The location and function of NMDA receptors in cat and kitten visual cortex

Fox, K; Sato, H; Daw, N

doi:10.1523/jneurosci.09-07-02443.1989

Cited by 307Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsNeurogenesis and neuroplasticity mechanisms

The location and function of NMDA receptors in cat and kitten visual cortex

Open access

Fox, K, Sato, H, Daw, N·1989·The Journal of Neuroscience

DOI 10.1523/jneurosci.09-07-02443.1989PMC PMC6569778

Open this paper in CoChat — free account Open PDF

Abstract

The role of N-methyl-D-aspartate (NMDA) receptors in cat visual cortex was studied as a function of both layer and age by iontophoresis of the NMDA antagonist (D)-2-amino-5-phosphonovaleric acid (APV). Effects on both visual responses and spontaneous activity were observed. In superficial layers (II and III), D-APV reduced visual responses substantially at all ages. Iontophoresis of D-APV with 10 nA of ejecting current for 2–3 min was sufficient to reduce the response to approximately one third of control levels. The magnitude of the reduction did not vary with age. In granular and deep layers (IV, V, and VI), D-APV affected the visual response in young animals but only spontaneous activity in older animals. On average, visual responses were reduced to about half at 20–23 days of age and to about 75% at 4 weeks of age but in most cases were not significantly affected in adults. The rapid change in the functional effect of NMDA receptors over the third and fourth week in granular and deep layers suggests a role in development. There was a reasonable age correlation between the change in effect and the period of geniculocortical afferent segregation. Further experiments will be necessary to determine whether NMDA receptors are necessary for segregation to occur. The presence of an NMDA component to the visual response in the adult in layers II and III argues either that these layers retain some form of plasticity in the adult or that NMDA receptors play a role in the transmission of normal visual input to these layers.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.09-07-02443.1989

