The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Functional Heterogeneity in the Bed Nucleus of the Stria Terminalis
Open accessAbstract
Early work stressed the differing involvement of the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) in the genesis of fear versus anxiety, respectively. In 2009, Walker, Miles, and Davis proposed a model of amygdala-BNST interactions to explain these functional differences. This model became extremely influential and now guides a new wave of studies on the role of BNST in humans. Here, we consider evidence for and against this model, in the process highlighting central principles of BNST organization. This analysis leads us to conclude that BNST's influence is not limited to the generation of anxiety-like responses to diffuse threats, but that it also shapes the impact of discrete threatening stimuli. It is likely that BNST-CeA interactions are involved in modulating responses to such threats. In addition, whereas current views emphasize the contributions of the anterolateral BNST region in anxiety, accumulating data indicate that the anteromedial and anteroventral regions also play a critical role. The presence of multiple functional subregions within the small volume of BNST raises significant technical obstacles for functional imaging studies in humans.
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“most of the projections to PVN originate from this area [51].”
From The bed nucleus of the stria terminalis as a brain correlate of psychological inflexibility in fibromyalgia (2020) · cites this paper as [51]
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“Although the GPe has only modest connections to the amygdala59,60, the central amygdala and the bed nucleus of the stria terminalis (BNST) are known to communicate reciprocally, a relationship critical for regulating anxiety levels61,62.”
From Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors (2026) · cites this paper as [62]
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“Although the GPe has only modest connections to the amygdala59,60, the central amygdala and the bed nucleus of the stria terminalis (BNST) are known to communicate reciprocally, a relationship critical for regulating anxiety levels61,62.”
From Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors (2026) · cites this paper as [62]
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Citations
Cites
Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Ricardo, J. A., & Koh, E. T. (1978) · Brain Research · doi:10.1016/0006-8993(78)91125-3 · Cited by 1,362
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322
Krettek, J. E., & Price, J. L. (1978) · Journal of Comparative Neurology · doi:10.1002/cne.901780204 · Cited by 1,293
Efferent connections of the parabrachial nucleus in the rat
Saper, C. B., & Loewy, A. D. (1980) · Brain Research · doi:10.1016/0006-8993(80)91117-8 · Cited by 1,217
Fallon, J. H., & Moore, R. Y. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800310 · Cited by 1,190
The connections of the septal region in the rat
Swanson, L. W., & Cowan, W. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901860408 · Cited by 1,136
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924
Cited by
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Armony, J. L., & Vuilleumier, P. O. (2025) · Cambridge University Press eBooks · doi:10.1017/9781009342919.002
Bedenbaugh, M. N., Doyle, M. A., Edwards, C. M., Petersen, N., Srisai, D., Hawkins, S., Thomas-Low, N. D., Mendoza-Romero, H. N., Brown, J. A., Vardy, A. S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.08.702109
Lv, X., Cao, Y., Wang, Y., Wu, Y., Zhang, Y., Ye, K., Qiu, X., Sun, Q., Bian, L., Paerhati, H., et al. (2026) · Advanced Science · doi:10.1002/advs.202521943
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Lorsung, R. M., Ji, Y., Cramer, N., Aitken, R., Han, S., Masri, R. M., & Keller, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.21.726958
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Didier, P. R., Grogans, S. E., Kaplan, C. M., Kim, H. C., Islam, S., Anderson, A. S., Tillman, R. M., Kuhn, M., Hur, J., Fox, A. S., et al. (2026) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsag040 · Cited by 1
Maladie de Parkinson et anxiété
Carey, G. (2026) · EMC - Neurologia · doi:10.1016/s0246-0378(25)50183-5
Regulation of amygdala and dopamine system in naïve and chronic alcohol states
Kameda-Henry, M. M., Kinser, C. M., Lapish, C. C., & Kuznetsov, A. S. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.06.002
The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy
Murray, J., Hong, E., Mulloy, S., & Nobis, W. P. (2026) · Frontiers in Network Physiology · doi:10.3389/fnetp.2026.1800427
The regulation of GABAergic nervous system in sleep‑wake states and general anesthesia
Dai, F., Dai, X., Song, W., & Mei, W. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112041 · Cited by 1
Su, W., Song, Y., Zhang, X., & Zhang, B. (2026) · Neurobiology of Stress · doi:10.1016/j.ynstr.2026.100841
Chen, M., Meng, H., Li, X., Guan, K., Shao, Y., Kong, D., Yue, W., Zhang, D., Sun, X., Wang, L., et al. (2026) · Neurobiology of Stress · doi:10.1016/j.ynstr.2026.100851
Zuo, H., Li, J., Li, J., Zhang, X., & Zhang, B. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.10.015
Metadata
- Authors
- Gungor, N. Z., & Pare, D.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2016-08-03
- Volume
- 36
- Issue
- 31
- Pages
- 8038-8049
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4971356
- OpenAlex
- W2491422019
- Cited by
- 214
- References
- 153
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 16 · 2023: 13 · 2022: 14 · 2021: 25 · 2020: 28 · 2019: 21 · 2018: 24 · 2017: 21 · 2016: 6
- FWCI
- 15.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (MH-098738, R01MH098738)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- bed nucleus of the stria terminalis, central amygdala, anxiety, fear, functional heterogeneity, threat response
- MeSH terms
- Animals, Anxiety, Fear, Humans, Models, Neurological, Nerve Net, Septal Nuclei, Stress, Psychological
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