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IQGAP1 Regulates NR2A Signaling, Spine Density, and Cognitive Processes

Gao, C., Frausto, S. F., Guedea, A. L., Tronson, N. C., Jovasevic, V., Leaderbrand, K., Corcoran, K. A., Guzman, Y. F., Swanson, G. T., Radulovic, J.·2011·Journal of Neuroscience
DOI 10.1523/jneurosci.1300-11.2011PMC PMC3121195
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Crossref · 10.1523/jneurosci.1300-11.2011

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  • Iqgap1, Iqgap2, Iqsec2, Kalirin, and Trio are localized in dendritic spines of hippocampal neurons and enriched in PSD fractions of the mouse hippocampus.

    “Iqgap1, Iqgap2, Iqsec2, Kalirin, and Trio are localized in dendritic spines of hippocampal neurons (Figure S3A) and enriched in PSD fractions of the mouse hippocampus (Figure S3B)”

    From Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies (2018) · cites this paper as Gao et al., 2011

    The Results section reports that IQGAP1 is present in hippocampal neuronal processes and that its loss reduces dendritic spine density. The Discussion identifies IQGAP1 in complexes with PSD-95, but neither passage establishes localization within spines or enrichment in mouse hippocampal PSD fractions. The paper does not establish those claims for IQGAP2, IQSEC2, Kalirin, or Trio either. Page numbers were not available in our copy. (LLM, conf=0.87)

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Metadata

Authors
Gao, C., Frausto, S. F., Guedea, A. L., Tronson, N. C., Jovasevic, V., Leaderbrand, K., Corcoran, K. A., Guzman, Y. F., Swanson, G. T., & Radulovic, J.
Venue
Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2011-06-08
Volume
31
Issue
23
Pages
8533-8542
ISSN
  • 0270-6474
  • 1529-2401
DOI
10.1523/jneurosci.1300-11.2011
PMC
PMC3121195
Cited by
85
References
6
Language
en

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