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Role of Ca2+/Calmodulin-Dependent Protein Kinase Type II in Mediating Function and Dysfunction at Glutamatergic Synapses

Mohanan, Archana G., Gunasekaran, Sowmya, Jacob, Reena Sarah, Omkumar, R. V.·2022·Frontiers in Molecular Neuroscience
DOI 10.3389/fnmol.2022.855752PMC PMC9252440
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Abstract

Glutamatergic synapses harbor abundant amounts of the multifunctional Ca 2+ /calmodulin-dependent protein kinase type II (CaMKII). Both in the postsynaptic density as well as in the cytosolic compartment of postsynaptic terminals, CaMKII plays major roles. In addition to its Ca 2+ -stimulated kinase activity, it can also bind to a variety of membrane proteins at the synapse and thus exert spatially restricted activity. The abundance of CaMKII in glutamatergic synapse is akin to scaffolding proteins although its prominent function still appears to be that of a kinase. The multimeric structure of CaMKII also confers several functional capabilities on the enzyme. The versatility of the enzyme has prompted hypotheses proposing several roles for the enzyme such as Ca 2+ signal transduction, memory molecule function and scaffolding. The article will review the multiple roles played by CaMKII in glutamatergic synapses and how they are affected in disease conditions.

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Metadata

Authors
Mohanan, A. G., Gunasekaran, S., Jacob, R. S., & Omkumar, R. V.
Venue
Frontiers in Molecular Neuroscience
Publisher
Frontiers Media SA
Published
2022-06-20
Volume
15
ISSN
1662-5099
DOI
10.3389/fnmol.2022.855752
PMC
PMC9252440
Cited by
55
References
47
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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