The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Stabilization of α-Synuclein Protein with Aging and Familial Parkinson's Disease-Linked A53T Mutation
Open accessAbstract
We examined the potential relationship between aging and α-synuclein (α-Syn) metabolism, both of which are implicated in the pathogenesis of Parkinson's disease (PD) and otherα-synucleinopathies. During aging,α-Syn and β-Syn mRNA expression in brain decreases, but the protein levels are maintained at high levels. Significantly, the α-Syn protein level increases with aging in human substantia nigra. Pulse-chase analyses of α-Syn half-lives in neurons and neuronal cell lines indicate that, in mature neurons, the expression of α-Syn is regulated by the post-translational stabilization of α-Syn protein. Moreover, A53T mutant human α-Syn exhibits increased stability in neuronal cell lines, leading to higher levels of the mutant protein in cells and transgenic mice. Inhibitor studies suggest that the proteasomal and lysosomal systems may not be responsible for the differential stabilization or metabolism of α-Syn protein in neuronal cells. Because increased stabilization of α-Syn protein is associated with increased protein levels and accumulation of pathogenic protein modifications, such as oxidative damage, the stabilization of α-Syn with aging may be a significant factor in the pathogenesis of α-synucleinopathies.
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Cites
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
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Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
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α-Synuclein Is Degraded by Both Autophagy and the Proteasome
Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., & Rubinsztein, D. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300227200 · Cited by 1,429
A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis
Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., & Zigmond, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03090.2002 · Cited by 598
Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway
Lee, H.-J., Khoshaghideh, F., Patel, S., & Lee, S.-J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3809-03.2004 · Cited by 445
Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions
Hasegawa, M., Fujiwara, H., Nonaka, T., Wakabayashi, K., Takahashi, H., Lee, V. M.-Y., Trojanowski, J. Q., Mann, D., & Iwatsubo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208046200 · Cited by 428
Degradation of α-Synuclein by Proteasome
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Cited by
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
Wong, Y. C., & Krainc, D. (2017) · Nature Medicine · doi:10.1038/nm.4269 · Cited by 897
Bendor, J. T., Logan, T. P., & Edwards, R. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.004 · Cited by 825
Martin, L. J., Pan, Y., Price, A. C., Sterling, W., Copeland, N. G., Jenkins, N. A., Price, D. L., & Lee, M. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4308-05.2006 · Cited by 684
Self-citationChu, Y., & Kordower, J. H. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.021 · Cited by 396
Parkinson’s disease as a result of aging
Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214
Metadata
- Authors
- Li, W., Lesuisse, C., Xu, Y., Troncoso, J. C., Price, D. L., & Lee, M. K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-08-18
- Volume
- 24
- Issue
- 33
- Pages
- 7400-7409
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2037460022
- Cited by
- 178
- References
- 7
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Li, W., Lesuisse, C., Xu, Y., Troncoso, J. C., Price, D. L., & Lee, M. K. (2004). Stabilization of α-Synuclein Protein with Aging and Familial Parkinson's Disease-Linked A53T Mutation. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1370-04.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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