Hippocampal and prefrontal dopamine D1/5 receptor involvement in the memory-enhancing effect of reboxetine
Abstract
Dopamine modulates cognitive functions through regulation of synaptic transmission and plasticity in the hippocampus and prefrontal cortex (PFC). Thus, dopamine dysfunction in depression may be particularly relevant for the cognitive symptoms. The norepinephrine transporter inhibitor reboxetine facilitates memory processing in both healthy volunteers and in depressed patients and increases dopamine release in both the hippocampus and PFC. We investigated the potential involvement of the hippocampal and PFC dopamine D1/5 receptors in the cognitive effects of reboxetine using the object recognition test in rats. Infusion of the D1/5 antagonist SCH23390 into the dorsal hippocampus or medial PFC prior to the exploration of the objects impaired memory. Conversely, infusion of the D1/5 agonist SKF81297 into the dorsal hippocampus or medial PFC facilitated memory. Reboxetine similarly facilitated recognition memory in healthy rats and the D1/5 antagonist SCH23390 reversed this effect when infused into the dorsal PFC, but not when infused into the hippocampus. Moreover, systemic reboxetine increased the levels of the NMDA subunit GluN2A in the PFC but not in the hippocampus. Finally, we demonstrate that a single dose of reboxetine does not affect immobility in the forced swim test but improves recognition memory in the Flinders sensitive line (FSL) rat model for depression. The present data in rats are in line with effects of reboxetine on memory formation in healthy volunteers and depressed patients and indicate the involvement of PFC dopamine D1/5 receptors.
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Microinjections of SCH23390 into the PFC, but not into the hippocampus, block the facilitating effects of systemic reboxetine on long-term NOP.
“Microinjections of SCH23390 into the PFC, but not into the hippocampus, also blocked the facilitating effects of systemic reboxetine, a norepinephrine (NE) reuptake inhibitor, on the performance of long-term NOP (De Bundel et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as De Bundel et al., 2013
Pre-sample microinjections into the mPFC of the DA D1/5-R agonist SKF81297 facilitate, and its antagonist SCH23390 disrupt, NOP memory tested 24 hours later.
“When administrated prior to the sample trial, microinjections into the mPFC of the DA D1/5-R agonist SKF81297 facilitated, and its antagonist SCH23390 disrupted, NOP memory tested 24 hours later (De Bundel et al., 2013; Nagai et al., 2007).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as De Bundel et al., 2013
Pre-sample hippocampal infusion of SCH23390, a D1/5-R antagonist, impaired long-term NOP memory.
“while that of SCH23390, a D1/5-R antagonist, impaired it”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as De Bundel et al., 2013
Pre-sample hippocampal infusion of the DA D1/5-R agonist SKF81297 improved long-term (24 hours interval) NOP memory.
“Pre-sample hippocampal infusion of the DA D1/5-R agonist SKF81297 improved long-term (24 hours interval) NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as De Bundel et al., 2013
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- Authors
- De Bundel, D., Femenía, T., DuPont, C. M., Konradsson-Geuken, Å., Feltmann, K., Schilström, B., & Lindskog, M.
- Affiliations
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
- Karolinska Institutet (SE)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
- Corresponding author
- Lindskog, Maria
- Venue
- International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-10-01
- Volume
- 16
- Issue
- 9
- Pages
- 2041-2051
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2060835688
- Cited by
- 37
- References
- 58
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 3 · 2015: 3 · 2014: 2 · 2013: 3
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Gunvor och Josef Anérs Siftelse
- Svenska Läkaresällskapet
- Socialstyrelsen
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- reboxetine, hippocampus, prefrontal cortex, recognition memory, norepinephrine transporter inhibitor, depression, Flinders Sensitive Line rats, GluN2A, NMDA receptor subunits, SCH 23390, SKF 81297, forced swim test, cognitive symptoms of depression
- MeSH terms
- Reboxetine, Animals, Antidepressive Agents, Behavior, Animal, Cognition, Depression, Disease Models, Animal, Hippocampus, Male, Morpholines, Motor Activity, Swimming, Time Factors, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Dopamine D1, Dopamine Agonists, Dopamine Antagonists, Nootropic Agents, Adrenergic Uptake Inhibitors, Recognition, Psychology, Receptors, Dopamine D5, Rats
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