas activity-dependent postsynaptic translocation of CaMKIIalpha was preserved. In addition, CaMKIIalpha (K42R) mice showed a severe impairment in inhibitory avoidance learning, a form of memory that is dependent on the hippocampus. These results demonstrate that kinase activity of CaMKIIalpha is a common critical gate controlling structural, functional, and behavioral expression of synaptic memory.

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Authors: Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T., & Okabe, S.
Affiliations: National Institute for Physiological Sciences (JP)
Institute of Medical Science, The University of Tokyo (JP)
Tokyo Medical and Dental University (JP)
Kitasato University (JP)
Hokkaido University (JP)
Japan Science and Technology Agency (JP)
The University of Osaka (JP)
The Graduate University for Advanced Studies, SOKENDAI (JP)
Gunma University (JP)
The University of Tokyo (JP)
ORCID: Yamagata, Y.
Kobayashi, S.
Umeda, T.
Sakagami, H.
Fukaya, M.
Yagi, T.
Imoto, K.
Yanagawa, Y.
Manabe, T.
Okabe, S.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2009-06-10
Volume: 29
Issue: 23
Pages: 7607-7618
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0707-09.2009
PMC: PMC6665418
OpenAlex: W2049217965
Cited by: 146
References: 53
Citations by year: 2026: 7 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 11 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 12
FWCI: 4.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Novartis Foundation
Brain Science Foundation
NOVARTIS Foundation (Japan) for the Promotion of Science
Japan Society for the Promotion of Science
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: CaMKIIα, kinase activity, knock-in mice, long-term potentiation, synaptic plasticity, hippocampus-dependent learning, passive avoidance, Schaffer collateral-CA1 synapses, synaptic memory
MeSH terms: Animals, Avoidance Learning, Cells, Cultured, Female, Hippocampus, Male, Mice, Transgenic, Neuronal Plasticity, Neurons, Synapses, Long-Term Potentiation, Mice, Knockout, Excitatory Postsynaptic Potentials, Mutation, Missense, Dendritic Spines, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Gene Knock-In Techniques, In Vitro Techniques

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Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase II in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

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