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Together these findings suggest that the switch from NR2B to NR2A dominated receptors terminates the critical period of experience-dependent plasticity for establishment of ocular dominance columns in the visual cortex.
“Together these findings suggest that the switch from NR2B to NR2A dominated receptors terminates the critical period of experience-dependent plasticity for establishment of ocular dominance columns in the visual cortex.”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [107]
In “Mechanisms for plasticity” (page not available), the paper reports that NMDA receptor activity in layer IV declines around the end of geniculocortical afferent segregation. It does not discuss an NR2B-to-NR2A switch or conclude that such a switch terminates the critical period; it says the critical period may outlast the decline in NMDA activity and that further experiments are needed to establish whether NMDA receptors are necessary for segregation. (LLM, conf=0.84)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE
Wiesel, T. N., & Hubel, D. H. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.1003 · Cited by 2,628 · see citing works
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413 · see citing works
COMPARISON OF THE EFFECTS OF UNILATERAL AND BILATERAL EYE CLOSURE ON CORTICAL UNIT RESPONSES IN KITTENS
Wiesel, T. N., & Hubel, D. H. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.6.1029 · Cited by 1,598 · see citing works
NMDA receptors - their role in long-term potentiation
Collingridge, G. L., & Bliss, T. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90175-5 · Cited by 1,174 · see citing works
The development of ocular dominance columns in normal and visually deprived monkeys
Le Vay, S., Wiesel, T. N., & Hubel, D. H. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901910102 · Cited by 1,123 · see citing works
Long-term potentiation and NMDA receptors in rat visual cortex
Artola, A., & Singer, W. (1987) · Nature · doi:10.1038/330649a0 · Cited by 966 · see citing works
Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex
Kleinschmidt, A. K., Bear, M. F., & Singer, W. (1987) · Science · doi:10.1126/science.2443978 · Cited by 906 · see citing works
Anatomical organization of excitatory amino acid receptors and their pathways
Cotman, C. W., Monaghan, D. T., Ottersen, O. P., & Storm‐Mathisen, J. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90172-x · Cited by 875 · see citing works
Modulation of visual cortical plasticity by acetylcholine and noradrenaline
Bear, M. F., & Singer, W. (1986) · Nature · doi:10.1038/320172a0 · Cited by 858 · see citing works
Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex
Stryker, M., & Harris, W. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02117.1986 · Cited by 687 · see citing works
Innate and environmental factors in the development of the kitten's visual cortex.
Blakemore, C. B., & Sluyters, R. C. V. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp010995 · Cited by 679 · see citing works
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
Cline, H. T., Debski, E. A., & Constantine‐Paton, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.12.4342 · Cited by 523 · see citing works
NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats
Tsumoto, T., Hagihara, K., Sato, H., & Hata, Y. (1987) · Nature · doi:10.1038/327513a0 · Cited by 440 · see citing works
Self-citation
Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.
Greenamyre, J. T., Olson, J. M., Penney, J. B., & Young, A. B. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21125-9 · Cited by 370 · see citing works
Local circuitry of identified projection neurons in cat visual cortex brain slices
Katz, L. C. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-04-01223.1987 · Cited by 356 · see citing works
Preservation of binocularity after monocular deprivation in the striate cortex of kittens treated with 6‐Hydroxydopamine
Kasamatsu, T., & Pettigrew, J. D. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901850109 · Cited by 314 · see citing works
Projection patterns of individual X‐ and Y‐cell axons from the lateral geniculate nucleus to cortical area 17 in the cat
Humphrey, A. L., Sur, M., Uhlrich, D. J., & Sherman, S. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902330203 · Cited by 291 · see citing works
Aspartate and glutamate as possible neurotransmitters in the visual cortex
Baughman, R., & Gilbert, C. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-04-00427.1981 · Cited by 220 · see citing works
Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colliculus in rats
Karlsen, R. L., & Fonnum, F. (1978) · Brain Research · doi:10.1016/0006-8993(78)91079-x · Cited by 186 · see citing works
Central core control of developmental plasticity in the kitten visual cortex: I. Diencephalic lesions
Singer, W. (1982) · Experimental Brain Research · doi:10.1007/bf00239380 · Cited by 182 · see citing works
Dark rearing prolongs physiological but not anatomical plasticity of the cat visual cortex
