Cited by 214Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Functional Heterogeneity in the Bed Nucleus of the Stria Terminalis

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Gungor, N. Z., Pare, D.·2016·Journal of Neuroscience

DOI 10.1523/jneurosci.0856-16.2016PMC PMC4971356

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Abstract

Early work stressed the differing involvement of the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) in the genesis of fear versus anxiety, respectively. In 2009, Walker, Miles, and Davis proposed a model of amygdala-BNST interactions to explain these functional differences. This model became extremely influential and now guides a new wave of studies on the role of BNST in humans. Here, we consider evidence for and against this model, in the process highlighting central principles of BNST organization. This analysis leads us to conclude that BNST's influence is not limited to the generation of anxiety-like responses to diffuse threats, but that it also shapes the impact of discrete threatening stimuli. It is likely that BNST-CeA interactions are involved in modulating responses to such threats. In addition, whereas current views emphasize the contributions of the anterolateral BNST region in anxiety, accumulating data indicate that the anteromedial and anteroventral regions also play a critical role. The presence of multiple functional subregions within the small volume of BNST raises significant technical obstacles for functional imaging studies in humans.

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Authors: Gungor, N. Z., & Pare, D.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2016-08-03
Volume: 36
Issue: 31
Pages: 8038-8049
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0856-16.2016
PMC: PMC4971356
OpenAlex: W2491422019
Cited by: 214
References: 153
Citations by year: 2026: 20 · 2025: 26 · 2024: 16 · 2023: 13 · 2022: 14 · 2021: 25 · 2020: 28 · 2019: 21 · 2018: 24 · 2017: 21 · 2016: 6
FWCI: 15.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Mental Health (MH-098738, R01MH098738)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: bed nucleus of the stria terminalis, central amygdala, anxiety, fear, functional heterogeneity, threat response
MeSH terms: Animals, Anxiety, Fear, Humans, Models, Neurological, Nerve Net, Septal Nuclei, Stress, Psychological

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Functional Heterogeneity in the Bed Nucleus of the Stria Terminalis

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