Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters

Yuste, Rafael; Katz, Lawrence C.

doi:10.1016/0896-6273(91)90243-s

Cited by 591Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNeural dynamics and brain function

Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters

Yuste, Rafael, Katz, Lawrence C.·1991·Neuron

DOI 10.1016/0896-6273(91)90243-s

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Abstract

We assessed the pathways by which excitatory and inhibitory neurotransmitters elicit postsynaptic changes in [Ca2+]i in brain slices of developing rat and cat neocortex, using fura 2. Glutamate, NMDA, and quisqualate transiently elevated [Ca2%]i in all neurons. While the quisqualate response relied exclusively on voltage-gated Ca2+ channels, almost all of the NMDA-induced Ca2+ influx was via the NMDA ionophore itself, rather than through voltage-gated Ca2+ channels. Glutamate itself altered [Ca2+]i almost exclusively via the NMDA receptor. Furthermore, synaptically induced Ca2+ entry relied almost completely on NMDA receptor activation, even with low-frequency stimulation. The inhibitory neurotransmitter GABA also increased [Ca2+]i, probably via voltage-sensitive Ca2+ channels, whereas the neuromodulator acetylcholine caused Ca2+ release from intracellular stores via a muscarinic receptor. Low concentrations of these agonists produced nonperiodic [Ca2+]i oscillations, which were temporally correlated in neighbouring cells. Optical recording with Ca2(+)-sensitive indicators may thus permit the visualization of functional networks in developing cortical circuits.

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Authors: Yuste, R., & Katz, L. C.
Affiliations: Rockefeller University (US)
ORCID: Yuste, Rafael
Venue: Neuron
Publisher: Elsevier BV
Published: 1991-03
Volume: 6
Issue: 3
Pages: 333-344
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(91)90243-s
OpenAlex: W1973108213
Cited by: 591
References: 56
Citations by year: 2026: 3 · 2025: 4 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 16 · 2019: 11 · 2018: 9 · 2017: 11 · 2016: 6 · 2015: 14 · 2014: 7 · 2013: 12 · 2012: 10
FWCI: 8.23
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: neocortex development, glutamate, NMDA receptor, quisqualate, GABA, acetylcholine, muscarinic receptors, voltage-gated calcium channels, intracellular calcium stores, calcium oscillations, cortical circuits, excitatory and inhibitory neurotransmitters
MeSH terms: Acetylcholine, Animals, Biological Transport, Active, Calcium, Carbachol, Cats, Cerebral Cortex, gamma-Aminobutyric Acid, Glutamates, Neurons, Calcium Channels, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Quisqualic Acid, Neurotransmitter Agents, Glutamic Acid, Rats

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Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters

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