Mower, G. D., Caplan, C. J., Christen, W. G., & Duffy, F. H. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902350404 · Cited by 169 · see citing works
Long-term potentiation of synaptic transmission in kitten visual cortex
Komatsu, Y., Fujii, K., Maeda, J. E. M. S., Sakaguchi, H., & Toyama, K. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.1.124 · Cited by 144 · see citing works
Synaptic organization of claustral and geniculate afferents to the visual cortex of the cat
LeVay, S. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-12-03564.1986 · Cited by 129 · see citing works
Cortical activity blockade prevents ocular dominance plasticity in the kitten visual cortex
Reiter, H. O., Waitzman, D. M., & Stryker, M. P. (1986) · Experimental Brain Research · doi:10.1007/bf00243841 · Cited by 108 · see citing works
Excitatory amino acid transmitters in neuronal circuits of the cat visual cortex
Tsumoto, T., Masui, H., & Sato, H. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.55.3.469 · Cited by 96 · see citing works
Self-citation
A method for etching the tips of carbon fibre microelectrodes
Armstrong‐James, M., Fox, K. D., & Millar, J. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90009-6 · Cited by 90 · see citing works
Self-citation
Cortical Plasticity in Monocularly Deprived Immobilized Kittens Depends on Eye Movement
Freeman, R. D., & Bonds, A. B. (1979) · Science · doi:10.1126/science.493996 · Cited by 86 · see citing works
The pharmacology of synapses formed by identified corticocollicular neurons in primary cultures of rat visual cortex
Huettner, J., & Baughman, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-01-00160.1988 · Cited by 85 · see citing works
Absence of ocular dominance patches in dark-reared cats
Swindale, N. V. (1981) · Nature · doi:10.1038/290332a0 · Cited by 82 · see citing works
Selective retrograde labeling with D‐[3H]‐aspartate in afferents to the mammalian superior colliculus
Matute, C., & Streit, P. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410104 · Cited by 81 · see citing works
The role of the anterior intralaminar nuclei and N-methyl D-aspartate receptors in the generation of spontaneous bursts in rat neocortical neurones
Fox, K. D., & Armstrong‐James, M. (1986) · Experimental Brain Research · doi:10.1007/bf00237474 · Cited by 78 · see citing works
Self-citation
Quantitative ionophoresis of catecholamines using multibarrel carbon fibre microelectrodes
Armstrong‐James, M., Fox, K. D., Kruk, Z. L., & Millar, J. (1981) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(81)90008-x · Cited by 72 · see citing works
Self-citation
Actions of excitatory amino acid antagonists on geniculo-cortical transmission in the cat's visual cortex
Hagihara, K., Tsumoto, T., Sato, H., & Hata, Y. (1988) · Experimental Brain Research · doi:10.1007/bf00247586 · Cited by 71 · see citing works
Self-citation
D‐[3H]aspartate retrograde labelling of callosal and association neurones of somatosensory areas I and II of cats
Barbaresi, P., Mara Fabri, C., Conti, F., & Manzoni, T. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902630202 · Cited by 70 · see citing works
Restriction of visual experience to a single orientation affects the organization of orientation columns in cat visual cortex
Singer, W., Freeman, B., & Rauschecker, J. P. (1981) · Experimental Brain Research · doi:10.1007/bf00238877 · Cited by 64 · see citing works
Role of visual experience in promoting segregation of eye dominance patches in the visual cortex of the cat
Swindale, N. V. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902670403 · Cited by 55 · see citing works
Comparison of the critical periods for monocular and directional deprivation in cats.
Berman, N. E. J., & Daw, N. W. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011715 · Cited by 48 · see citing works
Self-citation
Measurement of the concentration of 5-hydroxytryptamine ejected during iontophoresis using multibarrel carbon fibre microelectrodes
Kruk, Z. L., Armstrong‐James, M., & Millar, J. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90490-7 · Cited by 33 · see citing works
Acutely induced shift in ocular dominance during brief monocular exposure: Effects of cortical noradrenaline infusion
Imamura, K., & Kasamatsu, T. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90315-1 · Cited by 19 · see citing works
The character and influence of the claustral pathway to the striate cortex of the cat
Boyapati, J., & Henry, G. H. (1985) · Experimental Brain Research · doi:10.1007/bf00235629 · Cited by 14 · see citing works
Long-Term Potentiation of Synaptic Transmission in Kitten Visual Cortex
Komatsu, Y., Fujii, K., Maeda, J. E. M. S., Sakaguchi, H., & Toyama, K. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.1.1-a · Cited by 6 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Gilbert. C. D., and T. N. Wiesel (1981) Laminar specialisation and intracorticai connections in cat pnmaj visual cortex. In The Orga- nisation of the Cerebral Cortex. F. 0. Schmitt. F. G. Worden. G. Adelman,-and S. G. Dennis, eds., pp. 163-191, MIT Press, Cam- bridge, MA.

