The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain
Open accessAbstract
Astrocytes are an essential component of the CNS, and recent evidence points to an increasing diversity of their functions. Identifying molecular pathways that mediate distinct astrocyte functions, is key to understanding how the nervous system operates in the intact and pathological states. In this study, we demonstrate that the Hedgehog (Hh) pathway, well known for its roles in the developing CNS, is active in astrocytes of the mature mouse forebrain in vivo. Using multiple genetic approaches, we show that regionally distinct subsets of astrocytes receive Hh signaling, indicating a molecular diversity between specific astrocyte populations. Furthermore, we identified neurons as a source of Sonic hedgehog (Shh) in the adult forebrain, suggesting that Shh signaling is involved in neuron–astrocyte communication. Attenuation of Shh signaling in postnatal astrocytes by targeted removal of Smoothened, an obligate Shh coreceptor, resulted in upregulation of GFAP and cellular hypertrophy specifically in astrocyte populations regulated by Shh signaling. Collectively, our findings demonstrate a role for neuron-derived Shh in regulating specific populations of differentiated astrocytes.
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Molecular dissection of reactive astrogliosis and glial scar formation
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Neuronal specification in the spinal cord: inductive signals and transcriptional codes
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Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
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Astrocytic Purinergic Signaling Coordinates Synaptic Networks
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STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
Herrmann, J. E., Imura, T., Song, B., Qi, J., Ao, Y., Nguyen, T. K., Korsak, R. A., Takeda, K., Akira, S., & Sofroniew, M. V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1709-08.2008 · Cited by 958
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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
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Self-citationAstrocytic Ca2+ signaling evoked by sensory stimulation in vivo
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Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
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Identification of region-specific astrocyte subtypes at single cell resolution
Batiuk, M. Y., Martirosyan, A., Wahis, J., de Vin, F., Marneffe, C., Kusserow, C., Koeppen, J., Viana, J. F., Oliveira, J. F., Voet, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14198-8 · Cited by 805
Sofroniew, M. V. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020420 · Cited by 695
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Haim, L. B., & Rowitch, D. H. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.159 · Cited by 618
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Metadata
- Authors
- Garcia, A. D. R., Petrova, R., Eng, L., & Joyner, A. L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-10-13
- Volume
- 30
- Issue
- 41
- Pages
- 13597-13608
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1964423453
- Cited by
- 175
- References
- 10
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Garcia, A. D. R., Petrova, R., Eng, L., & Joyner, A. L. (2010). Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0830-10.2010
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