The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Early Stress Is Associated with Alterations in the Orbitofrontal Cortex: A Tensor-Based Morphometry Investigation of Brain Structure and Behavioral Risk
Open accessAbstract
Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, early life trauma is linked to less cortical thickness of the prefrontal cortex (Hanson et al., 2010), and in a sample of adolescents exposed to child abuse, a reduction in resting state connectivity between the amygdala and ventral medial PFC (Herringa et al., 2013).”
From More than a feeling: A unified view of stress measurement for population science (2018) · cites this paper as Hanson et al., 2010
Experimental — accuracy not yet measuredIn the citing paper
“threat exposure in childhood is associated with reduced volume and/or thickness of the vmPFC”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as Hanson et al., 2010
In the citing paper
“Earlier studies have explored that exposure to sexual abuse may affect smaller thalamic volume as well [ 70 , 71 ].”
From Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis (2023) · cites this paper as [71]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542
Variations in pattern of pubertal changes in girls
Marshall, W. A., & Tanner, J. M. (1969) · Archives of Disease in Childhood · doi:10.1136/adc.44.235.291 · Cited by 5,963
Avants, B., Epstein, C. L., Grossman, M., & Gee, J. C. (2007) · Medical Image Analysis · doi:10.1016/j.media.2007.06.004 · Cited by 5,924
Self-citationVariations in the pattern of pubertal changes in boys
Marshall, W. A., & Tanner, J. M. (1970) · Archives of Disease in Childhood · doi:10.1136/adc.45.239.13 · Cited by 5,147
A nonparametric method for automatic correction of intensity nonuniformity in MRI data
Sled, J. G., Zijdenbos, A. P., & Evans, A. C. (1998) · IEEE Transactions on Medical Imaging · doi:10.1109/42.668698 · Cited by 4,731
Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299
Straus, M., Hamby, S., Finkelhor, D., Moore, D. W., & Runyan, D. K. (1998) · International Journal of Child Abuse & Neglect · doi:10.1016/s0145-2134(97)00174-9 · Cited by 2,528
Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration
Klein, A., Andersson, J., Ardekani, B. A., Ashburner, J., Avants, B., Chiang, M.-C., Christensen, G. E., Collins, D. L., Gee, J., Hellier, P., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.037 · Cited by 2,227
Self-citationKRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977
Cognitive Neuroscience: The Biology of the Mind
Gazzaniga, M. S., Ivry, R. B., & Mangun, G. R. (1998) · Cited by 1,392
A General Statistical Analysis for fMRI Data
Worsley, K. J., Liao, C. H., Aston, J. A. D., Petre, V., Duncan, G. H., Morales, F., & Evans, A. C. (2002) · NeuroImage · doi:10.1006/nimg.2001.0933 · Cited by 1,170
Multisubject fMRI Studies and Conjunction Analyses
Friston, K. J., Holmes, A. P., Price, C. J., Büchel, C., & Worsley, K. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0484 · Cited by 1,090
Urry, H. L., van Reekum, C. M., Johnstone, T., Kalin, N. H., Thurow, M. E., Schaefer, H. S., Jackson, C. A., Frye, C. J., Greischar, L. L., Alexander, A. L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3215-05.2006 · Cited by 1,056
Self-citationDevelopmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.
De Bellis, M. D., Keshavan, M. S., Clark, D. B., Casey, B. J., Giedd, J. N., Boring, A. M., Frustaci, K., & Ryan, N. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00045-1 · Cited by 974
Toga, A. W., Thompson, P. M., & Sowell, E. R. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.007 · Cited by 872
Diagnostic Interview for Children and Adolescents (DICA)
Reich, W. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00017 · Cited by 831
“Voxel-Based Morphometry” Should Not Be Used with Imperfectly Registered Images
Bookstein, F. L. (2001) · NeuroImage · doi:10.1006/nimg.2001.0770 · Cited by 665
Rudolph, K. D., & Hammen, C. (1999) · Child Development · doi:10.1111/1467-8624.00048 · Cited by 646
De Bellis, M. D., Keshavan, M. S., Shifflett, H., Iyengar, S., Beers, S. R., Hall, J., & Moritz, G. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01459-2 · Cited by 632
Pubertal Development: Correspondence Between Hormonal and Physical Development
Shirtcliff, E. A., Dahl, R. E., & Pollak, S. D. (2009) · Child Development · doi:10.1111/j.1467-8624.2009.01263.x · Cited by 614
Self-citationRudolph, K. D., Hammen, C. L., Burge, D., Lindberg, N. M., Herzberg, D. S., & Daley, S. E. (2000) · Development and Psychopathology · doi:10.1017/s0954579400002066 · Cited by 476
Manly, J. T., Cicchetti, D., & Barnett, D. (1994) · Development and Psychopathology · doi:10.1017/s0954579400005915 · Cited by 470
Ashburner, J., & Friston, K. J. (2007) · Elsevier eBooks · doi:10.1016/b978-012372560-8/50007-3 · Cited by 445
Ellis, B. J., & Garber, J. (2000) · Child Development · doi:10.1111/1467-8624.00159 · Cited by 438
Geodesic estimation for large deformation anatomical shape averaging and interpolation
Avants, B., & Gee, J. C. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.010 · Cited by 427
Self-citationA Unified Statistical Approach to Deformation-Based Morphometry
Chung, M. K., Worsley, K. J., Paus, T., Cherif, C., Collins, D. L., Giedd, J. N., Rapoport, J. L., & Evans, A. C. (2001) · NeuroImage · doi:10.1006/nimg.2001.0862 · Cited by 414
Self-citationThe orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism
Bachevalier, J., & Loveland, K. A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.07.002 · Cited by 402
Unified univariate and multivariate random field theory
Worsley, K. J., Taylor, J. E., Tomaiuolo, F., & Lerch, J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.026 · Cited by 370
Association of neural and physiological responses during voluntary emotion suppression
Ohira, H., Nomura, M., Ichikawa, N., Isowa, T., Iidaka, T., Sato, A., Fukuyama, S., Nakajima, T., & Yamada, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.047 · Cited by 318
Decision-Making Dysfunctions in Psychiatry—Altered Homeostatic Processing?