Sorted by citations

CORTICAL PLASTICITY: From Synapses to Maps
Buonomano, D. V., & Merzenich, M. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.149 · Cited by 2,083 · see citing works
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,001 · see citing works
Developmental mechanisms that generate precise patterns of neuronal connectivity
Goodman, C. S., & Shatz, C. J. (1993) · Cell · doi:10.1016/s0092-8674(05)80030-3 · Cited by 1,425 · see citing works
Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
McDonald, J. W., & Johnston, M. V. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90011-c · Cited by 1,403 · see citing works
Excitatory amino acid receptors and synaptic plasticity
Collingridge, G. L., & Singer, W. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90011-v · Cited by 862 · see citing works
Patterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways
Constantine-Paton, M., Cline, H. T., & Debski, E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001021 · Cited by 784 · see citing works
Impulse activity and the patterning of connections during cns development
Shatz, C. J. (1990) · Neuron · doi:10.1016/0896-6273(90)90333-b · Cited by 766 · see citing works
Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex
Carmignoto, G., & Vicini, S. (1992) · Science · doi:10.1126/science.1279803 · Cited by 716 · see citing works
Somatodendritic expression of an immediate early gene is regulated by synaptic activity.
Link, W., Konietzko, U., Kauselmann, G., Krug, M., Schwanke, B., Frey, U., & Kuhl, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5734 · Cited by 706 · see citing works
Development and plasticity of cortical processing architectures
Singer, W. (1995) · Science · doi:10.1126/science.270.5237.758 · Cited by 669 · see citing works
Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters
Yuste, R., & Katz, L. C. (1991) · Neuron · doi:10.1016/0896-6273(91)90243-s · Cited by 591 · see citing works
Maturation of a Central Glutamatergic Synapse
Wu, G.-Y., Malinow, R., & Cline, H. T. (1996) · Science · doi:10.1126/science.274.5289.972 · Cited by 546 · see citing works
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
Davis, S., Butcher, S., & Morris, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-01-00021.1992 · Cited by 539 · see citing works
Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist
Bear, M., Kleinschmidt, A., Gu, Q., & Singer, W. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-03-00909.1990 · Cited by 488 · see citing works
A role for synaptic plasticity in the adolescent development of executive function
Selemon, L. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.7 · Cited by 439 · see citing works
“have shown that cortical layer 4 neurons, but not layer 2/3 cells, exhibit reduced sensitivity of visual and spontaneous activity to an NMDAR antagonist at the end of the critical period.(107) Together these findings suggest that the switch from NR2B to NR2A dominated receptors terminates the critical period of experi…”
Background
Reentry and the Problem of Integrating Multiple Cortical Areas: Simulation of Dynamic Integration in the Visual System
Tononi, G., Sporns, O., & Edelman, G. M. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.4.310 · Cited by 435 · see citing works
Modeling Sleep and Wakefulness in the Thalamocortical System
Hill, S., & Tononi, G. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00915.2004 · Cited by 417 · see citing works
Temporal and spatial properties of local circuits in neocortex
Thomson, A. M., & Deuchars, J. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90121-x · Cited by 421 · see citing works
Ca2+ Oscillations Mediated by the Synergistic Excitatory Actions of GABAA and NMDA Receptors in the Neonatal Hippocampus
Leinekugel, X., Medina, I., Khalilov, I., Ben-Ari, Y., & Khazipov, R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80265-2 · Cited by 407 · see citing works
Bidirectional, experience-dependent regulation of N- methyl- d -aspartate receptor subunit composition in the rat visual cortex during postnatal development
Quinlan, E. M., Olstein, D. H., & Bear, M. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12876 · Cited by 382 · see citing works
Development and plasticity of cortical areas and networks
Sur, M., & Leamey, C. A. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067562 · Cited by 372 · see citing works
NMDA receptors: from genes to channels
Sucher, N. J., Awobuluyi, M., Choi, Y., & Lipton, S. A. (1996) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(96)80008-3 · Cited by 316 · see citing works
The role of NMDA receptors in information processing
Daw, N. W., Stein, P. S. G., & Fox, K. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.001231 · Cited by 311 · see citing works
Self-citation
Involvement of the N -Methyl D-Aspartate (NMDA) Receptor in Synapse Elimination During Cerebellar Development
Rabacchi, S. A., Bailly, Y. J. R., Delhaye‐Bouchaud, N., & Mariani, J. (1992) · Science · doi:10.1126/science.1352066 · Cited by 308 · see citing works
NMDA receptor antagonists disrupt the retinotectal topographic map
Cline, H. T., & Constantine‐Paton, M. (1989) · Neuron · doi:10.1016/0896-6273(89)90201-8 · Cited by 285 · see citing works
NMDA Receptor Subunit-Dependent [Ca2+] Signaling in Individual Hippocampal Dendritic Spines
Sobczyk, A., Scheuß, V., & Svoboda, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1221-05.2005 · Cited by 280 · see citing works
Modulation of NMDA receptor function: implications for vertebrate neural development
Scheetz, A. J., & Constantine‐Paton, M. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.10.8050674 · Cited by 285 · see citing works
