The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Induction of interleukin-6 in axotomized sensory neurons
Open accessAbstract
RNA from rat dorsal root ganglia was analyzed in search of potentially beneficial cytokines that are induced in dorsal root ganglia by nerve injury. By reverse transcription, the PCR, and Southern blotting, interleukin-6 mRNA was detected during development but not in normal adult dorsal root ganglia, reappeared within 1 d of sciatic nerve transection, was maximally increased after 2 and 4 d, and decreased below the threshold of detection within 1 week. By RNase protection assay, interleukin-6 mRNA was consistently present in RNA from dorsal root ganglia removed from rats 4 d following transection but not in control dorsal root ganglia. Interleukin-6 bioactivity was also present in dorsal root ganglia following nerve injury. By in situ hybridization, interleukin-6 mRNA was localized within large and medium- sized axotomized neurons. In summary, some sensory neurons respond to axotomy with a brisk transient increase in synthesis of interleukin-6. Injury to the sciatic nerve also induced mRNAs for interleukin-1 beta and tumor necrosis factor-alpha in dorsal root ganglia. The inductions of interleukin-1 beta and tumor necrosis factor-alpha mRNAs were later and more sustained than that of interleukin-6 mRNA. The cellular sources of these two cytokines have not been defined.
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Cited by
The induction of pain: an integrative review
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Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States
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Inflammation and neurodegenerative diseases
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Metadata
- Authors
- Murphy, P., Grondin, J., Altares, M., & Richardson, P.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1995-07-01
- Volume
- 15
- Issue
- 7
- Pages
- 5130-5138
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1646647792
- Cited by
- 273
- References
- 60
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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