Paulus, M. P. (2007) · Science · doi:10.1126/science.1142997 · Cited by 311
Differential rearing affects corpus callosum size and cognitive function of rhesus monkeys
Sánchez, M. M., Hearn, E. F., Do, D., Rilling, J. K., & Herndon, J. G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00857-9 · Cited by 282
Mechanisms Linking Early Experience and the Emergence of Emotions
Pollak, S. D. (2008) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2008.00608.x · Cited by 270
Self-citation(1989) · Cambridge University Press eBooks · doi:10.1017/cbo9780511665707 · Cited by 235
Urinary Catecholamine Excretion in Sexually Abused Girls
DE BELLIS, M. D., LEFTER, L., TRICKETT, P. K., & PUTNAM, F. W. (1994) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199403000-00004 · Cited by 230
The Diagnostic Interview for Children and Adolescents
Batts, K. R., & Reich, W. (2002) · Cited by 222
Role of Orbitofrontal Cortex Connections in Emotion
Rempel-Clower, N. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.026 · Cited by 188
Neural basis of emotional self-regulation in childhood
Lévesque, J., Joanette, Y., Mensour, B., Beaudoin, G., Leroux, J.-M., Bourgouin, P., & Beauregard, M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.032 · Cited by 184
Nichols, E. A., Kao, Y.-C., Verfaellie, M. H., & Gabrieli, J. D. E. (2006) · Hippocampus · doi:10.1002/hipo.20190 · Cited by 180
Peper, J. S., Schnack, H. G., Brouwer, R. M., Van Baal, G. C. M., Pjetri, E., Székely, E., van Leeuwen, M., van den Berg, S. M., Collins, D. L., Evans, A. C., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20660 · Cited by 177
Carrion, V. G., Weems, C. F., Watson, C., Eliez, S., Menon, V., & Reiss, A. L. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.07.008 · Cited by 165
Astley, S. J., Stachowiak, J. A., Clarren, S. K., & Clausen, C. L. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.129030 · Cited by 163
Wilke, M., Schmithorst, V. J., & Holland, S. K. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10606 · Cited by 157
Braun, K., Lange, E., Metzger, M., & Poeggel, G. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00420-0 · Cited by 152
Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study
Richert, K. A., Carrion, V. G., Karchemskiy, A., & Reiss, A. L. (2006) · Depression and Anxiety · doi:10.1002/da.20131 · Cited by 118 · cited 1×
“Although previous neuroimaging investigations have noted structural brain differences among maltreated children (De Bellis et al., 1999, 2002; Richert et al., 2006; Carrion et al., 2009), extant studies have not found robust connections between brain and behavior.”
ResultMeasured Gene–Environment Interactions and Mechanisms Promoting Resilient Development
Kim‐Cohen, J., & Gold, A. L. (2009) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2009.01624.x · Cited by 105
Helmeke, C., Seidel, K., Poeggel, G., Bredy, T. W., Abraham, A., & Braun, K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.008 · Cited by 102
Child physical abuse: Risk for psychopathology and efficacy of interventions
Brown, E. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0024-2 · Cited by 33
Cited by
Sorted by citations
A reproducible evaluation of ANTs similarity metric performance in brain image registration
Avants, B. B., Tustison, N. J., Song, G., Cook, P. A., Klein, A., & Gee, J. C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.025 · Cited by 4,796
Self-citationAdverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
The effects of childhood maltreatment on brain structure, function and connectivity
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389
Metadata
- Authors
- Hanson, J. L., Chung, M. K., Avants, B. B., Shirtcliff, E. A., Gee, J. C., Davidson, R. J., & Pollak, S. D.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Pennsylvania (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-06-02
- Volume
- 30
- Issue
- 22
- Pages
- 7466-7472
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2893146
- OpenAlex
- W1987683287
- Cited by
- 455
- References
- 50
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 30 · 2023: 23 · 2022: 32 · 2021: 26 · 2020: 65 · 2019: 28 · 2018: 33 · 2017: 34 · 2016: 29 · 2015: 35 · 2014: 22 · 2013: 27 · 2012: 26
- FWCI
- 22.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH61285, MH84051)
- National Institute of Mental Health (MH84051, MH61285, R01MH068858, MH 68858, P50MH084051, R01MH061285)
- U.S. Children's Bureau
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- childhood adversity, child abuse, physical abuse, orbitofrontal cortex, brain structure, social behavior, social difficulties, individual differences, behavioral risk, pediatric neuroimaging
- MeSH terms
- Adaptation, Psychological, Adolescent, Brain Mapping, Child, Child Abuse, Child Behavior Disorders, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Neuropsychological Tests, Stress, Psychological, Diffusion Tensor Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