Disruption of retinogeniculate afferent segregation by antagonists to NMDA receptors
Hahm, J., Langdon, R. B., & Sur, M. (1991) · Nature · doi:10.1038/351568a0 · Cited by 270 · see citing works
Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?
Morris, R., Davis, S., & Butcher, S. P. (1990) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1990.0164 · Cited by 265 · see citing works
Cellular and subcellular localization of NMDA-R1 subunit immunoreactivity in the visual cortex of adult and neonatal rats
Aoki, C. J., Venkatesan, C., Go, C. G., Mong, J., & Dawson, T. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05202.1994 · Cited by 255 · see citing works
Involvement of Subplate Neurons in the Formation of Ocular Dominance Columns
Ghosh, A., & Shatz, C. J. (1992) · Science · doi:10.1126/science.1542795 · Cited by 249 · see citing works
Modeling perceptual grouping and figure-ground segregation by means of active reentrant connections.
Sporns, O., Tononi, G., & Edelman, G. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.129 · Cited by 213 · see citing works
Different glutamate receptors convey feedforward and recurrent processing in macaque V1
Self, M. W., Kooijmans, R. N., Supèr, H., Lamme, V. A., & Roelfsema, P. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119527109 · Cited by 184 · see citing works
A developmental handshake: Neuronal control of ionic currents and their control of neuronal differentiation
Spitzer, N. C. (1991) · Journal of Neurobiology · doi:10.1002/neu.480220702 · Cited by 202 · see citing works
NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection
Cline, H., & Constantine‐Paton, M. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01197.1990 · Cited by 190 · see citing works
Neural dynamics in a model of the thalamocortical system. I. Layers, loops and the emergence of fast synchronous rhythms
Lumer, E. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.3.207 · Cited by 186 · see citing works
Developmental Switch in the Contribution of Presynaptic and Postsynaptic NMDA Receptors to Long-Term Depression
Corlew, R., Wang, Y., Ghermazien, H., Erişir, A., & Philpot, B. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5494-06.2007 · Cited by 184 · see citing works
Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition
Lu, H., Gonzalez, E., & Crair, M. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00501-3 · Cited by 180 · see citing works
Involvement of Serotonin in Developmental Plasticity of Kitten Visual Cortex
Gu, Q., & Singer, W. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01104.x · Cited by 173 · see citing works
The contribution of NMDA and non-NMDA receptors to fast and slow transmission of sensory information in the rat SI barrel cortex
Armstrong‐James, M., Welker, E., & Callahan, C. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02149.1993 · Cited by 171 · see citing works
N-methyl-D-aspartate receptors are transiently expressed in the developing spinal cord ventral horn.
Kalb, R. G., Lidow, M. S., Halsted, M. J., & Hockfield, S. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8502 · Cited by 168 · see citing works
Excitatory amino acid transmitters and their receptors in neural circuits of the cerebral neocortex
Tsumoto, T. (1990) · Neuroscience Research · doi:10.1016/0168-0102(90)90025-a · Cited by 165 · see citing works
Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus
Smith, P. F., Darlington, C. L., & Hubbard, J. I. (1990) · Brain Research · doi:10.1016/0006-8993(90)91101-l · Cited by 163 · see citing works
Distribution and synaptic localization of immunocytochemically identified NMDA receptor subunit proteins in sensory-motor and visual cortices of monkey and human
Huntley, G., Vickers, J., Janssen, W., Brose, N., Heinemann, S., & Morrison, J. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03603.1994 · Cited by 161 · see citing works
Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits.
Cain, D. P., Saucier, D. M., Hall, J., Hargreaves, E. L., & Boon, F. H. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.1.86 · Cited by 157 · see citing works
Spatial Signaling in the Development and Function of Neural Connections
Montague, P. R., Gally, J. A., & Edelman, G. M. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.3.199 · Cited by 150 · see citing works
Enhanced NR2A Subunit Expression and Decreased NMDA Receptor Decay Time at the Onset of Ocular Dominance Plasticity in the Ferret
Roberts, E. B., & Ramoa, A. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.5.2587 · Cited by 150 · see citing works
Cellular and synaptic localization of NMDA and non-NMDA receptor subunits in neocortex: organizational features related to cortical circuitry, function and disease
Huntley, G. W., Vickers, J. C., & Morrison, J. H. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90158-9 · Cited by 149 · see citing works
NMDA-Based Pattern Discrimination in a Modeled Cortical Neuron
Mel, B. W. (1992) · Neural Computation · doi:10.1162/neco.1992.4.4.502 · Cited by 149 · see citing works
Relationship between excitation and inhibition underlying size tuning and contextual response modulation in the cat primary visual cortex
Ozeki, H., Sadakane, O., Akasaki, T., Naito, T., Shimegi, S., & Sato, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3852-03.2004 · Cited by 136 · see citing works
Self-citation
Development of the calcium‐binding proteins parvalbumin and calbindin in monkey striate cortex
Hendrickson, A. E., van Brederode, J. F. M., Mulligan, K. A., & Celio, M. R. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903070409 · Cited by 142 · see citing works
