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Early Stress Is Associated with Alterations in the Orbitofrontal Cortex: A Tensor-Based Morphometry Investigation of Brain Structure and Behavioral Risk
Open accessAbstract
Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.
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“Additionally, early life trauma is linked to less cortical thickness of the prefrontal cortex (Hanson et al., 2010), and in a sample of adolescents exposed to child abuse, a reduction in resting state connectivity between the amygdala and ventral medial PFC (Herringa et al., 2013).”
From More than a feeling: A unified view of stress measurement for population science (2018) · cites this paper as Hanson et al., 2010
Experimental — accuracy not yet measuredIn the citing paper
“threat exposure in childhood is associated with reduced volume and/or thickness of the vmPFC”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as Hanson et al., 2010
In the citing paper
“Earlier studies have explored that exposure to sexual abuse may affect smaller thalamic volume as well [ 70 , 71 ].”
From Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis (2023) · cites this paper as [71]
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Metadata
- Authors
- Hanson, J. L., Chung, M. K., Avants, B. B., Shirtcliff, E. A., Gee, J. C., Davidson, R. J., & Pollak, S. D.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Pennsylvania (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-06-02
- Volume
- 30
- Issue
- 22
- Pages
- 7466-7472
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2893146
- OpenAlex
- W1987683287
- Cited by
- 455
- References
- 50
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 30 · 2023: 23 · 2022: 32 · 2021: 26 · 2020: 65 · 2019: 28 · 2018: 33 · 2017: 34 · 2016: 29 · 2015: 35 · 2014: 22 · 2013: 27 · 2012: 26
- FWCI
- 22.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH61285, MH84051)
- National Institute of Mental Health (MH84051, MH61285, R01MH068858, MH 68858, P50MH084051, R01MH061285)
- U.S. Children's Bureau
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- childhood adversity, child abuse, physical abuse, orbitofrontal cortex, brain structure, social behavior, social difficulties, individual differences, behavioral risk, pediatric neuroimaging
- MeSH terms
- Adaptation, Psychological, Adolescent, Brain Mapping, Child, Child Abuse, Child Behavior Disorders, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Neuropsychological Tests, Stress, Psychological, Diffusion Tensor Imaging
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