Translation-Invariant Orientation Tuning in Visual “Complex” Cells Could Derive from Intradendritic Computations
Mel, B. W., Ruderman, D., & Archie, K. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04325.1998 · Cited by 142 · see citing works
Receptive field analysis and orientation selectivity of postsynaptic potentials of simple cells in cat visual cortex
Pei, X., Vidyasagar, T. R., Volgushev, M., & Creutzfeldt, O. D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-07130.1994 · Cited by 137 · see citing works
Suppression of NMDA Receptor Function Using Antisense DNA Blocks Ocular Dominance Plasticity While Preserving Visual Responses
Roberts, E. B., Meredith, M. A., & Ramoa, A. S. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.3.1021 · Cited by 135 · see citing works
Activity-regulated genes as mediators of neural circuit plasticity
Leslie, J. H., & Nedivi, E. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.002 · Cited by 133 · see citing works
The Formation of Cooperative Cell Assemblies in the Visual Cortex
Singer, W. (1991) · Springer series in synergetics · doi:10.1007/978-3-642-84301-3_8 · Cited by 130 · see citing works
Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: Memory impairments depend on familiarity with the environment, drug dose, and training duration.
Caramanos, Z., & Shapiro, M. L. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.30 · Cited by 128 · see citing works
Do NMDA receptors have a critical function in visual cortical plasticity?
Fox, K. D., & Daw, N. W. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90136-a · Cited by 127 · see citing works
Self-citation
High-Fidelity Transmission Acquired via a Developmental Decrease in NMDA Receptor Expression at an Auditory Synapse
Futai, K., Okada, M., Matsuyama, K., & Takahashi, T. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03342.2001 · Cited by 126 · see citing works
Temporal Correlations between Functional and Molecular Changes in NMDA Receptors and GABA Neurotransmission in the Superior Colliculus
Shi, J., Aamodt, S. M., & Constantine‐Paton, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-16-06264.1997 · Cited by 122 · see citing works
Two-Stage, Input-Specific Synaptic Maturation in a Nucleus Essential for Vocal Production in the Zebra Finch
Stark, L. L., & Perkel, D. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-09107.1999 · Cited by 120 · see citing works
The formation of cooperative cell assemblies in the visual cortex
Singer, W. (1990) · Journal of Experimental Biology · doi:10.1242/jeb.153.1.177 · Cited by 123 · see citing works
NMDA and non-NMDA receptors contribute to synaptic transmission between the medial geniculate body and the lateral nucleus of the amygdala
Li, X., Phillips, R. G., & LeDoux, J. E. (1995) · Experimental Brain Research · doi:10.1007/bf00242185 · Cited by 118 · see citing works
Activity Dependence of Cortical Axon Branch Formation: A Morphological and Electrophysiological Study Using Organotypic Slice Cultures
Uesaka, N., Hirai, S., Maruyama, T., Ruthazer, E. S., & Yamamoto, N. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3855-04.2005 · Cited by 113 · see citing works
Decline of the Critical Period of Visual Plasticity Is Concurrent with the Reduction of NR2B Subunit of the Synaptic NMDA Receptor in Layer 4
Erisir, A., & Harris, J. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05208.2003 · Cited by 111 · see citing works
Mechanisms underlying orientation selectivity of neurons in the primary visual cortex of the macaque.
Sato, H., Katsuyama, N., Tamura, H., Hata, Y., & Tsumoto, T. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021530 · Cited by 112 · see citing works
Self-citation
Forward and backward connections in the brain: a DCM study of functional asymmetries
Chen, C. C., Henson, R. N., Stephan, K. E., Kilner, J. M., & Friston, K. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.041 · Cited by 109 · see citing works
Experience-Dependent Plasticity and the Maturation of Glutamatergic Synapses
Feldman, D. E., & Knudsen, E. I. (1998) · Neuron · doi:10.1016/s0896-6273(00)80488-2 · Cited by 108 · see citing works
Dark-rearing delays the loss of NMDA-receptor function in kitten visual cortex
Fox, K. D., Daw, N. W., Sato, H., & Czepita, D. (1991) · Nature · doi:10.1038/350342a0 · Cited by 108 · see citing works
Self-citation
The effect of visual experience on development of NMDA receptor synaptic transmission in kitten visual cortex
Fox, K. D., Daw, N. W., Sato, H., & Czepita, D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02672.1992 · Cited by 107 · see citing works
Self-citation
Learning and memory
Alkon, D. L., Amaral, D. G., Bear, M. F., Black, J., Carew, T. J., Cohen, N. J., Disterhoft, J. F., Eichenbaum, H., Golski, S., Gorman, L. K., et al. (1991) · Brain Research Reviews · doi:10.1016/0165-0173(91)90005-s · Cited by 212 · see citing works
Evidence for the Hebbian hypothesis in experience-dependent physiological plasticity of neocortex: a critical review
Cruikshank, S. J., & Weinberger, N. M. (1996) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00015-x · Cited by 102 · see citing works
Enhanced activation of NMDA receptor responses at the immature retinogeniculate synapse
Ramoa, A., & McCormick, D. A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02098.1994 · Cited by 101 · see citing works
Activity-Dependent Regulation of NMDAR1 Immunoreactivity in the Developing Visual Cortex
Catalano, S. M., Chang, C. K., & Shatz, C. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08376.1997 · Cited by 98 · see citing works
LTP, NMDA, genes and learning
Cain, D. P. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80012-8 · Cited by 97 · see citing works
Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramidal cells
Bowe, M. A., & Nadler, J. V. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90164-t · Cited by 97 · see citing works
Different Roles for Simple-Cell and Complex-Cell Inhibition in V1
Lauritzen, T. Z., & Miller, K. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10201.2003 · Cited by 94 · see citing works
Suppression of Cortical NMDA Receptor Function Prevents Development of Orientation Selectivity in the Primary Visual Cortex
Ramoa, A. S., Mower, A. F., Liao, D. S., & Jafri, S. I. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04299.2001 · Cited by 82 · see citing works
Neuronal and glial localization of NMDA receptors in the cerebral cortex
Conti, F., Minelli, A., Debiasi, S., & Melone, M. (1997) · Molecular Neurobiology · doi:10.1007/bf02740618 · Cited by 86 · see citing works
Developmental changes in the expression of NMDA receptor subunits (NR1, NR2A, NR2B) in the cat visual cortex and the effects of dark rearing
Chen, L., Cooper, N. G. F., & Mower, G. D. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00076-0 · Cited by 86 · see citing works
Activity-dependent remodeling of connections in the mammalian visual system
Cramer, K. S. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80094-8 · Cited by 86 · see citing works
The drugs don’t work—or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory
Bannerman, D. M., Rawlins, J. N. P., & Good, M. A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0403-6 · Cited by 83 · see citing works
Pre- and postnatal development of GABA receptors in Macaca monkey visual cortex
Shaw, C., Cameron, L., March, D., Cynader, M., Zielinski, B. S., & Hendrickson, A. E. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-12-03943.1991 · Cited by 81 · see citing works
Effects of Neurotrophins on Cortical Plasticity: Same or Different?
Lodovichi, C., Berardi, N., Pizzorusso, T., & Maffei, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02155.2000 · Cited by 79 · see citing works
NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus
Kwon, Y. H., Esguerra, M., & Sur, M. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.2.414 · Cited by 79 · see citing works
Newly Learned Auditory Responses Mediated by NMDA Receptors in the Owl Inferior Colliculus
Feldman, D. E., Brainard, M. S., & Knudsen, E. I. (1996) · Science · doi:10.1126/science.271.5248.525 · Cited by 78 · see citing works
Actions of excitatory amino acid antagonists on synaptic potentials of layer II/III neurons of the cat's visual cortex
Shirokawa, T., Nishigori, A., Kimura, F., & Tsumoto, T. (1989) · Experimental Brain Research · doi:10.1007/bf00230237 · Cited by 78 · see citing works
Evidence for Cross-Modal Plasticity in Adult Mouse Visual Cortex Following Monocular Enucleation
Brussel, L. V., Gerits, A., & Arckens, L. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq286 · Cited by 77 · see citing works
NMDA receptor modification in the fetal guinea pig brain during hypoxia
Mishra, O. P., & Delivoria‐Papadopoulos, M. (1992) · Neurochemical Research · doi:10.1007/bf00968402 · Cited by 73 · see citing works
Injection of MK-801 Affects Ocular Dominance Shifts More Than Visual Activity
Daw, N. W., Gordon, B., Fox, K. D., Flavin, H. J., Kirsch, J., Beaver, C. J., Ji, Q.-H., Reid, S. N. M., & Czepita, D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.1.204 · Cited by 70 · see citing works
Self-citation
Birth, migration, incorporation, and death of vocal control neurons in adult songbirds
Álvarez-Buylla, A., & Kirn, J. R. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19971105)33:5 · Cited by 208 · see citing works
Nerve growth factor-induced ocular dominance plasticity in adult cat visual cortex.
Gu, Q., Liu, Y., & Cynader, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8408 · Cited by 69 · see citing works
N-methyl-d-aspartate receptor mediated component of field potentials evoked in horizontal pathways of rat motor cortex
Hess, G., Jacobs, K. M., & Donoghue, J. P. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90226-7 · Cited by 70 · see citing works
NMDA-receptor antagonists disrupt the formation of the auditory space map in the mammalian superior colliculus
Schnupp, J. W. H., King, A. J., Smith, A. L., & Thompson, I. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01516.1995 · Cited by 70 · see citing works
Calcium, network activity, and the role of NMDA channels in synaptic plasticity in vitro
Fields, R. D., Yu, C., & Nelson, P. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-01-00134.1991 · Cited by 70 · see citing works
Experience-dependent homeostatic synaptic plasticity in neocortex
Whitt, J. L., Petrus, E., & Lee, H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.016 · Cited by 66 · see citing works
The Role of Cortical Activity in Experience-Dependent Potentiation and Depression of Sensory Responses in Rat Barrel Cortex
Wallace, H., Glazewski, S., Liming, K., & Fox, K. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03881.2001 · Cited by 68 · see citing works
Self-citation
Critical period control in sensory cortex
Fox, K. D., & Zahs, K. R. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90040-x · Cited by 67 · see citing works
Self-citation
Segregation of geniculocortical afferents during the critical period: a role for subplate neurons
Ghosh, A., & Shatz, C. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03862.1994 · Cited by 66 · see citing works
Mechanisms of Plasticity in the Visual Cortex
Daw, N. W. (1995) · Springer eBooks · doi:10.1007/978-1-4757-6940-1_12 · Cited by 64 · see citing works
Self-citation

The location and function of NMDA receptors in cat and kitten visual cortex. J Neurosci 9:2443–2454
Fox, K., Sato, H., & Daw, N. W. (1989)
Self-citation
The development of receptors in cat visual cortex
Bode-Greuel, K. M., & Singer, W. (1989) · Developmental Brain Research · doi:10.1016/0165-3806(89)90283-6 · Cited by 130 · see citing works
Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing
Binns, K. E., & Salt, T. E. (1998) · Experimental Brain Research · doi:10.1007/s002210050407 · Cited by 24 · see citing works
Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.
Miller, K. D., Chapman, B., & Stryker, M. P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5183 · Cited by 181 · see citing works
Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex
Carmignoto, G., & Vicini, S. (1992) · Science · doi:10.1126/science.1279803 · Cited by 716 · see citing works

Authors: Fox, K., Sato, H., & Daw, N.
Affiliations: Washington University in St. Louis (US)
ORCID: Fox, K
Sato, H
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1989-07-01
Volume: 9
Issue: 7
Pages: 2443-2454
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.09-07-02443.1989
PMC: PMC6569778
OpenAlex: W2166938907
Cited by: 307
References: 41
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 4
FWCI: 9.22
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (EY-00053)
National Institute of Neurological Disorders and Stroke (NS18070)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: NMDA receptor, visual cortex, kitten development, D-APV, visual responses, spontaneous activity, cortical layers, synaptic plasticity, cats
MeSH terms: Aging, Animals, Cats, Dose-Response Relationship, Drug, Neurons, Tissue Distribution, Valine, Visual Cortex, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The location and function of NMDA receptors in cat and kitten visual cortex

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks